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| 1 | Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models显示文摘Mesenchymal stem cells(MSCs),which are pluripotent cells with immunomodulatory properties,have been considered good candidates for the therapy of several immune disorders,such as inflammatory bowel diseases,concanavalin A-induced liver injury,and graft-versus-host disease.The embryo is a natural allograft to the maternal immune system.A successful pregnancy depends on the timely extinction of the inflammatory response induced by embryo implantation,followed by the switch to a tolerant immune microenvironment in both the uterus and the system.Excessive infiltration of immune cells and serious inflammatory responses are triggers for embryo rejection,which results in miscarriage.Here,we demonstrated that adoptive transfer of MSCs could prevent fetal loss in a lipopolysaccharide(LPS)-induced abortion model and immune response-mediated spontaneous abortion model.The immunosuppressive MSCs alleviated excessive inflammation by inhibiting CD4+T cell proliferation and promoting the decidual macrophage switch to M2 in a tumor necrosis factor-stimulated gene-6(TSG-6)-dependent manner.Cell-tocell contact with proinflammatory macrophages increased the TSG-6 production by the MSCs,thereby enhancing the suppressive regulation of T cells and macrophages.Moreover,proinflammatory macrophages in contact with the MSCs upregulated the expression of CD200 on the stem cells and facilitated the reprogramming of macrophages towards an anti-inflammatory skew through the interaction of CD200 with CD200R on proinflammatory macrophages.Therefore,the results demonstrate that a TSG-6-mediated paracrine effect,reinforced by cell-to-cell contact between MSCs and proinflammatory macrophages,is involved in the mechanism of MSC-mediated abortion relief through the induction of immune tolerance.Our study also indicates the potential application of MSCs in clinical recurrent miscarriages. | Yanhong Li Di Zhang Ling Xu Lin Dong Ji Zheng Yikong Lin Jiefang Huang Yanyun Zhang Yu Tao Xingxing Zang Dajin Li Meirong Du | 2019 | Cellular & Molecular Immunology2019，16，12： | 23 |
| 2 | Oil-soluble ionic liquids as antiwear and extreme pressure additives in poly-α-olefin for steel/steel contacts显示文摘To enhance the lubricating and extreme pressure(EP) performance of base oils, two types of oil-soluble ionic liquids(ILs) with similar anion albeit dissimilar cations were synthesized. The physical properties of the prepared ILs were measured. The anticorrosion properties of ILs were assessed by conducting corrosion tests on steel discs and copper strips, which revealed the remarkable anticorrosion properties of the ILs in comparison with those of the commercial additive zinc dialkyldithiophosphate(ZDDP). The tribological properties of the two ILs as additives for poly-α-olefin-10(PAO10) with various mass concentrations were investigated. The tribological test results indicate that these ILs as additives are capable of reducing friction and wear of sliding contacts remarkably as well as enhance the EP performance of blank PAO10. Under similar test conditions, these IL additives exhibit higher lubricating and anti-wear(AW) performances than those of ZDDP based additive package in PAO10. Subsequently, X-ray photoelectron spectroscopy(XPS) and energy dispersive spectrometer(EDS) were conducted to study the lubricating mechanism of the two ILs. The results indicate that the formation of tribochemical film plays the most crucial role in enhancing the lubricating and AW behavior of the mixture lubricants. | Guowei HUANG Qiangliang YU Zhengfeng MA Meirong CAI Feng ZHOU Weimin LIU | 2019 | Friction2019，7，1： | 15 |
| 3 | SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways显示文摘In creasi ng amounts of evidence dem on strated that accumulative reactive oxyge n species (ROS) and apoptosis of human endometrial stromal cells (ESCs) are closely associated with endometrial dysfunction induced by oxidative stress, which plays an important role in the pathological process of multiple gyn ecological and reproduction-related diseases. SCM-198, an alkaloid active component of Leonurus japonicas Houtt, has been reported to have anti-oxidative activity. However, the specific mechanisms of SCM-198 in the prevention of endometrial damage remain unknown. In the present study, we assessed the effect of SCM-198 on hydrogen