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| 1 | Therapeutic effects of endoscopic therapy combined with enteral nutrition on acute severe biliary pancreatitis显示文摘背景尖锐严重胆汁的胰腺炎(ASBP ) 是严重、致命的疾病,并且开销是巨大的,治疗学的效果仍然不是令人满意的。试图改进治疗学的效果并且减少 105 个病人与 ASBP 诊断了的 ASBP treatment.Methods 的开销的这研究被指我们从 2004 年 1 月的部门到 2009 年 7 月。诊断基于外科的中国社会的 2007 个标准。病人们被划分成二个组;E 组:经历了的 50 个病人内视镜后退 choledochopancreatography (ERCP )+ 内视镜的 sphincterotomy (EST )+ 内视镜的 lithotripsy 篮子(ESR )+endoscopic 后退胆汁的排水(ERBD ) 和 enteral 营养(在) ,并且 R 组:没有 ERCP,经历了传统的治疗的 55 个病人。随后,主观症状,症状,生物化学的分析,浆液内毒素,肿瘤坏死因素一,由计算断层摄影术(CT ) 的等级,住院的费用和一些停留在二 groups.Results 之间被比较所有注册病人与所有治疗学的政体应允了很好。联合了在的内视镜的治疗能显著地改进症状,临床的符号,实验室价值,肿瘤坏死因素 and 内毒素当显著地减少时,医院的医院开销和长度留下来。试验性的调查结果表明与内视镜的治疗与结合了的 R group.Conclusions 相比在 E 组有明显的优点在是 ASBP 的有效、安全、经济的治疗学的政体。 | ZHOU Wen-ce LI Yu-min ZHANG Hui LI Xun ZHANG Lei MENG Wen-bo ZHU Ke-xiang ZHANG Quan-bao HE Min-yan | 2011 | Chinese Medical Journal2011，，19： | 22 |
| 2 | A voltage resonance-based single-ended online fault location algorithm for DC distribution networks显示文摘A novel single-ended online fault location algorithm is investigated for DC distribution networks. The proposed algorithm calculates the fault distance based on the characteristics of the voltage resonance. The Prony's method is introduced to extract the characteristics. A novel method is proposed to solve the pseudo dual-root problem in the calculation process. The multiple data windows are adopted to enhance the robustness of the proposed algorithm. An index is proposed to evaluate the accuracy and validity of the results derived from the various data windows. The performances of the proposed algorithm in different fault scenarios were evaluated using the PSCAD/EMTDC simulations. The results show that the algorithm can locate the faults with transient resistance using the 1.6 ms data of the DC-side voltage after a fault inception and offers a good precision. | JIA Ke LI Meng BI Tian Shu YANG Qi Xun | 2016 | Science China(Technological Sciences)2016，59，5： | 13 |
| 3 | Sociodemographic characteristics and risk factor analysis of Demodex infestation(Acari:Demodicidae)显示文摘To identify sociodemographic characteristics and risk factor of Demodex infestation,756 students aged 13-22 years in Xi'an,China were sampled for the school-based cross-sectional study.Demodex was examined using the cellophane tape method(CTP).The results showed that the total detection rate of Demodex was 67.6%.Logistic regression analysis revealed that five variables(gender,residence,sharing sanitary ware,frequency of face-wash per day,and use of facial cleanser) were found to be uncorrelated with Demodex infestation,whereas three variables(age,skin type,and skin disease) were found to be independent correlates.Students aged over 18 years had 22.1 times higher odds of Demodex infestation compared to those under 16 years and students aged 16-18 years also had 2.1 times higher odds compared to those aged 13-15 years.Odds of having a Demodex infestation for oily or mixed skin were 2.1 times those for dry or neutral skin.Students with a facial skin disease had 3.0 times higher odds of being infested with Demodex compared to those without.The inception rate of students with facial dermatoses increased in parallel with increasing mite count.The inception rates were 