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| 1 | Update on medical and surgical options for patients with acute severe ulcerative colitis: what is new?显示文摘Acute severe ulcerative colitis(UC) is a highly morbid con dition that requires both medical and surgical managementhrough the collaboration of gastroenterologists and colorectal surgeons. First line treatment for patients presenting with acute severe UC consists of intravenous steroids, but those who do not respond require escalation of therapy or emergent colectomy. The mortality of emergent colectomy has declined significantly in recent decades, but due to the morbidity of this procedure, second line agents such as cyclosporine and infliximab have been used as salvage therapy in an attempt to avoid emergent surgery. Unfortunately, protracted medical therapy has led to patients presenting for surgery in a poorer state of health leading to poorer post-operative outcomes. In this era of multiple medical modalities available in the treatment of acute severe UC, physicians must consider the advantages and disadvantages of prolonged medical therapy in an attempt to avoid surgery. Colectomy remains a mainstay in the treatment of severe ulcerative colitis not responsive to corticosteroids and rescue therapy, and timely referral for surgery allows for improved post-operative outcomes with lower risk of sepsis and improved patient survival. Options for reconstructive surgery include three-stage ileal pouchanal anastomosis or a modified two-stage procedure that can be performed either open or laparoscopically. The numerous avenues of medical and surgical therapy have allowed for great advances in the treatment of patients with UC. In this era of options, it is important to maintain a global view, utilize biologic therapy when indicated, and then maintain an appropriate threshold for surgery. The purpose of this review is to summarize the growing number of medical and surgical options available in the treatment of acute, severe UC. | Rachel E Andrew Evangelos Messaris | 2016 | World Journal of Gastrointestinal Surgery2016，8，9： | 4 |
| 2 | Single-Site Laparoscopic Colorectal Surgery Provides Similar Clinical Outcomes Compared With Standard Laparoscopic Surgery : An Analysis of 626 Patients 显示文摘 | Sangster W Messaris E Berg AS | 2015 | Dis Colon Rectum2015，58，9： | 1 |
| 3 | Administra- tion of human protein C improves survival in an experi- mental model of sepsis显示文摘 | Messaris E Betrosian AP Memos N | 2010 | Crit Care Med2010，38，1： | 1 |
| 4 | Time-dependent mitochondrial- mediated programmed neuronal cell death prolongs survival in sepsis显示文摘 | Messaris E Memos N Chatzigianni E | 2004 | Crit Care Med2004，32，8： | 1 |
| 5 | Management of blunt hepatic and splenic trauma in a Greek level I trauma centre显示文摘 | Markogiannakis H Sanidas E Messaris E | 2006 | Acta Chir Belg2006，106，5： | 1 |
| 6 | Perioperative erythropoieetin adminstration in patients with gastrointestinal tract cancer显示文摘 | Kosmadakis N Messaris E Maris A | | Ann Surg0，237，3： | 1 |
| 7 | Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis显示文摘 | Messaris E Memos N Chatzigianni E | 2004 | Crit Care Med2004，32，8： | 1 |
| 8 | Time-dependent mitochondrial-mediated programmed neuronal cell death survival in sepsis显示文摘 | Messaris E Memos N Chatzigianni E | 2004 | Crit Care Med2004，32，8： | 1 |
| 9 | Apoptotic death of re- nal tubular cells inexperimental sepsis 显示文摘 | Messaris E Memos N Chatziqianni E at el | 2008 | Surq Infect2008，9，3： | 1 |
| 10 | Perioperative erythropoietin administration in patients with gastrointestinal tract cancer:prospective randomized double-blind study显示文摘 | Kosmadakis N Messaris E Maris A | 2003 | Ann Surg2003，237，3： | 1 |
| 11 | Time-dependent mitochondrial-medlated programmed neuronal cell death survival in sepsis显示文摘 | Messaris E Memos N Chatzigianni E | 2004 | Crit Care Med2004，32，8： | 1 |
| 12 | Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis显示文摘 | Messaris E Memos N Chatzigianni E | 2004 | Crit Care Med2004，32，8： | 1 |
| 13 | Apoptotic death of renal tubular cells in experimental sepsis显示文摘 | MESSARIS E MEMOS N CHATZIQIANNI E at el | 2008 | Surq Infect(Larchmt)2008，9，3： | 1 |
| 14 | Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis显示文摘 | Messaris E Memos N Chatzigianni E | 2004 | Crit Care Med2004，32，8： | 1 |
| 15 | Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis显示文摘 | Messaris E Memos N Chatzigianni E | | 0，，08： | 1 |
| 16 | Apoptotic death of renal tubular cells in experimental sepsis显示文摘 | Messaris E Memos N Chatzigianni E | 2008 | Surgical Infect2008，9，3： | 1 |
| 17 | Administration of human protein C improves survival in an experimental model of sepsis 显示文摘 | Messaris E Betrosian AP Memos N | 2010 | Crit Care Med2010，38，1： | 1 |
| 18 | Time-dependent mitochondrlal- mediated programmed neuronal cell death prolongs survival in sepsis显示文摘 | Messaris E Memos N Chatzigianni E | 2004 | Crit Care Med2004，32，： | 1 |
| 19 | Single-site laparoscopic coIorectal surgery provides similar lengths of hospital stay and similar costs compared with standard laparoscopy: results of a retrospective cohort study 显示文摘 | Stewart DB Berg A Messaris E | 2014 | J Gastrointest Surg2014，18，4： | 1 |
| 20 | Dehydration is the most common indication for readmission after diverting ileostomy creation显示文摘 | Messaris E Sehgal R Deiling S | 2012 | Dis Colon Rectum2012，55，： | 1 |
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