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| 1 | Genetic changes of p53,K-ras,and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary显示文摘AIM: To disclose geographic differences in genetic changes involved in gallbladder carcinogenesis between two distinct high-incidence areas of Japan and Hungary.METHODS: We examined 42 cases of gallbladder carcinoma: 22 Japanese and 20 Hungarian cases. p53 mutations at exons 5 to 8 and K-ras mutations at codon 12 were tested by direct sequencing. Microsatellite instability was determined from fluorescent dye-labeled PCR amplifications of five-microsatellite markers (BAT-25, BAT-26, D2S123, D5S346, and D17S250).RESULTS: Mutations of p53 were detected in 11 of 22 Japanese cases and 6 of 18 Hungarian cases (11/22 vs 6/18, P = 0.348). Transition at CpG sites was found in none of 11 Japanese cases and 2 of 6 Hungarian cases; the difference was marginally significant (0/11 vs 2/6, P = 0.110). K-ras mutations were detected in only one of the Hungarian cases. Eight of 19 (42.1%) Japanese cases were MSI-high (presence of novel peaks in more than one of the five loci analyzed), whereas only 1 of 15 (6.7%) Hungarian cases was MSI-high (P = 0.047).CONCLUSION: It appears that the p53 mutations and MSI differ in patients with gallbladder carcinoma between two distinct high-incidence areas. Geographic variation might exist in the process of gallbladder carcinogenesis. | Masayuki Nagahashi Yoichi Ajioka Istvan Lang Zoltan Szentirmay Miklos Kasler Hiroto Nakadaira Naoyuki Yokoyama Gen Watanabe Ken Nishikura Toshifumi Wakai Yoshio Shirai Katsuyoshi Hatakeyama Masaharu Yamamoto | 2008 | World Journal of Gastroenterology2008，14，1： | 9 |
| 2 | Burden of Clostridium difficile infection between 2010 and 2013:Trends and outcomes from an academic center in Eastern Europe显示文摘AIM:To analyze the incidence and possible risk factors in hospitalized patients treated with Clostridium difficile infection(CDI).METHODS:A total of 11751 patients were admitted to our clinic between 1 January 2010 and 1 May2013.Two hundred and forty-seven inpatients were prospectively diagnosed with CDI.For the risk analysis a 1:3 matching was used.Data of 732 patients matched for age,sex,and inpatient care period and unit were compared to those of the CDI population.Inpatient records were collected from an electronic hospital database and comprehensively reviewed.RESULTS:Incidence of CDI was 21.0/1000 admissions(2.1%of all-cause hospitalizations and 4.45%of total inpatient days).The incidence of severe CDI was 12.6%(2.63/1000 of all-cause hospitalizations).Distribution of CDI cases was different according to the unit type,with highest incidence rates in hematology,gastroenterology and nephrology units(32.9,25 and24.6/1000 admissions,respectively) and lowest rates in 1.4%(33/2312) in endocrinology and general internal medicine(14.2 and 16.9/1000 admissions)units.Recurrence of CDI was 11.3%within 12 wk after discharge.Duration of hospital stay was longer in patients with CDI compared to controls(17.6 ± 10.8d vs 12.4 ± 7.71 d).CDI accounted for 6.3%of allinpatient deaths,and 30-d mortality rate was 21.9%(54/247 cases).Risk factors for CDI were antibiotic therapy[including third-generation cephalosporins or fluoroquinolones,odds ratio(OR) = 4.559;P < 0.001],use of proton pump inhibitors(OR = 2.082,P< 0.001),previous hospitaiization within 12 mo(OR = 3.167,P < 0.001),previous CDI(OR = 15.32;P < 0.001),while presence of diabetes mellitus was associated with a decreased risk for CDI(OR = 0.484;P< 0.001).Treatment of recurrent cases was significantly different from primary infections with more frequent use of vancomycin alone or in combination(P < 0.001),and antibiotic therapy duration was longer(P < 0.02).Severity,mortality and outcome of primary infections and relapsing cases did not significantly differ.CONCLUSION:CDI was accounted for significant burden with longer hospitaiization and adverse outcomes.Antibiotic,PPI therapy and previous hospitaiization or CDI were risk factors for CDI. | Zsuzsanna Kurti Barbara D Lovasz Michael D Mandel Zoltan Csima Petra A Golovics Bence D Csako Anna Mohas Lorant Gnczi Krisztina B Gecse Lajos S Kiss Miklos Szathmari Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，21： | 6 |