21.3%,40.7%,59.2%,and 67.7% in the negative,mild,moderate,and severe infestation groups,respectively(χ2=60.6,P<0.001).Specifically,the amount of infested mites and inception rate of acne vulgaris were positively correlated(R2=0.57,moderate infestation odds ratio(OR)=7.1,severe infestation OR=10.3).It was concluded that Demodex prevalence increases with age,and Demodex presents in nearly all adult human.Sebaceous hyperplasia with oily or mixed skin seems to favour Demodex proliferation.Demodex infestation could be associated with acne vulgaris.The CTP is a good sampling method for studies of Demodex prevalence. | Ya-e ZHAO Na GUO Meng XUN Ji-ru XU Mei WANG Duo-lao WANG | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 12 |
| 4 | Mechanisms of improvement of left ventricle remodeling by transplanting two kinds of autologous bone marrow stem cells in pigs显示文摘背景在尖锐心肌的梗塞( AMI )以后的很多心肌的房间的坏死导致心脏的功能和移植能改进的室 remodeling.Stem 房间的减少在 AMI 以后的心脏的功能,但是包含的机制一直不是完全学习试图在改变的室上经由冠的动脉调查自体同源的骨头髓 mononuclear 房间( BM-MNC )和 rnesenchymal 干细胞( MSC )的移植的效果的在场的 understood.The 控制组,简单梗塞模型组, BM-MNC 移植组,和 MSC 移植当有 AMI 的一个缩小的猪的模型被建立时, 90 纪录的 group.At ,自体同源的 BM-MNC 的移植(( 4.7ntraoperative ,并且手术后)被评估, compared.The 病态和死亡结果在二 groups.The 后续结果被比较,在二组织的 surgery.Results 与外科手术前的高风险的侧面有病人的类似的百分比以后。 | LI Shu-ren QI Xiao-yong HU Fu-li ZHANG Jian-qing WANG Tian-hong DANG Yi MENG Cun-liang LIU Hui-liang LI Ying-xiao WU Di DONG Jie XUN Li-ying GAO Li-hui JIN Fu-chang | 2008 | Chinese Medical Journal2008，，23： | 12 |
| 5 | Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer显示文摘BACKGROUND Early gastric cancer(EGC), compared with advanced gastric cancer(AGC), has a higher 5-year survival rate. However, due to the lack of typical symptoms and the difficulty in diagnosing EGC, no effective biomarkers exist for the detection of EGC, and gastroscopy is the only detection method.AIM To provide new biomarkers with high specificity and sensitivity through analyzed the differentially expressed microRNAs(miRNAs) in EGC and AGC and compared them with those in benign gastritis(BG).METHODSWe examined the differentially expressed miRNAs in the plasma of 30 patients with EGC, AGC, and BG by miRNA chip analysis. Then, we analyzed and selected the significantly different miRNAs using bioinformatics. Reverse transcription quantitative real-time polymerase chain reaction(RT-qPCR)confirmed the relative transcription level of these miRNAs in another 122 patients, including patients with EGC, AGC, Helicobacter pylori(H. pylori)-negative gastritis(Control-1), and H. pylori-positive atrophic gastritis(Control-2).To establish a diagnostic model for the detection of plasma miRNA in EGC, we chose miRNAs that can be used to determine EGC and AGC from Control-1 and Control-2 and miRNAs in EGC from all other groups.RESULTS Among the expression profiles of the miRNA chips in the three groups in the discovery set, of 117 aberrantly expressed miRNAs, 30 confirmed target prediction, whereas 14 were included as potential miRNAs. The RT-qPCR results showed that 14 potential miRNAs expression profiles in the two groups exhibited no differences in terms of H. pylori-negative gastritis(Control-1) and H. pyloripositive atrophic gastritis(Control-2). Hence, these two groups were incorporated into the Control group. A combination of four types