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| 1 | Hepatocellular carcinoma: From clinical practice to evidence-based treatment protocols显示文摘Hepatocellular carcinoma(HCC) is one of the major malignant diseases in many healthcare systems. The growing number of new cases diagnosed each year is nearly equal to the number of deaths from this cancer. Worldwide, HCC is a leading cause of cancerrelated deaths, as it is the fifth most common cancer and the third most important cause of cancer related death in men. Among various risk factors the two are prevailing: viral hepatitis, namely chronic hepatitis C virus is a well-established risk factor contributing to the rising incidence of HCC. The epidemic of obesity and the metabolic syndrome, not only in the United States but also in Asia, tend to become the leading cause of the long-term rise in the HCC incidence. Today, the diagnosis of HCC is established within the national surveillance programs in developed countries while the diagnosis of symptomatic, advanced stage disease still remains the characteristic of underdeveloped countries. Although many different staging systems have been developed and evaluated the BarcelonaClinic Liver Cancer staging system has emerged as the most useful to guide HCC treatment. Treatment allocation should be decided by a multidisciplinary board involving hepatologists, pathologists, radiologists, liver surgeons and oncologists guided by personalized-based medicine. This approach is important not only to balance between different oncologic treatments strategies but also due to the complexity of the disease(chronic liver disease and the cancer) and due to the large number of potentially efficient therapies. Careful patient selection and a tailored treatment modality for every patient, either potentially curative(surgical treatment and tumor ablation) or palliative(transarterial therapy, radioembolization and medical treatment, i.e., sorafenib) is mandatory to achieve the best treatment outcome. | Danijel Galun Dragan Basaric Marinko Zuvela Predrag Bulajic Aleksandar Bogdanovic Nemanja Bidzic Miroslav Milicevic | 2015 | World Journal of Hepatology2015，7，20： | 13 |
| 2 | Modalities of testing Helicobacter pylori in patients with nonmalignant bile duct diseases显示文摘AIM: This paper describes the procedure of detection ofHelicobacter pylori ( H. pylori) in bile specimens in patientssuffering from benign diseases of biliary ducts (lithiasiswith/without nonspecific cholangitis).METHODS: The group of 72 patients entering the studyconsisted of 32 male and 40 female (45 % and 55 %,respectively). Bile was obtained during ERCP in 68 patients,and during cholecystectomy in 4 patients. A fast urease test(FUT) to determine the existence of H. pylori in gastricmucosa was carried out for all the patients during theendoscopic examination. The existence of genetic materialof H. pylori was determined by detection of ure A gene bythe method of nested PCR. The results of this reaction wereshown by electrophoresis on l0 g@ L-1 agarose gel in a bandof 256 bp.RESULTS: The majority of the patients included in our studyhad biliary lithiasis without signs of cholangitis (48 patients,67 %), whereas other patients were complicated bycholangitis (17 patients, 24 %). Seven patients (9 %) hadnormal ERCP, forming thus the control group. In the groupof patients with lithiasis 26 patients (54.2 %) had positivePCR of H. pylori in bile and among the patients withassociated cholangitis positive PCR was detected in 9patients (52.9 % ). Among the seven patients with nornalERCP only one (14 %) had positive PCR of H. pylori. Ahigh percentage of H. pylori infection of gastric mucosawas observed (57 patients, 79 % ) : It was also observed thatits slightly higher positivity was in the patients with distinctbile pathology: 81% FUT positive patients in the group withcholedocholithiasis alone and 76 % in the group withcholedocholithiasis associated with cholangitis. Seventy-onepercent of the patients with regular findings had positive FUT.CONCLUSION: The prevalence of H. pylori infection both inbile and in gastric mucosa in patients with benign diseasesof biliary ducts does not show a statistically significantdifference in relation to the prevalence of the same with thepatients with normal ERCP. The existence of H. pyloriinfection possibly does not play a role in pathogenesis ofbenign biliary diseases. | Milutin Bulajic Bojan Stimec Miroslav Milicevic Matthias Loehr Petra Mueller Ivan Boricic Nada Kovacevic Mirko Bulajic | 2002 | World Journal of Gastroenterology2002，8，2： | 6 |
