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| 1 | Toll-like receptor expression and signaling in human diabetic wounds显示文摘AIM: To examine the contribution of toll-like receptors(TLRs) expression and activation to the prolonged inflammation often seen in human diabetic wounds.METHODS: Debridement wound tissue was collected from diabetic patients with informed consent. Total RNA and protein were isolated and subjected to real-time polymerase chain reaction and Western blot analyses. RESULTS: TLR1, 2, 4, and 6 mRNA expressions were increased significantly in wounds of diabetic patients compared with non-diabetic wounds(P < 0.05). MyD88 protein expression was significantly increased in diabetic wounds compared to non-diabetic wounds. Interleukin-1beta, tumor necrosis factor-alpha concentration nuclear factor-kappa B activation, and thiobarbituric acid reactive substances were increased in diabetic wounds compared to non-diabetic wounds(P < 0.01). CONCLUSION: Collectively, our novel findings show that increased TLR expression, signaling, and activation may contribute to the hyper inflammation in the human diabetic wounds. | Mohan R Dasu Sandra J Martin | 2014 | World Journal of Diabetes2014，5，2： | 2 |
| 2 | Effects of cadmium salt on phosphomonoesterases activity and fertilizing ability of fowl spermatozoa显示文摘 | Mohan J Moudgal R P Panda J N | 1992 | Indian J Experi Biol1992，30，： | 1 |
| 3 | Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK显示文摘 | Mohan RR Hutcheon AE Choi R Hong J Lee J Mohan RR | 2003 | Exp Eye Res2003，76，： | 1 |
| 4 | Band parameters for Ⅲ-V compound semiconductors and their alloys 显示文摘 | Vurqaftman I Meyer J R Mohan L R R | 2001 | J Appl Phys2001，89，11： | 1 |
| 5 | Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland,tears,and cornea显示文摘 | Li Q Weng J Mohan R R | 1996 | Invest Ophthalmol Vis Sci1996，37，5： | 1 |
| 6 | Effects of cadmium salt on phosphomonoes terases activity and fertilizing ability of fowl spermatozoa 显示文摘 | Mohan J Mrudgal R P Panda J N | 1992 | Indian Journal of Experimental Biol- ogy1992，30，3： | 1 |
| 7 | Band parameters for Ⅲ-Ⅴ compound semiconductors and their alloys 显示文摘 | Vurgaftman I Meyer J R Ram - Mohan L R | 2001 | J Appl Phys2001，89，11： | 1 |
| 8 | Spasmogenic effect of a Solanum melongena leaf extract on guiea pig tracheal chains and its possible mechanism (s) 显示文摘 | Mans D R A Toelsie J Mohan S | 2004 | J Ethnopharma:ol2004，95，： | 1 |
| 9 | Effects of cadmium salt on phosphomonoesterases activity and fertilizing ability of fowl spermatozoa 显示文摘 | Mohan J Moudagal R P Panda J N | 1992 | Indian J Experi Biol1992，30，： | 1 |
| 10 | The effects of geometry, fluid properties and pressure on the hydrodynamics of gas-liquid cylindrical cyclone separators 显示文摘 | Movafaghian S Jaua-Marturet J A Mohan R S | 2000 | International Journal of Muhiphase Flow2000，26，16： | 1 |
| 11 | The effects of geometry, fluid properties and pressure on the hydrodynamics of gas-liquid cylindrical cyclone separators 显示文摘 | Movafaghian S Jaua-Marturet J A Mohan R S | 2000 | International Journal of Multiphase Flow2000，26，： | 1 |
| 12 | Prevalence and risk factors for diabetic neuropathy in an urban south Indian population:the Chennai Urban Rural Epidemiology Study( CURES-55 ) 显示文摘 | Pradeepa R Rema M Vignesh J Deepa M Deepa R Mohan Y | 2008 | Diabet Med2008，25，4： | 1 |
| 13 | Reactivity of i-onic liquids显示文摘 | Chowdhury S Mohan R S Scott J L | 2007 | Tetrahedron2007，63，11： | 1 |
| 14 | Iron (III) to- sylate catalyzed synthesis of 3, 4-dihydropyrimidin-2 (1H) -ones/thiones via the Biginelli reaction 显示文摘 | Starcevich J T Laughlin T J Mohan R S | 2013 | Tetra- hedron Letter2013，54，8： | 1 |
| 15 | Deaths in children during an outbreak of hand, foot, and mouth disease in Peninsular Malaysia--clin- ical and pathological characteristics 显示文摘 | Shekhar K Lye MS Norlijah O Ong F Looi LM Khuzai- ah R Marzuki I Hussein I Wong SL Mohan J Sinniah M Abu Bakar S | 2005 | Med J Malaysia2005，60，3： | 1 |
| 16 | Preliminary observa- tions on effect of Lactohacillus sporogenes on serum lipid levels in hypercholesterolemic patients显示文摘 | Mohan J C Arora R Khalilullah M | 1990 | The Indian jour- nal of medical research1990，92，： | 1 |
| 17 | Number and orientation of beams in intensity modulated radiation therapy显示文摘 | Stein J Mohan R | 1997 | Meal Phys1997，24，： | 1 |
| 18 | Isolation, molecular characterization and phylogenetic analysis of canine parvovirus 显示文摘 | Mohan R J Mukhopadhyay H K Thanislass J | 2010 | Infect Genet Evol2010，10，： | 1 |
| 19 | Adapting multimedia intemet content for universal access显示文摘 | MOHAN R SMITH J R LI C S | 1999 | IEEE Transactions Multimedia1999，1，1： | 1 |
| 20 | The wound healing response after laser in situ keratomileusis and photorefractive keratectomy显示文摘 | Wilson S E Mohan R R Hong J W | 2001 | J Arch Ophthalmol2001，119，： | 1 |
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