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| 1 | Overview of macroautophagy regulation in mammalian cells显示文摘Macroautophagy 是 multistep, vacuolar,在 lysosomal 分隔空间终止的降级小径,和它具有在织物动态平衡的基本重要性。在这评论,我们在我们 autophagosomes 的形成的理解根据最近的进展考虑 macroautophagy,它是扣押的 double-membrane-bound 液泡细胞质的货物并且把他们送到 lysosomes。在大多数情况中,这最后的步被成熟步在哪个 autophagosomes 与 endocytic 小径交往期间先于。AuTophaGy 相关的基因的发现极大地关于为 autophagosome 形成负责的机制增加了我们的知识,并且也在 autophagosome 成熟的分子的方面的理解有进步。最后,因为 Atg 建筑群的活动被蛋白质 kinases 指向的发现, autophagy 的规定现在更好被理解,并且由于经由在调整 autophagy 基因的表示的抄写因素的原子规定的重要性。 | Maryam Mehrpour | 2010 | Cell Research2010，20，7： | 66 |
| 2 | 知识管理和知识管理系统:概念基础和研究课题显示文摘知识是一个广泛而抽象的概念——早在古希腊时代,西方哲学已经使用这一概念来界定认识论上的争议。然而,在最近的几年,越来越多的学者倾向于将知识视为一种重要的组织资源。信息系统研究人员顺应了组织知识和知识管理的发展趋势,在信息系统的基础上发展出了知识管理系统(KMS)。知识管理系统的目标是支持组织中知识的创造、转移和应用。知识和知识管理是复杂多面的概念,因此,从已有的丰富文献中,挖掘并找到知识管理的理论基础,这将对知识管理系统的有效开发和应用提供支撑。更确切地说,知识管理系统应该以相关领域现有的重要文献为基础展开研究。本文回顾并解释了不同领域中有关知识管理的理论文献,同时确定了重要的研究领域。我们提出了一个详细的组织知识管理的过程观点,并重点关注了信息技术在知识管理过程中的潜在作用。依据文献回顾和知识管理过程的分析,我们围绕知识管理过程和信息技术在该过程中的支持作用讨论几个重要的研究课题。 | Maryam Alavi Dorothy E. Leidner 郑文全(译) | 2012 | 管理世界2012，28，5： | 68 |
| 3 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 4 | Association between heat stress and oxidative stress in poultry;mitochondrial dysfunction and dietary interventions with phytochemicals显示文摘Heat as a stressor of poultry has been studied extensively for many decades; it affects poultry production on a worldwide basis and has significant impact on well-being and production. More recently, the involvement of heat stress in inducing oxidative stress has received much interest. Oxidative stress is defined as the presence of reactive species in excess of the available antioxidant capacity of animal cells. Reactive species can modify several biologically cellular macromolecules and can interfere with cell signaling pathways. Furthermore, during the last decade, there has been an ever-increasing interest in the use of a wide array of natural feed-delivered phytochemicals that have potential antioxidant properties for poultry. In light of this, the current review aims to(1) summarize the mechanisms through which heat stress triggers excessive superoxide radical production in the mitochondrion and progresses into oxidative stress,(2) illustrate that this pathophysiology is dependent on the intensity and duration of heat stress,(3) present different nutritional strategies for mitigation of mitochondrial dysfunction, with particular focus on antioxidant phytochemicals.Oxidative stress that occurs with heat exposure can be manifest in all parts of the body; however, mitochondrial dysfunction underlies oxidative stress. In the initial phase of acute heat stress, mitochondrial substrate oxidation and electron transport chain activity are increased resulting in excessive superoxide production. During the later stage of acute heat stress, down-regulation of avian uncoupling protein worsens the oxidative stress situation causing mitochondrial dysfunction and tissue damage. Typically, antioxidant enzyme activities are upregulated. Chronic heat stress, however, leads to downsizing of mitochondrial metabolic oxidative capacity, up-regulation of avian uncoupling protein, a clear alteration in the pattern of antioxidant enzyme activities, and depletion of antioxidant reserves.Some phytochemicals, such as various types of flavonoids and related compounds, were shown to be beneficial in chronic heat-stressed poultry, but were less or not effective in non-heat-stressed counterparts. This supports the contention that antioxidant phytochemicals have potential under challenging conditions. Though substantial progress has been made in our understanding of the association between heat stress and oxidative stress, the means by which phytochemicals can alleviate oxidative stress have been sparsely explored. | Abdollah Akbarian Joris Michiels Jeroen Degroote Maryam Majdeddin Abolghasem Golian Stefaan De Smet | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 21 |
