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| 1 | Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics显示文摘几个抄写因素的宫外的表示能恢复胚胎的房间命运到有教养的体的房间并且产生导致的 pluripotent 干细胞(iPSCs ) ,揭示到 pluripotency 的一条以前未知的小径。然而,这种技术被低效率,慢动力学和多因素的要求当前限制。这里,我们证明 reprogramming 能被优化文化条件改进并且戏剧性地加速了。首先,我们开发了优化定义媒介, iCD1,它允许 Oct4/Sox2/Klf4 (OSK ) 完成的调停的 reprogramming 超离频效率(~10% 在白天 8 点) 。我们也发现这个优化条件使 Sox2 和 Klf4 变为非必需,尽管这二个因素的消除导致更低的效率和更慢的动力学。我们的研究定义一条弄短的线路,两个在预定和因素要求,向 pluripotency。这个新范例不仅提供一个基本原理进一步改进 iPSC 产生而且由定义因素简化 reprogramming 的概念的理解。 | Jiekai Chen Jing Liu You Chen Jiaqi Yang Jing Chen He Liu Xiangjie Zhao Kunlun Mo Hong Song Lin Guo Shilong Chu Deping Wang Ke Ding Duanqing Pei | 2011 | Cell Research2011，21，6： | 9 |
| 2 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 3 | Xuefuzhuyu injection induces neuronal differentiation of rat bone morrow mesenchymal stem cells显示文摘The primary effective components of Xuefuzhuyu,including Rhizoma Chqanxiong,Radix Salviae Miltiorrhiae,and Radix Angelicae Sinensis,have been shown to induce the differentiation of bone marrow mesenchymal stem cells(BMMSCs) into neuronal-like cells.However,there is little available evidence on the effects of the Chinese herbal compound Xuefuzhuyu on BMMSC differentiation.The present study investigated the effects of Xuefuzhuyu on differentiation of rat BMMSCs into neuronal-like cells,and evaluated the optimal concentration for inducing differentiation.Inverted microscopy was used to observe BMMSCs induced by Xuefuzhuyu;immunocytochemistry revealed expression of the neuronal marker neuron-specific enolase surface antigen in the majority of BMMSCs following treatment with Xuefuzhuyu at concentrations of 1,3,5,and 10 g/L.A concentration of 3 g/L resulted in highest neuron-specific enolase expression.These results suggest that BMMSCs can be induced to differentiate into neuronal-like cells with Xuefuzhuyu,and 3 g/L is the optimal inductive concentration for effective differentiation. | Yin, Yanqing Chen, Bing Ke, Junlong Mo, Wei Zou, Xinhui Liang, Yuansheng | 2011 | Neural Regeneration Research2011，6，3： | 6 |
| 4 | Sufficient or insufficient: Assessment of the intended nationally determined contributions (INDCs) of the world's major greenhouse gas emitters显示文摘The recent Conference of the Parties of the United Nations Framework Convention on Climate Change has resulted in the submission of the Intended Nationally Determined Contributions (INDCs) of 190 countries. This study aims to provide an analysis of the ambitiousness and fairness of the mitigation components of the INDCs submitted by various parties. We use a unified framework to assess 23 INDCs that cover 50 countries, including European Union (EU)-28 countries as parties to the Convention, which represent 87.45% of the global greenhouse gas emissions in 2012. First, we transform initial INDC files into reported reduction targets. Second, we create four schemes and six scenarios to determine the required reduction effort, which considers each nation's reduction responsibility, capacity, and potential, thereby reflecting their historical and current development status. Finally, we combine the reported reduction target and the required reduction effort to assess INDCs. Evaluation results of the 23 emitters indicate that 2 emitters (i.e., EU and Brazil) are rated as 'sufficient,' 7 emitters (e.g., China, the United States, and Canada) are rated as 'moderate,' and 14 emitters (e.g., India, Russia, and Japan) are rated as 'insufficient.' Most pledges exhibit a considerable distance from representing a fair contribution. | Ge GAO Mo CHEN Jiayu WANG Kexin YANG Yujiao XIAN Xunpeng SHI Ke WANG | 2019 | Frontiers of Engineering Management2019，6，1： | 6 |
