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| 1 | Inhibitory Activity of Honeysuckle Extracts against Influenza A Virus In Vitro and In Vivo显示文摘Honeysuckle has been used in the treatment of influenza virus infection for thousands of years in China.However,its main active components and the functional mechanisms remain to be elucidated.Here,four honeysuckle extracts,including acids extract,flavonoids extract,total extract and acids-flavonoids mixture,were prepared to clarify the main active antiviral components.The cytopathic effect reduction assay showed that all the four extracts inhibited the replication of influenza viruses H1N1,H3N2 and the oseltamivir-resistant mutant strain H1N1-H275Y.The acids-flavonoids mixture had the strongest inhibitory effects in vitro with EC_(50) values of 3.8,4.1,and >20 lg/m L against H1N1,H3N2 and H1N1-H275Y,respectively,showing competitive antiviral activity with oseltamivir and ribavirin.Honeysuckle acids extract also showed the most significant antiviral activity in vivo.Oral administration of the acids extract at a dosage of 600 mg/kg/d effectively alleviated viral pneumonia,maintained body weight and improved the survival rate to 30% of the mice infected with a lethal dose of H1N1.The results of time-of-drug addition experiment and neuraminidase (NA) inhibition assay showed that honeysuckle extracts had a broad-spectrum inhibitory effect against influenza virus NAs.The flavonoid extract showed the strongest inhibitory effect on the NA of influenza virus H7N9 with an IC_(50) of 24.7 lg/m L.These results suggested that these extracts might exert their antiviral activity by suppressing the release of influenza viruses.Briefly,our findings demonstrate that acids and flavonoids extracts of honeysuckle are the major antiviral active components,and the acids extract has the potential to be developed into an antiviral agent against influenza virus,especially for oseltamivirresistant viruses. | Mengwei Li Yuxu Wang Jing Jin Jie Dou Qinglong Guo Xue Ke Changlin Zhou Min Guo | 2021 | Virologica Sinica2021，36，3： | 11 |
| 2 | Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis显示文摘OBJECTIVE: To address the optimal Chinese herbal injections(CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.METHODS: Several electronic databases were searched up to June 1 st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization(TACE). Primary outcomes were 1-year and 2-year survival rate, the secondary outcomes includes the clinical effective rate, performance status and the adverse reactions(ADRs). Data analysis was applied Stata 13.0 and Win BUGS 1.4 software.RESULTS: A total of 105 randomized controlled trials(RCTs) were identified for inclusion in this analysis, with data for 7683 patients and 13 CHIs. The results suggested that Javanica oil emulsion,Huachansu injection plus TACE were more favorable for 1-year and 2-year survival rate than other CHIs. Kanglaite, Astragalus polysaccharide injection plus TACE showed superiority in the clinical effective rate and performance status over other CHIs.And Shenmai injection plus TACE was superior to reducing ADRs than other CHIs for patients with liver cancer.CONCLUSION: Our findings indicated that receiving CHIs combined with TACE may have therapeutic benefits for patients with liver cancer in improving survival rate, clinical effective rate, the performance status and alleviating the ADRs. | Zhang Dan Wang Kaihuan Zheng Jiewen Wu Jiarui Duan Xiaojiao Ni Mengwei Liu Shuyu Zhang Bing Zhao Yi | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 9 |
