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| 1 | Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. | Ashraf Ali Hany Abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，30： | 29 |
| 2 | Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy显示文摘Colorectal cancer(CRC)is a predominant life-threatening cancer,with liver and peritoneal metastases as the primary causes of death.Intestinal inflammation,a known CRC risk factor,nurtures a local inflammatory environment enriched with tumor cells,endothelial cells,immune cells,cancer-associated fibroblasts,immunosuppressive cells,and secretory growth factors.The complex interactions of aberrantly expressed cytokines,chemokines,growth factors,and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes.Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment,which is partly achieved by the recruitment of immunosuppressive cells.These cells impart features such as cancer stem cell-like properties,drug resistance,invasion,and formation of the premetastatic niche in distant organs,promoting metastasis and aggressive CRC growth.A deeper understanding of the cytokineand chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC.Here,we summarized the current knowledge of cytokine-and chemokine-mediated crosstalk in the inflammatory tumor microenvironment,which drives immunosuppression,resistance to therapeutics,and metastasis during CRC progression.We also outlined the potential of this crosstalk as a novel therapeutic target for CRC.The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review. | Ajaz A.Bhat Sabah Nisar Mayank Singh Bazella Ashraf Tariq Masoodi Chandra P.Prasad Atul Sharma Selma Maacha Thasni Karedath Sheema Hashem Syed Besina Yasin Puneet Bagga Ravinder Reddy Michael P.Frennaux Shahab Uddin Punita Dhawan Mohammad Haris Muzafar A.Macha | 2022 | Cancer Communications2022，42，8： | 8 |
| 3 | Rapunzel syndrome:The unsuspected culprit显示文摘Trichobezoar is a rare intriguing disorder in which swallowed hairs accumulates in the stomach. Being indigestible and slippery, it could not be propulsed and becomes entrapped within the stomach. Large amounts can thus accumulate over the years forming a hair ball. Rapunzel syndrome is a variant where hair accumulation reaches the small gut and beyond in some cases. Although the syndrome has been known for many years, only 24 cases have been reported in the literature and the discovery of a new case is always surprising. In this report, we present two cases discovered within a period of three months. One of them was pregnant and had small bowel intussusception and perforation, a very rare combination. We hereby add two more cases to the literature. To our knowledge, this is the first report on two cases of Rapunzel syndrome, the diagnosis of which demands a high index of suspicion. | Mohammad Ezzedien Rabie Abdul Rahman Arishi Ashraf Khan Hussein Ageely Gaffar Abbas Seif El-Nasr Mohammad Fagihi | 2008 | World Journal of Gastroenterology2008，14，7： | 4 |
| 4 | Hemoglobin A1C in non-diabetic patients: An independent predictor of coronary artery disease and its severity显示文摘 | Haleh Ashraf Mohammad Ali Boroumand Alireza Amirzadegan Shaghayegh Ashraf Talesh Gholamreza Davoodi | 2013 | Diabetes Research and Clinical Practice2013，，3： | 2 |
| 5 | Amblyopia screening for first and second-grade children in Jordan显示文摘AIM:To share the results of a national screening program for amblyopia in school children in the north of Jordan.METHODS:This is a prospective national screening study for amblyopia.The program rolls first and second-grade children(6 to 7 years old) in the north of Jordan.The eye examination included:best-corrected visual acuity,cover-uncover test,and cycloplegic retinoscopy.Monocular visual acuity was tested using an ETDRS visual acuity chart without correction.Moreover,children were tested with full cycloplegic refraction when the test criteria were