peroxide (H2O2Hnduced oxidative injury in ESCs. ESCs were pretreated with SCM-198 for 4 h and then challenged with H2O2.Morphology ch a nges, apoptosis rate, and intracellular ROS producti on were measured to assess the level of oxidative injury. Flow cytometry and western blot analysis were performed to detect the expression levels of Bax, Bcl-2, active-caspase-3, and mitogen-activated protein kinases pathways. Classic inflammation cytokines were measured by real-time polymerase chain reactions. Our results showed that SCM-198 attenuated apoptosis and ROS generation of ESCs induced by H2O2. H2O2 induced the apparent apoptotic characteristics, including fragmentation of DNA, upregulation of Bax/Bcl2, activation of caspase-3, and secretion of inflammation cytokines, which were all ameliorated by SCM-198. Furthermore, H2O2-induced apoptosis-related ERK1/2 pathway activation was restrained by SCM-198 pretreatme nt. These fin dings suggested that SCM-198 could protect ESCs from oxidative injury, mainly by inhibiting oxidative stress and reducing apoptosis. | Yunyun Li Yikong Lin Xixi Huang Chunfang Xu Xinhua Liu Li Wang Min Yu Dajin Li Yizhun Zhu Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 10 |
| 4 | Numerical simulation of hydrodynamic and water quality effects of shoreline changes in Bohai Bay显示文摘 | Han JIA 1Yongming SHEN Meirong SU Chunxue YU | 2018 | Frontiers of Earth Science2018，12，3： | 9 |
| 5 | Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves implanting survival in diabetic wounds显示文摘Background:Gelatin methacryloyl(GelMA)hydrogels loaded with stem cells have proved to be an effective clinical treatment for wound healing.Advanced glycation end product(AGE),interacting with its particular receptor(AGER),gives rise to reactive oxygen species(ROS)and apoptosis.Curcumin(Cur)has excellent antioxidant activity and regulates intracellular ROS production and apoptosis.In this study,we developed a Cur-incorporated 3D-printed GelMA to insert into adiposederived stem cells(ADSCs)and applied it to diabetic wounds.Methods:GelMA hydrogels with Cur were fabricated and their in vitro effects on ADSCs were investigated.We used structural characterization,western blot,ROS and apoptosis assay to evaluate the antioxidant and anti-apoptotic activity,and assessed the wound healing effects to investigate the mechanism underlying regulation of apoptosis by Cur via the AGE/AGER/nuclear factor-κB(NF-κB)p65 pathway.Results:A 10%GelMA scaffold exhibited appropriate mechanical properties and biocompatibility for ADSCs.The circular mesh structure demonstrated printability of 10%GelMA and Cur-GelMA bioinks.The incorporation of Cur into the 10%GelMA hydrogel showed an inhibitory effect on AGEs/AGER/NF-κB p65-induced ROS generation and ADSC apoptosis.Furthermore,Cur-GelMA scaffold promoted cell survival and expedited in vivo diabetic wound healing.Conclusions:The incorporation of Cur improved the antioxidant activity of 3D-printed GelMA hydrogel and mitigated AGE/AGER/p65 axis-induced ROS and apoptosis in ADSCs.The effects of scaffolds on wound healing suggested that Cur/GelMA-ADSC hydrogel could be an effective biological material for accelerating wound healing. | Sizhan Xia Tingting Weng Ronghua Jin Min Yang Meirong Yu Wei Zhang Xingang Wang Chunmao Han | 2022 | Burns & Trauma2022，10，1： | 4 |
| 6 | Physicochemical and tribological properties of gemini-type halogen-free dicationic ionic liquids显示文摘A series of new halogen-free dicationic ionic liquids(ILs)with different alkyl chain lengths were prepared,and the relationship between the alkyl chain length,physicochemical and tribological properties of ILs,and their role as neat lubricant for steel–steel friction pairs,was investigated.Evaluation of stability during hydrolysis and copper strip corrosion test results show that synthetic ILs are stable and not corrosive to metal contacts,due to the halogen-free anions.The friction and wear test results indicate that ILs with long alkyl chains have excellent friction-reducing and anti-wear properties,especially at high temperatures.Based on the surface three-dimensional(3D)profiles,electrical contact resistance,scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),and the X-ray photoelectron spectrometry(XPS)analysis of the worn surfaces of steel discs,we can conclude that the efficiency of ILs is due to the formation of high quality tribofilms that consist of both tribochemical reaction and ordered absorption films. | Qiangliang YU Chaoyang ZHANG Rui DONG Yijun SHI Yurong WANG Yanyan BAI Jiaying ZHANG Meirong CAI Feng ZHOU Weimin LIU | 2021 | Friction2021，9，2： | 3 |