| 3 | Trends in insulin resistance:insights into mechanisms and therapeutic strategy显示文摘The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.Insulin is a key peptide hormone and mediates the systemic glucose metabolism in different tissues.Insulin resistance(IR)is a disordered biological response for insulin stimulation through the disruption of different molecular pathways in target tissues.Acquired conditions and genetic factors have been implicated in IR.Recent genetic and biochemical studies suggest that the dysregulated metabolic mediators released by adipose tissue including adipokines,cytokines,chemokines,excess lipids and toxic lipid metabolites promote IR in other tissues.IR is associated with several groups of abnormal syndromes that include obesity,diabetes,metabolic dysfunction-associated fatty liver disease(MAFLD),cardiovascular disease,polycystic ovary syndrome(PCOS),and other abnormalities.Although no medication is specifically approved to treat IR,we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin sensitivity.Ultimately,the systematic discussion of complex mechanism will help to identify potential new targets and treat the closely associated metabolic syndrome of IR. | Mengwei Li Xiaowei Chi Ying Wang Sarra Setrerrahmane Wenwei Xie Hanmei Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 5 |
| 4 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bddsq9q0kpqon0506n05.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 5 | Late Holocene mangrove development and response to sea level change in the northwestern South China Sea显示文摘Mangroves,widely distributed along the coasts of tropical China,are influenced by Asia monsoon,relative sea level change and enhanced human activity.To predict the impacts of future climate change on mangrove ecosystems,it can be understood by reconstructing past mangrove dynamics using proxies preserved in coastal sediments.In this study,we quantitatively partitioned buried organic matter(OM)sources,collected from a vulnerable mangrove swamp in the Qinzhou Bay of northwestern South China Sea,using a ternary end-member mixing model of δ^13C and C:N values.Mangrove-derived OM(MOM)contribution was used as a tracer for mangrove development since 2.34 cal ka BP.This information,together with paleoclimate records(i.e.,speleothem δ^18O values,sea level change,grain size parameters)and human activity,was used to divide mangrove development into three stages during the late Holocene:relative flourish(2.34-1.13 cal ka BP),relative degradation(1.13-0.15 cal ka BP)and further degradation(0.15-0 cal ka BP).Before 1.13 cal ka BP,mangroves flourished with a high MOM contribution((88.9±10.6)%),corresponding to stable and high sea level under a warm and humid climate.After 1.13 cal ka BP,rapid fall in relative sea level coupled with the strengthening of the Asian winter monsoon,resulted in mangrove degradation and MOM reduction((62.4±18.9)%).Compared with air temperature and precipitation,the relative sea level fall was the main controlling factor in mangrove development before entering the Anthropocene(the time of the Industrial Revolution).After^150 cal a BP,reclamation of mangrove swamps to shrimp ponds is the main factor causing mangrove degradation and MOM reduction. | Peng Xia Xianwei Meng Zhen Li Pengyao Zhi Mengwei Zhao Enkang Wang | 2019 | Acta Oceanologica Sinica2019，38，11： | 4 |
| 6 | Enzymology properties of two different xylanases and their impacts on growth performance and intestinal microflora of weaned piglets显示文摘The enzyme xylanase is more and more widely used in feed production, but different xylanase have different properties, mechanism and application effects. To provide a theoretical basis for choosing more suitable xylanase in feed production, we selected bacterial xylanase(BX), labeled enzyme A, and trichoderma xylanase(TX), labeled enzyme B, and studied the enzymology properties and application effects on growth performance and gut flora in weaned piglets. The results showed that the activity levels of both appear parabolic along with increasing pH or temperature, but the amplitude of enzyme activity changing curves and the pH/temperature of optimal activity level are different, where enzyme A has the optimal activity level at 50 ℃ with a pH value of 5.0. The optimal activity level of enzyme B was achieved at 70 ℃ with a pH around 6.0. Enzyme B suffered very little activity loss with moisture level at16% and temperature from 80℃ to 90 ℃. Enzyme A suffered a big drop in activity level when processed with high temperature from around 80 ℃ to 90 ℃, and it was even completely inactivated at 90 ℃,Enzyme A has very low activity level after being processed in acid environment, but enzyme B has minor changes in activity level with respect to changes in acid level, indicating