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| 1 | Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia显示文摘Transient ischemia in the whole brain leads to neuronal loss/death in vulnerable brain regions. The striatum, neocortex and hippocampus selectively loose specific neurons after transient ischemia. Just 5 minutes of transient ischemia can cause pyramidal neuronal death in the hippocampal cornu ammonis (CA) 1 field at 4 days after transient ischemia. In this study, we investigated the effects of 5-minute (mild), 15-minute (severe), and 20-minute (lethal) transient ischemia by bilateral common carotid artery occlusion (BCCAO) on behavioral change and neuronal death and gliosis (astrocytosis and microgliosis) in gerbil hippocampal subregions (CA1-3 region and dentate gyrus). We performed spontaneous motor activity test to evaluate gerbil locomotor activity, cresyl violet staining to detect cellular distribution, neuronal nuclei immunohistochemistry to detect neuronal distribution, and Fluoro-Jade B histofluorescence to evaluate neuronal death. We also conducted immunohistochemical staining for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 (Ibal) to evaluate astrocytosis and microgliosis, respectively. Animals subjected to 20-minute BCCAO died in at least 2 days. BCCAO for 15 minutes led to pyramidal cell death in hippocampal CA1-3 region 2 days later and granule cell death in hippocampal de匚tate gyrus 5 days later. Similar results were not found in animals subjected to 5-minute BCCAO. Gliosis was much more rapidly and severely progressed in animals subjected to 15-minute BCCAO than in those subjected to 5- minute BCCAO. Our results indicate that neuronal loss in the hippocampal formation following transient ischemia is significantly different according to regions and severity of transient ischemia. The experimental protocol was approved by Institutional Animal Care and Use Committee (AICUC) of Kangwon National University (approval No. KW-180124-1) on May 22, 2018. | Tae-Kyeong Lee Hyunjung Kim Minah Song Jae-Chul Lee Joon Ha Park Ji Hyeon Ahn Go Eun Yang Hyeyoung Kim Taek Geun Ohk Myoung Cheol Shin Jun Hwi Cho Moo-Ho Won | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 2 | Clinical effects of simultaneous ultrasonic scaling and subgingival irrigation with chlorhexidine, mediating influence of periodontal probing depth 显示文摘 | Reynolds MA Lavigne C Minah GE | 1992 | J Clin Periaodontal1992，19，8： | 1 |
| 3 | Hospitality language as an professional Skill 显示文摘 | George Blue M Minah Harun | 2003 | English for Specific Purposes2003，，22： | 1 |
| 4 | Candida albicans colonization of surface-sealed interim soft liners显示文摘 | Minah GE Driscoll CF | 2000 | J Prosthodont2000，9，4： | 1 |
| 5 | The relationship between the bone mineral density and urinary cadmium concentration of residents in an industrial complex显示文摘 | Minah Shin Domyung Paek Chungsik Yoon | 2010 | Environmental Research2010，，1： | 1 |
| 6 | The effect of a denture adhesive on the colonization of Candida species in vivo显示文摘 | Kim E Driscoll CF Minah GE | 2003 | Journal of Prosthodontics2003，12，3： | 1 |
| 7 | Nurses Perception of Error Reporting and Patient Safety Culture in Korea显示文摘 | Jeongeun Kirn Kyungeh An Minah Kang Kim | 2007 | West J Nurs Res2007，29，： | 1 |
| 8 | Microbiological studies of carious dentine from human teeth with irreversible pulpitis显示文摘 | Hahn CL Falkler WA Minah GE | 1991 | Arch Oral Biol1991，36，2： | 1 |
| 9 | Effects of an intracanal glass ionomer barrier on coronal microlea- kage in teeth with post space显示文摘 | Mavec JC McClanahan SB Minah GE | 2006 | J Endod2006，32，2： | 1 |
| 10 | Removal of As and Heavy Metals (Cd, Cu and Pb) in Fine Soil from Soil Washing Process Using Chelating Agent显示文摘 | Minah Oh So Young Moon SeungJin Oh HeeHoon Chae Jai-Young Lee | 2012 | Journal of Earth Science and Engineering2012，2，10： | 1 |
| 11 | Inhibition of pure cuhures of oral bacteria by root canal filling materials 显示文摘 | Tchaou WS Turng BF Minah GE | 1996 | Pediatr Dent1996，18，7： | 1 |
| 12 | Candida albieans colonization of surface-sealed interim soft liners显示文摘 | Olan-Rodriguez L Minah GE Driscoll CF | 2000 | J Prosthodont2000，9，4： | 1 |
| 13 | The effect of a denture adhesive onthe colonization of Candida species in vivo显示文摘 | Kim E Driscoll C F Minah G E | 2003 | Journal of Prosthodontics2003，12，3： | 1 |
| 14 | Oral malodor in children and volatile sulfur compound-producing bacteria in saliva:preliminary microbiological investigation显示文摘 | Paryavi-Gholami F Minah GE Turng BF | 1999 | Pediatr Dent1999，21，6： | 1 |
| 15 | In vitro inhibition of-bacteria form root canals of primary teeth by various dental material 显示文摘 | Tchaou WS Tumy BF Minah GE | 1995 | PediatrDent1995，17，5： | 1 |
| 16 | Inhibition of pure cultures of oral bacteria by root canal filling materials显示文摘 | Tchaou WS Turng BF Minah GE | 1996 | Pediatr Dent1996，18，7： | 1 |
| 17 | Oral malodor in chil-dren and volatile sulfur compound-producing bacteria in saliva :preliminary microbiological investigation显示文摘 | Paryavi-Gholami F Minah GE Tumg BF | 1999 | Pediatr Dent1999，21，6： | 1 |
| 18 | Effect of granulocytopenia on oral microbial relationships in patients with acute leukemia显示文摘 | Peterson DE Minah GE Reynolds MA | 1990 | Oral Surg Oral Med Oral Pathol1990，70，： | 1 |
| 19 | Oral malodor in children and volatile sulfur compound-producing bacteria in saliva: preliminary microbiological investigation 显示文摘 | Paryavi-Gholami F Minah GE Turng BF | 1999 | Pediatr Dent1999，21，6： | 1 |
| 20 | Clinical effects of simul taneous ultrasonic scaling and subgingival irrigation with chlorhexidine :Mediating influence of periodontal probing depth显示文摘 | Lavigne C Minah GE | 1992 | J Clin Periodontol1992，19，： | 1 |
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