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| 1 | 源于近端股骨间充质干细胞免疫抑制作用的研究显示文摘目的探讨源于成人近端股骨的间充质干细胞(MSC)是否具有免疫抑制功能,为临床移植物抗宿主病的防治寻找理想的细胞储备库。方法从全髋关节置换术患者的近端股骨中分离并培养MSC,将不同数量的细胞直接或以Transwell法加入混合淋巴细胞反应(MLR)中,检测MSC对外周血淋巴细胞(PBL)增殖水平的影响。以ELISA法及抗体中和法探讨细胞因子TGFβ1在MSC免疫调节中的作用。结果3×103、1×104、3×104、1×105个源于近端股骨的MSC对PBL增殖的抑制率分别为62%±18%、38%±4%、31%±16%、28%±12%,与采自髂骨骨髓穿刺物MSC的抑制作用相比差异无统计学意义(均P>0.05),后者对PBL的增殖抑制率为58%±12%、37%±8%、28%±6%、27%±6%;以0.2μm的微孔膜对MSC与MLR进行分隔,3×104及1×104个MSC对PBL的增殖抑制率为36%±8%和53%±12%;在ELISA实验中,MSC单独培养,MSC与MLR直接接触,或经Transwell共培养的这3种上清中转化生长因子(TGF)β1的表达水平差异无统计学意义,加入浓度递增的TGFβ1抗体不能逆转MSC对PBL增殖的抑制作用。结论源于近端股骨的MSC具有一定的免疫抑制功能,除TGFβ1外其他可溶性因子可能介导这一作用。 | 张翼鷟 Loic Fouillard Alain Chapel Morad Bensidhoum Christelle Mazurier Aish Nasef Sandrine Bouchet Manuel Lopez Dominique Thierry Norbert Cclaucle Gorin 达万明 | 2005 | 中华医学杂志2005，85，39： | 11 |
| 2 | Quantitative and qualitative in vitro analysis of the stem cell potential of hematopoietic cells purified from murine skeletal muscle显示文摘鼠科的骨胳的肌肉包含造血的干细胞,而是这个潜力到目前为止没被学习份量上或品质上试管内。确定造血的干细胞潜力,我们在 long-termculture 开始使用了高度净化的 SP/CD45 (+) 房间房间(LTC-IC ) 试金。从鼠科的肌肉净化的 SP/CD45 (+) 房间人口被发现从肌肉与 1/640 .Single-cell-sorted SP/CD45 (+) 房间的 LTC-IC 频率举办重要干细胞活动在白天 16 点的展出柔韧的 proliferative 活动试管内(380 褶层扩大) ,特别在有 OP-9 层的文化以后,那也支持胚胎的干细胞。放大房间人口与 myeloid 的证据从单个房间 exhibitedmultilineage 区别能力发源,淋巴并且 NK 房间标记。因此,我们的结果证明能被 LTC-IC 试金确定的造血的干细胞第一次也在鼠科的骨胳的肌肉和表演存在,在单个房间的水平,这些房间展出多行的年龄区别能力和主要 proliferative 潜力。 | Celine Haond Frangoise Farace Martine Guillier Yann Lecluse Frederic Mazurier William Vainchenker Ali G Turhan | 2007 | Cell Research2007，17，9： | 4 |
| 3 | Human lactotransferrin: Molecular, functional and evolutionary comparisons with human serum transferrin and hen ovotransferrin显示文摘 | J. Mazurier M. -H. Metz-Boutigue J. Jollès G. Spik J. Montreuil P. Jollès | 1983 | Experientia1983，，2： | 2 |
| 4 | Effects of human lactoferrin on NK cell cytotoxicity against haematopoietic and epithelial tumour cells显示文摘 | Damiens E Mazurier J el Y | 1998 | Biochimica et Biophysica Acta1998，1402，3： | 1 |
| 5 | Lactoferrin inhibits the lipopolysaccharide-induced expresssion and proteoglycanbinding ability of interleukin-8 in human endothelial cells显示文摘 | ELASS E MASSON M MAZURIER J | 2002 | Infect mmun2002，70，： | 1 |
| 6 | Ciculating van Willebrand factor antigen Ⅱ in atherosclerosis:a comparison with yon Willebrand factor and soluble thrombomodulin显示文摘 | Blann AD de Romeuf C Mazurier C | 1998 | Blood Coagul Fibrinolysis1998，9，3： | 1 |
| 7 | Lactoferrin inhibits GI cyclin-de- pendent kinases during growth arrest of human breast carcinoma 显示文摘 | Damiens E Elyazidi I Mazurier J | 1999 | J Cell Biochem1999，74，3： | 1 |
| 8 | Vibrio car- chariae, a pathogen of the abalone Haliotis tuberculata 显示文摘 | NICOLAS J L BASUYAUX O MAZURIE J | 2002 | Dis Aquat Org2002，50，1： | 1 |
| 9 | Relationships between oyster mortality patterns and environmental data from monitoring databases along the coasts of France显示文摘 | Soletchnik P Ropert M Mazurie J Fleury P G Le Coz F | | 0，，1： | 1 |
| 10 | Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppression 显示文摘 | NasefA Mazurier C Bouchet S | 2008 | Cell Immunol2008，253，12： | 1 |
| 11 | Mesenchymal stem cell abnormalities in patients with multiple myeloma 显示文摘 | Garderet L Mazurier C Chapel A | 2007 | Leuk Lymphoma2007，48，10： | 1 |
| 12 | Effects of human la-ctoferrin on NK cell eytotoxicity against haematopoietie and epithelial tumour eells显示文摘 | Damiens E Mazurier J E1 Yazidi I | 1998 | Biochim Biophys Acta1998，1402，3： | 1 |
| 13 | Lentivector-mediatedclonal tracking reveals intrinsic heterogeneity in the humanhematopoietic stem cell compartment and culture- induced stemcell impairment 显示文摘 | Mazurier F Gan 01 McKenzie JL | 2004 | Blood2004，103，2： | 1 |
| 14 | Human lactotrans- ferrin: amino acid sequence and structural comparisons with other-transferrins显示文摘 | Metz- Boutigue MH Jolles J Mazurier J | 1984 | Eur J Biochem1984，145，3： | 1 |
| 15 | Identification of IL-10 and TGF-beta transcripts involved in the inhibition of T-lymphocyte proliferation during cell contact with human mesenehymal stem ceils 显示文摘 | Nasef A Chapel A Mazurier C | 2007 | Gene Expr2007，13，： | 1 |
| 16 | Identification of IL- 10 and TGF-beta transcripts involved in the inhibition of T- lymphocyte proliferation during cell contact with human mesenchymal stem cells 显示文摘 | Nasef A Chapel A Mazurier C | 2007 | Gene Expr2007，13，45： | 1 |
| 17 | Lactotransferrin binding to its platelet receptor inhibits platelet aggregation 显示文摘 | Leveugle B Mazurier J Legrand D | 1993 | EurJ Biochem1993，213，3： | 1 |
| 18 | Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice显示文摘 | Varon C Dubus P Mazurier F | | 0，，02： | 1 |
| 19 | Lactoferrina multifunctional protein 显示文摘 | Pierce A Legrand D Mazurier J | 2009 | Med Sci(Paris)2009，25，3： | 1 |
| 20 | Benefit of intensity modulated and image-guided radiotherapy in prostate caneer 显示文摘 | Latorzeff 1 Mazurier J Boutry C | 2010 | Cancer Ra- diother2010，14，67： | 1 |
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