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| 1 | Receiver function analysis for seismic structure of the crust and uppermost mantle in the Liupanshan area, China显示文摘A portable broadband seismic array was deployed from the northeast Tibetan Plateau to the southwest Ordos block, China. The seismic structure of the crust and uppermost mantle of the Liupanshan area is obtained using receiver function analysis of teleseismic body waves. The crustal thickness and Poisson's ratios are estimated by stacking the weighted amplitudes of receiver functions. Our results reveal complex seismic phases in the Liupanshan area, implying intense deformation at the boundary between the Tibetan Plateau and the Ordos block. The average crustal thickness is 51.5 km in the northeast Tibetan Plateau, 53.5 km in the Liupan Mountain and 50 km in the southwest Ordos block, resulting in a concave Moho beneath the Liupan Mountain. The Poisson's ratio of the Liupanshan area varies between 0.27-0.29, higher than the value of 0.25-0.26 to the east and west of the Liupan Mountain, suggesting partial melting in the lower crust. The variance in Poisson's ratio across the Liupan Mountain indicates notable changes in the crustal composition and mechanical properties, which may be formed by the northeastward flow of the Tibetan lower crust during the India-Eurasia collision. | TONG WeiWei WANG LiangShu MI Ning XU MingJie LI Hua YU DaYong LI Cheng LIU ShaoWen LIU Mian Eric SanDvol | 2007 | Science China Earth Sciences2007，50，z2： | 9 |
| 2 | Collaborative Control of Novel Uninterrupted Propulsion System for All-Climate Electric Vehicles显示文摘Over the past decade,the electric vehicle industry of China has developed rapidly,reaching one of the highest technological levels in the world.Nevertheless,most electric buses currently serve urban areas,being unsuitable for all-climate operations.In response to the objective of massively adopting electric vehicles for transportation during all the events of the 2022 Beijing Winter Olympics,a dual-motor coaxial propulsion system for all-climate electric vehicles is proposed.The system aims to meet operating requirements such as high speed and adaptability to mountainous roads under severely cold environments.The system provides three operating modes,whose characteristics are analyzed under different conditions.In addition,dual-motor collaborative control strategy with collaborative gearshift and collaborative power distribution is proposed to eliminate power interruption during gearshift process and achieve intelligent power distribution,thus improving the gearshift quality and reducing energy consumption.Finally,gear position calibration for all-climate operation and proper gearshift is introduced.Experimental results demonstrate the advantages of the proposed dual-motor coaxial propulsion system regard-ing gearshift compared with the conventional single-motor automatic transmission. | Cheng Lin Xiao Yu Mingjie Zhao Jiang Yi Ruhui Zhang | 2022 | Automotive Innovation2022，5，1： | 4 |
| 3 | Interleukin-25 in sputum as a marker of airway inflammation in children asthma显示文摘Dear Editor,Interleukin-25(IL-25,also called IL-17E)is an important IL-17 family member that helps initialize and regulate type 2 immunity,exerting an important influence on the pathogenesis of asthma(Corrigan et al.,2011;Barlow et al.,2012).Furthermore,it plays a vital role in initiating type 2 innate lymphoid cell activation and maintenance(Tong and Li,2018)and inducing Th2-type cytokine-mediated allergic airway eosinophilia(Morita et al.,2015).IL-25 expression increases in patients with asthma in different types of lung cells,including lung structural cells(such as endothelium and airway epithelium),eosinophils,T-cells,and mast cells.Following allergen exposure,cells in the bronchial submucosa increase and secrete or respond to IL-25(Corrigan et al.,2011).Plasma IL-25 levels increase in patients with asthma and correlate with lung function(Cheng et al.,2014).The association between IL-25 cells and pulmonary function indicates that IL-25 could be used to monitor asthma severity.In some mouse models,epithelial IL-25 cytokines are closely related with a range of airway inflammation modalities,including type 2 cytokine production,airway eosinophil inflammation,mucinous epithelial metaplasia,and airway hyperresponsiveness(AHR)(Suzukawa et al.,2012). | Yun Zhang Cuifen Zhao Xiuxia Zhao Qingyu Kong Mingjie Dingi Yuling Han Xiang Ma Lu Cheng | 2019 | Science China(Life Sciences)2019，62，12： | 3 |
