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| 1 | Pancreatic head cancer in patients with chronicpancreatitis显示文摘BACKGROUND: Chronic pancreatitis (CP) is a risk factor of pancreatic adenocarcinoma (PA). The discovery of a pancreatic head lesion in CP frequently leads to a pancreaticoduo denectomy (PD) which preceded by a multidisciplinary meeting(MM). The aim of this study was to evaluate the relevance between this indication of PD and the definitive pathological results.METHODS: Between 2000 and 2010, all patients with CP who underwent PD for suspicion of PA without any histological proof were retrospectively analyzed. The operative decision has always been made at an MM. The definitive pathological finding was retrospectively confronted with the decision made at an MM, and patients were classified in two groups according to this concordance (group 1) or not (group 2). Clinical and biological parameters were analyzed, preoperative imaging were reread and confronted to pathological findings in order to identify predictive factors of malignant degeneration.RESULTS: During the study period, five of 18 (group 1) patients with CP had PD were histologically confirmed to have PA, and the other 13 (group 2) did not have PA. The median age was52.5 ±8.2 years (gender ratio 3.5). The main symptoms were pain (94.4%) and weight loss (72.2%). There was no patient's death. Six (33.3%) patients had a major complication (ClavienDindo classification ≥3). There was no statistical difference in clinical and biological parameters between the two groups. The rereading of imaging data could not detect efficiently all patients with PA.CONCLUSIONS: Our results confirmed the difficulty in detecting malignant transformation in patients with CP before surgery and therefore an elevated rate of unnecessary PD was found. A uniform imaging protocol is necessary to avoid PD as a less invasive treatment could be proposed. | Aude Merdrignac Laurent Sulpice Michel Rayar Tanguy Rohou Emmanuel Quéhen Ayman Zamreek Karim Boudjema Bernard Meunier | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 6 |
| 2 | Comparison of alternative arterial anastomosis site during liver transplantation when the recipient’s hepatic artery is unusable显示文摘Background:Few studies have analyzed outcomes of liver transplantation(LT)when the recipient hepatic artery(HA)was not usable.Methods:We retrospectively evaluated the outcomes of LT performed using the different alternative sites to HA.Results:Between 2002 and 2017,1,677 LT were performed in our institution among which 141(8.4%)with unusable recipient HA were analyzed.Four groups were defined according to the site of anastomosis:the splenic artery(SA group,n=26),coeliac trunk(CT group,n=12),aorta using or not the donor’s vessel(Ao group,n=91)and aorta using a vascular prosthesis(Ao-P group,n=12)as conduit.The median number of intraoperative red blood cell transfusions was significantly increased in the Ao and Ao-P groups(5,5,8.5 and 16 for SA,CT,Ao and Ao-P group respectively,P=0.002),as well as fresh frozen plasma(4.5,2.5,10,17 for the SA,CT,Ao and Ao-P groups respectively,P=0.001).Hospitalization duration was also significantly increased in the Ao and Ao-P groups(15,16,24,26.5 days for the SA,CT,Ao and Ao-P groups respectively,P<0.001).The occurrence of early allograft dysfunction(EAD)(P=0.07)or arterial complications(P=0.26)was not statistically different.Level of factor V,INR,bilirubin and creatinine during the 7th postoperative days(POD)was significantly improved in the SA group.No difference was observed regarding graft(P=0.18)and patient(P=0.16)survival.Conclusions:In case of unusable HA,intraoperative and postoperative outcomes are improved when using the SA or CT compared to aorta. | Jean Marie Beaurepaire Francesco Orlando Giovanni Battista Levi Sandri Caroline Jezequel Edouard Bardou-Jacquet Christophe Camus Mohamed Lakehal Veronique Desfourneaux Aude Merdrignac Elodie Gaignard Alexandre Thobie Damien Bergeat Bernard Meunier Michel Rayar | 2022 | Hepatobiliary Surgery and Nutrition2022，11，1： | 3 |