| 5 | Holocene environmental changes around Xiaohe Cemetery and its effects on human occupation, Xinjiang, China显示文摘Xiaohe 公墓考古学的地点(Cal。4-3.5 ka BP ) 是在 Xinjiang 的最重要的青铜时代地点之一,中国。尽管包围环境现在是极其干旱的沙漠,丰富的考古学的遗体显示人的职业在在 Holocene 的某些时期期间是普通的。当地区性的环境在那里是在整个 Holocene 的干旱沙漠时,地调查和 Xiaohe 公墓附近的沉积侧面的实验室分析显示那是在时期 4.8-3.5 ka BP, 2.6-2.1 ka BP 和 1.2-0.9 的地点附近的湖形成的三个事件 ka BP。似地球形状并且当水开始从 Kongque 河被导出然后推延进 Xiaohe 河盆时,水文学调查表明一个湖或湖在一个低区域形成了。在在 4.8-3.5 ka BP 之间的湖的沉积的活跃化学元素的低数量在湖显示丰富、连续的水体积;活跃化学元素的内容在 2.6-2.1 ka BP 之间增加了,但是仍然在一相对低级,建议水和减少的流入的衰退数量。在 1.2-0.9 ka BP 之间,有活跃元素的一个很高的内容,建议减少的水体积并且显示湖是停滞。相反,气候状况在那里看那的将军在这个区域在 2.9-0.9 ka BP 在 8-6 ka BP,在 6-2.9 ka BP 的一个凉爽潮湿的阶段和一个温暖干燥的阶段有一个温暖潮湿的阶段。在 Xiaohe 公墓附近的水文学进化没与气候变化有一对一的通讯。地区性的比较显示宽广规模的气候的条件通过它对 Tarim 河和 Kongque 河的水体积的影响起了一个重要作用。但是,湖的形成和他们的水平被影响了体积多少水能从 Kongque 被推延到 Xiaohe 河的似地球形状的条件控制河。Xiaohe 公墓和附近的区域的人的职业在青铜时代和 Han-Jin 时期(202 BC-420 广告) 期间对应于二个更早的湖时期,当因为减少的水体积,没有人的活动在第三个湖时期存在时。 | ZHANG Yifei MO Duowen HU Ke BAO Wenbo LI Wenying Idilisi Abuduresule Michael J. STOROZUM Tristram R. KIDDER | 2017 | Journal of Geographical Sciences2017，27，6： | 6 |
| 6 | Synthesis and activity evaluation of some novel derivatives of 4,5,6,7-tetrahydrothieno [3,2-c]-pyridine显示文摘4,5,6,7-tetrahydrothieno 的新奇衍生物的二个系列[3,2-c ] pyridine 被 1H NMR 和 MS 综合,在结构上描绘了。他们的在里面 vivo antiplatelet 聚集活动被评估。 | Die Cheng Deng Ke Liu MO Liu Ying Liu Wei Ren Xu Chang Xiao Liu | 2008 | Chinese Chemical Letters2008，19，6： | 4 |
| 7 | Pelvic lipomatosis with cystitis glandularis managed with cyclooxygenase-2 inhibitor:A case report显示文摘BACKGROUND Pelvic lipomatosis(PL)is a rare benign condition with characteristic overgrowth of histologically benign fat and invasion and compression of pelvic organs,often leading to non-specific lower urinary tract symptoms(LUTS).Approximately 40%of patients with PL have cystitis glandularis(CG).The cause of PL combined with CG is poorly understood,and there is currently no effective treatment.Refractory CG with upper urinary tract obstruction even requires partial or radical bladder resection.CASE SUMMARY In this case,a patient suffering from PL with CG was treated by transurethral resection of bladder tumour(TUR-BT)and oral administration of celecoxib,a selective cyclooxygenase-2(COX-2)inhibitor.The LUTS were alleviated,and the cystoscopy results improved significantly.Immunohistochemistry showed upregulated COX-2 expression in the epithelium of TUR-BT samples,suggesting that COX-2 may participate in the pathophysiological process of PL combined with CG.CONCLUSION We report for the first time that celecoxib may be an effective treatment strategy for PL combined with refractory CG. | Li-Cai Mo Song-Zhe Piao Hai-Hong Zheng Tao Hong Qin Feng Mang Ke | 2021 | World Journal of Clinical Cases2021，9，17： | 4 |
| 8 | Contribution of syncollisional felsic magmatism to continental crust growth: A case study of the Paleogene Linzizong volcanic Succession in southern Tibet显示文摘 | Xuanxue Mo Yaoling Niu Guochen Dong Zhidan Zhao Zengqian Hou Su Zhou Shan Ke | 2008 | Chemical Geology2008，，1： | 2 |
| 9 | Synthesis, activity evaluation and 3D-QSAR study of some novel derivatives of 4, 5, 6, 7-tetrahydrothieno [3,2-c] pyridine显示文摘4 的一系列新奇衍生物, 5, 6, 7-tetrahydrothieno [3,2-c ] pyridine 被 1H NMR 和 MS 综合,在结构上描绘了。他们的在里面 vivo 反血小板聚集活动被评估。A 3D-QSAR 用 CoMFA 和 CoMSIA 被执行。这个模型为新奇反血小板 thienopyridines 设计提供了有用指南。 | Die Cheng Deng Ke Liu Mo Liu Ying Liu Wei Ren Xu Chang Xiao Liu | 2008 | Chinese Chemical Letters2008，19，9： | 2 |
