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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 3 | International experts consensus guidelines on robotic liver resection in 2023显示文摘The robotic liver resection(RLR)has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system,however,controversies still exist.Based on the foundation of the previous consensus statement,this new consensus document aimed to update clinical recommendations and provide guidance to improve the outcomes of RLR clinical practice.The guideline steering group and guideline expert group were formed by 29 international experts of liver surgery and evidence-based medicine(EBM).Relevant literature was reviewed and analyzed by the evidence evaluation group.According to the WHO Handbook for Guideline Development,the Guidance Principles of Development and Amendment of the Guidelines for Clinical Diagnosis and Treatment in China 2022,a total of 14 recommendations were generated.Among them were 8 recommendations formulated by the GRADE method,and the remaining 6 recommendations were formulated based on literature review and experts’opinion due to insufficient EBM results.This international experts consensus guideline offered guidance for the safe and effective clinical practice and the research direction of RLR in future. | Rong Liu Mohammed Abu Hilal Go Wakabayashi Ho-Seong Han Chinnusamy Palanivelu Ugo Boggi Thilo Hackert Hong-Jin Kim Xiao-Ying Wang Ming-Gen Hu Gi Hong Choi Fabrizio Panaro Jin He Mikhail Efanov Xiao-Yu Yin Roland S Croner Yu-Man Fong Ji-Ye Zhu Zheng Wu Chuan-Dong Sun Jae Hoon Lee Marco V Marino Iyer Shridhar Ganpati Peng Zhu Zi-Zheng Wang Ke-Hu Yang Jia Fan Xiao-Ping Chen Wan Yee Lau | 2023 | World Journal of Gastroenterology2023，29，32： | 2 |
| 4 | Radiofrequency assisted liver resection:Analysis of 604 consecutive cases显示文摘 | Pai M Frampton AE Mikhail S | 2012 | Eur J Surg Oncol2012，38，3： | 1 |
| 5 | On - line solid - phase extraction and HPLC determination of polyeyclie aromatic hydrocarbons in water using fluorocarbon polymer sorbents 显示文摘 | Lubov O Mikhail S Grigoriy T | 2005 | Analytica Chimica Aeta2005，538，： | 1 |
| 6 | Digital Communication Using Chaotic-Pulse-Position Modulation显示文摘 | Nikolai F Rulkov Mikhail M Sushchik Lev S Tsimring | 2001 | IEEE Trans on Circuits and Systems -I :Fundamental Theory and Applications2001，48，12： | 1 |
| 7 | Black nickel coating for solar collec- tors 显示文摘 | Shawki S Mikhail S | 2000 | Mater Manufact Proc2000，15，5： | 1 |
| 8 | Radiofrequency-assisted hepatic resection显示文摘 | Pai M Kyriakides C Mikhail S | 2011 | Ann Surg Oncol2011，18，12： | 1 |
| 9 | Generalized synchronization of chaos in directionally coupled chaotic system显示文摘 | Nikolai F Rulkov Mikhail M Sushchik Lev S Tsimring | 1995 | Phys Rev E1995，51，： | 1 |
| 10 | information content of equity analyst reports显示文摘 | Asquith Paul Michael B Mikhail and Andrea S Au | 2005 | Journal of Financial Economics2005，75，： | 1 |
| 11 | Information content of equity analyst reports 显示文摘 | Asquith P Mikhail M B Au A S | 2005 | Journal of Financial Economics2005，75，2： | 1 |
| 12 | Two-machine flow shop no-wait scheduling with a nonavailability interval显示文摘 | MIKHAIL A K VITALY A S | 2004 | Naval Research Logistics2004，5，4： | 1 |
| 13 | Type E Hepatitis:State of the Art显示文摘 | Mikhail S Balayan MD | 1997 | International Journal of Infectious Diseases1997，2，2： | 1 |
| 14 | Radiofrcqueney assisted liv- er resection: analysis of 604 consecutive eases显示文摘 | Pai M Frampton AE Mikhail S | 2012 | Eur J Surg On- col2012，38，3： | 1 |
| 15 | Radiofrequency assisted liver resection: analysis of 604 consecutive cases显示文摘 | Pai M Frampton AE Mikhail S | 2012 | Eur J Surg Oncol2012，38，3： | 1 |
| 16 | Image coding through D Lattice quantization of wavelet coefficients显示文摘 | Mikhail S Andrew P P | 1997 | Graphical Models and Image Processing1997，59，4： | 1 |
| 17 | A kinetic model of the choline chloride synthesis显示文摘 | Roman A K Valery F S Mikhail G M | 1999 | Organic Process Research Development1999，3，5： | 1 |
| 18 | Desulfurization by an economically adsorption technique显示文摘 | Mikhail S Zaki T Khalil L | 2002 | Applied Catalysis A:General2002，227，： | 1 |
| 19 | Exploiting Growing Stock Volume Maps for Large Scale Forest Resource Assessment: Cross- Comparisons of ASAR- and PALSAR-Based GSV Estimates with Forest Inventory in Central Siberia 显示文摘 | Christian H Mikhail K Sergey B Vasily Z Dmitry S Anatoly S Christiane S | 2014 | Forests2014，5，7： | 1 |
| 20 | Rights protection for relational data显示文摘 | RADU S MIKHAIL A SUNIL P | 2004 | IEEE Transactions on Knowledge and Data Engineering2004，16，2： | 1 |
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