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| 1 | PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15显示文摘Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer patients.Recently,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse models.Herein,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer patients.Single-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)TILs.Furthermore,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)TILs.Transcriptionally and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 expression.Notably,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)TILs.Taken together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies. | Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 2 | Analysis of direct operating cost of wide-body passenger aircraft: A parametric study based on Hong Kong显示文摘Analysis of the Direct Operating Cost(DOC) of aircraft is an important step towards achieving financially sustainable aviation operations. However, the value of the DOC for different aircraft types and flight scenarios is not widely available. In this study, we perform a systematic analysis of the DOC of every wide-body passenger aircraft currently in production, using the method of the Association of European Airlines(AEA). The elements of the DOC, e.g. financial costs, maintenance costs, and flight costs, are evaluated individually. Several realistic flight scenarios are considered, each with differences in route distance, fuel price, passenger number, and seating arrangement. For each flight scenario, the most cost-efficient aircraft type is identified and evaluated in the context of operations from Hong Kong International Airport. The information provided in this study could be useful to airline operators and policy makers. | Minwoo LEE Larry K.B.LI Wenbin SONG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 4 |
| 3 | Multi-directionally wrinkle-able textile OLEDs for clothing-type displays显示文摘A clothing-type wearable display can be utilized in fashion,bio-healthcare,and safety industries as well as smart textiles for the internet of things(IoTs)and wearable devices.In response to this trend,we demonstrate a textile display that can endure the active movements of a human body.It can be applied to any kind of textile,and is durable against conditions such as rain,sweat,and washing.As a key technology for realizing the multi-directional wrinkle-able textile display,we fabricated a stress-lowering textile platform with an ultrathin planarization layer replicated from the flat surface of glass.An elastomeric strain buffer for reducing mechanical stress is also inserted into the textile platform.Here,organic light-emitting diodes(OLEDs)with red,green and blue color,thin film transistors(TFTs)fabricated at a low temperature below 150℃,and a washable encapsulation layer blocking both gas and liquid were demonstrated on the textile platform. | Seungyeop Choi Woosung Jo Yongmin Jeon Seonil Kwon Jeong Hyun Kwon Young Hyun Son Junmo Kim Jun Hong Park Hyuncheol Kim Ho Seung Lee Minwoo Nam Eun Gyo Jeong Jeong Bin Shin Taek-Soo Kim Kyung Cheol Choi | 2020 | npj Flexible Electronics2020，4，1： | 3 |
| 4 | Review on the characteristics of liver-pacifying medicinal in relation to the treatment of stroke: from scientific evidence to traditional medical theory显示文摘OBJECTIVE: To analyze the characteristics of liver pacifying medicinal in the treatment of brain disease to provide scientific evidence in clinical usage on stroke.METHODS: MEDLINE/Pub Med, Google Scholar,and China National Knowledge Infrastructure Database were used as the literature sources. The Scientific name, Latin pharmaceutical name,Chinese name of 7 kinds of liver pacifying medicinal including Gouteng(Ramulus Uncariae Rhynchophyllae cum Uncis), Tianma(Rhizoma Gastrodiae), Juemingzi(Semen Cassiae Obtusifoliae),Quanxie(Scorpio), Wugong(Scolopendra), Jiangcan(Bombyx Batryticatus), and Dilong(Pheretima Aspergillum) were used as the keywords to search the databases for relevant publications up to July2016. Their major compounds were also used as the keywords. The papers were selected based on the pharmacological activities and mechanisms of action related to brain diseases and subsequently,were