of miRNAs,miR-7641, miR-425-5 p, miR-1180-3 p and miR-122-5 p, were used to effectively distinguish the Cancer group(EGC + AGC) from the Control group [area under the curve(AUC) = 0.799, 95% confidence interval(CI): 0.691-0.908, P < 0.001].Additionally, miR-425-5 p, miR-24-3 p, miR-1180-3 p and miR-122-5 p were utilized to distinguish EGC from the Control group(AUC = 0.829, 95%CI: 0.657-1.000, P =0.001). Moreover, the miR-24-3 p expression level in EGC was lower than that in the AGC(AUC = 0.782, 95%CI: 0.571-0.993, P = 0.029), and the miR-4632-5 p expression level in EGC was significantly higher than that in AGC(AUC = 0.791,95%CI: 0.574-1.000, P = 0.024).CONCLUSION The differentially expressed circulatory plasma miR-425-5 p, miR-1180-3 p, miR-122-5 p, miR-24-3 p and miR-4632-5 p can be regarded as a new potential biomarker panel for the diagnosis of EGC. The prediction and early diagnosis of EGC can be considerably facilitated by combining gastroscopy with the use of these miRNA biomarkers, thereby optimizing the strategy for effective detection of EGC. Nevertheless, larger-scale human experiments are still required to confirm our findings. | Xiao-Liang Zhu Long-Fei Ren Hai-Ping Wang Zhong-Tian Bai Lei Zhang Wen-Bo Meng Ke-Xiang Zhu Fang-Hui Ding Long Miao Jun Yan Yan-Ping Wang Yu-Qin Liu Wen-Ce Zhou Xun Li | 2019 | World Journal of Gastroenterology2019，25，13： | 11 |
| 6 | Stromal cell derived factor-1 enhances bone marrow mononuclear cell migration in mice with acute liver failure显示文摘AIM:To evaluate the number of bone marrow mononuclear cells(BMMC) that are migrated to the liver following transplantation of murine BMMC into mice with acute liver injury.METHODS:BMMC were isolated from the bone marrow of mice in a lymphocyte separation medium and then labeled with PKH26.The labeled cells were subsequently infused into the caudal veins of BALB/c mice with hepatic injury induced by carbon tetrachloride and 2-acetylaminofluorene.Mice in experimental group were treated with stromal cell-derived factor-1(SDF-1) which was injected intraperitoneally after trans-plantation of BMMC.Mice in control group were injected intraperitoneally with 0.1 mL of saline(0.9% NaCl) after transplantation of BMMC.After 2 wk,migration of the cells in experimental group was studied by fluorescence microscopy.The expression of proliferating cell nuclear antigen and albumin was quantified with manual methods in both groups.The serum transaminase levels at different time points were compared between the two groups.RESULTS:The labeled 'cells' were found in the portalregion and central veins of hepatic lobules.The PKH26-labeled cells appeared at an average frequency of 108 ± 8/high power field in the experiment group and 65 ± 8/high power field in the control group(P < 0.05).The total number of positive cells was 29 ± 7/high power field in the experimental group and 13 ± 2/high power field in the control group.The albumin expres-sion level was also higher in the experimental group than in the control group(29 ± 7 vs 13 ± 2,P < 0.05).The total number of crossing points was 156 ± 5/high power field in the experimental group and 53 ± 5/high power field in the control group(P < 0.05).The serum alanine aminotransferase levels in experimental and control groups were measured at different time points(120 ± 40 vs 118.50 ± 1.75,P > 0.05;80.60 ± 6.50 vs 101.08 ± 5.67,P < 0.05;50.74 ± 5.38 vs 80.47 ± 4.62,P < 0.05;30.54 ± 2.70 vs 60.72 ± 4.37,P < 0.05;30.77 ± 5.36 vs 40.47 ± 6.50,P < 0.05).At the same time,the serum aspartate aminotransferase levels were measured in experimental and control groups at different time points(122.55 ± 1.46 vs 120.70 ± 4.22,P > 0.05;54.26 ± 6.50 vs 98.70 ± 8.20,P < 0.05;39.47 ± 5.39 vs 78.34 ± 4.50,P < 0.05;28.94 ± 2.70 vs 56.44 ± 4.28,P < 0.05;30.77 ± 5.45 vs 42.50 ± 6.28,P < 0.05).CONCLUSION:SDF-1 can promote the migration of BMMC to the liver of mice with acute liver failure. | Shi-Zhu Jin Xiang-Wei Meng Ming-Zi Han Xun Sun Li-Ying Sun Bing-Rong Liu | 2009 | World Journal of Gastroenterology2009，15，21： | 10 |
| 7 | First dark matter search results from the PandaX-Ⅰ experiment显示文摘We report on the first dark-matter(DM)search results from PandaX-I,a low threshold dual-phase xenon experiment operating at the China JinPing Underground Laboratory.In the 37-kg liquid xenon target with 17.4 live-days of exposure,no DM particle candidate event was found.This result sets a stringent limit for low-mass DM particles and disfavors the interpretation of previously-reported positive experimental results.The minimum upper limit,3.7×10-44cm2,for the spin-independent isoscalar DM-particle-nucleon scattering cross section is obtained at a DM-particle mass of 49 GeV/c2at 90%confidence level. | XIAO MengJiao XIAO Xiang ZHAO Li CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HU Jie HUANG XingTao JI XiangDong JU YongLin LEI SiAo LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing STEPHENSON Scott TAN AnDi TARL Greg WANG HongWei WANG JiMin WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIE PengWei YOU YingHui ZENG XiongHui ZHANG Hua ZHANG Tao ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，11： | 10 |
| 8 | Surface integrity of GH4169 affected by cantilever finish grinding and the application in aero-engine blades显示文摘GH4169 is the main material for aero-engine blades and integrated blisks. Because GH4169 has a poor milling performance, the profile precision and surface integrity of blades and integrated blisks are difficult to be met by utilizing the conventional milling process, which directly influence the global performance and reliability of aero-engines. Through grinding experiments on parameters and surface integrity optimization, the helical cantilever grinding process utilizing a300# CBN RB wheel is presented and applied in finish machining of GH4169 blades. The profile errors of the blade surface are within ±0.01 mm, the roughness is less than 0.4 lm, the residual compressive stresses and the hardening rate are appropriate, there are no phenomena of burr and smearing with the grinding chips, and the leading/trailing edge can be smoothly connected with the suction/pressure surface. All the experimental results indicate that this grinding process is greatly suitable for the profile finish machining of GH4169 blades. | Li Xun Ma Shuang Meng Fanjun | 2015 | Chinese Journal of Aeronautics2015，28，5： | 9 |
