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| 1 | 1400W reduces ischemia reperfusion injury in an ex-vivo porcine model of the donation after circulatory death kidney donor显示文摘AIM: To investigate the effects of 1400W-a selective inducible nitric oxide synthase(iN OS) inhibitor in a model of donation after circulatory death(DCD) kidneys. METHODS: Porcine kidneys were retrieved after 25 min warm ischemia. They were then stored on ice for 18 h before being reperfused ex vivo with oxygenated autologous blood on an isolated organ perfusion system. The selective i NOS inhibitor 1400W(10 mg/kg) was administered before reperfusion(n = 6) vs control group(n = 7). Creatinine(1000 μmol/L) was added to the system, renal and tubular cell function and the level of ischemia reperfusion injury were assessed over 3 h of reperfusion using plasma, urine and tissue samples. RESULTS: Kidneys treated with 1400 W had a higher level of creatinine clearance(CrC l) [area under the curve(AUC) CrC l: 2.37 ± 0.97 mL /min per 100 g vs 0.96 ± 0.32 mL /min per 100 g, P = 0.004] and urine output [Total: 320 ± 96 mL vs 156 ± 82 mL, P = 0.008]. There was no significant difference in levels of fractional excretion of sodium(AUC, Fr ex Na+: Control, 186.3% ± 81.7%.h vs 1400 W, 153.4% ± 12.1%.h, P = 0.429). Levels of total protein creatinine ratio were significantly lower in the 1400 W group after 1 h of reperfusion(1h Pr/Cr: 1400 W 9068 ± 6910 mg/L/mmol/L vs Control 21586 ± 5464 mg/L/mmol/L, P = 0.026). Levels of 8-isoprostane were significantly lower in the 1400 W group [8-iso/creatinine ratio: Control 239 ± 136 pg/L/mmol/L vs 1400 W 139 ± 47 pg/L/mmol/L, P = 0.041].CONCLUSION: This study demonstrated that 1400 W reduced ischaemia reperfusion injury in this porcine kidney model of DCD donor. Kidneys had improved renal function and reduced oxidative stress. | Sarah A Hosgood Phillip J Yates Michael L Nicholson | 2014 | World Journal of Transplantation2014，4，4： | 2 |
| 2 | A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients witb hypercholesterolemia显示文摘 | Anthony Dart George Jerums Geoffrey Nicholson Michael d’Emden Ian Hamilton-Craig George Tallis James Best Malcolm West David Sullivan Peter Braes Donald Black | 1997 | The American Journal of Cardiology1997，，： | 2 |
| 3 | A systematic assessment of Morchella using RFLP analysis of the rRNA gene显示文摘 | Michael S Nicholson Daniel J Royse | 1994 | Mycologia1994，86，6： | 1 |
| 4 | Experiences creating three implementations of the repast agent modeling toolkit显示文摘 | Michael J North Nicholson T Collier Jerry R Vos | 2006 | ACM Transactions on Modeling and Computer Simulation2006，16，1： | 1 |
| 5 | The Effect of Rock- tape on Rating of Perceived Exertion and Cycling Efficiency显示文摘 | Miller MG Michael TJ Nicholson KS | 2015 | J Strength Cond Res2015，29，9： | 1 |
| 6 | RTO: An overview and assessment of current practice显示文摘 | Mark L. Darby Michael Nikolaou James Jones Doug Nicholson | 2011 | Journal of Process Control2011，，6： | 1 |
| 7 | Dietary selenium and major depression: a nested case-control study显示文摘 | Julie A. Pasco Felice N. Jacka Lana J. Williams Melinda Evans-Cleverdon Sharon L. Brennan Mark A. Kotowicz Geoffrey C. Nicholson Madeleine J. Ball Michael Berk | 2012 | Complementary Therapies in Medicine2012，，3： | 1 |
