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| 1 | Systematic review of anastomotic complications of esophagojejunostomy after laparoscopic total gastrectomy显示文摘AIM: To investigate the anastomotic complications ofesophagojejunostomy(EJS) after laparoscopic total gastrectomy(LTG), we reviewed retrospective studies.METHODS: A literature search was conducted in Pub Med for studies published from January 1, 1994 through January 31, 2015. The search terms included 'laparoscopic,' 'total gastrectomy,' and 'gastric cancer.' First, we selected 16 non-randomized controlled trials(RCTs) comparing LTG with open total gastrectomy(OTG) and conducted an updated meta-analysis of anastomotic complications after total gastrectomy. The Newcastle-Ottawa scoring system(NOS) was used to assess the quality of the non-RCTs included in this study. Next, we reviewed anastomotic complications in 46 case studies of LTG to compare the various procedures for EJS. RESULTS: The overall incidence of anastomotic leakage associated with EJS was 3.0%(30 of 984 patients) among LTG procedures and 2.1%(31 of 1500 patients) among OTG procedures in the 16 non-RCTs. The incidence of anastomotic leakage did not differ significantly between LTG and OTG(odds OR = 1.42, 95%CI: 0.86-2.33, P = 0.17, I2 = 0%). Anastomotic stenosis related to EJS was reported in 72(2.9%) of 2484 patients, and the incidence was 3.2% among LTG procedures and 2.7% among OTG procedures. The incidence of anastomotic stenosis related to EJS was slightly, but not significantly, higher in LTG than in OTG(OR = 1.55, 95%CI: 0.94-2.54, P = 0.08, I2 = 0%). The various procedures for LTG were classified into six categories in the review of case studies of LTG. The incidence of EJS leakage was similar(1.1% to 3.2%), although the incidence of EJS stenosis was relatively high when the Or VilTM device was used(8.8%) compared with other procedures(1.0% to 3.6%).CONCLUSION:The incidence of anastomotic complications associated with EJS was not different between LTG and OTG. Anastomotic stenosis was relatively common when the Or VilTM device was used. | Mikito Inokuchi Sho Otsuki Yoshitaka Fujimori Yuya Sato Masatoshi Nakagawa Kazuyuki Kojima | 2015 | World Journal of Gastroenterology2015，21，32： | 23 |
| 2 | Clinical significance of MET in gastric cancer显示文摘Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer(GC),although outcomes remain unfavorable.Many molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed,and monoclonal antibodies targeting human epidermal growth factor receptor 2 or vascular endothelial growth factor receptor 2 have become standard therapy for GC.Hepatocyte growth factor and its receptor,c-MET(MET),play key roles in tumor growth through activated signaling pathways from receptor in GC cells.Genomic amplification of MET leads to the aberrant activation found in GC tumors and is related to survival in patients with GC.This review discusses the clinical significance of MET in GC and examines MET as a potential therapeutic target in patients with GC.Preclinical studies in animal models have shown that MET antibodies or smallmolecule MET inhibitors suppress tumor-cell proliferation and tumor progression in MET-amplified GC cells.These drugs are now being evaluated in clinical trials as treatments for metastatic or unresectable GC. | Mikito Inokuchi Sho Otsuki Yoshitaka Fujimori Yuya Sato Masatoshi Nakagawa Kazuyuki Kojima | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 5 |
| 3 | Addition of docetaxel to S-1 without platinum prolongs survival of patients with advanced gastric cancer: a randomized study (START)显示文摘 | Wasaburo Koizumi Yeul Hong Kim Masashi Fujii Hoon Kyo Kim Hiroshi Imamura Kyung Hee Lee Takuo Hara Hyun Cheol Chung Taroh Satoh Jae Yong Cho Hisashi Hosaka Akihito Tsuji Akinori Takagane Mikito Inokuchi Kazuaki Tanabe Tatsuya Okuno Mariko Ogura Kazuhiro Y | 2014 | Journal of Cancer Research and Clinical Oncology2014，，2： | 2 |