significantly different enzymatic properties between the two different sources of xylanases. In feeding experiment, the control group, was fed the basal diet, and the BX group and TX group were fed basal diets supplemented with 0,01% bacterial and fungal xylanases, respectively. The results showed that ADG of the BX group and TX group increased by 3.25%(P> 0.05) and 8.22%(P < 0.05), respectively, and the feed conversion ratio decreased by 6.74% and 7.86%(P > 0.05), respectively compared with the control group; TX group had significantly higher(P < 0.05) ADG compared with BX group; BX group and TX group had significantly lower ileum Escherichia coli level than the control group, which were reduced by up to 12.98%(P < 0.05) and 11.68%(P < 0.05), respectively, but the ileal lactic acid bacteria levels were significantly increased by 16.21%(P < 0.01) and 27.02%(P < 0.01),respectively. There were no significant differences(P > 0.05) between BX group and TX group in terms of lactic acid bacteria E. coli level. We concluded that fungal xylanase(enzyme B) has better performances in improving weaned piglet growth and in increasing ileal lactic acid bacteria level compared with bacterial xylanase(enzyme A). | Qinghua Chen Mengwei Li Xiong Wang | 2016 | Animal Nutrition2016，，1： | 3 |
| 7 | Preparation and application of a phosphorous free and non- nitrogen scale inhibitor in industrial cooling water systems显示文摘钙碳酸盐,锌(II ) 和铁(III ) 的一种新奇环境地友好的类型规模禁止者丙烯酸的 acidallylpolyethoxy 羧化物共聚物(AAAPEL ) 被综合。向 CaCO 的 AA-APEL 的反规模性质 < 潜水艇 class= “ a-plus-plus ” > 3 , 锌(II ) 和人工的冷却水里的铁(III ) 通过静态的规模抑制测试被学习。观察证明两钙碳酸盐,锌(II ) 和铁(III ) 抑制与增加 AA-APEL 的剂量增加。CaCO 的形成上的效果 < 潜水艇 class= “ a-plus-plus ” > 3 与扫描电子显微镜学(SEM ) 的联合被调查,传播电子显微镜学(TEM ) , X 光检查粉末衍射(XRD ) 分析和 fourier 分别地转变红外线的分光计。结果证明 AA-APEL 共聚物不仅影响的钙碳酸盐水晶形态学和水晶尺寸而且 crystallinity。CaCO 的结晶化 < 潜水艇 class= “ a-plus-plus ” > 当禁止者不在时的 3 是菱形的方解石水晶,而有 vaterite 晶体的方解石的混合物面对 AAAPEL 共聚物被发现。抑制机制被建议在钙或铁离子和聚乙烯乙二醇(木钉) 之间的相互作用是基本动力在使水系统凉下来制止规模的形成。 | Guangqing LIU Mengwei XUE Jingyi HUANG Huchuan WANG Yuming ZHOU Qingzhao YAO Lei LING Ke CAO Yahui LIU Yunyun BU Yiyi CHEN Wendao WU Wei SUN | 2015 | Frontiers of Environmental Science & Engineering2015，9，3： | 3 |
| 8 | Ultrathin hexagonal boron nitride as a van der Waals,force initiator activated graphene for engineering efficient non-metal electrocatalysts of Li-CO_(2) battery显示文摘Reasonably regulating electronic coupling to promote charge transfer and exciton separation has been regarded a promising approach in catalysis.The material engineering of van der Waals heterojunction(vdWsH)based on two-dimensional(2D)materials would be a potential way to optimize the as-prepared extrinsic physicochemical characteristics.However,it was still an almost uncultivated land waiting for exploration in catalysis.Herein,we introduced the inert h-boron nitride(h-BN)in non-metal reduced graphene oxide(GN)catalysts and constructed BN-GN vdWsH.The theoretical calculation demonstrated that the h-BN can effectively modify the electronic properties of graphene.With the introduction of h-BN,the BN-GN vdWsH can obviously enhance the catalytic activity of Li-CO_(2) battery.The existence of BN-GN vdWsH can reduce the overpotential more than 700 mV compared with reduced graphene oxide during the CO_(2) reduction reaction(CO_(2)RR)and CO_(2) evolution reaction(CO_(2)ER),and it extended cyclic stability more than three times,which was one structure design made it work as a high efficient electrocatalyst,catalytic materials. | Zemin Sun Di Wang Liu Lin Yuhui Liu Mengwei Yuan Caiyun Nan Huifeng Li Genban Sun Xiaojing Yang | 2022 | Nano Research2022，15，2： | 3 |