| 5 | Insulin-like growth factor(IGF)signaling in tumorigenesis and the development of cancer drug resistance显示文摘One of the greatest obstacles to current cancer treatment efforts is the development of drug resistance by tumors.Despite recent advances in diagnostic practices and surgical interventions,many neoplasms demonstrate poor response to adjuvant or neoadjuvant radiation and chemotherapy.As a result,the prognosis for many patients afflicted with these aggressive cancers remains bleak.The insulin-like growth factor(IGF)signaling axis has been shown to play critical role in the development and progression of various tumors.Many basic science and translational studies have shown that IGF pathway modulators can have promising effects when used to treat various malignancies.There also exists a substantial body of recent evidence implicating IGF signaling dysregulation in the dwindling response of tumors to current standard-of-care therapy.By better understanding both the IGF-dependent and-independent mechanisms by which pathway members can influence drug sensitivity,we can eventually aim to use modulators of IGF signaling to augment the effects of current therapy.This review summarizes and synthesizes numerous recent investigations looking at the role of the IGF pathway in drug resistance.We offer a brief overview of IGF signaling and its general role in neoplasia,and then delve into detail about the many types of human cancer that have been shown to have IGF pathway involvement in resistance and/or sensitization to therapy.Ultimately,our hope is that such a compilation of evidence will compel investigators to carry out much needed studies looking at combination treatment with IGF signaling modulators to overcome current therapy resistance. | Sahitya K.Denduluri Olumuyiwa Idowu Zhongliang Wang Zhan Liao Zhengjian Yan Maryam K.Mohammed Jixing Ye Qiang Wei Jing Wang Lianggong Zhao Hue H.Luu | 2015 | Genes & Diseases2015，2，1： | 21 |
| 6 | Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance显示文摘AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients. | Kamran Ghaffarzadehgan Mostafa Jafarzadeh Hamid Reza Raziee Hamid Reza Sima Ehsan Esmaili-Shandiz Hanieh Hosseinnezhad Ali Taghizadeh Kermani Omeed Moaven Maryam Bahrani | 2008 | World Journal of Gastroenterology2008，14，41： | 18 |
| 7 | Crop photosynthetic response to light quality and light intensity显示文摘Under natural conditions, plants constantly encounter various biotic and abiotic factors, which can potentially restrict plant growth and development and even limit crop productivity. Among various abiotic factors affecting plant photosynthesis, light serves as an important factor that drives carbon metabolism in plants and supports life on earth. The two components of light(light quality and light intensity) greatly affect plant photosynthesis and other plant's morphological, physiological and biochemical parameters. The response of plants to different spectral radiations and intensities differs in various species and also depends on growing conditions. To date, much research has been conducted regarding how different spectral radiations of varying intensity can affect plant growth and development. This review is an effort to briefly summarize the available information on the effects of light components on various plant parameters such as stem and leaf morphology and anatomy, stomatal development, photosynthetic apparatus, pigment composition, reactive oxygen species(ROS) production, antioxidants, and hormone production. | Iram SHAFIQ Sajad HUSSAIN Muhammad Ali RAZA Nasir IQBAL Muhammad Ahsan ASGHAR Ali RAZA FAN Yuan-fang Maryam MUMTAZ Muhammad SHOAIB Muhammad ANSAR Abdul MANAF YANG Wen-yu YANG Feng | 2021 | Journal of Integrative Agriculture2021，20，1： | 16 |
