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| 1 | Engineering Microneedle Patches for Improved Penetration:Analysis,Skin Models and Factors Affecting Needle Insertion显示文摘Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the skin.To serve as a substitute for common hypodermic needles,MNs must pierce the human stratum corneum(~10 to 20μm),without rupturing or bending during penetration.This ensures that the cargo is released at the predetermined place and time.Therefore,the ability of MN patches to sufficiently pierce the skin is a crucial requirement.In the current review,the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared.This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice.Factors that affect insertion(e.g.,geometry,material composition and cross-linking of MNs),along with recent advancements in developed strategies(e.g.,insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography)to improve the skin penetration are highlighted to provide a backdrop for future research. | Pooyan Makvandi Melissa Kirkby Aaron RJHutton Majid Shabani Cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan Jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli Ryan F.Donnelly | 2021 | Nano-Micro Letters2021，13，6： | 5 |
| 2 | Increased cardiac anglotensin H levels induce right and left ventrlcular hypertrophy in normotensive mice显示文摘 | Mazzolai L Pedrazzini T Nicoud F | 2000 | Hypertension2000，35，4： | 1 |
| 3 | Severe hyperlipidemia causes impaired renin-angiotensin system function in apolipoprotein E deficient mice 显示文摘 | MAZZOLAI L KORBER M BOUZOURENE K | 2006 | Atherosclerosis2006，186，1： | 1 |
| 4 | Two-Kidney, One clip and one-kidney, one clip hypertension in mice显示文摘 | Wiesel P Mazzolai L Nussberger J | 1997 | Hypertension1997，29，： | 1 |
| 5 | Tissue factor activity is upregulated in human endothelial cells exposed to oscillatory shear stress显示文摘 | Mazzolai L Silacci P Bouzourene K | 2002 | Thromb Haemost2002，87，6： | 1 |
| 6 | Comparative safety and tolerability of angiotension Ⅱ receptor antagonists显示文摘 | Burnier M | 1999 | Drug Safety1999，21，： | 1 |
| 7 | Blood pressure indepengdent cardiac hypertrophy induced by local activiated rennin-angiotensin system显示文摘 | Mazzolai L Nussberger J Auber J | 1998 | hypertension1998，31，： | 1 |
| 8 | Angiotension Ⅱ receptor blockade in normal subjects:a direct comparison of three AT1 receptor antagonists显示文摘 | Maillard M Rossat J | 1999 | Hypertension1999，33，： | 1 |
| 9 | Connexin40 regulates renin production and blood pressure 显示文摘 | Krattinger N Capponi A Mazzolai L | 2007 | Kidney Int2007，72，7： | 1 |
| 10 | Severe hyperlipidemia causes impaired rennin-angiotensin system function in apolipoprotein E deficient mice 显示文摘 | Mazzolai L Korber M Bouzourene K | 2006 | Atherosclerosis2006，186，1： | 1 |
| 11 | Angiotensin Ⅱ blockade in normotensive subject:A direct comparison of three AT1 receptor antagonists显示文摘 | Mazzolai L Maillard M Rossat J | 1999 | Hypertension1999，33，3： | 1 |
| 12 | Gelsolin superfamily proteins : key regulators of cellular functions 显示文摘 | Silacci P Mazzolai L Gauci C | 2004 | Cell Mol Life Sci2004，61，1920： | 1 |
| 13 | Endogenous angiotensin Ⅱ induces atherosclerotic plaque vulnerability and elicits a Thl re- sponse in ApoE - / - mice 显示文摘 | Mazzolai L Duchosal MA Korber M | 2004 | Hypertension2004，44，3： | 1 |
| 14 | Application of statistical mechanics to solid solutions of interstitial impurities in binary alloys显示文摘 | BiscarinI A Coluzzi B Mazzolai F M | | 0，，12： | 1 |
| 15 | Hydrogen diffusion and interpretation of the 200 K anelastic relaxation in NiTi alloys显示文摘 | Mazzolai F Coluzzi B Mazzolai G | 2004 | Applied Physics Letters2004，85，14： | 1 |
| 16 | Increased cardiac angiotensin Ⅱ levels induce right and left ventricular hypertrophy in normotensive mice显示文摘 | Lucia Mazzolai Thierry Pedrazzini Francoise Nicoud | 2000 | hypertension2000，32，2： | 1 |
| 17 | Endog- enous angiotensin II induces atherosclerotic plaque vulnerability and elicits a Thl response in ApoEI -/- mice 显示文摘 | Mazzolai L Duchosal MA Korber M | 2004 | Hypertension2004，44，： | 1 |
| 18 | Gelsolin superfamily proteins:key regulators of cellular functions显示文摘 | Silacci P Mazzolai L Gauci C | 2004 | Cell Mol Life Sci2004，61，1920： | 1 |
| 19 | Interplay be- tween connexin40 and nitric oxide signaling during hyper- tension显示文摘 | LE GAL L ALONSO F MAZZOLAI L | 2015 | Hypertension2015，65，4： | 1 |
| 20 | Blood pressure-independent cardiac hypertrophy induced by locally activated rennin-angiotensin system 显示文摘 | Mazzolai L Nussberger J Aubert JF Brunner DB Gabbiani G Brunner HR | 1998 | Hypertension1998，31，6： | 1 |
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