| 7 | Application of computational fluid dynamics simulation for submarine oil spill显示文摘Computational fluid dynamics(CFD) codes are being increasingly used in the simulation of submarine oil spills.This study focuses on the process of oil spills, from damaged submarine pipes, to the sea surface, using numerical models. The underwater oil spill model is developed, and a description of the governing equations is proposed,along with modifications required for the particalization of the control volume. Available experimental data were introduced to evaluate the validity of the CFD predictions, the results of which proved to be in good agreement with the experimental data. The effects of oil leak rate, leak diameter, current velocity, and oil density are investigated, by the validated CFD model, to estimate the undersea leakage time, the lateral migration distance,and surface diffusion range when the oil reaches the sea surface. Results indicate that the leakage time and lateral migration distance increase with decreasing leak rates and leak diameter, and increase with increasing current velocity and oil density. On the other hand, a large leak diameter, high density, high leak rate, or fast currents result in a greater surface diffusion range. The findings and analysis presented here will provide practical predictions of oil spills, and guidance for emergency rescues. | YANG Zhenglong YU Jianxing LI Zhigan CHEN Haicheng JIANG Meirong CHEN Xi | 2018 | Acta Oceanologica Sinica2018，37，11： | 3 |
| 8 | THE APPLICATION OF THE ELECTRIC INFORMATION MEASURE ON HUMAN AURICULAR POINTS TO THE UPPER-DIGESTIVE-TRACT CANCER SURVEY显示文摘THEAPPLICATIONOFTHEELECTRICINFORMATIONMEASUREONHUMANAURICULARPOINTSTOTHEUPPER￣DIGESTIVE-TRACTCANCERSURVEYZhuBing,LiNingshen,Y... | Zhu Bing, Li Ningshen, Yu Zheng, Jia Meirong, Li Heshen(Department of Physics, Naming University, Naming,210008, China)Wang Yuexiang, Ding Jianhua, Gao Changming(Jiangsu Provincial institute of Prevention andTreatment of Tumour, Naming, 210008, China)Zhou | 1994 | Chinese Journal of Biomedical Engineering(English Edition)1994，3，2： | 2 |
| 9 | Laboratory investigation into the oil diffusion from submarine pipeline under water flow显示文摘A physical model test has been conducted to study the oil diffusion from the submarine pipeline under water flow.The crude oil in the flume is spilled from a leakage point of the pipeline and diffused from the seabed to the surface. By the non-contact optical measuring technology, an image acquisition and data analysis system is designed to explore the spilled mechanism and characteristic. The oil trajectory, velocity and the rising time to the surface are obtained through this system. The influence of the water flow and the spilled discharge on the behavior of the spilled oil are analyzed from both qualitative and quantitative perspectives. The sensitivity study of the characteristic physical quantities to various factors are presented afterward. The spilled oil under water is mainly distributed in the form of the scattered particles with different sizes. The rising process of the oil can be divided into three stages: full, dispersion and aggregation period. The spilled discharge is the primary factor affecting the rising time of the oil particles. In the rising process of the oil particles, the vertical velocity of the oil is mainly affected by the spilled discharge, and the transverse velocity is more dependent on the water velocity. The deviation of the transverse oil velocity is much larger than that of the rising time and the vertical oil velocity. The study can provide a theoretical reference for the prediction system of oil spill emergency. | JIANG Meirong YU Jianxing LI Zhigang ZHONG Wenjun WU Zhaohui YU Yang | 2018 | Acta Oceanologica Sinica2018，37，11： | 2 |
| 10 | Potential of amphiphilically modified low molecular weight chitosan as a novel carrier for hydrophobic anticancer drug: Synthesis, characterization, micellization and cytotoxicity evaluation显示文摘 | Yong Zhang Meirong Huo Jianping Zhou Di Yu Yiping Wu | 2009 | Carbohydrate Polymers2009，，2： | 1 |