| 9 | Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats显示文摘OBJECTIVE: To investigate the role of Eclipta prostrata (E. prostrata) extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats. METHODS: Rats were divided into five groups, with 10 animals in each group. Aging rats were produced by treatment with 100 mg·kg-1·d-1 of D-galactose for 6 weeks. Rats in the E. prostrata treatment groups received an aqueous extract of E. prostrata orally at a concentration of 50, 100, or 200 mg·kg-1· d-1 for 3 weeks. Animals in both the normal and model groups were treated with similar volumes of saline. Spatial memory performance was measured using the Morris water maze. The mRNA levels and enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) were analyzed using real- time quantitative PCR and spectrophotometry,respectively. The levels of induced nitric oxide synthase (iNOS), nitric oxide (NO), dopamine (DA), norepinephrine (NE), and serotonin (5-HT) were determined using enzyme-linked immunosorbent assay and spectrophotometry. RESULTS: Compared with the normal group, rats in the D-galactose-treated model group exhibited significant memory loss. There was severe damage to the hippocampal CA1 area, and expression levels of SOD, CAT, GPx, and GR were significantly decreased in the model group compared with the normal group. In the model group, levels of iNOS and NO were significantly increased compared with the normal group. However, treatment with E. prostrata extract reversed the conditions caused by D-galactose- induced aging, especially in the groups with higher treatment concentrations. Compared with the normal group, the levels of DA, NE, and 5-HT were significantly lower in the D-galactose-treated model group. In the E. prostrata extract-treated groups, however, there was a dose-dependent upregulation of DA, NE, and 5-HT expression. CONCLUSION: Our results suggest that administration of E. prostrata extract can result in an improvement in the learning and memory impairments that are induced by D-galactose treatment in rats. This improvement may be the result of enhanced antioxidative ability, decreased iNOS and NO levels, and the induction of DA, NE, and 5-HT expression in the brain. | Xia Xichao Yu Ruixue Wang Xiaowei Wei Mengwei Yi Li Wang Aimei Ma Yuhong Zhang Junfeng Ji Zhaohui Li Yuan Wang Qiong | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 10 | Spatial variation in grain-size population of surface sediments from northern Bering Sea and western Arctic Ocean: Implications for provenance and depositional mechanisms显示文摘In general,sediments in nature comprise populations of various diameters.Accurate information regarding the sources and depositional mechanisms of the populations can be obtained through their temporal and spatial comparisons.In this study,the grain size distribution of surface sediments from the Bering Sea and western Arctic Ocean were fitted and partitioned into populations using a log-normal distribution function.The spatial variations in the populations indicate differences in their sources and deposition mechanisms.The sediments on most of the Bering Sea Shelf originated from the Yukon River,and were transported westward by waves and currents.However,the presence of a coarser population outside Anadyr Bay was the result of Anadyr River transport.Additionally,a northward transport trend of fine suspended particles was observed on the west side of the Bering Sea Shelf.The sediments in Hope Valley in the south Chukchi Sea also originated from the Yukon River.The coarser population on the central Chukchi Sea Shelf originated from coast of Alaska to the east,not the Yukon River,and was transported by sea ice and bottom brine water.The populations of sediments from the Chukchi Basin and the base of the Chukchi Sea Slope are the result of sea ice and eddy action.Surface sediments from the western high Arctic Ocean predominantly comprised five populations,and two unique populations with mode diameters of 50–90μm and 200–400μm,respectively,were ubiquitous in the glacial and interglacial sediments.It was difficult to distinguish whether these two populations originated from sea ice or icebergs.Therefore,caution should be exercised when using either the>63μm or>250μm fractions in sediments as a proxy index for iceberg and ice sheet variation in the high Arctic Ocean. | WANG Weiguo YANG Jichao ZHAO Mengwei DONG Linsen JIANG Min HUANG Erhui | 2020 | Advances in Polar Science2020，31，3： | 2 |