| 4 | Prognostic significance of the co?overexpression of fibroblast growthfactor receptors 1, 2 and 4 in gastric cancer显示文摘 | Hideaki Murase Mikito Inokuchi Yoko Takagi Keiji Kato Kazuyuki Kojima Kenichi Sugihara | 2014 | Molecular and Clinical Oncology2014，，4： | 2 |
| 5 | Long-term comparison of laparoscopy-assisted distal gastrectomy and open distal gastrectomy in advanced gastric cancer显示文摘 | Andrew C. Gordon Kazuyuki Kojima Mikito Inokuchi Keiji Kato Kenichi Sugihara | 2013 | Surgical Endoscopy2013，，2： | 2 |
| 6 | Methylation of BNIP3 and DAPK indicates lower response to chemotherapyand poor prognosis in gastric cancer显示文摘 | Hirofumi Sugita Satoru Iida Mikito Inokuchi Keiji Kato Megumi Ishiguro Toshiaki Ishikawa Yoko Takagi Megumu Enjoji Hiroyuki Yamada Hiroyuki Uetake Kazuyuki Kojima Kenichi Sugihara | 2011 | Oncology Reports2011，，2： | 2 |
| 7 | β-Shaped intracorporeal Roux-en-Y reconstruction after totally laparoscopic distal gastrectomy显示文摘 | Kazuo Motoyama Kazuyuki Kojima Mikiko Hayashi Keiji Kato Mikito Inokuchi Kenichi Sugihara | 2014 | Gastric Cancer2014，，3： | 1 |
| 8 | Petersen’s hernia after laparoscopic distal gastrectomy with Roux-en-Y reconstruction for gastric cancer显示文摘 | Kazuyuki Kojima Mikito Inokuchi Keiji Kato Kazuo Motoyama Kenichi Sugihara | 2014 | Gastric Cancer2014，，1： | 1 |
| 9 | Functional evaluation after vagus nerve–sparing laparoscopically assisted distal gastrectomy显示文摘 | Kazuyuki Kojima Hiroyuki Yamada Mikito Inokuchi Tatuyuki Kawano Kenichi Sugihara | 2008 | Surgical Endoscopy2008，，9： | 1 |
| 10 | Long-term comparison of laparoscopy-assisted distal gastrectomy and open distal gastrectomy in advanced gastric cancer显示文摘 | Andrew C. Gordon Kazuyuki Kojima Mikito Inokuchi Keiji Kato Kenichi Sugihara | 2013 | Surgical Endoscopy2013，，2： | 1 |
| 11 | Laparoscopy-Assisted Gastrectomy in Patients Older Than 80显示文摘 | Hiroyuki Yamada Kazuyuki Kojima Mikito Inokuchi Tatsuyuki Kawano Kenichi Sugihara | 2010 | Journal of Surgical Research2010，，2： | 1 |
| 12 | Long-term outcomes of Roux-en-Y and Billroth-I reconstruction after laparoscopic distal gastrectomy显示文摘 | Mikito Inokuchi Kazuyuki Kojima Hiroyuki Yamada Keiji Kato Mikiko Hayashi Kazuo Motoyama Kenichi Sugihara | 2013 | Gastric Cancer2013，，1： | 1 |
| 13 | Feasibility of laparoscopy-assisted gastrectomy for patients with chronic obstructive pulmonary disease显示文摘 | Mikito Inokuchi Kazuyuki Kojima Keiji Kato Kazuo Motoyama Hirofumi Sugita Kenichi Sugihara | 2013 | Surgical Endoscopy2013，，6： | 1 |
| 14 | Feasibility of laparoscopic total gastrectomy in overweight patients: Implications of less impact of overweight on laparoscopic versus open approach显示文摘AIM To investigate safety and oncological feasibility of laparoscopic total gastrectomy(LTG) in overweight(OW) patients.METHODS Patients who underwent total gastrectomy(110 laparoscopic, 211 open) for gastric cancer between January 1999 and July 2016 were included. Propensity score matching selected 152 patients(76 laparoscopic, 76 open), which were subsequently divided into the OW(≥ 25) or non-OW(< 25) group by body mass index. Postoperative outcomes of laparoscopic versus open approaches were compared between OW and non-OW groups. RESULTS In the propensity-matched population, baseline characteristics were comparable between the OW and nonOW groups for the laparoscopy and open groups. In the laparoscopy group, operative time was longer(P = 0.01) in the OW group, however, other perioperative results including complication rates were comparable between the non-OW and OW groups. In the open group, number of retrieved lymph nodes were less(P = 0.03) and local complication rate was more frequent(P = 0.03) in the OW group. CONCLUSION LTG in OW patients remains technically challenging but can be performed safely. Our findings imply that OW has a lesser effect on the laparoscopic versus open approach to total gastrectomy. | Masatoshi Nakagawa Kazuyuki Kojima Mikito Inokuchi Kenta Kobayashi Toshiro Tanioka Keisuke Okuno Kentaro Gokita | 2018 | World Journal of Clinical Cases2018，6，16： | 0 |
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