| 9 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 10 | Extracellular matrix from human umbilical cordderived mesenchymal stem cells as a scaffold for peripheral nerve regeneration显示文摘The extracellular matrix,which includes collagens,laminin,or fibronectin,plays an important role in peripheral nerve regeneration.Recently,a Schwann cell-derived extracellular matrix with classical biomaterial was used to mimic the neural niche.However,extensive clinical use of Schwann cells remains limited because of the limited origin,loss of an autologous nerve,and extended in vitro culture times.In the present study,human umbilical cord-derived mesenchymal stem cells(h UCMSCs),which are easily accessible and more proliferative than Schwann cells,were used to prepare an extracellular matrix.We identified the morphology and function of h UCMSCs and investigated their effect on peripheral nerve regeneration.Compared with a non-coated dish tissue culture,the h UCMSC-derived extracellular matrix enhanced Schwann cell proliferation,upregulated gene and protein expression levels of brain-derived neurotrophic factor,glial cell-derived neurotrophic factor,and vascular endothelial growth factor in Schwann cells,and enhanced neurite outgrowth from dorsal root ganglion neurons.These findings suggest that the h UCMSC-derived extracellular matrix promotes peripheral nerve repair and can be used as a basis for the rational design of engineered neural niches. | Bo Xiao Feng Rao Zhi-yuan Guo Xun Sun Yi-guo Wang Shu-yun Liu Ai-yuan Wang Quan-yi Guo Hao-ye Meng Qing Zhao Jiang Peng Yu Wang Shi-bi Lu | 2016 | Neural Regeneration Research2016，11，7： | 8 |
| 11 | Emergent Endoscopic Retrograde Cholangiopancreatography with Placement of Biliary Double Stents to Salvage Endoscopic Retrograde Cholangiopancreatography-lnduced Stapfer's Type Ⅱ Perforation显示文摘 | Ping Yue Wen-Bo Meng Joseph W Leung Lei Zhang Xiao-Liang Zhu Hui Zhang Hai-Ping Wang Zheng-Feng Wang Ke-Xiang Zhu Long Miao Wen-Ce Zhou Xun Li | 2018 | Chinese Medical Journal2018，，19： | 7 |
| 12 | Effect of endoscopic retrograde cholangiopancreatography combined with laparoscopy and choledochoscopy on the treatment of Mirizzi syndrome显示文摘 | LI Bo LI Xun ZHOU Wen-ce HE Ming-yan MENG Wen-bo ZHANG Lei LI Yu-min | 2013 | Chinese Medical Journal2013，，18： | 7 |
| 13 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 14 | Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities bv DRm217显示文摘多糖症在糖尿病是为心肌的 apoptosis 和机能障碍负责的主要因素之一。许多研究证明了在减少的 Na +/K+-ATPase 活动和糖尿病的心肌症之间有一种靠近的关系。然而,高导致葡萄糖的心肌的损害上的直接激活的 Na +/K+-ATPase 的效果仍然是未知的。这里,我们发现了那 DRm217, Na +/K+-ATPases 医生区域特定的 monoclonal 抗体和直接使活跃之物,能阻止高导致葡萄糖的 H9c2 细胞损害,反应的氧种(ROS ) 版本,和 mitochondrial 机能障碍。高葡萄糖处理减少了 Na +/K+-ATPase 活动和增加的细胞内部的 Ca 2+ 铺平,而 DRm217 增加了 Na +/K+-ATPase 活动和减轻的 Ca 2+ 超载。Ca 2+ 超载或关门的钠钙 exchanger (NCX 隧道) 的抑制能颠倒高导致葡萄糖的 ROS 增加和房间损害。另外, DRm217 能显著地稀释高导致葡萄糖的 p38, JNK 和 ERK1/2 phosphorylation,它涉及高导致葡萄糖的房间损害和 ROS 累积。我们的调查结果建议 DRm217 可以在心免于高葡萄糖的有害效果。由特定的 Na +/K+-ATPase 使活跃之物的高导致葡萄糖的心肌的房间损害的预防可以是一种吸引人的治疗学的选择。 | Xiaofei Yan Meng Xun Jing Li Litao Wu Xiaojuan Dou Jin Zheng | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 5 |