| 10 | Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine显示文摘Exposure to ionizing radiation,a physical treatment that inactivates live tumor cells,has been extensively applied to enhance the antitumor responses induced by cancer cell vaccines in both animal research and human clinical trials.However,the mechanisms by which irradiated cells function as immunogenic tumor vaccines and induce effective antitumor responses have not been fully explored.Here,we demonstrate that oxidized mitochondrial DNA(mtDNA)and stimulator of interferon genes(STING)signaling play a key roles in the enhanced antitumor effect achieved with an irradiated tumor cell vaccine.Elevations in ROS and oxidized mtDNA 8-OHG content could be induced in irradiated tumor cells.Oxidized mtDNA derived from irradiated tumor cells gained access to the cytosol of dendritic cells(DCs).Oxidized mtDNA,as a DAMP or adjuvant,activated the STING-TBK1-IRF3-IFN-β pathway in DCs,which subsequently cross-presented irradiated tumor cell-derived antigens to CD8^(+)T cells and elicited antitumor immunity.The results of our study provide insight into the mechanism by which an irradiated cell vaccine mediates antitumor immunity,which may have implications for new strategies to improve the efficacy of irradiated vaccines. | Chunju Fang Fei Mo Li Liu Jing Du Min Luo Ke Men Feifei Na Wei Wang Hanshuo Yang Xiawei Wei | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 11 | Utilization of a spiropyran derivative in a polymeric film optode for selective fluorescent sensing of zinc ion显示文摘A new spiropyran derivative was synthesized and first utilized in a polymeric film-based optical sensor for zinc ion. Spiropyrans, combining the characteristics of metal binding and signal transduction, show potential function in the design of optical chemical sensors (optodes) toward metal ions. When embedded in a plasticized poly (vinyl chloride) (PVC) membrane, the newly synthesized spiropyran derivative 1 exhibits obvious fluorescence enhancement at 630 nm in the presence of zinc ion in aqueous solution. With the optimum condition described, the optode membrane responds to zinc ion over a dynamic range of 4.94×10?7 to 4.15×10?4 mol·L?1, with a detection limit of 1.51×10?7 mol·L?1. The membrane not only displays excellent photostability, reproducibility and reversibility, but also exhibits high selectivity toward zinc ion over transition metal ions including Hg2+, Cd2+, Pb2+, Cu2+, Fe3+and common cationic ions presented in the physiological fluids. | ZHANG Ying1, SHAO Na1, YANG Ronghua1, LI Ke’an1, LIU Feng1, CHAN Winghong2 & MO Tian2 1. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China 2. Department of Chemistry, Hong Kong Baptist University, Hong Kong, China | 2006 | Science China Chemistry2006，49，3： | 1 |
| 12 | Patellar fractures:contemporary approach to treatment显示文摘 | Crammer KE Moed BR | 1997 | J Am Acad Orthop Surg1997，5，1： | 1 |
| 13 | Patellar fratures: contemporary ap-proach to treatment 显示文摘 | Cramer KE Moed BR | 1997 | J Am Acad Orthop Surg1997，5，6： | 1 |
| 14 | Multiple outbreaks of acute hemorrhagic conjunctivitis due to a variant of coxsakirvirus A24:Guangdong,China 2007 显示文摘 | WU D KE CW MO YL | 2008 | J Med Virol2008，80，10： | 1 |
| 15 | A metaanalysis of noninvasive weaning to facilitate liberation from mechanical ventilation显示文摘 | Bums KE Adhikari NK Meade MO | 2006 | Can J Anaesth2006，53，3： | 1 |
| 16 | Pharmacologic treatments for acute respiratory distress syndrome and acute lung injury: systematic review and meta- analysis显示文摘 | Adhikari N Burns KE Meade MO | 2004 | Treat Respir Med2004，3，5： | 1 |
| 17 | Multiple outbreaks of acute hemorrhagic conjunctivitis due to a variant of coxsackievirus A24:Guangdong,China,2007显示文摘 | Wu D Ke CW Mo YL | 2008 | J Med Virol2008，80，： | 1 |
| 18 | Comparison of the compression hip screw with the Medoff sliding plate for intertrochanteric fractures显示文摘 | Watson JT Moed BR Cramer KE | 1998 | Clin Orthop Relat Res1998，348，： | 1 |
| 19 | Comparison of the compression hip screm with the Medoff sliding plate for intertrochanteric fractures显示文摘 | Watson JT Moed BR Cramer KE | 1998 | Clin Orthop1998，，348： | 1 |
| 20 | Wean earlier and automatically with new technology (the WEAN study):a protocol of a multicentre,pilot randomized controlled trial显示文摘 | Burns KE Meade MO Lessard MR | 2009 | Trials2009，10，1： | 1 |
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