| 3 | Size exclusionchromatography : characterization of heavy petroleum resi-dues, application to resid desulfurization process显示文摘 | Merdrignac I Truchy C Robert E | 2004 | Pe-troleum Science and Technology2004，22，78： | 1 |
| 4 | Size exclusion chromatography : characterization of heavy petro- leum residues 显示文摘 | MERDRIGNAC I TRUCHY C ROBERT E | 2005 | Petroleum Science Technology2005，22，78： | 1 |
| 5 | E- volution of asphaltene structure during hydroconversion conditions 显示文摘 | MERDRIGNAC I QUOINEAUD A-A GAUTHIER T | 2006 | Energy & Fuels2006，20，5： | 1 |
| 6 | Studies on the evolution of asphaltene structure dur- ing hydroconversion of petroleum residues 显示文摘 | GAUTHIER T DANIAL-FORTAIN P MERDRIGNAC I | 2008 | Catalyst Today2008，130，234： | 1 |
| 7 | Stepwise structural characterization of asphaltenes during deep hydroconversion processes determined by atmospheric pressure photoionization (APPI) Fourier transform ion cyclotron resonance ( FT-ICR ) mass spectrometry 显示文摘 | PURCELL J M MERDRIGNAC I ROIERS R P | 2010 | Energy & Fuels2010，24，4： | 1 |
| 8 | Sensitivity improvement in ICP MS analysis of fuels and light petroleum matrices using a microflow nebulizer and heated spray chamber sample introduction显示文摘 | Caumette G Lienemann C Merdrignac l | 2009 | Talanta2009，80，2： | 1 |
| 9 | Detection of NH3 and H2S with thick film semiconductor sensors based on Cd2-x GeO4-z-3y N2y oxynitrides显示文摘 | Louis Eugene dit Picard C Bemicot Y Merdrignac O | 1997 | Seniors and Actuators B1997，42，1： | 1 |
| 10 | Sensi- tivity improvement in ICP MS analysis of fuels and light petroleum matrices using a microflow nebulizer and heated spray chamber sam- ple introduction 显示文摘 | CAUMETTE G LIENEMANN C P MERDRIGNAC I | 2009 | Talanta2009，80，2： | 1 |
| 11 | Element speciation analysis of petroleum and related materials显示文摘 | Caumette G Lienemann C Merdrignac l | 2009 | Journal of Analytical Atomic Spectrometry2009，24，3： | 1 |
| 12 | Stepwise structural characterization of asphaltenes during deep hy-droconversion processes determined by atmospheric pres- sure photoionization (APPI) Fourier Transform Ion Cyclo-tron Resonance (FT-ICR) Mass Spectrometry显示文摘 | Purcell J M Merdrignac I Rodgers R P | 2010 | Energy Fuels2010，24，4： | 1 |
| 13 | Size exclusionchromatography : characterization of heavy petroleum resi-dues, application to resid desulfurization process显示文摘 | Merdrignac I Truchy C Robert E | 2004 | Pe-troleum Science and Technology2004，22，78： | 1 |
| 14 | In 2002 International Conference on Heavy Organic Depositions显示文摘 | Merdrignac C Truchy E Robert | 2002 | Lira-Galeana C Ed Jalisco Mexico2002，，： | 1 |
| 15 | Stepwise structural characterization of asphaltenes during deep hydroconversion processes determined by atmospheric pressure photoionization (APPI) Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry显示文摘 | Purcell J M Merdrignac I Rodgers R P | 2010 | Energy Fuels2010，24，4： | 1 |
| 16 | Stepwise structural characterization of asphaltenes during deep hydroconversion processes determined by atmospheric pressure photoionization (APPI) fourier transform ion cyclotron resonance (FF-ICR) mass spectrometry 显示文摘 | PURCELL J M MERDRIGNAC I RODGERS R P MARSHALL A G GAUTHIER T GUIBARD I | 2009 | Energy Fuels2009，24，4： | 1 |
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