met.Unilateral amblyopia was defined as a best-corrected visual acuity difference of 2 or more lines.In comparison,bilateral amblyopia was defined as a best-corrected visual acuity of 20/40 or worse in the best eye.RESULTS:The prevalence of amblyopia for the total sample tested(n=17 203) was 2.78%(n=479).The most common cause of amblyopia was hypermetropia(64.45%),followed by previous ocular surgeries(15.1%),myopia(10.43%),strabismus(9.39%),and congenital cataract(0.63%).CONCLUSION:This is the first and only study,identifing modifiable risk factors in Jordanian children with amblyopia.In their first couple of years of elementary education,many Jordanian children are affected by amblyopia and pass unnoticed.A more governmental effort is needed into screening programs to improve vision in the Jordanian population. | Khalil M.Al-Salem Mohammad S.Saleem Ismat Ereifej Hamzeh M.Alrawashdeh Rayed Falah Hussein Obeidat Asma Ali Abdlmohdi Raeda Zaki Al-Momani Layal Mohammed Hammad Omar Ahmad al-Habahbeh Yaqeen M.Assassfeh Laith Ramzi Najib Al-Qsous Ashraf Hatim Adeeb Nasraween Tariq A.Al Maaitah Deya'-Aldin Muneer Hasan Aqeel Ibtehal Eyadeh Awad Alabdulrazzg Abdullah Mahmoud Mohammad Murad Amany Jehad Faleh AL-Zurqan Enas Jamal Mohammad Jaradat Slsabela Emad Suliman Aldhoon Ala'a Majed Dmour Ahmad Talal Asassfeh Jeries Ayman Halaseh Abdel Aziz Ammar Daoud Waha Ayman Alkasasbeh Kholoud GH.Matar | 2022 | International Journal of Ophthalmology(English edition)2022，15，2： | 1 |
| 6 | Transient analysis of a three-layer microbeam subjected to electric potential显示文摘In this paper,free vibration,wave propagation,and bending analyses of a sandwich microbeam integrated with piezoelectric face-sheets resting on Pasternak foundation under electric potential are presented based on the strain gradient theory and Euler–Bernoulli beam theory.The material properties of core are assumed variable along the thickness direction and piezoelectric face-sheets are assumed homogeneous piezoelectric materials.A two-dimensional electric potential distribution along the axial and transverse direction is applied on the face-sheets of microbeam.Hamilton principal is used to derive governing differential equations of motion.Three behaviors of sandwich microbeam including free vibration,wave propagation,and bending analyses are studied in this paper.Some numerical results are presented to capture the effect of important parameters of the problem such as in-homogeneous index,applied voltage,parameters of foundation,and material length scales.The numerical results indicate that the effect of electric potential along the axial direction is very small rather than one along the transverse direction where initial voltage is applied. | Mohammad Arefi Ashraf M.Zenkour | 2017 | International Journal of Smart and Nano Materials2017，8，1： | 1 |
| 7 | Development of vapor generation combined with potentiometric detection for determination of sulfite in beverages显示文摘 | Mohammad Hossein Arbab-Zavar Gholam Hossein Rounaghi Somayeh Rajabzadeh Narges Ashraf | 2013 | Journal of Food Measurement and Characterization2013，，2： | 1 |
| 8 | Liver transplantation using fatty livers: Always feasible?显示文摘 | Lucas McCormack Philipp Dutkowski Ashraf Mohammad El-Badry Pierre-Alain Clavien | 2010 | Journal of Hepatology2010，，5： | 1 |
| 9 | Antitubereular activity of substituted 4, 5-dihydro-lH-1- pyrazolylmethanethiones 显示文摘 | Mohamed Ashraf Ali Mohammad shahar Yar | 2007 | Journal of Enzyme Inhibition and Medicinal Chemistry2007，22，2： | 1 |
| 10 | Isolation and characterization of alkane degrading bacteria from petroleum reservoir waste water in Iran (Kerman and Tehran provenances)显示文摘 | Mehdi Hassanshahian Mohammad Ahmadinejad Hamid Tebyanian Ashraf Kariminik | 2013 | Marine Pollution Bulletin2013，，： | 1 |
| 11 | Cardiac dysfunction in liver cirrhosis: A tissue Doppler im- aging study from Egypt显示文摘 | Fatma Mohammad Nasr Amna Metwaly Ashraf Abdel khalik | 2015 | Electronic physician2015，7，4： | 1 |