analyzed and reviewed. We first described the origin, efficacy, and clinical indications of selected medicines, then brain disease specific activities focusing on stroke after the description of the general pharmacological activities.RESULTS: On the basis of the literature of scientific studies and clinical use in traditional medicine, we found and discussed the characteristics of liver pacifying medicinal in stroke treatment. First, liver-pacifying medicinal,or their components, might pass through the blood-brain barrier and act directly on neurons or on the neural network to provide protective effects against brain disease. Second, although it could be used throughout the disease duration,treatment of stroke might be more effective from the subacute up to the convalescent phase than the acute phase.CONCLUSION: We can suggest that live pacifying medicinal has beneficial pharmacological activities directly or indirectly on neurons in brain disease and is useful for the treatment of stroke from subacute to convalescent phase. | Kyungjin Lee Hyejin Joo Meixiang Sun Minwoo Kim Bumjung Kim Beom-Joon Lee Jae-Heung Cho Jae-Young Jung Jae-Woo Park Youngmin Bu | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 2 |
| 5 | Flocculation model of cohesive sediment using variable fractal dimension显示文摘 | Son Minwoo Hsu Tianjian | 2008 | Environmental Fluid Mechanics2008，，1： | 1 |
| 6 | Triangular- Chain Conditional Random Fields 显示文摘 | Minwoo Jeong and Gary Geunbae Lee | 2008 | IEEE Transactions on Audio Speech and Language Processing2008，16，7： | 1 |
| 7 | Surface characterization of 8-quinolinyl acrylate-grafted poly(ethylene terephthalate) prepared by plasma glow discharge and it's antibacterial activity 显示文摘 | HYUN Seokhee KIM Minwoo OH Daehee | 2006 | Appl Polym Sci2006，101，2： | 1 |
| 8 | Functional Materials and Innovative Strategies for Wearable Thermal Management Applications显示文摘Thermal management is essential in our body as it affects various bodily functions,ranging from thermal discomfort to serious organ failures,as an example of the worst-case scenario.There have been extensive studies about wearable materials and devices that augment thermoregulatory functionalities in our body,employing diverse materials and systematic approaches to attaining thermal homeostasis.This paper reviews the recent progress of functional materials and devices that contribute to thermoregulatory wearables,particularly emphasizing the strategic methodology to regulate body temperature.There exist several methods to promote personal thermal management in a wearable form.For instance,we can impede heat transfer using a thermally insulating material with extremely low thermal conductivity or directly cool and heat the skin surface.Thus,we classify many studies into two branches,passive and active thermal management modes,which are further subdivided into specific strategies.Apart from discussing the strategies and their mechanisms,we also identify the weaknesses of each strategy and scrutinize its potential direction that studies should follow to make substantial contributions to future thermal regulatory wearable industries. | Yeongju Jung Minwoo Kim Taegyeom Kim Jiyong Ahn Jinwoo Lee Seung Hwan Ko | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 9 | 显示文摘 | Jung Minwoo Ahn Kyuhong Lee Yonghun | 2001 | Journal of Chromatography A2001，917，12： | 1 |
| 10 | Protective effect of overlying geosynthetic on geomembrane liner observed from landfill field tests and inclined board laboratory experiments显示文摘 | CHUNG MOONKYUNG SEO MINWOO KIM KANGSUK | 2006 | Waste Management and Research2006，24，3： | 1 |
| 11 | Effect of prestrain on and prediction of fatigue limit in carbon steel 显示文摘 | Minwoo K Yuuta A Hiroshi N | 2007 | International Journal of Fatigue2007，29，： | 1 |
