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| 1 | Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy显示文摘AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related. | Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre | 2016 | World Journal of Clinical Oncology2016，7，5： | 6 |
| 2 | Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short term, high-carbohydrate diets显示文摘 | Mittendorfer B Sidossis LS | 2001 | Am J Clin Nutr2001，73，： | 1 |
| 3 | The E75 HER2/neu peptide vaccine 显示文摘 | Mittendorf E A Holmes J P Ponniah S | 2008 | Cancer Immunol lmmu- nother2008，57，10： | 1 |
| 4 | Discovery of riociguat( BAY 63-2521 ) :a potent, oral stimulator of solu- ble guanylate cyclase for the treatment of pulmonary hyperten- sion 显示文摘 | MITTENDORF J EIGAND S STASCH J P | 2009 | ChemMedChern2009，4，5： | 1 |
| 5 | Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer:the ACOSOG Z1071(Alliance) clinical trial显示文摘 | Boughey JC Suman VJ Mittendorf EA | 2013 | JAMA2013，310，14： | 1 |
| 6 | The E75 HER2/neu peptide vaccine显示文摘 | Mittendorf EA Holmes JP Ponniah S | | 0，，： | 1 |
| 7 | Post parathyroidectomy hypocalcemia: incidence, risk factors, and management显示文摘 | Mittendorf EA Merlino JI McHenry CR | 2004 | Am Surg2004，70，2： | 1 |
| 8 | Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial显示文摘 | Boughey J C Suman V J Mittendorf E A Ahrendt G M Wilke L G Taback B | 2013 | JAMA2013，310，： | 1 |
| 9 | Factors affecting sentinel lymph node identification rate after neoadjuvant chemotherapy for breast cancer patients enrolled in ACOSOG Z1071(Alliance)显示文摘 | Boughey JC Suman VJ Mittendorf EA | 2015 | Ann Surg2015，261，3： | 1 |
| 10 | CD4 T cells in antitumor immunity: utility of an Ii-key HER2/ neu hybrid peptide vaccine (AE37) 显示文摘 | Mittendorf E A Holmes J P Murray J L | 2009 | Expert Opin Biol Ther2009，9，1： | 1 |
| 11 | Sentinel lymph node surgery after neoadjuvant chemotherapy is accurate and reduces the need for axillary dissection in breast cancer patients显示文摘 | Hunt KK Yi M Mittendorf EA | 2009 | Ann Surg2009，250，4： | 1 |
| 12 | Parathyroid carcinoma显示文摘 | Elizabeth A Mittendorf McHenry CR | 2005 | Adv Anat Pathol2005，12，： | 1 |
| 13 | Gastric bypass and banding equally improve insulin sensitivity and β cell function显示文摘 | Bradley D Conte C Mittendorfer B | 2012 | J Clin Invest2012，122，12： | 1 |
| 14 | Occult axillary lymph nodemetastases do not have prognostic significance in early stage breastcancer显示文摘 | Wu Y Mittendorf EA Kelten C | 2012 | Cancer2012，118，6： | 1 |
| 15 | Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short term, high-carbohydrate diets显示文摘 | Mittendorfer B Sidossis LS | 2001 | Am J Clin Nutr2001，73，： | 1 |
| 16 | Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infant 显示文摘 | Mittendorf R Dambrosia J Pryde PG | 2002 | Am J Obstet Gynecol2002，186，6： | 1 |
| 17 | The make-or-buy decision in the presence of a rival: Strategic outsourcing to a common supplier 显示文摘 | Arya A Mittendorf B Sappington D E M | 2008 | Management Science2008，54，10： | 1 |
| 18 | Thyroidectomy for selected patients with thyotocxicosis显示文摘 | Mittendorf EA Mchenry CR | 2002 | Arch Otolaryngol Head Neck Surg2002，127，1： | 1 |
| 19 | Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer:the ACOSOG Z1071 (Alliance) clinical trial显示文摘 | Boughey JC Suman VJ Mittendorf EA | 2013 | JAMA2013，310，14： | 1 |
| 20 | Resection of liver metastases from breast cancer: estrogen receptor status and re- sponse to chemotherapy prior to surgery define outcome显示文摘 | Abbott D E Brouquet A Mittendorf E A | 2012 | Sur gery2012，151，5： | 1 |
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