| 8 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 9 | Systematic review and meta-analysis of colon cleansing preparations in patients with inflammatory bowel disease显示文摘AIM To performed a systematic review and meta-analysis to determine any possible differences in terms of effectiveness, safety and tolerability between existing colon-cleansing products in patients with inflammatory bowel disease.METHODS Systematic searches were performed( January 1980-September 2016) using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials assessing preparations with or without adjuvants, given in split and non-split dosing, and in high(> 3 L) or low-volume(2 L or less) regimens. Bowel cleansing quality was the primary outcome. Secondary outcomes included patient willingness-torepeat the procedure and side effects/complications.RESULTS Out of 439 citations, 4 trials fulfilled our inclusion criteria(n = 449 patients). One trial assessed the impact of adding simethicone to polyethylene glycol(PEG) 4 L with no effect on bowel cleansing quality, but a better tolerance. Another trial compared senna to castor oil, again without any differences in term of bowel cleansing. Two trials compared the efficacy of PEG high-volume vs PEG low-volume associated to an adjuvant in split-dose regimens: PEG low-dose efficacy was not different to PEG high-dose; OR = 0.84(0.37-1.92). A higher proportion of patients were willing to repeat low-volume preparations vs high-volume; OR = 5.11(1.31-20.0). CONCLUSION In inflammatory bowel disease population, PEG lowvolume regimen seems not inferior to PEG high-volume to clean the colon, and yields improved willingness-torepeat. Further additional research is urgently required to compare contemporary products in this population. | Sophie Restellini Omar Kherad Talat Bessissow Charles Ménard Myriam Martel Maryam Taheri Tanjani Peter L Lakatos Alan N Barkun | 2017 | World Journal of Gastroenterology2017，23，32： | 16 |
| 10 | Osteoporosis:A Silent Disease with Complex Genetic Contribution显示文摘Osteoporosis is the most common multifactorial metabolic bone disorder worldwide with a strong genetic component. In this review, the evidence for a genetic contribution to osteoporosis and related phenotypes is summarized alongside with methods used to identify osteoporosis susceptibility genes. The key biological pathways involved in the skeleton and bone development are discussed with a particular focus on master genes clustered in these pathways and their mode of action. Furthermore, the most studied single nucleotide polymorphisms(SNPs) analyzed for their importance as genetic markers of the disease are presented. New data generated by nextgeneration sequencing in conjunction with extensive meta-analyses should contribute to a better understanding of the genetic basis of osteoporosis and related phenotype variability. These data could be ultimately used for identifying at-risk patients for disease prevention by both controlling environmental factors and providing possible therapeutic targets. | Maryam Marl Golchin Laleh Heidari Seyyed Mohammad Hossein Ghaderian Haleh Akhavan-Niaki | 2016 | Journal of Genetics and Genomics2016，43，2： | 15 |
| 11 | 利用力学试验和热加工图分析近α钛合金的热加工行为显示文摘利用热加工图对具有针状初始组织的Ti-5.7Al-2.1Sn-3.9Zr-2Mo-0.1Si (Ti-6242S)合金的热变形特征进行分析。单轴热压缩试验的温度为850~1000℃,应变速率为0.001~1 s-1。用热加工图确定合金的安全和不安全变形条件;利用扫描电镜(SEM)和光学显微镜(OM)分析合金的显微组织演变过程。研究发现,与在较低温度下变形相比,在1000℃下变形后合金在流动软化行为中的流动应力存在差异,这是由于显微组织发生变化。在950℃和0.001 s-1条件下变形,应变为0.7的两相区加工图表现出较高的功率耗散效率,约为55%,主要是由于发生大量球化。随着应变速率的增加和温度的降低,片层α相的球化减少,而扭折增加;最终,流动行为的失稳区发生在温度为850~900℃、应变速率高于0.01 s-1的条件下,其主要机制为局部流动和绝热剪切。综合考虑功率耗散效率和显微组织,理想的变形条件为:变形温度950~1000℃、应变速率0.001~0.01 s-1。该合金的最佳变形条件为:950℃,0.001 s-1。 | Maryam MORAKABATI Alireza HAJARI | 2020 | Transactions of Nonferrous Metals Society of China2020，30，6： | 13 |
