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| 1 | Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China显示文摘AIM:To investigate the prevalence of minimal hepatic encephalopathy(MHE)and to assess corresponding health-related quality of life(HRQoL)in hospitalized cirrhotic patients in China.METHODS:This multi-center cross-sectional study included 16 teaching hospitals,which were members of 'Hepatobiliary Cooperation Group,Society of Gastroenterology,Chinese Medical Association',from different areas of China carried out between June and October in 2011.All the eligible hospitalized cirrhotic patients(n = 538)were required to complete triplicate number connection tests combined with one digit symbol test for diagnosing MHE.Patients' clinical examination data were complemented by a modified questionnaire assessing HRQoL.Written informed consent was obtained from each patient.RESULTS:Male was predominant(68.6%)in 519 patients who met the criteria of the study,with a mean age of 49.17 ± 11.02 years.The most common cause of liver cirrhosis was chronic hepatitis B(55.9%).The prevalence of MHE was 39.9% and varied by ChildPugh-Classification score(CPC-A:24.8%,CPC-B:39.4% and CPC-C:56.1%,P < 0.01).MHE(P < 0.01)and higher CPC scores(P < 0.01)were associated with a high HRQoL scores(reflecting poorer quality of life).The prevalence of MHE was proportionate to CPC(P = 0.01)and high quality of life scores(P = 0.01).CONCLUSION:Hospitalized cirrhotic patients have a high prevalence of MHE that is proportionate to the degree of liver function and HRQoL impairment. | Ji-Yao Wang Ning-Ping Zhang Bao-Rong Chi Yu-Qing Mi Li-Na Meng Ying-Di Liu Jiang-Bin Wang Hai-Xing Jiang Jin-Hui Yang Yun Xu Xiao Li Jian-Ming Xu Guo Zhang Xin-Min Zhou Yu-Zheng Zhuge De-An Tian Jin Ye Yu-Lan Liu | 2013 | World Journal of Gastroenterology2013，19，30： | 64 |
| 2 | Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein显示文摘Beclin 1 基因是 haplo 不够的肿瘤 suppressor 并且在 autophagy 起一个必要作用。然而, Beclin 1 由工作的分子的机制仍然保持大部分未知。这里,我们在 1.6 Å 报导 Beclin 1 的 evolutionarily 保存的领域(ECD ) 的水晶结构;分辨率。Beclin 1 ECD 展览一以前 unreported 褶层,与在中央轴附近相称性地安排的三次结构的重复。Beclin 1 ECD 定义膜绑定领域的一个新奇的类,与为与 cardiolipin 充实的类脂化合物膜的强壮的偏爱。在 Beclin 1 ECD 的一个表面环的尖端,包括三芳香的氨基酸,与类脂化合物膜充当一根恐水病的手指到伙伴,因而导致膜和 liposomes 的变丑。这些芳香的残余的变化使 Beclin 1 变为不能稳定地在 vitro 与类脂化合物膜联系并且不能充分在 vivo 在 Beclin 1-knockdown 房间救 autophagy。这些观察为译解形成一个重要框架 Beclin 1 的生物功能。 | Weljlao Huang Wooyoung Chol Wanqiu Hu Na Mi Qiang Guo Meisheng Ma Mei Liu Yuan Tian Peilong Lu Feng-Liang Wang Haiteng Deng Lei Liu Ning Gao Li Yu Yigong Shi | 2012 | Cell Research2012，22，3： | 21 |
| 3 | Comparison of glycemic variability and glycated hemoglobin as risk factors of coronary artery disease in patients with undiagnosed diabetes显示文摘背景一个冠的动脉疾病( CAD )风险因素是著名的长期的多糖症的角色,并且 glycemic 可变性仍然是这研究的 debate.The 目的一件事是调查承认 glycemic 的协会有在有 undiagnosed 糖尿病 mellitus ( DM )的病人的 CAD 的存在和严厉的旅行和血红素 A1c ( HbA1c )我们学习了的 .Methods 286 最新诊断了 DM 没有优先的 revascularization 的病人为怀疑的 ischaemic ch 经历冠的 | MI Shu-hua SU Gong LI Zhao YANG Hong-xia ZHENG Hong TAO Hong ZHOU Yun TIAN Lei | 2012 | Chinese Medical Journal2012，，1： | 18 |
| 4 | A new flavone glycoside from Selaginella moellendorffii Hieron.显示文摘从 Selaginella moellendorffii 神庙的乙醇摘录,新黄酮 O-glycoside 和三已知的黄酮 C-glycosides 作为 5-carboxymethyl-4-hydroxyflavone-7-O--d-glucopyranoside 被孤立并且识别 1, 6,8-di-C--d-glucopyranosylapigenin 2, 6-C--d-glucopyranosyl-8-C--d-xylopyranosyl apigenin 3, 6-C--d-xylopyranosyl-8-C--d-glucopyranosylapigenin 4 分别地。他们的结构被分光镜的方法阐明。 | Tian Mi Zhu Ke Li Chen Wen Bing Zhou | 2008 | Chinese Chemical Letters2008，19，12： | 12 |
