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| 1 | Inflammatory status in chronic renal failure: The role of homocysteinemia and pro-inflammatory cytokines显示文摘AIM: To evaluate determinants of inflammatory markers in chronic renal failure patients according to the level of glomerular filtration rate. METHODS: One hundred fifty four patients(Age; 44 ± 06 years, male/female; 66/88) with chronic renal failure(CRF) were divided into 6 groups according to the National Kidney Foundation(NKF) classification. They included 28 primary stage renal failure patients(CRF 1), 28 moderate stage renal failure patients(CRF 2),28 severe stage renal failure patients(CRF 3), 18 endstage renal failure patients(CRF 4), 40 hemodialysis(HD) patients, and 12 peritoneal dialysis(PD) patients. Tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), interleukin-6(IL-6) and C-reactive protein(CRP) were analyzed by immunosorbent assay kit(ELISA)(Cayman Chemical's ACETM EIA kit). Immunoassay methods were used for total homocysteine(tH cy)(fluorescence polarization immunoanalysis HPLC, Perkin Emer 200 series), transferrin(MININEPHTM human transferin kit: ZK070.R), ferritin(ADVIA Centaur) and fibrinogen analysis(ACL 200). Differences between groups were performed using SPSS 20.0 and data are expressed as the mean ± SD.RESULTS: Results showed that in comparison with CRF 1 group and other groups, TNF-α and IL-6 levels were respectively more elevated in HD(16.38 ± 5.52 pg/mL vs 0.39 ± 0.03 pg/mL, 11.05 ± 3.59 pg/mL vs 8.20 ± 0.22 pg/mL, P < 0.001) and PD(14.04 ± 3.40 pg/m L vs 0.39 ± 0.03 pg/m L, 10.15 ± 1.66 pg/m L vs 8.20 ± 0.22 pg/m L, P < 0.001). IL-1β levels were increased in HD(9.63 ± 3.50 pg/m L vs 3.24 ± 0.10 pg/mL, P < 0.001) and CRF 4(7.76 ± 0.66 pg/mL vs 3.24 ± 0.10 pg/m L, P < 0.001) patients than in CRF 1 and in the other groups. Plasma t Hcy levels were higher in HD(32.27 ± 12.08 μmol/L) and PD(28.37 ± 4.98 μmol/L) patients compared to the other groups of CRF(P < 0.001). The serum CRP level was significantly increased in HD(18.17 ± 6.38 mg/L) and PD(17.97 ± 4.85 mg/L) patients compared to the other groups of CRF patients(P < 0.001). The plasma fibrinogen level was more elevated in HD(6.86 ± 1.06 g/L) and CRF 4(6.05 ± 0.57 g/L) than in the other groups(P < 0.001). Furthermore; the ferritin level was higher in HD(169.90 ± 62.16 ng/m L) and PD(90.08 ± 22.09 ng/m L) patients compared to the other groups of CRF(P < 0.001). The serum transferrin value was significantly decreased especially in PD(1.78 ± 0.21 g/L) compared to the other groups(P < 0.001). We found a negative correlationbetween glomerular filtration rate(GFR), TNF-α levels(r =-0.75, P < 0.001), and t Hcy levels(r =-0.68, P < 0.001). We observed a positive correlation between GFR and transferrin levels(r = 0.60, P < 0.001). CONCLUSION: CRF was associated with elevated inflammatory markers. The inflammation was observed at the severe stage of CRF and increases with progression of renal failure. | Hadja Fatima Tbahriti Djamel Meknassi Rachid Moussaoui Amar Messaoudi Lakhdar Zemour Abbou Kaddous Malika Bouchenak Khedidja Mekki | 2013 | World Journal of Nephrology2013，2，2： | 32 |