| 4 | Nickel single atom overcoordinated active sites to accelerate the electrochemical reaction kinetics for Li-S cathode显示文摘Lithium-sulfur(Li-S)batteries with high theoretical energy density are promising advanced energy storage devices.However,shuttling of dissolute lithium polysulfide(LiPSs)and sluggish conversion kinetics impede their applications.Herein,single nickel(Ni)atoms on two-dimensional(2D)nitrogen(N)-doped carbon with Ni-N_(4)-O overcoordinated structure(SANi-N_(4)-O/NC)are prepared and firstly used as a sulfur host of Li-S batteries.Due to the efficient polysulfides traps and highly LiPSs conversion effect of SANi-N_(4)-O/NC,the electrochemical performance of Li-S batteries obviously improved.The batteries can well operate even under high sulfur loading(5.8 mg cm^(-2))and lean electrolyte(6.1μL mg^(-1))condition.Meanwhile,density functional theory(DFT)calculations demonstrate that Ni single atom’s active sites decrease the energy barriers of conversion reactions from Li_(2)S_(8)to Li2S due to the strong interaction between SANi-N_(4)-O/NC and LiPSs.Thus,the kinetic conversion of LiPSs was accelerated and the shuttle effect is suppressed on SANi-N_(4)-O/NC host.This study provides a new design strategy for a 2D structure with single-atom overcoordinated active sites to facilitate the fast kinetic conversion of LiPSs for Li-S cathode. | Juan Zhu Xinyue Wang Tian Ke Mingji Jia Biyu Jin Yuanyuan Li Qiwei Yang Lanhui Ren Yongyuan Ren Dangguo Cheng Jianguo Lu Xiang Gao Qinggang He Yang Hou Xiaoli Zhan Qinghua Zhang | 2023 | Journal of Energy Chemistry2023，，3： | 2 |
| 5 | Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats显示文摘OBJECTIVE: To investigate the effect of osthole on isolated thoracic aortic rings, and to determine the potential mechanism of action.METHODS: Thoracic aortas were isolated from Wistar rats, and were suspended in tissue organ chambers for vascular tension measurement. The effect of cumulative osthole(10-9, 10-8, 10-7, 10-6, and 10-5 mol/L) on endothelium-intact and endothelium-denuded thoracic aortic rings pre-contracted with phenylephrine(PE, 10-6 mol/L) or KCl(6 × 10-2 mol/L) was recorded. Histomorphological changes of thoracic aorta were analyzed by hematoxylin-eosin. The effects of different osthole concentrations on endothelium-intact aortic rings, which were pre-inhibited with the non-selective nitric oxide synthase inhibitor L-Arg(NO2)-OMe·HCl(3 × 10-4 mol/L), endothelium-derived nitric oxide synthase inhibitor Nω-nitro-L-arginine(3 × 10-4 mol/L), guanylate cyclase inhibitor 1 H-[1,2,4] oxadiazolo [4,3-α]quinoxaline-1-one(10-5 mol/L), cyclooxygenase inhibitor indometacin(10-5 mol/L), and the Ca2+-activated potassium channel inhibitor tetraethylammonium nitrate(10-5 mol/L), and then contracted with PE, were examined. Aortic rings incubated with osthole(10-5 mol/L), phentolamine(10-5 mol/L), or verapamil(10-5 mol/L) in Ca2+-free Krebs-Henseleit solution(KHS) were stimulated with PE or KCl.RESULTS: There was a dose-dependent increase in vasorelaxation of isolated thoracic aortic rings(both with and without endothelium) with increasing osthole concentration. Hematoxylin-eosin staining showed that osthole significantly improved thoracic aorta ring morphology. Compared with the control group, there were also significant differences after incubation with L-Arg(NO2)-OMe ω-nitro-L-arginine, and 1 H-[1,2,4] oxadiazo·lo HCl,N [4,3-α] quinoxaline-1-one(P < 0.05 for all). The relaxation rate of the rings in the osthole group incubated with indometacin and tetraethylammonium nitrate were similar to controls. In Ca2+-free KHS, the PE-induced contraction was similar between the osthole(4.37% ± 0.41%) and control(4.21% ± 1.33%)groups. However, after cumulative CaCl2(0.5, 1, 1.5,2, 2.5, and 3 mmol/L), the Ca2+-induced contraction was significantly inhibited in the osthole and phentolamine groups compared with controls(P < 0.05).After cumulative CaCl2 was added to Ca2+-free KHS(high K+ concentration), the contraction rate was significantly higher than both of the control and the osthole groups(P < 0.05). The contraction rate in the osthole group was higher than the verapamil group(P < 0.05).CONCLUSION: Osthole has a vasorelaxant effect on isolated rat thoracic aortic rings, via inhibition of both receptor-operated and voltage-dependent Ca2+channels in arterial smooth muscle, leading to decreased Ca2+ influx, and via inhibition of nitric oxide release on arterial endothelial cells. | Huang Ying Kong Liting Wang Yanping Sun Mingjie Cui Haifeng Zhai Huaqiang LüCheng Fan Danping | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 1 |
| 6 | Antimold effect of\sultrasonic treatment on Chinese moso bamboo显示文摘 | Guan Mingjie Zhou Mingming Yong Cheng | 2013 | Forest Products\sJournal2013，63，78： | 1 |
| 7 | Heating Lithium-Ion Batteries at Low Temperatures for Onboard Applications:Recent Progress,Challenges and Prospects显示文摘Lithium-ion batteries(LIBs)are commonly used in electric vehicles(EVs)due to their good performance,long lifecycle,and environmentally friendly merits.Heating LIBs at low temperatures before operation is vitally important to protect the battery from serious capacity degradation and safety hazards.This paper reviews recent progress on heating methods that can be used onboard.The existing methods are divided into two categories,namely external heating methods and internal heating methods,mechanisms,advantages and limitations of each method are systematically reviewed.Then,the rates of temperature rise,energy consumptions,and maximum temperature gradient of different methods are quantitatively summa-rized to compare the heating performances of each method.In addition,features related to the onboard application of each method are qualitatively compared,which is essential for the rapid cold start of EVs in frigid weather.Finally,prospects of external and internal heating methods are given.This paper aims to provide researchers and engineers with guidelines about how to select a method based on their requirements and application environments. | Cheng Lin Weifeng Kong Yu Tian Wenwei Wang Mingjie Zhao | 2022 | Automotive Innovation2022，5，1： | 1 |
| 8 | Single-Atom Nanozymes Linked Immunosorbent Assay for Sensitive Detection of Aβ1-40:A Biomarker of Alzheimer’s Disease显示文摘Single-atom nanozymes(SANs)possess unique features of maximum atomic utilization and present highly assembled enzyme-like structure and remarkable enzyme-like activity.By introducing SANs into immunoassay,limitations of ELISA such as low stability of horseradish peroxidase(HRP)can be well addressed,thereby improving the performance of the immunoassays.In this work,we have developed novel Fe-N-C single-atom nanozymes(Fe-N_(x)SANs)derived from Fe-doped polypyrrole(PPy)nanotube and substituted the enzymes in ELISA kit for enhancing the detection sensitivity of amyloid beta 1-40.Results indicate that the Fe-N_(x)SANs contain high density of single-atom active sites and comparable enzyme-like properties as HRP,owing to the maximized utilization of Fe atoms and their abundant active sites,which could mimic natural metalloproteases structures.Further designed SAN-linked immunosorbent assay(SAN-LISA)demonstrates the ultralow limit of detection(LOD)of 0.88 pg/mL,much more sensitive than that of commercial ELISA(9.98 pg/mL).The results confirm that the Fe-N_(x)SANs can serve as a satisfactory replacement of enzyme labels,which show great potential as an ultrasensitive colorimetric immunoassay. | Zhaoyuan Lyu Shichao Ding Nan Zhang Yang Zhou Nan Cheng Maoyu Wang Mingjie Xu Zhenxing Feng Xiangheng Niu Yuan Cheng Chao Zhang Dan Du Yuehe Lin | 2020 | Research2020，，1： | 0 |