| 5 | Tectonic evolution of the Dabashan orocline, central China: Insights from the superposed folds in the eastern Dabashan foreland显示文摘The Dabashan orocline is situated in the northwestern margin of the central Yangtze block,central China.Previous studies have defned the orthogonal superposed folds growing in its central-western segment thereby confrming its two-stage tectonic evolution history.Geological mapping has revealed that more types of superposed folds have developed in the eastern segment of the orocline,which probably provides more clues for probing the structure and tectonic history of the Dabashan orocline.In this paper,based on geological mapping,structural measurements and analyses of deformation,we have identifed three groups of folds with different trends(e.g.NW-,NE-and nearly E-trending folds)and three types of structural patterns of superposed folds in the eastern Dabashan foreland(e.g.syn-axial,oblique,and conjunctional superposed folds).In combination with geochronological data,we propose that the synaxial superposed folds are due to two stages of wNeS shortening in the west and north of the Shennongjia massif,and that oblique superposed folds have been resulted from the superposition of the NW-and NE-trending folds onto the early ~E-W folds in the east of the Shennongjia massif in the late Jurassic to early Cretaceous.The conjunctional folds are composed of the NW-and NE-trending folds,corresponding to the regional-scale dual-orocline in the eastern Sichuan as a result of the southwestward expansion of the Dabashan foreland during late Jurassic to early Cretaceous,coeval with the northwestward propagation of the Xuefengshan foreland.Integration of the structure and geochronology of the belt shows that the Dabashan orocline is a combined deformation belt primarily experiencing a twostage tectonic evolution history in Mesozoic,initiation of the Dabashan orocline as a foreland basin along the front of the Qinling orogen in late Triassic to early Jurassic due to collisional orogeny,and the fnal formation of the Dabashan orocline owing to the southwestward propagation of the Qinling orogen during late Jurassic to early Cretaceous intra-continental orogeny.Our studies provide some evidences for understanding the structure and deformation of the Dabashan orocline. | Wei Shi Jianhua Li Mi Tian Guoli Wu | 2013 | Geoscience Frontiers2013，4，6： | 12 |
| 6 | Correlation of Vascular Endothelial Growth Factor Production with Photochemical Reaction-induced Retinal Edema显示文摘 | Liang Shan Mi Zheng Yuan Zhang Yuan Qu Tian Niu Qing Gu Xin Xia | 2016 | Chinese Medical Journal2016，，24： | 9 |
| 7 | Formation of the Moping Dome in the Xuefengshan Orocline, Central China and its Tectonic Significance显示文摘Many equiaxial dome-like structures developed in the north segment of the Xuefengshan orocline, Central China are obviously inconcordant with the NE-trending linear structures in this area, which contain important records for understanding the structural framework and evolution of this belt. In this paper, taking one of the typical dome-like structures in the Xuefengshan orcline (e.g. Moping dome-like structure) as an example, based on its structural framework interpratatoin, superposed deformation analysis and paleo-stress fields reconstruction, we propose the Moping dome-like structure is composed of two populations of different-striking thrust-fold structures, ~E-trending and NE-striking structures, indicative of two-stages shortening, ~N- and NW-striking, respectively. Together with the geochronological analysis, we suggest the first stage of shortening occurred in Late Triassic to Early Jurassic, due to the Indosinian intercollisional orogeny of the Yangtze Block and the North China Block. The second occurred during Late Jurassic Early Cretaceous owing to Yanshanian intracontinental orogeny, leading to the intensive superposition of the NE-trending structures onto the ~E-trending structures, and the final ocurrence of the Moping dome. Thus, our study indicates the Xuefengshan arc-shape belt also experienced two-phase deformation, and resulted from the superposition of NE SW structures onto ~E-W structures in Late Jurassic Early Cretaceous, which could provide new structural evidence for probing the Mesozoic tectonic framework and evolution of the Xuefengshan orocline. | SHI Wei DONG Shuwen LI Jianhua TIAN Mi WU Guoli | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 9 |