| 2 | MC4R、POU1F1基因对京海黄鸡生长性能的遗传效应显示文摘以MC4R和POU1F1基因为候选基因,采用PCR-SSCP和DNA测序技术检测两个候选基因在京海黄鸡群体中的单核苷酸多态性(SNPs),同时对候选基因与京海黄鸡生长性能的相关性进行了研究。结果表明,MC4R基因编码区第662bp位置有G→C碱基的点突变,在京海黄鸡中检测到AA、AB、BB3种基因型,A等位基因频率为0.929,B等位基因频率为0.071;在POU1F1基因exon3在序列的第5231bp位置有一个A→T碱基的点突变,检测到CC、CD、DD3种基因型,C等位基因频率为0.500,D等位基因频率为0.500。采用GLM模型分析基因型对生长性能的遗传效应,结果表明,MC4R基因AA基因型个体的4、8、12周龄体重显著地高于BB型个体(P<0.05),16周龄体重差异极显著(P<0.01);POU1F1基因CD基因型个体体重极显著高于CC型和DD型(P<0.01)。因此推测MC4R和POU1F1基因可能是影响鸡生长性状的主效基因或与主效基因紧密连锁的标记基因,能够在分子标记辅助选择中用于对鸡生长性状的遗传改良。 | 陶勇 李国辉 胡玉萍 M. Dafalla Mekki 陈宽维 王金玉 | 2008 | 遗传2008，30，7： | 17 |
| 3 | Endoscopic ultrasound in gastroenterology:From diagnosis to therapeutic implications显示文摘Since its advent in 1980,the scope of endoscopic ultrasound(EUS)has grown to include a wide range of indications,and it is now being incorporated as an integral part of everyday practice in the field of gastroenterology.Its use is extending from an adjuvant imaging aid to utilization as a therapeutic tool for various gastrointestinal disorders.EUS was first used to visualize remote organs,such as the pancreas and abdominal lymph nodes.When fine needle aspiration was introduced,the indications for EUS expanded to include tissue sampling for diagnostic purposes.At the same time,the needle can be used to convey a potential therapy to the internal organs,allowing access to remote sites.In this review,we aim to highlight the expanding spectrum of EUS indications and uses in the field of gastroenterology. | Mohamed A Mekky Wael A Abbas | 2014 | World Journal of Gastroenterology2014，20，24： | 4 |
| 4 | Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis?显示文摘 | Susumu Hijioka Mohamed A. Mekky Vikram Bhatia Akira Sawaki Nobumasa Mizuno Kazuo Hara Waki Hosoda Yasuhiro Shimizu Kiichi Tamada Yasumasa Niwa Kenji Yamao | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 5 | Evolution of several soil properties following amendment with olive mill wastewater显示文摘橄榄工厂废水(OMW ) 的出现土壤的几个化学、生物化学的性质上的改正被调查。比作控制,与未经治疗、对待的 OMW 修改的土壤(由一个综合过程,基于氧气的真菌的预告的处理使用, Phanerochaete chrysosporium DSMZ 6909 由厌氧的处理列在后面) 显示出的高水平器官并且矿物质事。与未经治疗的 OMW 修改的土壤介绍了全部、无机的氮的底层(0.38 和 0.08 mg g −1 干燥土壤) 。对待的 OMW 几乎没包含污染物质的小内容(货到付款 = 4 g l −1 ;酉分的混合物 = 0.6 g l −1) ;那么,这些残余带的有机物很快在土壤被使矿物化。不是自养的细菌的数字被增加(从 54 × 10 5 CFU g −1 在到 123 × 的控制土壤的干燥土壤; 10 5 CFU g −1 干燥土壤) 响应 OMW 改正,主要在 C/N 比率修正以后。未经治疗的 OMW 申请改进了土壤碳内容(高 2.18 倍) ,当特定的呼吸仍然保持很低时。然而,对待的 OMW 应用程序断然影响了在与对待的 OMW 修改的土壤在控制土壤从 6.1 增加了到 9.75 的土壤特定的呼吸。这现象被硝化细菌数字, urease 和铵氧化物 ases 活动的改进伴随。 | Ali Mekki Abdelhafidh Dhouib Sami Sayadi | 2009 | Progress in Natural Science:Materials International2009，19，11： | 3 |