| 15 | A general strategy for bimetallic Pt-based nano-branched structures as highly active and stable oxygen reduction and methanol oxidation bifunctional catalysts显示文摘The morphology and size of Pt-based bimetallic alloys are known to determine their electrocatalytic performance in reactions relevant to fuel cells.Here,we report a general approach for preparing Pt-M(M=Fe,Co and Ni)bimetallic nano-branched structure(NBs)by a simple high temperature solution-phase synthesis.As-prepared Pt-M NBs show a polycrystalline structure and are rich in steps and kinks on the surface,which promote them favorable bifunctional catalytic properties in acidic electrolytes,specifically in terms of the oxygen reduction reaction(ORR)and methanol oxidation reaction(MOR).Specially,Pt-Co NBs/C catalyst shows 6.1 and 5.3 times higher in specific activity(SA)and mass activity(MA)for ORR than state-of-the-art commercial Pt/C catalysts,respectively.Moreover,it exhibits a loss of 4.0%in SA and 14.4%in MA after 10,000 cycles of accelerated durability tests(ADTs)compared with the initial activities.In addition,we also confirmed the superior MOR activity of Pt-Co NBs/C catalyst in acidic electrolytes.For Pt-M NBs with other alloying metals,the ORR and MOR activities are both higher than commercial catalysts and are in the sequence of Pt-Co/C>Pt-Fe/C>Pt-Ni/C>commercial Pt/C(or PtRu/C).The improved activities and durability can benefit from the morphological and compositional effects.This synthesis approach may be applied to develop bifunctional catalysts with enhanced ORR and MOR properties for future fuel cells designs. | Wenjuan Lei Menggang Li Lin He Xun Meng Zijie Mu Yongsheng Yu Frances MRoss Weiwei Yang | 2020 | Nano Research2020，13，3： | 5 |
| 16 | Clinical significance of different periampullary diverticulum classifications for endoscopic retrograde cholangiopancreatography cannulation显示文摘BACKGROUND Different types of periampullary diverticulum(PAD) may differentially affect the success of endoscopic retrograde cholangiopancreatography(ERCP) cannulation,but the clinical significance of the two current PAD classifications for cannulation is limited.AIM To verify the clinical value of our newly proposed PAD classification.METHODS A new PAD classification(Li-Tanaka classification) was proposed at our center.All PAD patients with native papillae who underwent ERCP from January 2012 to December 2017 were classified according to three classification systems, and the effects of various types of PAD on ERCP cannulation were compared.RESULTS A total of 3564 patients with native papillae were enrolled, including 967(27.13%)PAD patients and 2597(72.87%) non-PAD patients. In the Li-Tanaka classification, type Ⅰ PAD patients exhibited the highest difficult cannulation rate(23.1%, P = 0.01), and type Ⅱ and Ⅳ patients had the highest cannulation success rates(99.4% in type Ⅱ and 99.3% in type Ⅳ, P < 0.001). In a multivariableadjusted logistic model, the overall successful cannulation rate in PAD patients was higher than that in non-PAD patients [odds ratio(OR) = 1.87, 95% confidence interval(CI): 1.04-3037, P = 0.037]. In addition, compared to the non-PAD group,the difficulty of cannulation in the type Ⅰ PAD group according to the Li-Tanaka classification was greater(OR = 2.04, 95%CI: 1.13-3.68, P = 0.004), and the successful cannulation rate was lower(OR = 0.27, 95%CI: 0.11-0.66, P < 0.001),while it was higher in the type Ⅱ PAD group(OR = 4.44, 95%CI: 1.61-12.29, P <0.01).CONCLUSION Among the three PAD classifications, the Li-Tanaka classification has an obvious clinical advantage for ERCP cannulation, and it is helpful for evaluating potentially difficult and successful cannulation cases among different types of PAD patients. | Ping Yue Ke-Xiang Zhu Hai-Ping Wang Wen-Bo Meng Jian-Kang Liu Lei Zhang Xiao-Liang Zhu Hui Zhang Long Miao Zheng-Feng Wang Wen-Ce Zhou Azumi Suzuki Kiyohito Tanaka Xun Li | 2020 | World Journal of Gastroenterology2020，26，19： | 5 |