| 8 | High density methane inclusions in Puguang Gasfield:Discovery and a T-P genetic study显示文摘Based on measurement of homogenization temperature of inclusions and Raman spectral analysis, high density methane inclusions were discovered in the Triassic reservoirs of Puguang Gasfield. The methane inclusions show a homogenization temperature Th = -117.5― -118.1℃, a corresponding density of 0.3455―0.3477 g/cm3, and a Raman scatter peak v1 shift varying between 2911―2910 cm-1, which signifies a very high density of methane inclusions. The salt water inclusions paragenetic with methane inclusions show a homogenization temperature Th=170―180℃. Based on the composition of methane inclusions as determined by Raman spectra, PVTsim software was used to simulate the trapping pressure for high density methane inclusions in geologic history, and the trapping pressure was found to be as high as 153―160 MPa. Even though Puguang Gasfield is currently a gas pool of normal pressure, and the fluid pressure for the gas pool ranges between 56―65 MPa. However, data from this study indicates that remarkable overpressure may be generated at the stage of mass production of gas cracked from oils in Cretaceous, as high density methane inclusions constitute key evidence for overpressure in gas pool in geologic history. Meanwhile, discovery of small amounts of H2S, CO2 or heavy hydrocarbon in part of the high density methane inclusions indicates that the geochemical environment for trapping of inclusions may be related to formation of H2S. Therefore, the observation results can help to explore the thermochemical sulfate reduction (TSR) conditions for oil cracking and H2S formation. | LIU Delian DAI JinXing XIAO XianMing TIAN Hui YANG Chun HU AnPing MI JingKui SONG ZhiGuang | 2009 | Chinese Science Bulletin2009，54，24： | 8 |
| 9 | Polybrominated diphenyl ethers in chicken tissues and eggs from an electronic waste recycling area in southeast China显示文摘The levels and distributions of polybrominated diphenyl ethers(PBDEs) in chicken tissues from an electronic waste(e-waste) recycling area in southeast China were investigated.Human dietary intake by local residents via chicken muscle and eggs was estimated.The mean PBDEs concentrations in tissues ranged from 15.2 to 3138.1 ng/g lipid weight(lw) and in egg the concentration was 563.5 ng/g lw.The results showed that the level of total PBDEs(ΣPBDEs) in the chicken tissue was 2-3 orders of magnitude higher than those reported in the literature.The large difference of ΣPBDEs concentrations between tissues confirmed that the distribution of PBDEs in tissues depend on tissue-specificity rather than the 'lipid-compartment'.BDE-209 was the predominant congener(82.5%-94.7% of ΣPBDEs) in all chicken tissues except in brain(34.7% of ΣPBDEs),which indicated that deca-BDE(the major commercial PBDE formulation comprising 65%-70% of total production) was major pollution source in this area and could be bioaccumulated in terrestrial animals.The dietary PBDEs intake of the local residents from chicken muscle and egg,assuming only local bred chickens and eggs were consumed,ranged from 2.2 to 22.5 ng/(day·kg body weight(bw)) with a mean value of 13.5 ng/(day·kg bw),which was one order of magnitude higher than the value reported in previous studies for consumption of all foodstuffs. | Xiaofei Qin Zhanfen Qin Yan Li Yaxian Zhao Xijuan Xia Shishuai Yan Mi Tian Xingru Zhao Xiaobai Xu Yongjian Yang | 2011 | Journal of Environmental Sciences2011，23，1： | 8 |
| 10 | Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress显示文摘Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis(RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema heterophyllum Blume(AHA) and explore the possible mechanisms in human non-small-cell lung cancer A549 cells. AHA with purity up to 95% was isolated and purified from Arisaema heterophyllum Blume using hydrophobic interaction chromatography. AHA dose-dependently inhibited the proliferation of A549 cells and induced G_1 phase cell cycle arrest. AHA induced apoptosis by up-regulating pro-apoptotic Bax, decreasing anti-apoptotic Bcl-2, and activating caspase-9 and caspase-3. In A549 cells treated with AHA, the PI3K/Akt pathway was inhibited. Furthermore, AHA induced increase in the levels of ER stress markers such as phosphorylated eukaryotic initiation factor 2α(p-eIF2α), C/EBP-homologous protein(CHOP), inositol-requiring enzyme 1α(IRE1α), and