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| 1 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 2 | Combination drug regimens for metastatic clear cell renal cell carcinoma显示文摘Renal cell carcinomas(RCC)make up about 90%of kidney cancers,of which 80%are of the clear cell subtype.About 20%of patients are already metastatic at the time of diagnosis.Initial treatment is often cytoreductive nephrectomy,but systemic therapy is required for advanced RCC.Single agent targeted therapies are moderately toxic and only somewhat effective,leading to development of immunotherapies and combination therapies.This review identifies limitations of monotherapies for metastatic renal cell carcinoma,discusses recent advances in combination therapies,and highlights therapeutic options under development.The goal behind combining various modalities of systemic therapy is to potentiate a synergistic antitumor effect.However,combining targeted therapies may cause increased toxicity.The initial attempts to create therapeutic combinations based on inhibition of the vascular endothelial growth factor or mammalian target of rapamycin pathways were largely unsuccessful in achieving a profile of increased synergy without increased toxicity.To date,five combination therapies have been approved by the U.S.Food and Drug Administration,with the most recently approved therapies being a combination of checkpoint inhibition plus targeted therapy.Several other combination therapies are under development,including some in the phase 3 stage.The new wave of combination therapies for metastatic RCC has the potential to increase response rates and improve survival outcomes while maintaining tolerable side effect profiles. | Viraj V Khetani Daniella E Portal Mansi R Shah Tina Mayer Eric A Singer | 2020 | World Journal of Clinical Oncology2020，11，8： | 2 |
| 3 | CDX2 protein expression compared to alcian blue staining in the evaluation of esophageal intestinal metaplasia显示文摘AIM:To compare the sensitivity and specificity of CDX2 and alcian blue(AB) p H 2.5 staining in identifying esophageal intestinal metaplasia.METHODS:One hundred and ninty-nine biopsies from 186 patients were retrospectively reviewed and categorized as Barrett's esophagus(BE)(n =108); non-Barrett's esophagus(NBE)(n =48); columnar blue cells(CB) and esophageal glands(EG)(n =43).The biopsies were stained with AB and immunostained for CDX2 using a mouse monoclonal antibody from Biogenex(clone CDX2-88) and the Ventana Discovery X automated immunostainer.The positive and negative predictive value of each group was used to determine the predictive power of CDX2 and AB in diagnosing intestinal metaplasia.RESULTS:All of the 108 BE biopsies(100%) were positive for AB and 102 of them(94.4%) were positive for CDX2.The six BE patients(5.6%) who failed to stain with CDX2 were found to have lost the focus of intestinal metaplasia upon deeper sectioning for immunostaining.Both AB and CDX2 were negative in 43 out of 48(89.6%) NBE cases.Five NBE patients(10.4%) were falsely positive for AB due to the presence of EG and CB in these biopsies.These cases were all CDX2 negative.In addition,5 AB negative NBE were found to be CDX2 positive.Based on these results the CDX2 immunostain had similar sensitivity but higher specificity(100% vs about 91%) than AB in detecting intestinal type metaplasia in these samples.Our data shows that CDX2 has a better PPV in detecting intestinal metaplasia as compared to AB(95.6% vs 71.5%,respectively).CONCLUSION:CDX2 has a better positive predictive value than AB in detecting intestinal metaplasia.CDX2may be useful when challenged by gastro-esophageal biopsies containing mimikers of BE. | Dennis R Johnson Maisoun Abdelbaqui Maryam Tahmasbi Zoltan Mayer Hung-Wei Lee Mokenge P Malafa Domenico Coppola | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 4 | Buckling,post-buckling and crippling of shallow curved composite plates with edge stiffeners显示文摘 | Arnold R R Yoo S Y Mayers J | 1985 | AIAA1985，23，5： | 2 |
| 5 | 以欧3柴油机为基础开发达到欧4标准的发动机显示文摘为了说明未来排放研究的重点,论述了排放法规和瞬态试验循环问题。给出了满足欧4排放标准的可供选择的对策,并讨论了达到排放标准所需的最重要的基本发动机技术和排气后处理技术。AVL研发工作的结果指出了进一步降低排放以达到欧4及以后排放标准要求的潜力。 | Mayer K P | 2007 | 国外内燃机2007，39，6： | 2 |
| 6 | Effects of cartilage-derived morphogenetic proteins and osteogenic protein-1 on osteochondrogenic differentiation of periosteum-derived cells显示文摘 | Gruber R Mayer C Bobacz K | 2001 | Endocrinology2001，142，5： | 1 |
| 7 | An Integration model of organizational trust显示文摘 | MAYER DAVIS R C DAVIS J H | 1995 | Academy of Management Review1995，20，3： | 1 |
| 8 | Self-focus, Helping Request Salience, Felt Responsibility, and Helping Behavior 显示文摘 | Mayer F S Duval T S Holtz R Bowman C | 1985 | Personality and Social Psychology Bulletin1985，，11： | 1 |
| 9 | Efficient screening of process variables 显示文摘 | STOWE R A MAYER R P | 1966 | Industrial and Engineering Chemistry1966，58，2： | 1 |
| 10 | High-resolution CT of the temporal bone in dysplasia of the auricle and external auditory canal显示文摘 | Mayer TE Brueckmann H Siegert R | 1997 | AJNR Am J Neuroradiol1997，18，1： | 1 |
| 11 | Fluorouracil and highdose leuco -vorin in previously untreated patients with advanced adenocarcinoma of the pancreas : re - suits of a phase * trial显示文摘 | DECAPRIO J A MAYER R J GONIN R | 1991 | J Clin Oncol1991，9，12： | 1 |
| 12 | A randomized controlled trial of intravesical bacillus calmette-guerin for treatment refractory interstitial cystitis显示文摘 | Mayer R Propert KJ Peters KM | 2005 | J Urol2005，173，4： | 1 |
| 13 | Ethoxyresorufin:direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene显示文摘 | BURKE M D MAYER R T | 1974 | Drug Metab Dispos1974，，2： | 1 |
| 14 | The nucleolus as a stress sensor:JNK2 inactivates the transcription factor TIF-Ⅰ A and down-regulates rRNA synthesis显示文摘 | Mayer C Bierhoff R Grummt I | 2005 | Genes Dev2005，19，8： | 1 |
| 15 | Emotional intelligence as a standard intelligence显示文摘 | MAYER J D SALOVEY P CARUSO D R SITARENIOS G | 2001 | Emotion2001，，3： | 1 |
| 16 | Does storage time influence post- thaw survival and pregnancy outcome? An analysis of 11 768 cryo- preserved human embryos显示文摘 | Riggs R Mayer J Chi TF | 2010 | Fertil Steril2010，93，1： | 1 |
| 17 | Chemical changes due to acid precipitation in a loess-derived soil in central Europe显示文摘 | Ulrich B Mayer R R Khanna P K | 1980 | Soil Science1980，130，4： | 1 |
| 18 | Assessment of intake from the diet显示文摘 | R Kroes D Müller J Lambe M.R.H L?wik J van Klaveren J Kleiner R Massey S Mayer I Urieta P Verger A Visconti | 2002 | Food and Chemical Toxicology2002，，2： | 1 |
| 19 | Cellulose biosynthesis and function in bacteria显示文摘 | Ross P Mayer R Benziman M | 1991 | Microbiological Reviews1991，55，1： | 1 |
| 20 | Improved performance seal for pipeline applications显示文摘 | Lai T Gabriel R Mayer Y L | 2003 | Lubrication Engineering2003，59，4： | 1 |
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