| 11 | Chromosome-level Genomes Reveal the Genetic Basis of Descending Dysploidy and Sex Determination in Morus Plants显示文摘Multiple plant lineages have independently evolved sex chromosomes and variable karyotypes to maintain their sessile lifestyles through constant biological innovation.Morus notabilis,a dioecious mulberry species,has the fewest chromosomes among Morus spp.,but the genetic basis of sex determination and karyotype evolution in this species has not been identified.In this study,three high-quality genome assemblies were generated for Morus spp.[including dioecious M.notabilis(male and female)and Morus yunnanensis(female)]with genome sizes of 301–329 Mb and were grouped into six pseudochromosomes.Using a combination of genomic approaches,we found that the putative ancestral karyotype of Morus species was close to 14 protochromosomes,and that several chromosome fusion events resulted in descending dysploidy(2n=2x=12).We also characterized a~6.2-Mb sex-determining region on chromosome 3.Four potential male-specific genes,a partially duplicated DNA helicase gene(named MSDH)and three Ty3_Gypsy long terminal repeat retrotransposons(named MSTG1/2/3),were identified in the Y-linked area and considered to be strong candidate genes for sex determination or differentiation.Population genomic analysis showed that Guangdong accessions in China were genetically similar to Japanese accessions of mulberry.In addition,genomic areas containing selective sweeps that distinguish domesticated mulberry from wild populations in terms of flowering and disease resistance were identified.Our study provides an important genetic resource for sex identification research and molecular breeding in mulberry. | Zhongqiang Xia Xuelei Dai Wei Fan Changying Liu Meirong Zhang Peipei Bian Yuping Zhou Liang Li Baozhong Zhu Shuman Liu Zhengang Li Xiling Wang Maode Yu Zhonghuai Xiang Yu Jiang Aichun Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 12 | SCM-198 ameliorates endometrial inflammation via suppressing the LPS-JNK-cJUN/cFOS-TLR4-NF-κB pathway显示文摘Endometritis is an inflammatory disease of the endometrium,which is responsible for endometrial dysfunction,decidualization failure,and increased incidence of early pregnancy loss.SCM-198,a synthetic form of leonurine,is well known to possess anti-inflammatory effects.SCM-198 has been reported to display beneficial effects on endometritis.However,the specific mechanisms of SCM-198 in preventing endometritis remain unknown.In this study,we focused on the molecular mechanism of SCM-198 in inhibiting endometritis.The anti-inflammatory effects and the related signaling pathways of SCM-198 were studied in vitro using human endometrial stromal cells(hESCs).Reverse transcriptase-polymerase chain reaction and western blot analysis results demonstrated that SCM-198 markedly inhibited lipopolysaccharide(LPS)-induced endometrial inflammatory response by suppressing the LPS-JNK-cJUN/cFOS-TLR4-NF-κB pathway.The preventive and therapeutic effects of SCM-198 on endometrial inflammation were explored by using a mouse model of LPS-induced endometritis.SCM-198 produced essentially the same effects when administered either post-treatment(after LPS)or pre-treatment(before LPS)via vaginal or intraperitoneal administration.In vivo results indicated that SCM-198 is a potential effective drug for the treatment of endometritis. | Yikong Lin Yunyun Li Xinyi Li Xinhua Liu Xiaolin Wang Min Yu Yizhun Zhu Meirong Du | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 1 |
| 13 | The Ecological Vulnerability Evaluation in Southwestern Mountain Region of China Based on GIS and AHP Method显示文摘 | Guoba. Song Yu Chen Meirong Tian Shihai Lv Shushen Zhang Suling Liu | 2010 | Procedia Environmental Sciences2010，，： | 1 |
| 14 | Development of an ecological security evaluation method based on the ecological footprint and application to a typical steppe region in China显示文摘 | Xiaobing Li Meirong Tian Hong Wang Han Wang Jingjing Yu | 2013 | Ecological Indicators2013，，： | 1 |
| 15 | Downregulated miR-33b is a novel predictor associated with disease progression and poor prognosis in multiple myeloma显示文摘 | Fei Li Mu Hao Xiaoyan Feng Meirong Zang Yu Qin Shuhua Yi Zengjun Li Yan Xu Lili Zhou Weiwei Sui Shuhui Deng Dehui Zou Fenghuang Zhan Lugui Qiu | 2015 | Leukemia Research2015，，7： | 1 |