phosphorylated c-Jun NH_2-terminal kinase(p-JNK). AHA also induced autophagy in A549 cells. Staining of acidic vesicular organelles(AVOs) and increase in the levels of LC3II and ATG7 were observed in AHA-treated cells. These findings suggested that AHA might be one of the active components with anti-cancer effects in Arisaema heterophyllum Blume. In conclusion, cytotoxicity of AHA on cancer cells might be related to its effects on apoptosis and autophagy through inhibition of PI3K/Akt pathway and induction of ER stress. | FENG Li-Xing SUN Peng MI Tian LIU Miao LIU Wang YAO Si CAO Yi-Min YU Xiao-Lu WU Wan-Ying JIANG Bao-Hong YANG Min GUO De-An LIU Xuan | 2016 | Chinese Journal of Natural Medicines2016，14，11： | 6 |
| 11 | Agricultural Heritage Systems Tourism: definition,characteristics and development framework显示文摘Architectural heritage comprises one o the most important elements of mountain settlements in Greece. It holds high cultural value, represents the tangible continuation of the past and forms the unique character and identity of each mountain region. Yet, controversy regarding funding for its preservation often arises. In this paper, we used two Contingent Valuation surveys to estimate the socia benefit deriving from protecting the traditiona architecture in the mountainous village of Sirako and through it, to examine perceptions and attitudes o local residents and visitors. Research findings revealed a strong social will in favor of the good's protection followed by high percentages of positive willingness to pay(WTP). However, WTP is significantly higher among residents. Cultura heritage value, of the good, appears to prevail, along with the environmental one. However, both residents and visitors pointed out that local heritage, if wellpreserved, will boost tourism development. Residents appeared to better recognize the true level o architectural decay, expressed higher apprehension for its protection and were willing to pay higher amount of money. Tourists, on the other side expressed high satisfaction for their visit, appreciated the beauty and serenity emerging from local built and natural environment and spent several days visiting the surrounding area. The longer they stayed and gotfamiliar with the village, the more willing they were to contribute to local heritage's protection. Percentages reflecting indifference for protecting architecture were extremely low. Yet, they were higher among tourists. Traditional architecture is considered as public good; an opinion resulting in an important percentage of visitors stating that national government should provide the necessary funding. In addition, the architecture appears to hold a high level of topicality. Those descending from Sirako or emotionally connected to it, of both social groups,turned out to be more concerned about the good and with a stronger sense of responsibility for it. Usevalue of the good holds high economic value, as well,while higher percentages of zero WTP appeared among non-users. Research findings revealed social attitudes and perceptions on what constitutes architectural heritage, in its cultural and economic frame. If taken under consideration, they may form useful drivers for local, heritage-based, | TIAN Mi MIN Qing-wen JIAO Wen-jun YUAN Zheng Anthony M.FULLER YANG Lun ZHANG Yong-xun ZHOU Jie CHENG Bing | 2016 | Journal of Mountain Science2016，13，3： | 6 |
| 12 | The protective effect of tetrahedral framework nucleic acids on periodontium under inflammatory conditions显示文摘Periodontitis is a common disease that causes periodontium defects and tooth loss.Controlling inflammation and tissue regeneration are two key strategies in the treatment of periodontitis.Tetrahedral framework nucleic acids can modulate multiple biological behaviors,and thus,their biological applications have been widely explored.In this study,we investigated the effect of tFNAs on periodontium under inflammatory conditions.Lipopolysaccharide and silk ligature were used to induce inflammation in vivo and in vitro.The results displayed that tFNAs decreased the release of pro-inflammatory cytokines and levels of cellular reactive oxygen species