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| 1 | Recent progress in α_1-adrenergic receptor research显示文摘α_t -Adrenergic receptors (AR) play an important role in the regulation of physiological responses mediated by norepinephrine and epinephrine, particularly in the cardiovascular system. The three cloned oc,-AR subtypes (α_(1A) α_(1B) and α_(1D)) are G protein-coupled receptors that signal through the G_(q/11) signaling pathway, each showing distinct pharmacological properties and tissue distributions. However, due to the lack of highly subtype-selective drugs, the functional roles of individual subtypes are still not clear. Development of new subtype-specific drugs will greatly facilitate the identification of the functions of each subtype. Conopeptide TIA has been found to be a new α_(1B)-AR selective antagonist with different modes of inhibition at α_1-AR subtypes. In addition, recent studies using genetically engineered mice have shed some light on α_1AR functions in vivo, especially in the cardiovascular system and brain. Several proteins have been shown to interact directly with particular α_1-AR, and may be important in regulating receptor function. Receptor heterodimerization has been shown to be important for cell surface expression, signaling and internalization. These new observations are likely to help elucidate the functional roles of individual a,-AR subtypes. | Kenneth P MINNEMAN | 2005 | Acta Pharmacologica Sinica2005，26，11： | 2 |
| 2 | Alpha1-adrenoceptor subtypes显示文摘 | Zhong H Minneman KP | 1999 | Eur J Pharmacol1999，375，13： | 1 |
| 3 | Relationship between environmental light intensity and retina-mediated suppression of rat pineal serotonin-N-acetyl-transferase显示文摘 | Minneman KP Lynch H Wurtman RJ | 1974 | Life Sci1974，15，10： | 1 |
| 4 | Antiviral lead compounds from marine sponges 显示文摘 | Sunil Sagar Mandeep Kaur Kenneth P Minneman | 2010 | Mar Drugs2010，8，10： | 1 |
| 5 | Specificity of 6-hydroxydopamine-induced destruction of mesolimbic or nigrostriatal dopamine-containing terminals显示文摘 | Joyce EM Minneman KP | 1977 | Brain Res1977，122，： | 1 |
| 6 | The pharmacology of the pineal gland显示文摘 | Wurtman R J | 1976 | Annu Rev Pharmacol Toxicol1976，16，： | 1 |
| 7 | Tyrosine kinase inhibitors and Ca2+ signaling: direct interactions with fura-2显示文摘 | Berts A Minneman KP | 2000 | Eur J Pharmacol2000，389，1： | 1 |
| 8 | International Union of Pharmacology nomenclature of adrenoceptors 显示文摘 | Bylund DB Eikenberg DC Hieble JP Langer SZ Lefkowitz RJ Minneman KP | 1994 | Pharmacol Rev1994，46，2： | 1 |
| 9 | 显示文摘 | ZHONG H MINNEMAN K P | 1999 | European Journal of Pharmacology1999，375，13： | 1 |
| 10 | Recent progress in alphaI - adrenergic receptor research 显示文摘 | Chen ZJ Minneman KP | | Acta Pharmacol Sin0，，： | 1 |
| 11 | Alpha 1-adrenergic receptor subtypes 显示文摘 | Minneman KP Esbenshade TA | 1994 | Annu Rev Pharmacol Toxicol1994，34，： | 1 |
| 12 | Differential activation of mitogen-activated protein kinase pathways in PC12 cells by closely related alphal-ad- renergic receptor subtypes 显示文摘 | Zhong H Minneman KP | 1999 | J Neurochem1999，72，6： | 1 |
| 13 | Differential coupling of alphal-, alpha2-, and beta-adrenergic receptors to mitogen- activated protein kinase pathways and differentiation in transfected PC12 cells显示文摘 | Williams N G Zhong H Minneman K P | 1998 | J Biol Chem1998，273，24： | 1 |
| 14 | Alphal-adrenoceptor subtypes 显示文摘 | Zhong H Minneman KP | 1999 | Eur J Pharmacol1999，375，13： | 1 |
| 15 | Heterodimerization and surface localization of G protein coupled receptors 显示文摘 | Kenneth P Minneman | 2007 | Biochemical pharmacology2007，73，8： | 1 |
| 16 | Recent progress in alphal-adrenergic recep- tor research显示文摘 | Chen ZJ Minneman KP | 2005 | Acta Phannaeol Sin2005，26，11： | 1 |
| 17 | Subtype-specific dimerization of alpha 1-adrenoceptors:effects on receptor expression and pharmaeo- logical properties显示文摘 | Uberti MA Hall RA Minneman KP | 2003 | Mol Pharmacol2003，64，6： | 1 |
| 18 | International Union of Pharmacology nomenclature of adrenoceptors显示文摘 | Bylund DB Eikenberg DC Hieble JP Langer SZ Lefkowitz RJ Minneman KP | 1994 | Pharmacol Rev1994，46，2： | 1 |
| 19 | N-terminal truncation of human alpha 1D-adrenoceptors increases expression of binding sites but not protein 显示文摘 | Pupo AS Uberti MA Minneman KP | 2003 | Eur J Pharmacol2003，462，13： | 1 |
| 20 | alphal -adrenoceptor subtypes显示文摘 | Zhong H Minneman KP | 1999 | Euro- pean Journal of Pharmacology ( 1999 ) 375 ( 1 - 3 ) 261 - 761999，，13： | 1 |
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