| 9 | Ungulate bocaparvovirus 4 and rodent bocavirus are different genotypes of the same species of virus显示文摘Bocaviruses are associated with many human infectious diseases, such as respiratory tract infections, gastroenteritis, and hepatitis. Rats are known to be reservoirs of bocaviruses, including rodent bocavirus and rat bocavirus.Recently, ungulate bocaparvovirus 4, a known porcine bocavirus, has also been found in rats. Thus, investigating bocaviruses in rats is important for determining the origin of the viruses and preventing and controlling their transmission. To the best of our knowledge, no study to date has investigated bocaviruses in the livers of rats. In this report, a total of 624 rats were trapped in southern China between 2014 and 2017. Liver and serum samples from rats were tested for the prevalence of bocaviruses using PCR. Sequences related to ungulate bocaparvovirus 4and rodent bocavirus were detected in both liver and serum samples. Interestingly, the prevalence of ungulate bocaparvovirus 4(reference strain: KJ622366.1) was higher than that of rodent bocavirus(reference strain:KY927868.1) in both liver(2.24% and 0.64%, respectively) and serum samples(2.19% and 0.44%, respectively).The NS1 regions of ungulate bocaparvovirus 4 and rodent bocavirus related sequences displayed over 84% and88% identity at the nucleic acid and amino acid levels, respectively. Furthermore, these sequences had similar genomic structure, genomic features, and codon usage bias, and shared a common ancestor. These viruses also displayed greater adaptability to rats than pigs. Our results suggested that ungulate bocaparvovirus 4 and rodent bocavirus may originate from rats and may be different genotypes of the same bocavirus species. | Wenqiao He Yuhan Gao Yuqi Wen Xuemei Ke Zejin Ou Jiaqi Fu Mingji Cheng Yun Mo Qing Chen | 2022 | Virologica Sinica2022，37，2： | 0 |
| 10 | Integrated genomic and transcriptomic analysis reveals genes associated with plant height of foxtail millet显示文摘Foxtail millet(Setaria italica)is an important C4 model crop;however,due to its high-density planting and high stature,lodging at the filling stage resulted in a serious reduction in yield and quality.Therefore,it is imperative to identify and deploy the genes controlling foxtail millet plant height.In this study,we used a semi-dwarf line 263A and an elite high-stalk breeding variety,Chuang 29 to construct an F2 population to identify dwarf genes.We performed transcriptome analysis(RNA-seq)using internode tissues sampled at three jointing stages of 263A and Chuang 29,as well as bulk segregant analysis(BSA)on their F2 population.A total of 8918 differentially expressed genes(DEGs)were obtained from RNA-seq analysis,and GO analysis showed that DEGs were enriched in functions such as‘‘gibberellin metabolic process”and‘‘oxidoreductase activity”,which have previously been shown to be associated with plant height.A total 593 mutated genes were screened by BSA-seq method.One hundred and seventy-six out of the 593 mutated genes showed differential expression levels between the two parental lines,and seven genes not only showed differential expression in two or three internode tissues but also showed high genomic variation in coding regions,which indicated they play a crucial role in plant height determination.Among them,we found a gibberellin biosynthesis related GA20 oxidase gene(Seita.5G404900),which had a single-base at the third exon,leading to the frameshift mutation at 263A.Cleaved amplified polymorphic sequence assay and association analysis proved the single-base in Seita.5G404900 co-segregated with dwarf phenotype in two independent F2 populations planted in entirely different environments.Taken together,the candidate genes identified in this study will help to elucidate the genetic basis of foxtail millet plant height,and the molecular marker will be useful for marker-assisted dwarf breeding. | Mengyuan Zhu Qiang He Mingjie Lyu Tiantian Shi Qian Gao Hui Zhi Huan Wang Guanqing Jia Sha Tang Xiliu Cheng Rui Wanga Andi Xu Haigang Wang Zhijun Qiao Jun Liu Xianmin Diao Ying Gao | 2023 | The Crop Journal2023，11，2： | 0 |