| 17 | Protective effects of organic extracts of Alpinia oxyphylla against hydrogen peroxide-induced cvtotoxicitv in PC12 cells显示文摘Alpinia oxyphylla,a traditional herb,is widely used for its neuroprotective,antioxidant and memory-improving effects.However,the neuroprotective mechanisms of action of its active ingredients are unclear.In this study,we investigated the neuroprotective effects of various organic extracts of Alpinia oxyphylla on PC12 cells exposed to hydrogen peroxide-induced oxidative injury in vitro.Alpinia oxyphylla was extracted three times with 95%ethanol(representing extracts 1–3).The third 95%ethanol extract was dried and resuspended in water,and then extracted successively with petroleum ether,ethyl acetate and n-butanol(representing extracts 4–6).The cell counting kit-8 assay and microscopy were used to evaluate cell viability and observe the morphology of PC12 cells.The protective effect of the three ethanol extracts(at tested concentrations of 50,100 and 200μg/mL)against cytotoxicity to PC12 cells increased in a concentration-dependent manner.The ethyl acetate,petroleum ether and n-butanol extracts(each tested at 100,150 and 200μg/mL)had neuroprotective effects as well.The optimum effective concentration ranged from 50–200μg/mL,and the protective effect of the ethyl acetate extract was comparatively robust.These results demonstrate that organic extracts of Alpinia oxyphylla protect PC12 cells against apoptosis induced by hydrogen peroxide.Our findings should help identify the bioactive neuroprotective components in Alpinia oxyphylla. | Li-Hong Duan Meng Li Chun-Bao Wang Qing-Mei Wang Quan-Quan Liu Wan-Feng Shang Ya-Jin Shen Zhuo-Hua Lin Tong-Yang Sun Zheng-Zhi Wu Ying-Hong Li Yu-Long Wang Xun Luo | 2020 | Neural Regeneration Research2020，15，4： | 4 |
| 18 | Proteomic analysis of HUH-7 cells harboring in vitro-transcribed fulllength hepatitis C virus 1b RNA显示文摘目的:现在的学习在在 抄录vitro 的全身的丙肝病毒磅 RNA ( HuH-7-HCV )怀有的 HuH-7 房间和 HuH-7 房间检验了蛋白质的微分表示,并且阐明对 HCV replication.Methods 的细胞的回答: HuH-7-HCV 房间和 HuH-7 嘲笑房间的匹配的对的蛋白质侧面被 2-D 电气泳动( 2DE )分析。Solubilized 蛋白质被等电位的集中,并且由 12.5%SDS 页在第二种尺寸在第一种尺寸分开。微分蛋白质表示被图象分析软件的使用分析为 HCV 联系感染的 proteins.Results 识别候选人: 总共, 29 个蛋白质点证明增加和 25 个蛋白质点作为与 HuH-7 嘲笑房间相比在 HuH-7-HCV 房间 2DE 侧面在信号显示出减少。在下一步,显示出最大的增加的 10 个点和显示出最大的减少的 10 个点从胶化被切除,在场的蛋白质到飞行质谱计(MALDI-TOF MS ) 或 MALDI-TOF/TOF MS.In 总数的帮助矩阵的激光 Desorption/Ioniza-tion 时间被识别, 13 蛋白质成功地被识别。微分表示的潜在的意义由于 HCVreplication 是 discussed.Conclusion : 我们的学习面对 HCV 复制和 HCV 的机制的收益信息在 HuH-7 房间的 proteome 识别变化致病。这些结果将为能是为处理的分子的目标的 HCV 联系感染的蛋白质的鉴定是有用的。 | Meng XUN Si-hai ZHAO Chun-xia CAO Juan SONG Ming-ming SHAO Yong-lie CHU | 2008 | Acta Pharmacologica Sinica2008，29，6： | 4 |