| 12 | Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials显示文摘Hepatocellular carcinoma(HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancerrelated death. The difficulty to diagnose early cancer stages, the aggressive behaviors of HCC, and the poor effectiveness of therapeutic treatments, represent the reasons for the quite similar deaths per year and incidence number. Considering the fact that the diagnosis of HCC typically occurs in the advanced stages of the disease when the therapeutic options have only modest efficacy, the possibility to identify early diagnostic markers could be of significant benefit. So far, a large number of biomarkers have been associated to HCC progression and aggressiveness, but many of them turned out not to be of practical utility. This is the reason why active investigations are ongoing in this field. Given the huge amount of published works aimed at the identification of HCC biomarkers, in this review we mainly focused on the data published in the last year, with particular attention to the role of(1) molecular and biochemical cellular markers;(2) micro-interfering RNAs;(3) epigenetic variations; and(4) tumor stroma. It is worth mentioning that a significant number of the HCC markers described in the present review may be utilized also as targets for novel therapeutic approaches, indicating the tight relation between diagnosis and therapy. In conclusion, we believe that integrated researches among the different lines of investigation indicated above should represent the winning strategies to identify effective HCC markers and therapeutic targets. | Bruna Scaggiante Maryam Kazemi Gabriele Pozzato Barbara Dapas Rosella Farra Mario Grassi Fabrizio Zanconati Gabriele Grassi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 13 | Synthesis of linear low-density polyethylene-g-poly(acrylic acid)-co-starch/organo-montmorillonite hydrogel composite as an adsorbent for removal of Pb(Ⅱ) from aqueous solutions显示文摘The purpose of this work is to remove Pb(II) from the aqueous solution using a type of hydrogel composite. A hydrogel composite consisting of waste linear low density polyethylene, acrylic acid, starch, and organo-montmorillonite was prepared through emulsion polymerization method. Fourier transform infrared spectroscopy(FTIR), Solid carbon nuclear magnetic resonance spectroscopy(CNMR)), silicon-29 nuclear magnetic resonance spectroscopy(Si NMR)), and X-ray diffraction spectroscope((XRD) were applied to characterize the hydrogel composite. The hydrogel composite was then employed as an adsorbent for the removal of Pb(II) from the aqueous solution. The Pb(II)-loaded hydrogel composite was characterized using Fourier transform infrared spectroscopy(FTIR)),scanning electron microscopy(SEM)), and X-ray photoelectron spectroscopy((XPS)). From XPS results, it was found that the carboxyl and hydroxyl groups of the hydrogel composite participated in the removal of Pb(II). Kinetic studies indicated that the adsorption of Pb(II)followed the pseudo-second-order equation. It was also found that the Langmuir model described the adsorption isotherm better than the Freundlich isotherm. The maximum removal capacity of the hydrogel composite for Pb(II) ions was 430 mg/g. Thus, the waste linear low-density polyethylene-g-poly(acrylic acid)-co-starch/organo-montmorillonite hydrogel composite could be a promising Pb(II) adsorbent. | Maryam Irani Hanafi Ismail Zulkifli Ahmad Maohong Fan | 2015 | Journal of Environmental Sciences2015，27，1： | 11 |
| 14 | Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the 5th most common malignancy which is responsible for more than half million annual mortalities; also, it is the third leading cause of cancer related death. Unfavorablesystemic side-effects of chemotherapeutic agents and susceptibility to the degradation of small interfering RNAs(si RNAs), which can knock down a specific gene involved in the disease, have hampered their clinical application. So, it could be beneficial to develop an efficient carrier for the stabilization and specific delivery of drugs and si RNA to cells. Targeted nanoparticles have gained considerable attention as an efficient drug and gene delivery system, which is due to their capability in achieving the highest accumulation of cytotoxic agents in tumor tissue, modifiable drug pharmacokinetic- and bio-distribution, improved effectiveness of treatment, and limited sideeffects. Recent studies have shed more light on the advantages of novel drug loaded carrier systems vs free drugs. Most of the animal studies have reported