| 12 | Assessment of circulating levels of microRNA-326,microRNA-424,and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common cancer.Differential expression of microRNAs(miRNAs)-326,miRNA-424,and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different populations.However,limited information is available regarding their expression in Egyptian HCC patients.AIM To assess the role of circulating miRNAs-326,miRNA-424,and miRNA-511 in Egyptian HCC patients.METHODS This prospective observational study included 70 HCC patients and 25 healthy controls.The circulating levels of these three miRNAs were evaluated by real-time PCR.Receiver operating characteristic curve analysis was used to test the diagnostic accuracy of micro RNA expression levels.RESULTS All miRNAs were differentially expressed in HCC patients;miRNAs326 and miRNA-424 were upregulated,while miRNA-511 was downregulated.Both miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%,71.4%,and 52%,60%,respectively,to differentiate HCC from controls.Moreover,miRNA-326 was associated with survival and could differentiate between Child grades(A vs B);miRNA-424 significantly differentiated early vs intermediate stages of HCC;while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors(m RECIST).CONCLUSION We conclude that miRNA-326,miRNA-424,and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management. | Samar Samir Youssef Asmaa Elfiky Mohamed M Nabeel Hend Ibrahim Shousha Tamer Elbaz Dalia Omran Mohammad Saeed Marie Mohammad A Elzahry Amr Abul-Fotouh Ahmed Hashem Mohamed F Guda Ashraf O Abdelaziz | 2022 | World Journal of Hepatology2022，14，8： | 1 |
| 13 | Biomarkers for virus-induced hepatocellular carcinoma (HCC)显示文摘 | Shilu Mathew Ashraf Ali Hany Abdel-Hafiz Kaneez Fatima Mohd Suhail Govindaraju Archunan Nargis Begum Syed Jahangir Muhammad Ilyas Adeel G.A. Chaudhary Mohammad Al Qahtani Salem Mohamad Bazarah Ishtiaq Qadri | 2014 | Infection, Genetics and Evolution2014，，： | 1 |
| 14 | An overview of liquid phase microextraction approaches combined with UV-Vis spectrophotometry显示文摘 | Malihe Dehghani Mohammad Abadi Narges Ashraf Mahmoud Cham-saz | | 0，，： | 1 |
| 15 | A Study of Neutron and Gamma Radiation Effects on Transmissionof Various Types of Glasses, Optical Coatings, Cemented Optics and Fiber显示文摘 | Javed Akhtar S M Mohammad Ashraf Shaukat Hameed Khan | 2007 | Optical Materials2007，29，： | 1 |
| 16 | Clinical and biochemical aspirin resistance in patients with recurrent cerebral ischemia显示文摘 | Ashraf EW Hanan A Mohammad All | 2013 | Clin Neurol Neurosurg2013，115，： | 1 |
| 17 | Assessment of Hepatic Steatosis by Expert Pathologists: The End of a Gold Standard显示文摘 | Ashraf Mohammad El-Badry Stefan Breitenstein Wolfram Jochum Kay Washington Valérie Paradis Laura Rubbia-Brandt Milo A. Puhan Ksenija Slankamenac Rolf Graf Pierre-Alain Clavien | 2009 | Annals of Surgery2009，，5： | 1 |
| 18 | Determining the effect of Plantago major L. and Rosa damascene herbal ointment for bedsore healing显示文摘Background:Bedsores are damage or loss of skin integrity due to prolonged pressure which there are several ways to treat and prevent them.The aim of the study was to determine the effect of Plantago major L.and Rosa damascene herbal ointment for bedsore healing in hospitalized patients.Methods:This clinical trial study was accomplished with 100 patients divided into control(50 patients)and intervention(50 patients)groups.The control group had received routine treatment(dressing with Comfeel),but the intervention group only had received herbal ointment and then both groups were compared with each other through the pressure ulcer scale for healing(PUSH)tool.Results:The mean and standard deviation of recovery time in the Comfeel group was 27.40±12.467 and in the herbal ointment group was 21.57±12.695.In the pre-intervention