| 19 | Genetic polymorphism and mRNA levels of cytochrome P450ⅡE1 and glutathione S-transferase P1 in patients with alcoholic liver disease in different nationalities显示文摘BACKGROUND:Alcohol abuse and dependence are major factors in the pathogenesis of alcoholic liver disease(ALD).Alcohol abuse is becoming an increasingly severe problem among the Han,Mongol,and Korean nationalities in northeast China.This study aimed to investigate the relationship between ALD and the genetic polymorphism and expression levels of two enzymes,cytochrome P450ⅡE1(CYPⅡE1)and glutathione S-transferase P1(GSTP1)in patients of three nationalities.METHODS:Peripheral blood was collected from 353 Chinese patients with ALD,300 alcohol dependent patients without liver disease(alcoholic),and 360 healthy controls.Each group included patients from the Han,Mongol and Korean nationalities.Real-time polymerase chain reaction(PCR)and PCR-restriction fragment length polymorphism(PCR-RFLP)were used.RESULTS:Regardless of nationality,patients who carried the rare CYPⅡE1 C2 and GSTP1 Val alleles were at higher risk of ALD.The frequency of C2 and Val in patients with ALD was respectively 50.00% and 26.98% in the Han,31.36% and 22.87% in the Mongol,and 45.87% and 22.02% in the Korean nationality.No significant differences were seen in the frequency of either C2 or Val alleles in ALD patients among the three nationalities.In each nationality,the frequency of both C2 and Val alleles was significantly higher in ALD compared to alcoholic and healthy controls.Except for nationality,the average mRNA levels of CYPⅡ E1 in ALD patients and healthy controls were 10.05%and 2.21%,respectively.The average mRNA levels of GSTP1 in ALD patients and healthy controls were 0.53%and 2.12%,respectively.The mRNA level of CYPⅡE1 was higher,and that of GSTP1 was lower in patients with ALD compared to the controls.CONCLUSIONS:Except for nationality,patients with ALD in this series tended to have a higher mRNA expression of CYPⅡE1 and to carry the C2 allele,and tended to have a lower mRNA expression of GSTP1 and to carry the Val allele.There is a causal relationship between the polymorphic alleles,which leads to different mRNA levels and the development of ALD. | Ying Liu,Xiang-Wei Meng,Ling-Yun Zhou,Pei-Yi Zhang,Xun Sun and Ping Zhang Department of Gastroenterology,First Affiliated Hospital,Jilin University,Changchun 130021,China Department of Gastroenterology,Heilongjiang Province Hospital,Harbin 150036,China Department of Medical Molecular Biology,Harbin Medical University,Harbin 150086,China | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 4 |
| 20 | U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control study in Chinese population显示文摘在由维持 chromosomal 正直并且阻止染色体的生物变老的一个关键角色结束的 Telomeres 玩熔化。流行病学的研究建议了 telomere 长度的内部个人的差别能影响倾向到多重癌症,但是关于食道的有鳞的房间癌(ESCC ) 的证据仍然是不明确的。几 telomere 在白种人的长度相关的单个核苷酸多型性(TLSNP ) 在染色体宽的协会研究被报导了。然而,在 ESCC 开发的 telomere 长度和 TL-SNPs 的效果是不清楚的。因此,我们进行了盒子控制研究(1045 个 ESCC 案例和 1433 控制) 在中国人口评估在 telomere 长度, TL-SNPs,和 ESCC 风险之间的协会。作为结果, ESCC 案例显示出全面更短的相对 telomere 长度(RTL )( 中部:1.34 ) 比控制(中部:1.50, P < 0.001 ) 。更有趣地,一个明显的非线性的U字形的协会在 RTL 和 ESCC 风险之间被观察( P < 0.001 )与比率(95%信心间隔)等于到 2.40 的机会( 1.843.14 ), 1.36 ( 1.031.79 ), 1.01 ( 0.761.35 ),并且 1.37 ( 1.031.82 )为个人在第一(最短),第二,第三,并且 第5 (最长) quintile 分别地,在是的 第4 quintile 与那些相比引用组。没有重要协会在八报导 TL-SNPs 和 ESCC 危险性之间被观察。这些调查结果建议短或极其长的 telomeres 可以是为在中国人口的 ESCC 的风险因素。 | Jiangbo Du Wenjie Xue Yong Ji Xun Zhu Yayun Gu Meng Zhu Cheng Wang Yong Gao Juncheng Dai Hongxia Ma Yue Jiang Jiaping Chen Zhibin Hu Guangfu Jin Hongbing Shen | 2015 | Frontiers of Medicine2015，9，4： | 4 |
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