| 16 | Network analysis of eight industrial symbiosis systems显示文摘工业共生是一个 eco 工业的公园的精华的特征。把公园划分成不同类型,主要集中于质的判断,并且没能使用度量标准在一个公园的内部结构或功能的特征上进行量的研究的以前的研究。分析一公园结构的属性,从网络分析的度量标准的一个范围被使用了,但是很少研究人员比较了二或用多重度量标准的更多的 symbioses。在这研究,我们使用了二个度量标准(密度和网络度集中化) 比较完全性的度和八个多样却代表性的工业共生网络的依赖。通过二个度量标准的联合,我们把网络划分了成三种类型:强壮的完全性的弱完全性,和二种形式,也就是抛锚承租人互助论和面向平等的互助论。结果证明有完全性的弱度的网络是稀少的并且在节点之中有很少连接;为锚承租人互助论,完全性的度相对高,但是 affiliated members 太依赖于核心成员;并且在有的面向平等的互助论的成员等于角色,与多样、灵活的共生路径。这些结果揭示了一些系统内部结构并且不同结构怎么在一个系统的成员之中影响了材料,精力,和知识的交换,从而提供卓见进可以使动摇的威胁网络。把分析基于这,我们在一个典型中国 eco 工业的公园(山东 Lubei ) 里提供优点的例子和最近的改进工程的有效性。 | Yan ZHANG Hongmei ZHENG Han SHI Xiangyi YU Gengyuan LIU Meirong SU Yating LI Yingying CHAI | 2016 | Frontiers of Earth Science2016，10，2： | 1 |
| 17 | Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment‐na?ve patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma显示文摘 | Meirong Wang Ning Qiu Shichun Lu Dianrong Xiu Jianguo Yu Xing tai Wang Fengmin Lu Tong Li Xueen Liu Hui Zhuang | 2012 | J. Med. Virol2012，，2： | 1 |
| 18 | Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia显示文摘Aberrant self-renewal of leukemia initiation cells(LICs)drives aggressive acute myeloid leukemia(AML).Here,we report that UHRF1,an epigenetic regulator that recruits DNMT1 to methylate DNA,is highly expressed in AML and predicts poor prognosis.UHRF1 is required for myeloid leukemogenesis by maintaining self-renewal of LICs.Mechanistically,UHRF1 directly interacts with Sin3A-associated protein 30(SAP30)through two critical amino acids,G572 and F573 in its SRA domain,to repress gene expression.Depletion of UHRF1 or SAP30 derepresses an important target gene,MXD4,which encodes a MYC antagonist,and leads to suppression of leukemogenesis.Further knockdown of MXD4 can rescue the leukemogenesis by activating the MYC pathway.Lastly,we identified a UHRF1 inhibitor,UF146,and demonstrated its significant therapeutic efficacy in the myeloid leukemia PDX model.Taken together,our study reveals the mechanisms for altered epigenetic programs in AML and provides a promising targeted therapeutic strategy against AML. | Cheng-Long Hu Bing-Yi Chen Zijuan Li Tianbiao Yang Chun-Hui Xu Ruirui Yang Peng-Cheng Yu Jingyao Zhao Ting Liu Na Liu Bin Shan Qunling Zhang Junhong Song Ming-Yue Fei Li-Juan Zong Jia-Ying Zhang Ji-Chuan Wu Shu-Bei Chen Yong Wang Binhe Chang Dan Hou Ping Liu Yilun Jiang Xiya Li Xinchi Chen Chu-Han Deng Yi-Yi Ren Roujia Wang Jiacheng Jin Kai Xue Ying Zhang Meirong Du Jun Shi Ling-Yun Wu Chun-Kang Chang Shuhong Shen Zhu Chen Sai-Juan Chen Xiaolong Liu Xiao-Jian Sun Mingyue Zheng Lan Wang | 2022 | Cell Research2022，32，12： | 1 |
| 19 | Lignin composite ionic liquid lubricants with excellent anti-corrosion,anti-oxidation,and tribological properties显示文摘A new type of lubricating material(BTA-P_(4444)-Lig)was synthesized by combining lignin with tetrabutylphosphorus and benzotriazole.The tribological properties,corrosion resistance,and anti-oxidation properties of BTA-P_(4444)-Lig as a lubricant were investigated.The lubricating material exhibits excellent friction reduction and wear resistance,as well as good thermal stability and excellent oxidation resistance.Mechanistic analysis reveals that the active elements N and P in the lubricating material react with the metal substrate,and the reaction film effectively blocks direct contact between the friction pairs,affording excellent friction reduction and wear resistance.At the same time,the phenolic hydroxyl group in lignin reacts with oxygen free radicals to form a resonance-stable semi-quinone free radical,which interrupts the chain reaction and affords good anti-oxidant activity. | Chaoyang ZHANG Zhiquan YANG Qing HUANG Xingwei WANG Wufang YANG Chunyu ZHOU Bo YU Qiangliang YU Meirong CAI Feng ZHOU | 2023 | Friction2023，11，7： | 0 |
| 20 | Correction: Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal lcancergrowth显示文摘In the process of collating the raw data,the authors noticed an inadvertent mistake occurred in Fig.3b that needs to be corrected after online publication of the article.In Fig.3b,as a result of an error in the graphics panel arrangement process,the band of NEMO was repeatedly inserted asβ-actin by mistake.The correct band is shown as below and in the updated Fig.3b.The correction did not affect any of our results or discussion as present in the original publication.We regret any inconvenience this has caused. | Zhenlong Yu Jian Gao Xiaolei Zhang Yulin Peng Wenlong Wei Jianrong Xu Zhenwei Li Chao Wang Meirong Zhou Xiangge Tian Lei Feng Xiaokui Huo Min Liu Mingliang Ye De-an Guo Xiaochi Ma | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
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