|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals显示文摘An efficient generic static headspace gas chromatography(HSGC) method was developed,optimized and validated for the routine determination of several residual solvents(RS) in drug substance,using a strategy with two sets of calibration.Dimethylsulfoxide(DMSO) was selected as the sample diluent and internal standards were used to minimize signal variations due to the preparative step.A gas chromatograph from Agilent Model 6890 equipped with flame ionization detector(FID) and a DB-624(30 m × 0.53 mm i.d.,3.00 μm film thickness) column was used.The inlet split ratio was 5:1.The influencing factors in the chromatographic separation of the analytes were determined through a fractional factorial experimental design.Significant variables:the initial temperature(IT),the final temperature(FT) of the oven and the carrier gas flow rate(F) were optimized using a central composite design.Response transformation and desirability function were applied to find out the optimal combination of the chromatographic variables to achieve an adequate resolution of the analytes and short analysis time.These conditions were 30 ℃ for IT,158 ℃ for FT and 1.90 mL/min for F.The method was proven to be accurate,linear in a wide range and very sensitive for the analyzed solvents through a comprehensive validation according to the ICH guidelines. | Carla M.Teglia Milagros Montemurro María M.De Zan María S.Cmara | 2015 | Journal of Pharmaceutical Analysis2015，5，5： | 8 |
| 2 | Risk assessment of chemical substances of safety concern generated in processed meats显示文摘This manuscript is reviewing the presence of substances of safety concern that may be generated in different types of meat products.Such substances include N-nitrosamines that can be generated under certain conditions when using nitrite as preservative,the polycyclic aromatic hydrocarbons generated as a consequence of particular smoking processes,heterocyclic aromatic amines generated under particular cooking conditions,compounds released from the oxidation of lipids and proteins,Maillard reaction products like acrylamide and carboxymethyl lysine,and amines that can be generated and accumulated in fermented meats.These hazardous compounds,their mechanisms of generation,risks for health and ways of preventing its presence in meat products are briefly described in this review. | Monica Flores Leticia Mora Milagro Reig Fidel Toldra | 2019 | Food Science and Human Wellness2019，8，3： | 7 |
| 3 | Tracking of iron-labeled human neural stem cells by magnetic resonance imaging in cell replacement therapy for Parkinson's disease显示文摘Human neural stem cells(h NSCs) derived from the ventral mesencephalon are powerful research tools and candidates for cell therapies in Parkinson's disease. However, their clinical translation has not been fully realized due, in part, to the limited ability to track stem cell regional localization and survival over long periods of time after in vivo transplantation. Magnetic resonance imaging provides an excellent non-invasive method to study the fate of transplanted cells in vivo. For magnetic resonance imaging cell tracking, cells need to be labeled with a contrast agent, such as magnetic nanoparticles, at a concentration high enough to be easily detected by magnetic resonance imaging. Grafting of human neural stem cells labeled with magnetic nanoparticles allows cell tracking by magnetic resonance imaging without impairment of cell survival, proliferation, self-renewal, and multipotency. However, the results reviewed here suggest that in long term grafting, activated microglia and macrophages could contribute to magnetic resonance imaging signal by engulfing dead labeled cells or iron nanoparticles dispersed freely in the brain parenchyma over time. | Milagros Ramos-Gómez Alberto Martínez-Serrano | 2016 | Neural Regeneration Research2016，11，1： | 5 |
| 4 | Alzheimer’s disease and type 2 diabetes mellitus:Pathophysiologic and pharmacotherapeutics links显示文摘At present,Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are two highly prevalent disorders worldwide,especially among elderly individuals.T2DM appears to be associated with cognitive dysfunction,with a higher risk of developing neurocognitive disorders,including AD.These diseases have been observed to share various pathophysiological mechanisms,including alterations in insulin signaling,defects in glucose transporters(GLUTs),and mitochondrial dysfunctions in the brain.Therefore,the aim of this review is to summarize the current knowledge regarding the molecular mechanisms implicated in the association of these pathologies as well as recent therapeutic alternatives.In this context,the hyperphosphorylation of tau and the formation of neurofibrillary tangles have been associated with the dysfunction of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in the nervous tissues as well as the decrease in the expression of GLUT-1 and GLUT-3 in the different areas of the brain,increase in reactive oxygen species,and production of mitochondrial alterations that occur in T2DM.These findings have contributed to the implementation of overlapping pharmacological interventions based on the use of insulin and antidiabetic drugs,or,more recently,azeliragon,amylin,among others,which have shown possible beneficial effects in diabetic patients diagnosed with AD. | Milagros Rojas Mervin Chávez-Castillo Jordan Bautista Ángel Ortega Manuel Nava Juan Salazar Edgar Díaz-Camargo Oscar Medina Joselyn Rojas-Quintero Valmore Bermúdez | 2021 | World Journal of Diabetes2021，12，6： | 5 |
