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| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | Pressure Dependence of the Atmospheric Electrolyte Cathode Glow Discharge Spectrum显示文摘 | Mezei P Cserfalvi T Janossy M | 1997 | Journal of Analytical Atomic Spectrometry1997，12，10： | 1 |
| 3 | Investigations on the Element Dependency of Sputtering Process in the Electrolyte Cathode Atmospheric Discharge显示文摘 | Cserfalvi T Mezei P J | 2005 | Iournal of Analytical Atomic Spectrometry2005，20，9： | 1 |
| 4 | Postoperative sore throat after ambulatory surgery显示文摘 | HIGGINS P P CHUNG F MEZEI G | 2002 | Br J Anaesth2002，88，4： | 1 |
| 5 | A non-empirical molecular orbital study on the relative stabilities of adenine and guanine tautomers 显示文摘 | Mezey P G Ladik J J | 1979 | Theor Chim Acta1979，52，： | 1 |
| 6 | Emission Studies on a Glow-Discharge in Atmospheric-Pressure Air Using Water as a Cathode显示文摘 | Cserfalvi T Mezei P Apai P | 1993 | Journal of Physics D:Applied Physics1993，26，12： | 1 |
| 7 | Postoperative soreh throat after am-bulatory surg ery显示文摘 | Higgins P P Chung F Mezei G | 2002 | Br Anaesth2002，88，： | 1 |
| 8 | Direct Solution Analysis by Glow Discharge:Electrolyte-Cathode Discharge Spectroscopy显示文摘 | Cserfalvi T Mezei P | 1994 | Journal of Analytical Atomic Spectrometry1994，9，3： | 1 |
| 9 | Operating Mechanism of the Electrolyte Cathode Atmospheric Glow Discharge显示文摘 | Cserfalvi T Mezei P | 1996 | Fresenius Journal of Analytical Chemistry1996，355，78： | 1 |
| 10 | Similarity Laws for Glow Discharges with Cathodes of Metal and an Electrolyte显示文摘 | Mezei P Cserfalvi T Janossy M | 1998 | Journal of Physics D:Applied Physics1998，31，20： | 1 |
| 11 | 查看详情显示文摘 | MEZEY P G LADIK J J | | 0，，： | 1 |
| 12 | The Gas Temperature in the Cathode Surface-Dark Space Boundary Layer of an Electrolyte Cathode Atmospherid Glow Discharge (ELCAD)显示文摘 | Mezei P Cserfalvi T Janossy M | 1998 | Journal of Physics D:Applied Physics1998，31，11： | 1 |
| 13 | 查看详情显示文摘 | MEZEY P G LADIK J J | | 0，，： | 1 |
| 14 | The Spatial Distribution of the Temperatures and the Emitted Spectrum in the Electrolyte Cathode Atmospheric Glow Discharge显示文摘 | Mezei P Cserfalvi T Csillag L | 2005 | Journal of Physics D:Applied Physics2005，38，16： | 1 |
| 15 | Electrolyte Cathode Atmospheric Glow Discharges for Direct Solution Analysis显示文摘 | Mezei P Cserfalvi T | 2007 | Applied Spectroscopy Reviews2007，42，6： | 1 |
| 16 | Charge Densities in the Electrolyte Cathode Atmospheric Glow Discharges(ELCAD)显示文摘 | Mezei P Cserfalvi T | 2007 | European Physical Journal:Applied Physics2007，40，1： | 1 |
| 17 | The Investigation of an Abnormal Electrolyte Cathode Atmospheric Glow Discharge (ELCAD)显示文摘 | Mezei P Cserfalvi T | 2006 | Journal of Physics D:Applied Physics2006，39，12： | 1 |
| 18 | Postoperative sore throat after ambulatory surgery显示文摘 | Higgins P P Chung F Mezei G | 2002 | Br Anaesth2002，88，： | 1 |
| 19 | Stability and thestructures of nitrogen clusters N10显示文摘 | Wang L J Mezey P G Zgierski M Z | | Chemical Phys-ics Letters0，391，46： | 1 |
| 20 | Anion encapsulation by neutral supramolecular assemblies of cyclic Cu(Ⅱ) complexes:a series of five polymerization isomers, ,n= 8,9,12,and 14显示文摘 | Mezei G Baran P Raptis R G | 2004 | Angew Chem Int Ed2004，43，： | 1 |
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