| 11 | Effective electromechanical coupling coefficient of high-overtone bulk acoustic resonator显示文摘A high-overtone bulk acoustic resonator(HEAR) is composed of a substrate,a piezoelectric film and upper and lower electrodes,the influences of their structure parameter(thickness) and performance parameter(characteristic impedance) on effective electromechanical coupling coefficient K_(eff)~2 are investigated systematically.The relationship between K_(eff)~2 and these parameters is obtained by a lumped parameter equivalent circuit instead of distributed parameter equivalent circuit near the resonant frequency,and K_(eff)~2 at the resonance frequency closest to the given frequency is analyzed.The results show that K_(eff)~2 declines rapidly and oscillatorily with the continuous increase of the substrate thickness when the piezoelectric film thickness is fixed,and decreases inversely proportion to the thickness when the substrate thickness is greater than a certain value.With the ratio of the characteristic impedance of the substrate to the piezoelectric layer increasing,the maximum of K_(eff)~2 obtained from the variation curve of K_(eff)~2 with the continuous increase of the piezoelectric film thickness decreases rapidly before reaching the minimum value,and later increases slowly.Fused silica with low impedance is appropriate as the substrate of HBAR to get a larger K_(eff)~2.Compared with Al electrode,Au electrode can obtain larger K_(eff)~2 when the appropriate electrode thickness is selected.The revealed laws above mentioned provide the theoretical basis for optimizing parameters of HBAR. | LI Jian WANG Chenghao LIU Mengwei | 2017 | Chinese Journal of Acoustics2017，36，1： | 2 |
| 12 | Reliable Medical Recommendation Based on Privacy-Preserving Collaborative Filtering显示文摘Collaborative filtering(CF)methods are widely adopted by existing medical recommendation systems,which can help clinicians perform their work by seeking and recommending appropriate medical advice.However,privacy issue arises in this process as sensitive patient private data are collected by the recommendation server.Recently proposed privacy-preserving collaborative filtering methods,using computation-intensive cryptography techniques or data perturbation techniques are not appropriate in medical online service.The aim of this study is to address the privacy issues in the context of neighborhoodbased CF methods by proposing a Privacy Preserving Medical Recommendation(PPMR)algorithm,which can protect patients’treatment information and demographic information during online recommendation process without compromising recommendation accuracy and efficiency.The proposed algorithm includes two privacy preserving operations:Private Neighbor Selection and Neighborhood-based Differential Privacy Recommendation.Private Neighbor Selection is conducted on the basis of the notion of k-anonymity method,meaning that neighbors are privately selected for the target user according to his/her similarities with others.Neighborhood-based Differential Privacy Recommendation and a differential privacy mechanism are introduced in this operation to enhance the performance of recommendation.Our algorithm is evaluated using the real-world hospital EMRs dataset.Experimental results demonstrate that the proposed method achieves stable recommendation accuracy while providing comprehensive privacy for individual patients. | Mengwei Hou Rong Wei Tiangang Wang Yu Cheng Buyue Qian | 2018 | Computers, Materials & Continua2018，，7： | 2 |
| 13 | Advanced noble-metal-free bifunctional electrocatalysts for metal-air batteries显示文摘The sluggish reaction kinetics at the oxygen cathode is one of the important issues hindering the commercialization of the metal-air batteries.Although the noble metal can be used as the high-efficiency electrocatalyst to solve the problems to some extent,the high cost and scarcity of these noble-metal catalysts have limited their application in electrocatalysis.In this review,we discussed the mecha-nisms of the ORR and OER,and proposed the principles for the bifunctional electrocatalysts firstly,and then the state-of-the-art bifunctional catalysts,including carbon-based materials and transition-metal-based materials.On the basis of that,the self-supporting 3D noble-metal-free bifunctional ORR/OER catalysts were also discussed.Finally,the perspectives for the bifunctional electrocatalysts were discussed. | Wenhao Tang Boya Li Kewei Teng Xiaodong Wang Ruiping Liu Mengwei Wu Lei Zhang Pengfei Ren Junqing Zhang Ming Feng | 2022 | Journal of Materiomics2022，8，2： | 2 |