| 11 | TEAseq-based identification of 35,696 Dissociation insertional mutations facilitates functional genomic studies in maize显示文摘In plants,transposable element(TE)-triggered mutants are important resources for functional genomic studies.However,conventional approaches for genome-wide identification of TE insertion sites are costly and laborious.This study developed a novel,rapid,and high-throughput TE insertion site identification workflow based on next-generation sequencing and named it Transposable Element Amplicon Sequencing(TEAseq).Using TEAseq,we systemically profiled the Dissociation(Ds)insertion sites in 1606 independent Ds insertional mutants in advanced backcross generation using K17 as background.The Ac-containing individuals were excluded for getting rid of the potential somatic insertions.We characterized 35,696 germinal Ds insertions tagging 10,323 genes,representing approximately 23.3%of the total genes in the maize genome.The insertion sites were presented in chromosomal hotspots around the ancestral Ds loci,and insertions occurred preferentially in gene body regions.Furthermore,we mapped a loss-of-function AGL2 gene using bulked segregant RNA-sequencing assay and proved that AGL2 is essential for seed development.We additionally established an open-access database named MEILAM for easy access to Ds insertional mutations.Overall,our results have provided an efficient workflow for TE insertion identification and rich sequence-indexed mutant resources for maize functional genomic studies. | Mingjie Lyu Huafeng Liu Joram Kiriga Waititu Ying Sun Huan Wang Junjie Fu Yanhui Chen Jun Liu Lixia Ku Xiliu Cheng | 2021 | Journal of Genetics and Genomics2021，48，11： | 0 |
| 12 | A cell wall invertase modulates resistance to fusarium crown rot and sharp eyespot in common wheat显示文摘Fusarium crown rot(FCR) and sharp eyespot(SE)are serious soil-borne diseases in wheat and its relatives that have been reported to cause wheat yield losses in many areas. In this study, the expression of a cell wall invertase gene, TaCWI-B1,was identified to be associated with FCR resistance through a combination of bulk segregant RNA sequencing and genome resequencing in a recombinant inbred line population. Two biparental populations were developed to further verify TaCWI-B1 association with FCR resistance.Overexpression lines and ethyl methanesulfonate(EMS) mutants revealed TaCWI-B1 positively regulating FCR resistance. Determination of cell wall thickness and components showed that the TaCWI-B1-overexpression lines exhibited considerably increased thickness and pectin and cellulose contents. Furthermore, we found that TaCWI-B1 directly interacted with an alphagalactosidase(TaGAL). EMS mutants showed that TaGAL negatively modulated FCR resistance. The expression of TaGAL is negatively correlated with TaCWI-B1 levels, thus may reduce mannan degradation in the cell wall, consequently leading to thickening of the cell wall. Additionally, TaCWI-B1-overexpression lines and TaGAL mutants showed higher resistance to SE;however, TaCWI-B1 mutants were more susceptible to SE than controls.This study provides insights into a FCR and SE resistance gene to combat soil-borne diseases in common wheat. | Guoguo Lv Yixiao Zhang Lin Ma Xiangning Yan Mingjie Yuan Jianhui Chen Yongzhen Cheng Xi Yang Qi Qiao Leilei Zhang Mohsin Niaz Xiaonan Sun Qijun Zhang Shaobin Zhong Feng Chen | 2023 | Journal of Integrative Plant Biology2023，65，7： | 0 |
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