| 3 | 为争夺客户而战:传统银行如何应对互联网金融挑战显示文摘全球银行业新的局面正在形成,数字化技术正在侵蚀银行业务和市场份额,重构客户关系,重点是银行最注重的中间业务收入。随着数字化变革的提速,银行将被卷入一场客户争夺战。如何与互联网企业合作竞争,维护客户关系将成为银行业未来思考的重要主题。未来银行必须向金融科技和互联网巨头的核心竞争力发起挑战,以客户需求为核心提供便捷、贴心的客户体验,同时通过数字化改造逐步将自身转型成为行动敏捷的低成本竞争者,从根本上赢回客户。 | Miklos Dietz Philipp Harle Somesh Khanna 倪以理 曲向军 Christopher Mazingo 韩峰 马奔 | 2017 | 新金融2017，，1： | 3 |
| 4 | 开辟银行业务新格局:如何利用生态圈赢得小微企业市场显示文摘对银行而言,小微企业将是其重要的利润来源。但是,小微企业'经营难、融资难'仍是亟待解决的关键问题。生态圈的经营模式,不是科技公司的专利,它也为银行提供了独特且可规模化的解决方案。银行在生态圈战略上拥有海量数据和客户信任等独特优势,未来银行可以利用生态圈,赢得小微业务市场,突破传统业务,以实现收益最大化。能够针对所在市场找到正确方法的银行,将拥有巨大竞争优势,在金融服务和非金融服务方面进一步巩固其在小微企业客户中的地位。先人一步采取行动的银行能够获得先发优势,解锁生态圈的巨大潜力。 | 无 曲向军 周宁人 郭明杰 Chira Barua Balazs Gati Tara Lajumoke Zubin Taraporevala Andras Havas Miklos Radnai | 2019 | 新金融2019，0，11： | 2 |
| 5 | Double-blind comparison of carbetocin versus oxytocin in prevention of uterine atony after cesarean section显示文摘 | Jerome Dansereau Arvind K. Joshi Michael E. Helewa Terence A. Doran Ian R. Lange Edwin R. Luther Dan Farine Miklos L. Schulz Gwendolyn L.A. Horbay Patricia Griffin Willem Wassenaar | 1999 | American Journal of Obstetrics and Gynecology1999，，3： | 2 |
| 6 | Hyponatremia, Hypernatremia, and Mortality in Patients With Chronic Kidney Disease With and Without Congestive Heart Failure显示文摘 | Csaba P. Kovesdy Evan H. Lott Jun Ling Lu Sandra M. Malakauskas Jennie Z. Ma Miklos Z. Molnar Kamyar Kalantar-Zadeh | 2012 | Circulation2012，，5： | 2 |
| 7 | 多瑙河六须鲶的生物学及其试养观察显示文摘多瑙河六须鲶为多瑙河流域重要的经济鱼类,最大个体可达308公斤。多瑙河六须鲶肉质细嫩、无肌间刺,蛋白含量高,肉味与中国长江大口鲶媲美。从1990年开始,由中、德、匈三国专家合作,进行从欧州移植多瑙河六须鲶到中国的驯养试验,现将初步试养观察情况综合报告如下: 一。 | 王佳喜 吴琅虎 顾雷 马达文 高锡荣 Miklos Bercsenyi Gebhard Reichle | 1993 | 淡水渔业1993，23，3： | 2 |
| 8 | 应用“A”型外展支具治疗股骨头缺血性坏死疗效分析显示文摘股骨头缺血性坏死的最佳治疗方法一直存在争议。包容治疗和手术包容治疗各有利弊。近期多中心的研究结果显示对于中度的股骨头缺血性坏死病变采用股骨或骨盆截骨术其结果优于未手术的患者。但对于大龄和严重的股骨头坏死病例,其结果并不理想。 | 刘双 张立军 Sandor Kiss Tamas Terebessy Gyorgy Szoke Janos Kiss Imre Antal Miklos Szendroi | 2014 | 中国矫形外科杂志2014，22，7： | 2 |
| 9 | Response of trigeminal neuralgia to decompression of sensory root; discussion of cause of trigeminal neuralgia显示文摘 | Gardner WJ Miklos MV | 1959 | JAMA1959，170，15： | 1 |
| 10 | Response of trigeminal neuralgia to decompression of sensory root显示文摘 | Gardner W J Miklos MV | 1959 | JAMA1959，170，： | 1 |
| 11 | On chiral drug action显示文摘 | Simonyi Miklos | 1984 | Medicinal Re-search Reviews1984，4，3： | 1 |
| 12 | R&D, Marketing, and the Success of Next-Generation Products显示文摘 | Miklos Sarvary | 2003 | Marketing Science2003，22，3： | 1 |
| 13 | Energy and centrality dependence of rapidity densities at RHIC energy 显示文摘 | Wang Xinnian Gyulassy Miklos | 2001 | Phys Rev Lett2001，86，： | 1 |
| 14 | Ultrasound and hookwire needle placement for localizatian of a hydrocele Of the canal of Nuck 显示文摘 | Miklos JR Karram NN Silver E | 1995 | Obstet Gynecol1995，85，5： | 1 |
| 15 | Ischaemic postconditioning reduces serum and tubular TNF-α expression in ischaemic-reperfused kidney in healthy rats显示文摘 | Miklos Z Kurthy M Degrell P | 2012 | Clin Hemorheol Microcirc2012，50，3： | 1 |
| 16 | Nonsurgical transurethral radiofrequency collagen denaturation:results at three years after treatment显示文摘 | Elser DM Mitchell GK Miklos JR | 2011 | Adv Urol2011，2011，87： | 1 |
| 17 | The Informational Role of Manufacturer Returns Policies: How They Can Help in Learning the Demand 显示文摘 | Miklos S Padmanabhan | 2001 | Marketing Letters2001，12，4： | 1 |
| 18 | Remanufacturing as a marketing strategy 显示文摘 | ATALAY ATASU MIKLOS SARVARY LUK N VAN WASSEN- HOVE | 2008 | Management Science2008，，10： | 1 |
| 19 | Uterine Sarcomas - a review显示文摘 | Kla<:ko M Babala P Miklos P | | Klin Onkol0，25，5： | 1 |
| 20 | A Systematic Correlation of Angiography and High-Resolution Optical Coherence Tomography in Diabetic Macular Edema显示文摘 | Matthias Bolz Markus Ritter Miklos Schneider Christian Simader Christoph Scholda Ursula Schmidt-Erfurth | 2009 | Ophthalmology2009，，1： | 1 |
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