improvement in treatment efficacy and survival rate using novel carrier systems. Targeted delivery may be achieved passively or actively. In passive targeting, no ligand as homing device is used, while targeting is achieved by incorporating the therapeutic agent into a macromolecule or nanoparticle that passively reaches the target organ. However, in active targeting, the therapeutic agent or carrier system is conjugated to a tissue or cell-specific receptor which is overexpressed in a special malignancy using a ligand called a homing device. This review covers a broad spectrum of targeted nanoparticles as therapeutic and nonviral si RNA delivery systems, which are developed for enhanced cellular uptake and targeted gene silencing in vitro and in vivo and their characteristics and opportunities for the clinical applications of drugs and therapeutic si RNA are discussed in this article. Asialoglycoprotein receptors, low-density lipoprotein, ganglioside GM1 cell surface ligand, epidermal growth factor receptor receptors, monoclonal antibodies, retinoic acid receptors, integrin receptors targeted by Arg-Gly-Asp peptide, folate, and transferrin receptors are the most widely studied cell surface receptors which are used for the site specific delivery of drugs and si RNA-based therapeutics in HCC and discussed in detail in this article. | Jaleh Varshosaz Maryam Farzan | 2015 | World Journal of Gastroenterology2015，21，42： | 10 |
| 15 | Hepatogenic differentiation of mesenchymal stem cells induced by insulin like growth factor-Ⅰ显示文摘AIM:To improve hepatic differentiation of human mesenchymal stem cell(MSC)using insulin growth factor 1(IGF-Ⅰ),which has important role in liver development,hepatocyte differentiation and function.METHODS:Bone marrow of healthy donors was aspirated from the iliac crest.The adherent cells expanded rapidly and were maintained with periodic passages until a relatively homogeneous population was established.The identification of these cells was carried out by immunophenotype analysis and differentiation potential into osteocytes and adipocytes.To effectively induce hepatic differentiation,we designed a protocol based on a combination of IGF-Ⅰ and liver specificfactors(hepatocyte growth factor,oncostatin M and dexamethasone).Morphological features,hepatic functions and cytological staining were assessed to evaluate transdifferentiation of human marrow-derived MSCs.RESULTS:Flow cytometric analysis and the differentiation potential into osteoblasts and adipocytes showed that more than 90% of human MSCs which were isolated and expanded were positive by specif ic markers and functional tests.Morphological assessment and evaluation of glycogen storage,albumin and α-feto protein expression,as well as albumin and urea secretion revealed a statistically signif icant difference between the experimental groups and control.CONCLUSION:In vitro differentiated MSCs using IGF-Ⅰwere able to display advanced liver metabolic functions,supporting the possibility of developing them as potential alternatives to primary hepatocytes. | Maryam Ayatollahi Masoud Soleimani Seyed Ziaadin Tabei Maryam Kabir Salmani | 2011 | World Journal of Stem Cells2011，3，12： | 10 |
| 16 | Use of Selection Indices Based on Multivariate Analysis for Improving Grain Yield in Rice | Hossein SABOURI Babak RABIEI Maryam FAZLALIPOUR | 2008 | Rice science2008，15，4： | 9 |
| 17 | Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering显示文摘Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature.Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue.Here,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue engineering.These include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling pathways.Transcriptional and epigenetic regulation of chondrogenesis will also be discussed.Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering. | Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary Collier Maryam K.Mohammed Rex C.Haydon Hue H.Luu Richard Kang Michael J.Lee Sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham | 2015 | Genes & Diseases2015，2，4： | 9 |
