|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gastrointestinal neuroendocrine tumors treated with high dose octreotide-LAR:A systematic literature review显示文摘AIM:To review literature on efficacy and safety of octreotide-long-acting repeatable(LAR)used at doses higher than the Food and Drug Administration(FDA)-approved 30 mg/mo for treatment of neuroendocrine tumors(NETs).METHODS:We searched Pub Med and Cochrane Library from 1998-2012,5 conferences(American Society of Clinical Oncology,Endocrine Society,European Neuroendocrine Tumor Society,European Society for Medical Oncology,North American Neuroendocrine Tumor Society)from 2000-2013 using Me SH and keyterms including neuroendocrine tumors,carcinoid tumor,carcinoma,neuroendocrine,and octreotide.Bibliographies of accepted articles were also searched.Two reviewers reviewed titles,abstracts,and full-length articles.Studies that reported data on efficacy and safety of≥30 mg/mo octreotide-LAR for NETs in human subjects,published in any language were included in the review.RESULTS:The search identified 1086 publications,of which 238 underwent full-text review(20 were translated into English);17 were included in the review.Studies varied in designs,subjects,octreotide-LAR regimens,and definition of outcomes.Eleven studies reported use of higher doses to control symptoms and tumor progression,although symptom severity and formal quality-of-life analysis were not quantitatively measured.Ten studies reported efficacy,describing 260 subjects with doses ranging from 40 mg/mo or 30 mg/3 wk up to 120 mg/mo.Eight studies reported expert clinical opinion that supported dose escalation of octreotide-LAR up to 60 mg/mo for symptom control and suggested increased doses may be effective at preventing tumor progression.Eight studies reported safety;there was no evidence of increased toxicity associated with doses of octreotide-LAR>30 mg/mo.CONCLUSION:As reported in this review,octreotide-LAR at doses>30 mg/mo is being prescribed for symptom and tumor control in NET patients.Furthermore,expert clinical opinion provided support for escalation of somatostatin analogs for refractory hormonal symptoms. | Michael S Broder David Beenhouwer Jonathan R Strosberg Maureen P Neary Dasha Cherepanov | 2015 | World Journal of Gastroenterology2015，21，6： | 8 |
| 2 | Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding显示文摘 | Joseph L Kim Kurt A Morgenstern James P Griffith Maureen D Dwyer John A Thomson Mark A Murcko Chao Lin Paul R Caron | 1998 | Structure1998，，1： | 1 |
| 3 | Metabolites from an antarctic sponge-associated bacterium,Pseudomonas aeruginosa显示文摘 | Gamini S J Maureen P T Bill J B | | 0，，3： | 1 |
| 4 | Structure and regulation of acetyl-CoA carboxyiase genes of metazoa显示文摘 | MICHAEL C B NIGEL T P MAUREEN T T | 2005 | Biochimica Biophysica Acta2005，1733，： | 1 |
| 5 | EGFR gene mutationsare common in lung cancers from 'Never smokers' and are associated with Sensitivity of tumors to gefitinib and erltinib显示文摘 | Vincent M Maureen Z | 2004 | Proc Nati Acad Sci2004，101，13： | 1 |
| 6 | Avifauna of the Gaoligong Shan Mountains of western China: a hotspot of avian species diversity显示文摘 | John P D Jeremy M Maureen E | 2010 | Or- nithological Monographs2010，70，： | 1 |
| 7 | Physiological adaptations to low-volume, high-inten- sity interval training in health and disease 显示文摘 | Martin J Gibala Jonathan P Little Maureen J Macdonald | 2012 | Journal of Physiology2012，590，5： | 1 |
| 8 | The influence of type Ⅰ collagen on the development and maintenance of the osteoblast phenotype in primary and passaged rat calvarial osteoblasts: Modification of expression of genes supporting cell growth, adhesion, and extraeellular matrix mineralization 显示文摘 | Maureen P Lynch Janet L | 1995 | Experinmental cell research1995，216，： | 1 |
| 9 | The role of subchondral bone remodeling in osteoarthritis reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciatel ligament transection model 显示文摘 | Tadashi H Maureen P Gregg A | 2004 | Arthritis & Rheumatism2004，4，： | 1 |
| 10 | Optic nerve blood flow in glaucoma: effect of systemic hypertension显示文摘 | Juan EG Jody P Seenu MH Joan D Maureen GM | 1999 | Am J Opthalmol1999，127，： | 1 |
| 11 | Life - cycle Analysis of wood products: cradle - to - gate LCI of residential wood building materials 显示文摘 | Maureen E P James B W | 2005 | Wood and Fiber Science2005，37，： | 1 |
| 12 | PDX:PBX complexes are required for normal proliferation of pancreatic cells during development显示文摘 | Sanjoy D Maureen G Bernard P | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 13 | Metabolites from an antarctic sponge-associated bacterium Pseudomonasae ruginosa 显示文摘 | Jayatilake G S Maureen P T Alan C L | 1996 | J Nat Prod1996，59，3： | 1 |
| 14 | Patientcontrolled analgesia versus patient-controlled analgesia plus continuous infusion after hip replacement surgery 显示文摘 | MAUREEN A S MARGIE B Z MAUREEN P O | 1996 | Ann Pharmacother1996，30，3： | 1 |
| 15 | Susceptibility to psoriatic arthritis;Influence of activating killer Ig-like receptor genes in the absence Of specific HLA-C alleles1显示文摘 | Maureen P M George N Lee J H | 2002 | J Immunol2002，169，： | 1 |
| 16 | A Turbulent Channel Flow Apparatus for theDetermination of the Adhesion Strength of Microfouling Organisms 显示文摘 | Michael P Schultz John A Finlay Maureen E Callow | 2000 | Biofouling:2000，15，4： | 1 |
| 17 | Quantitative expression profiling of immune response genes in rainbow tr out following infectious haematopoietic necrosis virus (IHNV) Infection or DNA vaccination显示文摘 | Maureen K P Gael K Kyle A G | 2004 | Fish & Shellfish Immunology2004，17，： | 1 |
| 18 | Impact of new leg- islation on presumed consent on organ donation on liver transplant in Singapore: a preliminary analysis显示文摘 | How-Cheng L Maureen Da C Krishnan P | 2006 | Transplantation2006，82，9： | 1 |
| 19 | The influenceof type I collagen on the development and maintenance of theosteoblast phenotype in primary and passaged rat calvarial osteoblast:modification of expression of genes supporting cell growth,adhesion,and extracellular matrix mineralization显示文摘 | MAUREEN P L JANET L S GARY S S | 1995 | ExperimentalCell Research1995，216，1： | 1 |
| 20 | Evidence based practice profiles: Differences among allied health professions 显示文摘 | Maureen P McEvoy Marie T Williams Timothy S Olds | 2010 | BMC Medical Education2010，69，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员