| 6 | To treat or not to treat the 'immunotolerant phase' of hepatitis B infection:A tunnel of controversy显示文摘Hepatitis B virus(HBV) infection is a global public health problem,with an estimated 350 million people worldwide chronically infected and approximately 500000 who die annually from HBV-related liver diseases.Management of chronic HBV is challenging and waves of guidelines emerge every year.One of the hottest topics and a matter of debate is the management of patients in their early immunotolerant phase of infection.With the lack of evidence,dealing with this particular subset of patients creates a great conflict with opposing views.In this review,the author highlights the pros and cons of these views and proposes a reasonable solution to resolve this dilemma. | Mohamed A Mekky | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 7 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 8 | Diagnostic utility of EUS-guided FNA in patients with gastric submucosal tumors显示文摘 | Mohamed A. Mekky Kenji Yamao Akira Sawaki Nobumasa Mizuno Kazuo Hara Mohamed A. Nafeh Ashraf M. Osman Takashi Koshikawa Yasushi Yatabe Vikram Bhatia | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 9 | Butter differs fromolive oil and sunflower oil in its effects on postprandiallipemia and triacylglycerol-rich lipoproteins after singlemixed meals in healthy young men显示文摘 | Mekki N Charbonnier M Borel P | 2002 | J Nutr2002，132，12： | 1 |
| 10 | Bio-CAD reverse engi- neering of free-form surfaces by planar contours显示文摘 | HACENE A MEKKI A | 2011 | Computer-Aided Design & Applications2011，8，1： | 1 |
| 11 | Structure of the linear trinuclear copper complex dichlorotetrakis - ( di - 2 -pyridylamido) tficopper显示文摘 | Pyrka G J E1 - Mekki M Pinkerton A A | 1991 | J Chem Soc Chem Comm1991，，2： | 1 |
| 12 | Spatial power amplifier using a passive and active TEM waveguide concept显示文摘 | Belaid Mekki Wu Ke | 2003 | IEEE Trans on MTT2003，51，3： | 1 |
| 13 | Effects of lowering fat and increasing dietary fiber on fasting and postprandial plasma lipids in hypercholesterolemic subjects consuming a mixed Mediterranean-Western diet显示文摘 | Mekki N Dubois C Charbonnier M | 1997 | Am J Clin Nutr1997，66，： | 1 |
| 14 | Digestive and metabolic effects of potato and maize fibres in human subjects 显示文摘 | Cherbut C Aube A C Mekki N | 1997 | Br J Nutr1997，77，： | 1 |
| 15 | Measuring Congestion in the Greater Toronto Area显示文摘 | Mekky Ali | 2004 | Traffic Engineering and Control2004，45，2： | 1 |
| 16 | Balloon dilatation of anastomotic strictures secondary to surgical repair of oesophageal atresia显示文摘 | Said M Mekki M Golli M | 2003 | B r J Radiol2003，76，901： | 1 |
| 17 | Study of synergism effect between TID and ATREE on the response of the LM124 operational amplifier显示文摘 | ROCHE N J PEREZ S MEKKI J | | 0，，06： | 1 |
| 18 | Digestive and metabolic effects of potato and maize fibres in human subjeets显示文摘 | Cherbut C Aube A C Mekki N | 1997 | Br J Nutr1997，77，： | 1 |
| 19 | Effect of time of meal consumption on bioavailability of a single oral 5mg tacrolimus dose 显示文摘 | Bekersky I Dressler D Mekki Q | 2001 | J Clin Pharmacol2001，41，3： | 1 |
| 20 | Canonical correlation analysis of body weight, body measurement and carcass characteristics of Jing hai Yellow chicken 显示文摘 | Yang Y Mekki D M Lv S J | 2006 | Journal of Animal and Veterinary Advances2006，5，11： | 1 |
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