| 5 | Mitochondrial Dysfunction and Antioxidant Therapy in Sepsis显示文摘 | Milagros Rocha R. Herance S. Rovira Antonio Hernandez-Mijares Victor M. Victor | 2012 | Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)2012，，2： | 3 |
| 6 | The Systemic Inflammatory Response Syndrome in Acute Liver Failure显示文摘 | Nancy Rolando Jim Wade Milagros Davalos Julia Wendon John Philpott-Howard Roger Williams | 2000 | Hepatology2000，，4： | 3 |
| 7 | The Systemic Inflammatory Response Syndrome in Acute Liver Failure显示文摘 | Nancy Rolando Jim Wade Milagros Davalos Julia Wendon John Philpott-Howard Roger Williams | 2000 | Hepatology2000，，4： | 3 |
| 8 | Recent advances in bird sperm morphometric analysis and its role in male gamete characterization and reproduction technologies显示文摘通过精子竞争的 Postcopulatory 性选择可以是影响许多繁殖特点的重要进化力量,包括精子 morphometrics。象污染物质,杀虫剂,和气候变化那样的环境因素可以影响不同精子特点,并且这样复制,在里面敏感的鸟种类。在帮助繁殖技术使用的许多处理精子的过程可以也影响精子房间的尺寸。精子房间结构(特别头) 的精确地测量的尺寸能因此被用作环境影响的指示物,在改进我们繁殖、进化的策略的理解,并且为优化帮助了繁殖技术(例如,精子 cryopreservation ) 为有鸟的使用。帮助计算机的精子 morphometry 分析(CASA-Morph ) 为估计精子 morphometry 提供一个精确、可靠的方法,减少与人的视觉评价联系的主观的问题。计算机化的系统从不同哺乳动物的种类与精液为使用被标准化了。然而,鸟的精子是丝状的,限制他们有如此的系统的分析,它被开发检查哺乳动物的精子房间的近似球形的负责人。帮助克服这,染色技术在估计计算机的轻显微镜的方法被过去常的标准化是优先级。现在的评论讨论这些点并且描述几野生、国内的鸟种的精子 morphometric 特征。 | Julian Santiago-Moreno Milagros Cristina Esteso Silvia Villaverde-Morcillo Adolfo Toledano-Diaz Cristina Castafio Rosario Velazquez Antonio Lopez-Sebastian Agustin Lopez Goya Javier Gimeno Martinez | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 9 | Extending the shelf life of fresh-cut eggplant with a soy protein–cysteine based edible coating and modified atmosphere packaging显示文摘 | Christian Ghidelli Milagros Mateos Cristina Rojas-Argudo María B. Pérez-Gago | 2014 | Postharvest Biology and Technology2014，，： | 2 |
| 10 | Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress显示文摘 | S. Gómez-Zorita A. Fernández-Quintela M. T. Macarulla L. Aguirre E. Hijona L. Bujanda F. Milagro J. A. Martínez M. P. Portillo | 2011 | British Journal of Nutrition2011，，2： | 2 |
| 11 | Biomonitoringusing accessible human cells for exposure and health risk assessment显示文摘 | Salama A Milagros William W A | 1998 | Mutat Res1998，7495，： | 2 |
| 12 | Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats显示文摘 | Leonor Rivera Rocío Morón Antonio Zarzuelo Milagros Galisteo | 2008 | Biochemical Pharmacology2008，，6： | 2 |
| 13 | Effects of dietary fibers on disturbances clustered in the metabolic syndrome显示文摘 | Milagros Galisteo Juan Duarte Antonio Zarzuelo | 2008 | The Journal of Nutritional Biochemistry2008，，2： | 2 |
| 14 | Leptin and TNF-alpha promoter methylation levels measured by MSP could predict the response to a low-calorie diet显示文摘 | Cordero P Campion J Milagro FI | | 0，，03： | 1 |
| 15 | Evaluation of seven housekeeping genes for multilocus sequence analysis of the genus Mesorhizobium : resolving the taxonomic affiliation of the Cicer canariense rhizobia显示文摘 | Juan Pérez-Yépez Natalia Armas-Capote Encarna Velázquez Ricardo Pérez-Galdona Raúl Rivas Milagros León-Barrios | 2014 | Systematic and Applied Microbiology2014，，： | 1 |
| 16 | Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes显示文摘 | Correale J de los Milagros Bassani Molinas M | 2003 | J Neuroimmunol2003，136，： | 1 |
| 17 | Diabetes self-management: Perspectives of Latino patients and their health care providers显示文摘 | Elena T. Carbone Milagros C. Rosal M. Idalí Torres Karin V. Goins Odilia I. Bermudez | 2006 | Patient Education and Counseling2006，，2： | 1 |
| 18 | Oligoclonal bands and antibody responses in multiple sclerosis显示文摘 | Correale J de los Milagros B Molinas M | | 0，，： | 1 |
| 19 | Pesticide analysis in teas and chamomile by liquid chromatography and gas chromatography tandem mass spectrometry using a modified QuEChERS method: Validation and pilot survey in real samples显示文摘 | Ana Lozano ?ukasz Rajski Noelia Belmonte-Valles Ana Uclés Samanta Uclés Milagros Mezcua Amadeo R. Fernández-Alba | 2012 | Journal of Chromatography A2012，，： | 1 |
| 20 | Differentiating walls from corners using the amplitude of ultrasonic echoes显示文摘 | Gin s Benet Milagros Martfnez Francisco Blanes | 2005 | Robotics and Autonomous Systems2005，50，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员