| 14 | Mechanical quality factor of high-overtone bulk acoustic resonator显示文摘Mechanical quality factor Qm is a key characteristic parameter of High-overtone bulk acoustic resonator(HBAR). The effects of structure parameter(thickness) and perfor?mance parameters(characteristic impedance and mechanical attenuation factor) of substrate,piezoelectric film and electrode constituting HBAR on Qm are carried out. The relationships between Qm and these parameters are obtained by a lumped parameter equivalent circuit instead of distributed parameter equivalent circuit near the resonance frequency, and the an?alytical expressions oi Qm are given. The results show that Qm increases non-monotonically with the continuous increase of the substrate thickness for HBAR with certain piezoelectric film thickness, and it approaches to the substrate material mechanical quality factor as the substrate thickness is large. Qm decreases wavily with the continuous increase of the piezoelectric film thickness for HBAR with certain substrate thickness. Sapphire and YAG with low mechanical loss are appropriate as the substrate to get a larger Qm- The electrode loss must be considered since it can reduce Qm- Compared with Au electrode, A1 electrode with lower loss can obtain higher Qm when the appropriate electrode thickness is selected. In addition, Qm decreases with the increase of frequency. These results provide the theoretical basis for optimizing the parameters of HBAR and show that trade-oflFs between Qm and must be considered in the design because their changes are often inconsistent. | LI Jian LIU Mengwei LI Junhong MA Jun WANG Chenghao | 2016 | Chinese Journal of Acoustics2016，35，3： | 2 |
| 15 | Self-Catalyzed Rechargeable Lithium-Air Battery by in situ Metal Ion Doping of Discharge Products: A Combined Theoretical and Experimental Study显示文摘Lithium-air battery has emerged as a viable electrochemical energy technology;yet a substantial overpotential is typically observed,due to the insulating nature of the discharge product Li_(2)O_(2) that hinders the reaction kinetics and device performance.Furthermore,finite solid–solid/-liquid interfaces are formed between Li_(2)O_(2) and catalysts and limit the activity of the electrocatalysts in battery reactions,leading to inadequate electrolytic efficiency.Herein,in-situ doping of Li_(2)O_(2) by select metal ions is found to significantly enhance the lithium-air battery performance,and Co^(2+)stands out as the most effective dopant among the series.This is ascribed to the unique catalytic activity of the resulting Co-O_(x) sites towards oxygen electrocatalysis,rendering the lithium-air battery self-catalytically active.Theoretical studies based on density functional theory calculations show that structural compression occurs upon Co^(2+)doping,which lowers the energy barrier of Li_(2)O_(2) decomposition.Results from this study highlight the significance of in situ electrochemical doping of the discharge product in enhancing the performance of lithium-air battery. | Mengwei Yuan Zemin Sun Han Yang Di Wang Qiming Liu Caiyun Nan Huifeng Li Genban Sun Shaowei Chen | 2023 | Energy & Environmental Materials2023，6，1： | 1 |
| 16 | Dynamic Characteristic Testing for MEMS Micro-Devices with Base Excitation显示文摘 | Wang Xiaodong Li Nan Wang Tao Liu Mengwei Wang Liding | 2007 | Measurement Science & Technology2007，18，6： | 1 |
| 17 | Syntheses and structural analyses of four isostructural lanthanide dimers derived from thiourea-based carboxylato ligands显示文摘 | WANG WENYUE GUO MENGWEI GUO XIAOFEbIG | 2011 | J Mol Struct2011，994，： | 1 |
