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| 1 | Long-term spaceflight and the cardiovascular system显示文摘While early investigations into the physiological effects of spaceflight suggest the body’s ability to reversibly adapt,the corresponding effects of long-term spaceflight(>6months)aremuch less conclusive.Prolonged exposure to microgravity and radiation yields profound effects on the cardiovascular system,including a massive cephalad fluid translocation and altered arterial pressure,which attenuate blood pressure regulatory mechanisms and increase cardiac output.Also,central venous pressure decreases as a result of the loss of venous compression.The stimulation of baroreceptors by the cephalad shift results in an approximately 10%–15%reduction in plasma volume,with fluid translocating from the vascular lumen to the interstitium.Despite possible increases in cardiac workload,myocyte atrophy and notable,yet unexplained,alterations in hematocrit have been observed.Atrophy is postulated to result from shunting of protein synthesis from the endoplasmic reticulum to the mitochondria via mortalin-mediated action.While data are scarce regarding their causative agents,arrhythmias have been frequently reported,albeit sublethal,during both Russian and American expeditions,with QT interval prolongation observed in long,but not short duration,spaceflight.Exposure of the heart to the proton and heavy ion radiation of deep space has also been shown to result in coronary artery degeneration,aortic stiffness,carotid intima thickening via collagen-mediated action,accelerated atherosclerosis,and induction of a pro-inflammatory state.Upon return,long-term spaceflight frequently results in orthostatic intolerance and altered sympathetic responses,which can prove hazardous should any rapidmobilization or evacuation be required,and indicates that these cardiac risks should be especially monitored for future missions. | Nicholas A.Vernice Cem Meydan Ebrahim Afshinnekoo Christopher E.Mason | 2020 | Precision Clinical Medicine2020，3，4： | 6 |
| 2 | Cell子刊:科学家发现关联焦虑和肥胖的新机制显示文摘焦虑和代谢相关的疾病一直是科学家们研究的焦点,虽然很多研究都表明,这两者之间有很强的关联,但是一直缺乏有力的科学依据来证实。近日,来自耶路撒冷希伯来大学的研究人员在分子水平上揭示了焦虑和代谢的联系——一种类型的microRNA将这两者联系在一起,并影响着它们共同的生物学机制。这项研究发表在2016年9月的《Trends in Molecular Medicine》杂志上。 | Meydan C Shenhar-Tsarfaty S Soreq H | 2016 | 疾病监测2016，31，9： | 2 |
| 3 | Screening for bovine leukocyte adhesion deficiency,deficiency of uridine monophosphate synthase,com-plex vertebral malformation,bovine citrullinaemia,and factor XI deficiency in Holstein cows reared in Turkey显示文摘 | MEYDAN H YILDIZ M A AGERHOLM J S | 2010 | Acta Vet Scand2010，52，1： | 1 |
| 4 | A system for measurement of AC Barkhausen noise in electrical steels显示文摘 | Hartmann K Moses A J Meydan T | 2003 | Journal of magnetism and magnetic materials2003，254，： | 1 |
| 5 | A novel accelerometer design using the inverse magnetostrictive effect显示文摘 | P. Choudhary T. Meydan | 1997 | Sensors & Actuators: A Physical1997，，1： | 1 |
| 6 | Multiple primary malignantneoplasms from the black sea region of Turkey 显示文摘 | Gursel B Meydan D Ozbek N | 2011 | J Int MedRes2011，39，2： | 1 |
| 7 | ld-t : regulator of EGFR and VEGF and potential target for colorectal cancer therapy显示文摘 | Meteoglu I Meydan N Erkus M | 2008 | J Exp Clin Cancer Res2008，27，1： | 1 |
| 8 | Inhibition of acute lymphoblastic leukemia by a Jak2 inhibitor显示文摘 | Meydan N Grunberger T Dadi W | 1996 | Nature1996，379，6566： | 1 |
| 9 | Inhibition of acute lymphoblastic leukaemia by a Jak2 inhibitor显示文摘 | Grunberger T Dadi H | 1996 | Nature1996，379，： | 1 |
| 10 | Ultrasound tissue characterization by integrated backscatter for analyzing fluorouraeil induced myocardia damage 显示文摘 | Ceyhan C Meydan N Barutca S | 2005 | Eehocardiography2005，22，3： | 1 |
| 11 | Urinary stone disease in diabetes mellitus显示文摘 | Meydan N Baruica S Caliskan S | 2003 | J Urol Nephrol2003，37，： | 1 |
| 12 | Ultrasound tissue characterization by integrated backscatter for analyzing Fluorouracil induced myocardial damage显示文摘 | Ceyhan C Meydan N Barutca S | 2005 | Echocardiogrphy2005，22，3： | 1 |
| 13 | An angular accelerometer using amorphous wire显示文摘 | Lassow R Meydan T | 1995 | Magnetics IEEE Transactions on1995，31，6： | 1 |
| 14 | Magnetic domain behavior in magnetostrictive torque sensors 显示文摘 | Hardcastle H Meydan M | 2000 | Sensors and Actuators A2000，81，13： | 1 |
| 15 | Id-1:regulator of EGFR and VEGF and potential target for colorectal cancer therapy显示文摘 | Meteoglu I Meydan N Erkus M | 2008 | J Exp Clin Cancer Res2008，27，： | 1 |
| 16 | Application of amorphous materials to sensors 显示文摘 | Meydan T | 1994 | Journal of Magnetism and Magnetic Materials1994，133，13： | 1 |
| 17 | Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor显示文摘 | Meydan N Grunberger T Dadi H | 1996 | Nature1996，379，6566： | 1 |
| 18 | Effects of tadalafil on ischemia/ reperfusion injury in rat brain显示文摘 | AltaM Aras M Meydan S | 2013 | Acta Neurol Belg2013，，： | 1 |
| 19 | NF - KappaB expression correlates with apoptosis and angiogenesis in clear cell renal cell carcinoma tissues 显示文摘 | Meteoglu I Erdogdu IH Meydan N | 2008 | J Exp Clin Cancer Res2008，27，： | 1 |
| 20 | Multiple primary malignant neoplasms from the black sea region of Turkey显示文摘 | Gursel B Meydan D Ozbek N | 2011 | J Int Med Res2011，39，2： | 1 |
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