evaluation,the mean and standard deviation of the PUSH score in the herbal ointment group was 10.44±0.323 while in the last evaluation in the same group it was 0.68±0.288 but in the Comfeel group,in the pre-intervention evaluation,the mean and standard deviation of the PUSH score was 10.68±0.317,while in the last evaluation it was 1.98±0.472.The highest frequency of bedsores in the study units was in the sacral region(49%)and the lowest frequency was in the sole of the foot with 1%.Conclusion:The results showed that Plantago major L.and Rosa damascene herbal ointment was effective in accelerating recovery time and wound healing. | Ashraf Salehi Mohammad Taheri Hamid Momeni Morteza Bakhshesh Davood Azadi Abdorrahim Absalan Mahdieh Azizi Amirhossein Latifi | 2022 | Aging Communications2022，4，4： | 0 |
| 19 | Generalized*-Lie Higher Derivable Mappings on*-Rings显示文摘Let R be a*-ring with the center Z(R)and N be the set of nonnegative integers.In this paper,it is shown that if R contains a nontrivial self-adjoint idempotent which admits a generalized Lie higher derivable mapping△={G_(n)}_(n∈N)associated with a*-Lie higher derivable mapping L={L_(n)}_(n∈N),then for any X,Y in R and for each n in N there exists an element Z_(X,Y)(depending on X and Y)in the center Z(R)such that G_(n)(X+Y)=G_(n)(X)+G_(n)(Y)+Z_(X,Y). | Mohammad Ashraf Mohd Shuaib Akhtar Bilal Ahmad Wani | 2020 | Algebra Colloquium2020，27，3： | 0 |
| 20 | Multi-objective vendor managed inventory system with interval type-2 fuzzy demand and order quantities显示文摘Purpose-The proposed IT2FMOVMI model intends to concurrently minimize total cost and warehouse space for the single vendor-retailer,multi-item and a consolidated vendor store.Regarding demand and order quantities with the deterministic and type-1 fuzzy numbers,we have also formulated the classic/crisp MOVMI model and type-1 fuzzy MOVMI(T1FMOVMI)model.The suggested solution technique can solve both crisp MOVMIand T1FMOVMIproblems.By finding the optimal ordered quantities and backorder levels,the Paretofronts are constructed to form the solution sets for the three models.Design/methodology/approach-A multi-objective vendor managed inventory(MOVMI)is the most recognized marketing and delivery technique for the service provider and the retail in the supply chain in Industry 4.0.Due to the evolving market conditions,the characteristics of the individual product,the delivery period and the manufacturing costs,the demand rate and order quantity of the MOVMI device are highly unpredictable.In such a scenario,a MOVMI system with a deterministic demand rate and order quantity cannot be designed to estimate the highly unforeseen cost of the problem.This paper introduces a novel interval type-2 fuzzy multi-objective vendor managed inventory(IT2FMOVMI)system,which uses interval type-2 fuzzy numbers(IT2FNs)to represent demand rate and order quantities.As the model is an NP-hard,the well-known meta-heuristic algorithm named NSGA-II(Non-dominated sorted genetic algorithm-II)with EKM(Enhanced Karnink-Mendel)algorithm based solution method has been established.Findings-The experimental simulations for the five test problems that demonstrated distinct conditions are considered from the real-datasets of SAPCO company.Experimental study concludes that T1FMOVMI and crisp MOVMI schemes are outclassed by IT2FMOVMI model,offering more accurate Pareto-Fronts and efficiency measurement values.Originality/value-Using fuzzy sets theory,a significant amount of work has been already done in past decades from various points of views to model the MOVMI.However,this is the very first attempt to introduce type-2 fuzzy modelling for the problem to address the realistic implementation of the imprecise parameters. | Zubair Ashraf Mohammad Shahid | 2021 | International Journal of Intelligent Computing and Cybernetics2021，14，3： | 0 |
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