in periodontal ligament stem cells,which promoted osteogenic differentiation.Furthermore,animal experiments showed that tFNAs ameliorated the inflammation of the periodontium and protect periodontal tissue,especially reducing alveolar bone absorption by decreasing inflammatory infiltration and inhibiting osteoclast formation.These findings suggest that tFNAs can significantly improve the therapeutic effect of periodontitis and have the great potential significance in the field of periodontal tissue regeneration. | Mi Zhou Shaojingya Gao Xiaolin Zhang Tianxu Zhang Tao Zhang Taoran Tian Songhang Li Yunfeng Lin Xiaoxiao Cai | 2021 | Bioactive Materials2021，6，6： | 5 |
| 13 | Metal-organic frameworks nanoswitch:Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference显示文摘Endo/lysosomal escape and gene release are two critical bottlenecks in gene delivery.Herein,a novel photo-controllable metal-organic frameworks(MOFs)nanoswitch is rationally designed for enhancing small interfering RNA(siRNA)delivery.One single laser triggers the“off-to-on”switching of MOFs nanocomplexes,inducing significant siRNA release accompanied by rapid MOFs dissociation into protonatable 2-methylimidazalo and osmotic rupturing Zn2+ions,which cooperatively contribute to remarkable endo/lysosomal rupture(∼90%).The simultaneous endo/lysosomal rupture and release enable a high spatio-temporal control on RNA interference for effective cancer therapy.Notably,the“off-to-on”switching also activates fluorescence recovery for real-time monitoring siRNA delivery.The nanoswitch could easily be extended to deliver other therapeutic agents(e.g.,DNA,protein,anticancer drug)for overcoming endo/lysosomal entrapment. | Gan Lin Yang Zhang Long Zhang Junqing Wang Ye Tian Wen Cai Shangui Tang Chengchao Chu JiaJing Zhou Peng Mi Xiaoyuan Chen Gang Liu | 2020 | Nano Research2020，13，1： | 5 |
| 14 | A Stator Current Vector Orientation Based Multi-objective Integrative Suppressions of Flexible Load Vibration and Torque Ripple for PMSM Considering Electrical Loss显示文摘To store energy from the grid into spiral torsion spring(STS)smoothly and efficiently via PMSM,a multi-objective control problem of flexible load’s vibration,PMSM’s torque ripple,and electrical loss is raised,where the current studies on vibration and torque ripple are mostly addressed separately,not to mention electrical loss.This research attempts to propose a multi-objective integrative control scenario that can simultaneously solve these problems satisfactorily in a unitary nonlinear control framework.Firstly,a dynamic mathematical model of PMSM is built under stator current vector orientation,and then the model of PMSM is combined with the vibration model of STS to establish the overall system model of STS driven by PMSM with considering motor’s electrical loss.Then,a backstepping control principle-based multi-objective integrative control approach is proposed to realize the suppression of flexible load’s vibration and the reduction of PMSM’s torque ripple and electrical loss concurrently.Meanwhile,this research also designs a wide range speed identification method based on the least square algorithm with a forgetting factor.Simulation and experimental results have verified that the proposed integrative control method enables the state variables to track their respective references quickly and accurately,both torque ripple and load vibration are effectively suppressed,and the operating efficiency of the whole system is improved. | Yang Yu Leyao Cong Xia Tian Zengqiang Mi Yang Li Zhen Fan Hui Fan | 2020 | CES Transactions on Electrical Machines and Systems2020，4，3： | 5 |