| 3 | Amperometric sensor for L-ascorbic acid determination base on MnO2bulk modified screen printed electrode显示文摘 | Emir Turkusic Vladimir Milicevic Hamid Tahmiscija | 2000 | Fresenius J Anal Chem2000，368，： | 2 |
| 4 | Direct observation of photonic Landau levels and helical edge states in strained honeycomb lattices显示文摘We report the realization of a synthetic magnetic field for photons and polaritons in a honeycomb lattice of coupled semiconductor micropillars.A strong synthetic field is induced in both the s and p orbital bands by engineering a uniaxial hopping gradient in the lattice,giving rise to the formation of Landau levels at the Dirac points.We provide direct evidence of the sublattice symmetry breaking of the lowest-order Landau level wavefunction,a distinctive feature of synthetic magnetic fields.Our realization implements helical edge states in the gap between n=0 and n=±1 Landau levels,experimentally demonstrating a novel way of engineering propagating edge states in photonic lattices.In light of recent advances in the enhancement of polariton–polariton nonlinearities,the Landau levels reported here are promising for the study of the interplay between pseudomagnetism and interactions in a photonic system. | Omar Jamadi Elena Rozas Grazia Salerno Marijana Milicevic Tomoki Ozawa Isabelle Sagnes Aristide Lemaitre Luc Le Gratiet Abdelmounaim Harouri Iacopo Carusotto Jacqueline Bloch Alberto Amo | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 5 | Automatic Model Transformations Using Extended UML Object Diagrams in Modeling Environments显示文摘 | Dragan Milicev | 2002 | IEEE SOFTWARE ENGINEERING2002，，： | 1 |
| 6 | Evaluation and validation of two chromatographic methods (HPLC-Fluorescence and LC-MS/MS) for the determination and confirmation of ochratoxin a in pig tissues显示文摘 | MILICEVIC D JURIC V STEFANOVIC S | 2010 | Arch Environ Contam Toxicol2010，58，4： | 1 |
| 7 | Molecular characterization of hsp90 isoforms in colorectal cancer cellsand its association with tumour progression显示文摘 | Z. Milicevic D. Bogojevic M. Mihailovic M. Petrovic Z. Krivokapic | 2008 | International Journal of Oncology2008，，6： | 1 |
| 8 | The value of ultrasound in staging the severity of acute pancreatitis显示文摘 | PANDEY L MILICEVIC M GRBIC R | 1997 | Acta Chir Iugosl1997，4445，11： | 1 |
| 9 | Natural history of candiovascular disease in patients with diabetes:role of hyperglycemia显示文摘 | Milicevic Z Raz I Beattie SD | | 0，，2： | 1 |
| 10 | Is There any Benefit from Expanding the Criteria for the Resection of Hepatocellular Carcinoma in Cirrhotic Liver? Experience from a Developing Country显示文摘 | Danijel Galun Predrag Bulajic Marinko Zuvela Dragan Basaric Tatjana Ille Miroslav Milicevic | 2012 | World Journal of Surgery2012，，7： | 1 |
| 11 | Analytical Support for Integrated Water Resources Management:A New Method for Addressing Spatial and Temporal Variability显示文摘 | NIKOLIC V V SIMONOVIC S P MILICEVIC D B | 2013 | Water Resources Management2013，27，2： | 1 |
| 12 | The evaluation of impact of BPH surgical treatment with the open prostatectomy and transurethral resection of the prostate methods on the quality of life显示文摘 | Milicevic S Grubor P Lucic N | 2011 | Med Arh2011，65，5： | 1 |
| 13 | Automatic model transformations using extended UML object diagrams in modeling environments显示文摘 | MILICEV D | 2002 | IEEE Transactions on Software Engineering2002，28，4： | 1 |
| 14 | Social Tagging in Recommender Systems: A Survey of the State-of-the-art and Possible Extensions 显示文摘 | Milicevic A K Nanopoulos A Ivanovic M | 2010 | Artificial Intelligence Review2010，33，3： | 1 |
| 15 | Autologous infusion of expanded mobilized adult bone marrow-derived CD34+ cells into patients with alcoholic liver cirrhosis显示文摘 | Pai M Zacharoulis D Milicevic MN | 2008 | Am J Gastroenterol2008，103，8： | 1 |
| 16 | Early use of insulin in type-2 diabetes显示文摘 | Eldor R Stern E Milicevic Z | 2005 | Diabetes Research and Clinical Practice2005，68，1： | 1 |
| 17 | First report of Neofusicoccum par- rum associated with grapevine trunk diseases in Croatia显示文摘 | Kaliternam J Milicevic T | 2013 | Plant Disease2013，97，12： | 1 |
| 18 | Autologous infusion of expanded mobilized adult bone marrow-derived CD34 + cells into pa- tients with alcoholic liver cirrhosis 显示文摘 | Pai M Zacharoulis D Milicevic MN | 2008 | Am J Gastroenterol2008，103，8： | 1 |
| 19 | Early use of insulin in type 2 diabetes显示文摘 | Eldor R Stern E Milicevic Z | 2005 | Diabetes Res Clin Pract2005，68，1： | 1 |
| 20 | Infection in hernia surgery 显示文摘 | Zuvela M Milicevic M Galun D | 2005 | Acta Chir Iugosl2005，52，1： | 1 |
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