| 12 | Design of 2D massless Dirac fermion systems and quantum spin Hall insulators based on sp-sp^(2) carbon sheets显示文摘Grapheneis a massless Dirac fermion system,featuring Dirac points in momentum space.It was also first identified as a quantum spin Hall(QSH)insulator when considering spin–orbit coupling(SOC),which opens a band gap at the Dirac points.This discovery has initiated new research efforts to study the QSH effect,towards its application for quantum computing and spintronics.Although the QSH effect has been observed in HgTe quantum wells,the SOC strength of graphene is too small(~1μeV)to induce the topological insulator phase in an experimentally achievable temperature regime.Here,we perform a systematic atomistic simulation to design two-dimensional sp–sp^(2) hybrid carbon sheets to discover new Dirac systems,hosting the QSH phase.21 out of 31 newly discovered carbon sheets are identified as Dirac fermion systems without SOC,distinct from graphene in the number,shape,and position of the Dirac cones occurring in the Brillouin zone.Moreover,we find 19 out of the 21 new Dirac fermion systems become QSH insulators with a sizable SOC gap enhanced up to an order of meV,thus allowing for the QSH effect at experimentally accessible temperatures.In addition,based on the 26 Dirac fermion systems,we make a connection between the number of Dirac points without SOC and the resultant QSH phase in the presence of SOC.Our findings present new prospects for the design of topological materials with desired properties. | Minwoo Park Youngkuk Kim Hoonkyung Lee | 2018 | npj Computational Materials2018，，1： | 1 |
| 13 | A numerical study on thegeneration of impulsive noise by complex flows discharging from amuzzle显示文摘 | Jonghoon B Minwoo K Soogab L | 2008 | International Journal for Numerical Methods in Engi-neering2008，75，8： | 1 |
| 14 | Practical use of non-local features for statistical spoken language understanding 显示文摘 | Jeong Minwoo Lee Gary Geunbae | 2008 | Computer Speech & Language2008，22，2： | 1 |
| 15 | Finite-element simulation of quenching incorporating improved transformation kinetics in a plain medium-carbon steel显示文摘 | Minsu Jung Minwoo Kang Young-Kook Lee | 2011 | Acta Materialia2011，，2： | 1 |
| 16 | Molecular cloning of a novel pathogen-inducible cDNA encoding a putative acyl-CoA synthetase from Capsicum annuum L.显示文摘 | Sang Jik Lee Mi-Chung Suh Shinje Kim Jin-Kyung Kwon Minwoo Kim Kyung-Hee Paek Doil Choi Byung-Dong Kim | 2001 | Plant Molecular Biology2001，，6： | 1 |
| 17 | Isolation of cDNA clones differentially accumulated in the placenta of pungent pepper by suppression subtractive hybridization 显示文摘 | Minwoo Kim Shinje Kim Soohyun Kim | 1991 | Molecules and Cells1991，11，2： | 1 |
| 18 | Reduced interface energy loss in non-fullerene organic solar cells using room temperature-synthesized SnO2 quantum dots显示文摘We herein report the room temperature synthesis of colloidal SnO2 quantum dots and their application in non-fullerene organic solar cells as an excellent electron transport layer.The thiourea-assisted hydrolysis at room temperature affords the nanocrystalline SnO2 quantum dots with a diameter of 3-4 nm.The utilization of the SnO2 quantum dots as an electron transporting layer effectively reduces the interfacial trap density and charge recombination in the solar cell devices,leading to not only the reduced energy loss but also excellent photocurrent generation.The optimized organic solar cells employing SnO2 quantum dots with polyethylenimine ethoxylated achieves power conversion efficiencies up to 12.023%with a VOC,a JSC,and a FF of 0.89 V,18.89 mA cm^–2,and 0.72.This work suggest that the SnO2 quantum dot is a promising electron transporting material to construct efficient organic solar cells for practical applications.This work also demonstrates the key strategy for thiourea-assisted hydrolysis to synthesize fine and nanocrystalline SnO2 quantum dots. | In Su Jin Minwoo Park Jae Woong Jung | 2020 | Journal of Materials Science & Technology2020，52，17： | 0 |
| 19 | 一抹清新色显示文摘2月,除了气温略有浮动,深圳这座城市在颜色上似乎没有一点变化。马路旁紫红色的筘杜鹃依然开得欢腾,城市绿廊也还是小草青青、生机盎然。都说南方没有秋天,没有见到日渐萧疏的秋林和漫天飘落的黄叶,好像一阵冷风拂过,就这样捎给了我们下一季的消息。南方没有北方那么长时间的季节过渡,相应地也略过了自然中很多烂漫鲜活的色彩。 | Minwoo Lee mischer' traxler Nir Meiri Quentin de Coster Jean Louis Iratzoki Sokoa Sander Lorier Studio Dessuant Bone Studio Julien Carretero TOKUJIN YOSHIOKA DESIGN Portego Kazuhiro Yamanaka 彭佳 | 2017 | 现代装饰2017，0，2： | 0 |
| 20 | An Effective Management of Personal Paper Outcome Using Open Service显示文摘 | Heeseok Choi Wonkyun Joo Minwoo Park Kiseok Choi Jaesoo Kim | 2013 | Computer Technology and Application2013，4，8： | 0 |
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