| 15 | Muscle RING-finger protein-1 (MuRFl) functions and cellular localization are regulated by SUMOl post-translational modification显示文摘The muscle RING-finger protein-1 (MuRFl) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRFl gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRFl gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We have discovered that MuRFl turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASy/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. We provided evidence that SUMOylation is essential for MuRFl nuclear translocation and its mitochondria accumulation is enhanced in hyper? glycemic conditions delivering a stabilization of the overall SUMOylated proteins in cultured myocytes. Thus, our findings add this SUM01 post-translational modification as a new concept to understand muscle disorders related to the defect in MuRFl activity. | Gabriel Heras Arvind Venkat Namuduri Leonardo Traini Ganna Shevchenko Alexander Falk Sara Bergstrom Lind Mi Jia Geng Tian Stefano Gastaldello | 2019 | Journal of Molecular Cell Biology2019，11，5： | 4 |
| 16 | In situ generation of Li_(3)N concentration gradient in 3D carbon-based lithium anodes towards highly-stable lithium metal batteries显示文摘The uncontrolled dendrite growth of lithium metal anodes(LMAs)caused by unstable anode/electrolyte interface and uneven lithium deposition have impeded the practical applications of lithium metal batteries(LMBs).Constructing a robust artificial solid electrolyte interphase(SEI)and regulating the lithium deposition behavior is an effective strategy to address these issues.Herein,a three-dimensional(3D)lithium anode with gradient Li_(3)N has been in-situ fabricated on carbon-based framework by thermal diffusion method(denoted as CC/Li/Li_(3)N).Density functional theory(DFT)calculations reveal that Li_(3)N can effectively promote the transport of Li^(+)due to the low energy barrier of Li^(+)diffusion.As expected,the Li_(3)N-rich conformal artificial SEI film can not only effectively stabilize the interface and avoid parasitic reactions,but also facilitate fast Li^(+)transport across the SEI layer.The anode matrix with uniformly distributed Li3N can enable homogenous deposition of Li,thus preventing Li dendrite propagation.Benefiting from these merits,the CC/Li/Li_(3)N anode achieves ultralong-term cycling for>1000 h at a current density of 2 m A cm^(-2)and dendrite-free Li deposition at an ultrahigh rate of 20 m A cm^(-2).Moreover,the full cells coupled with LiFePO4cathodes show extraordinary cycling stability for>300 cycles in liquidelectrolyte-based batteries and display a high-capacity retention of 96.7%after 100 cycles in solid-state cells,demonstrating the promising prospects for the practical applications of LMBs. | Wenzhu Cao Weimin Chen Mi Lu Cheng Zhang Du Tian Liang Wang Faquan Yu | 2023 | Journal of Energy Chemistry2023，，1： | 4 |
| 17 | Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice显示文摘Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphorata(PDCA) is expected to develope as a substitute. In this paper, nineteen triterpenes were isolated from PDCA, and thirteen of them were the unique anthroic acids in A. camphorata, including the main content antcin K, which suggested that PDCA produced a large array of the same anthroic acids as the wild one. Furthermore, no obvious acute toxicity was found suggesting the edible safety of PDCA. In mice alcohol-induced liver injury model, triglyceride(TG), aspartate aminotransferase(AST), alanine aminotransferase(ALT), and malondialdehyde(MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases. | WU Yu TIAN Wen-Jing GAO Shuo LIAO Zu-Jian WANG Guang-Hui LO Jir-Mehng LIN Pei-Hsin ZENG De-Quan QIU Da-Ren LIU Xiang-Zhong ZHOU Mi LIN Ting CHEN Hai-Feng | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 4 |
| 18 | Bufalin derivative BF211 inhibits proteasome activity in human lung cancer cells in vitro by inhibiting β1 subunit expression and disrupting proteasome assembly显示文摘 | Peng SUN Li-xing FENG Dong-mei ZHANG Miao LIU Wang LIU Tian MI Wan-ying WU Bao-hong JIANG Min YANG Li-hong HU De-an GUO Xuan LIU | 2016 | Acta Pharmacologica Sinica2016，37，7： | 4 |