| 18 | S100A6基因对胃癌细胞系MKN45生长增殖影响的实验研究(英文)显示文摘Objective: S100A6 (a.k.a., calcyclin) is over-expressed in several human tumors, including gastric carcinoma, human melanoma, pancreatic carcinoma, squamous cell carcinoma, malignant fibrous histiocytoma (MFH), and carcinomas of the thyroid, breast, and colon. However, little is known about the role S100A6 plays in gastric adenocarcinoma. In the present study, we intended to investigate the influence of S100A6 on the growth, proliferation, apoptosis, invasion and cell cycle of the gastric cancer cell MKN45. Methods: As an important member of S100 family, S100A6 cDNA was subcloned into a constitutive vector pcDNA3.1 followed by transfection in gastric cancer cell line MKN45 by using liposome. Then stable transfectants were selected and appraised. The apoptosis and cell cycles of these clones were analyzed by using flow cytometric assay. The growth and proliferation were analyzed by cell growth curves and colony-forming assay respectively. The S100A6 stable expression clones (MKN-S100A6) were detected and compared with their control groups respectively. Results: MKN-S100A6 grew faster than MKN45 and MKN-PC (MKN45 transfected with pcDNA3.1 vector). The cell counts of MKN-S100A6 in the fifth, sixth and seventh days were significantly more than those of control groups (P < 0.05). Cell cycle analysis showed that proportions of MKN-S100A6 in G0-G1 and G2-M were different significantly with those of its control groups respectively (P < 0.05). The apoptosis rate of MKN-S100A6 was significantly lower than those of control groups (P < 0.05). Results of colony-forming assay showed that the colon formation rate of MKN-S100A6 was higher than those of control groups (P < 0.05). Conclusion: S100A6 can promote the growth and proliferation of gastric cancer cells. It can help tumor cell maintain malignant phenotype. In gastric cancer, S100A6 could be thought as a tumor-enhancing gene in some distance, but its role could be complicated. | Lin Zhang Yanhong Hou Nan Li Mengwei Wang Benyan Wu Kai Wu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，9： | 1 |
| 19 | Diazocine as a Versatile Building Block Enables Excellent Photoswitching and Chromic Properties in Self-Assembled Organogels显示文摘Novel types of photoresponsive organogelators containing a diazocine moiety have been synthesized,and their gelation behaviors have been characterized systematically.Subtle changes in the pendant structure of these bent-core molecules cause significant changes in the molecular packing mode in their self-assembled gels.By making use of the unconventional conformational and photochromic properties of the diazocine core,the obtained gels exhibited excellent photoswitching and-chromic properties.For the first time,the diazocine unit has been demonstrated as a versatile building block to construct photoresponsive supramolecular gels.The sensitive interconversion between multiple states of these chromic gels highlights their promising applications in fabricating logic gates with appropriate addressing mode(stimulated by visible light or heating). | Yingying Wang Mengwei Li Chunmei Yan Ning Ma Yulan Chen | 2022 | CCS Chemistry2022，4，2： | 1 |
| 20 | Natural killer cell-derived exosomal miR-1249-3p attenuates insulin resistance and inflammation in mouse models of type 2 diabetes显示文摘Natural killer(NK)cells have been suggested to be associated with type 2 diabetes by regulating systemic inflammation.However,the mechanism by which NK cells regulate insulin sensitivity remains unknown.This study shows that NK-derived exosomes from lean mice attenuate obesity-induced insulin resistance and inflammation in mice of type 2 diabetes.Moreover,lean NK-derived exosomes enhance insulin sensitivity and relieve inflammation in adipocytes and hepatocytes.MiR-1249-3p,which is significantly upregulated in lean NK-derived exosomes,can be transferred from NK cells to adipocytes and hepatocytes via exosomes.NKderived exosomal miR-1249-3p dramatically induces cellular insulin sensitivity and relieves inflammation.Mechanistically,exosomal miR-1249-3p directly targets SKOR1 to regulate the formation of ternary complex SMAD6/MYD88/SMURF1,which mediates glucose homeostasis by suppressing the TLR4/NF-κB signaling pathway.This study reveals an emerging role for NK-derived exosomal miR1249-3p in remission of insulin resistance,and provides a series of potential therapeutic targets in type 2 diabetes. | Ying Wang Mengwei Li Lin Chen Huan Bian Xiangying Chen Huilin Zheng Peiwei Yang Quan Chen Hanmei Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
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