| 18 | Treatment of laryngopharyngeal reflux disease: A systematic review显示文摘BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success rate.AIM To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD treatment.METHODS Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of LPRD.Clinical prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed LPRD.The criteria for considering studies for the review were based on the population,intervention,comparison,and outcome framework.RESULTS The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 wk.The most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor antagonists.CONCLUSION Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux. | Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci Seyyedeh Maryam Khoddami Necati Enver Sampath Kumar Raghunandhan Christian Calvo-Henriquez Young-Gyu Eun Sven Saussez | 2019 | World Journal of Clinical Cases2019，7，19： | 9 |
| 19 | 表面活性物质替代治疗新生儿呼吸窘迫综合征的疗效评估(英文)显示文摘目的呼吸窘迫综合征(RDS)是早产儿发病和死亡的重要原因。RDS主要由肺表面活性物质缺乏所致。该研究调查了表面活性物质治疗在减少早产儿死亡率中的作用,并评估了表面活性物质疗效与一些RDS相关危险因素的关系。方法通过简单抽样抽取符合入选要求的89例RDS早产儿,他们均来自于ShaheedBeheshti医院新生儿重症监护室。生后48 h内给予表面活性物质治疗(100 mg/kg)。结果89例得到表面活性物质治疗的RDS早产儿中,34例(38.2%)幸存,55例死亡。其中胎龄大于32周,表面活性物质治疗开始于生后24 h内,1,5分钟Apgar评分大于7/10分,或出生体重大于1 500 g者治疗效果较好,存活率分别为47.5%,43.3%,48.1%,52.5%。表面活性物质治疗后母亲孕前经过激素治疗的RDS早产儿的存活率(41.7%)显著高于那些母亲孕前未经激素治疗者(34.2%)(P<0.05)。结论表面活性物质替代治疗新生儿RDS应尽可能早地进行,能减少38.2%的死亡率。新生儿胎龄、出生体重、Apgar评分、表面活性物质治疗开始时间及母亲孕期是否经激素治疗等均可影响表面活性物质替代治疗的疗效。 | Sedigheh GHAEMI Maryam MOHAMADYMASODI Roya KELISHADI | 2009 | 中国当代儿科杂志2009，11，3： | 9 |
| 20 | Efficacy of topical chamomile on the incidence of phlebitis due to an amiodarone infusion in coronary care patients:a double-blind,randomized controlled trial显示文摘BACKGROUND:Amiodarone is a useful antiarrhythmic drug.Phlebitis,caused by intravenous amiodarone,is common in patients in coronary care units(CCUs).OBJECTIVE:The aim of this study was to evaluate the effect of topical chamomile on the incidence of phlebitis due to the administration of an amiodarone infusion into the peripheral vein.DESIGN,SETTING,PARTICIPANTS AND INTERVENTIONS:This was a randomized,double-blind clinical trial,conducted on 40 patients(n=20 per group)in two groups—an intervention group(chamomile ointment)and a control group(lanoline,as a placebo),hospitalized in the CCUs and undergoing an amiodarone infusion into the peripheral vein over 24 h.Following the cannulation and commencement of the infusion,placebo or chamomile ointment was rubbed in,up to 10 cm superior to the catheter and repeated every eight hours for three days.The cannula site was then assessed based on the phlebitis checklist.MAIN OUTCOME MEASURES:The incidence and time of occurrence of phlebitis,relative risk,severity of phlebitis were the main outcome measures.RESULTS:Nineteen patients(19/20)in the control group had phlebitis on the first day of the study and one patient(20/20)on the second day.In the intervention group,phlebitis occurred in 13 cases(13/20)on the first day and another two(2/7)was found on the second day.The incidence of phlebitis was significantly different between two groups(P=0.023).The cumulative incidence of phlebitis in the intervention group(15/20)is significantly later and lower than that in the control group(20/20)during two days(P=0.008).Two patients in the intervention group did not develop phlebitis at all during the 3-day study.Also,the relative risk of phlebitis in the two groups was 0.68(P=0.008 5).A significant difference was not observed with regard to phlebitis severity in both groups.CONCLUSION:It seems that phlebitis occurred to a lesser extent and at a later time frame in the intervention group compared to control group.Topical chamomile may be effective in decreasing the incidence of phlebitis due to an amiodarone infusion. | Maryam Sharifi-Ardani Leili Yekefallah Saeed Asefzadeh Marjan Nassiri-Asl | 2017 | Journal of Integrative Medicine2017，15，5： | 9 |
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