| 19 | Application of the Guiding Template Designed by Three-dimensional Printing Data for the Insertion of Sacroiliac Screws:a New Clinical Technique显示文摘This study is aimed to explore the clinical application of the guiding template designed by three-dimensional printing data for the insertion of sacroiliac screws.A retrospective study of 7 cases (from July 2016 to December 2016),in which the guiding template printed by the three-dimensional printing technique was used for the insertion of sacroiliac screws of patients with posterior ring injuries of pelvis,was performed.Totally,4 males and 3 females were included in template group,aged from 38to 65years old (mean 50.86±8.90).Of them,5 had sacral fractures (3 with Denis type Ⅰ and 2 with type Ⅱ)and 2 the separation of sacroiliac joint.Guiding templates were firstly made by the three-dimensional printing technique based on the pre-operative CT data. Surgical operations for the stabilization of pelvic ring by applying the guiding templates were carried out.A group of 8 patients with sacroiliac injuries treated by percutaneous sacroiliac screws were analyzed as a control group retrospectively.The time of each screw insertion,volume of intra-operative blood loss,and the exposure to X ray were analyzed and the Matta's radiological criteria were used to evaluate the reduction quality.The Majeed score was used to evaluate postoperative living quality.The visual analogue scale (VAS)was applied at different time points to judge pain relief of coccydynia.All the 7 patients in the template group were closely followed up radiographically and clinically for 14 to 20 months,mean (16.57±2.44)months.Totally 9 sacroiliac screws for the S 1 and S2 vertebra were inserted in the 7 patients.The time length for each screw insertion ranged from 450 to 870 s,mean (690.56±135.68)s,and the number of times of exposure to X ray were 4 to 8,mean (5.78±1.20).The intra-operative blood loss ranged from 45to 120 mL,mean (75±23.32)mL.According to Matta's radiology criteria,the fracture and dislocation reduction were excellent in 6cases and good in 1.The pre-operative VAS score ranged from 5.2 to 8.1,mean (7.13±1.00).The average one-week/six-month post-operative VAS was (5.33±0.78)and (1.33±0.66),respectively (P<0.05 when compared with pre-operative VAS).The 12-month post-operative Majeed score ranged from 86 to 92,mean (90.29±2.21).The three-dimensional printed guiding template for sacroiliac screw insertion,which could significantly shorten the operation time,provide a satisfied outcome of the stabilization of the pelvic ring,and protect doctors and patients from X-ray exposure,might be a practical and valuable new clinical technique. | Yi LIU Wu ZHOU Tian XIA Jing LIU Bo-bin MI Liang-cong HU Zeng-wu SHAO Guo-hui LIU | 2018 | Current Medical Science2018，38，6： | 4 |
| 20 | Pt-Co single atom alloy catalysts: Accelerated water dissociation and hydrogen evolution by strain regulation显示文摘The alkaline hydrogen evolution reaction(HER) on Pt-based catalysts is largely limited by the slow water dissociation kinetics. Pt-based single atom alloy catalysts(SAAC) with water dissociation sites have been demonstrated as excellent alkaline HER catalysts. However, the regulation of their activity and stability at the atomic scale is still a great challenge. Herein, the kinetic and stability issues are successfully resolved via engineering the electronic structure of Pt-Co SAAC by Au-induced tensile strain. The atomic dispersion of Co into the Pt shell was confirmed by extended X-ray absorption fine structure and the electronic structure and catalytic HER performance was modulated by the tensile strain induced by the Pt shell thickness. An inverse volcano-type relation between HER activity and surface strain was found.Density functional theory(DFT) calculations reveal that the Au-induced tensile strain on Pt-Co shell can not only boost the adsorption and dissociation kinetics of water at Co site by upshifting the dband and promoting the electron transfer, but also downshift the d-band center of Pt in Pt-Co shell, leading to optimized H* adsorption/desorption. The champion catalyst provides an overpotential of only 14 m V at the current density of 10 mA cm^(-2). This work not only provides an effective strategy for the construction of single-atom alloy electrocatalysts for high performance toward alkaline HER but also sheds light on the understanding of the reaction mechanism at the atomic level. | Rendian Wan Mi Luo Jingbo Wen Shilong Liu Xiongwu Kang Yong Tian | 2022 | Journal of Energy Chemistry2022，31，6： | 3 |
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