| 8 | Optimality of the heating-rate-constrained aerocruise maneuver 显示文摘 | ROSS I MICHAEL NICHOLSON C JOHN | 1998 | Journal of Spacecraft and Rockets1998，35，3： | 1 |
| 9 | Complex adaptive systems modeling with Repast Simphony显示文摘 | Michael J North Nicholson T Collier Jonathan Ozik Eric R Tatara Charles M Macal Mark Bragen Pam Sydelko | 2013 | Complex Adaptive Systems Modeling2013，，1： | 1 |
| 10 | Community-based treatment of acute uncomplicated bacterial rhinosinusitis with gatifloxacin显示文摘 | Lawrence D. Sher Michael D. Poole Kristen Von Seggern Matthew A. Wikler Susan C. Nicholson George A. Pankey | 2002 | Otolaryngology - Head and Neck Surgery2002，，3： | 1 |
| 11 | Experiences Creating Three Implementations of the Repast Agent Modeling Tool-kit 显示文摘 | Michael J North Nicholson T Collier and Jerry R Vos | 2006 | ACM Transactions on Modeling and Computer Simulation2006，16，1： | 1 |
| 12 | Destruction of Cyanobacterial Peptide Hepatotoxins by Chlorine and Chloraminc显示文摘 | BRE NTON C Nicholson JOANNA Rositano MICHAEL D Burch | 1994 | Wat Res1994，28，6： | 1 |
| 13 | Design and Testing of a Percutaneously Implantable Fetal Pacemaker显示文摘 | Gerald E. Loeb Li Zhou Kaihui Zheng Adriana Nicholson Raymond A. Peck Anjana Krishnan Michael Silka Jay Pruetz Ramen Chmait Yaniv Bar-Cohen | 2013 | Annals of Biomedical Engineering2013，，1： | 1 |
| 14 | Lexical Access and Phonological Decoding in Adult Dyslexic Subtypes 显示文摘 | Milne RD Nicholson T C Michael C | 2003 | Neuropsyehology2003，17，3： | 1 |
| 15 | In situ formation of lead phosphates as a method to immobilize lead显示文摘 | Michael V Ruby Andy Davis Andrew Nicholson | 1994 | Environmental Science & Technology1994，28，： | 1 |
| 16 | Experiences Creating Three Implementations of the Repast Agent Modeling Toolkit 显示文摘 | Michael J North Nicholson T Collier Jerry R Vos | 2006 | ACM Transactions on Modeling and Computer Simulation (S1049-3301)2006，16，1： | 1 |
| 17 | Effect of the ionic liquid 1-ethyl-3-methylimidazolium acetate on the phase transition of starch: Dissolution or gelatinization?显示文摘 | Sainimili Mateyawa David Fengwei Xie Rowan W. Truss Peter J. Halley Timothy M. Nicholson Julia L. Shamshina Robin D. Rogers Michael W. Boehm Tony McNally | 2013 | Carbohydrate Polymers2013，，1： | 1 |
| 18 | Phase I study to determine the safety,toler ability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers显示文摘 | Bartlett J B Michael A Clarke I A Dredge K Nicholson S Kristeleit H | 2004 | Br J Cancer2004，90，： | 1 |
| 19 | A comparison of the vegetation response to rainfall in the Sahel and East Africa, using normalized difference vegetation index from NOAA AVHRR显示文摘 | Sharon E. Nicholson Michael L. Davenport Ada R. Malo | 1990 | Climatic Change (-)1990，，23： | 1 |
| 20 | 车厂当代表演艺术中心显示文摘车厂是当代艺术中心在悉尼的新家,这个项目是由新南威尔士州政府通过'艺术之新南威尔士'发展项目开发而来,对始建于1888年的位于悉尼伊夫利的一处车辆厂进行了改造,旨在建造一座集概念、发展和展示表演艺术为-体的新艺术中心.来自Tonkin Zulaikha Greet Architects事务所的主持建筑师Tim Greer 在尊重建筑历史的基础上,对车辆厂进行了适应性的改造再利用,赋予建筑崭新的未来. | Tim Greer Julie Mackenzie Jeremy Hughes Brian Zulaikha John Chesterman Bettina Siegmund Trina Day Vanessa Vorster Amelia Holliday Christian Williams Michael Nicholson Prudence Upton 朱晓琳 | 2010 | 建筑技艺2010，16，11： | 0 |
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