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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | The diagnosis, treatment, and follow-up of cesarean scar pregnancy显示文摘 | Ilan E. Timor-Tritsch Ana Monteagudo Rosalba Santos Tanya Tsymbal Grace Pineda Alan A. Arslan | 2012 | American Journal of Obstetrics and Gynecology2012，，1： | 3 |
| 3 | Cesarean scar pregnancy and early placenta accreta share common histology显示文摘 | I. E. Timor‐Tritsch A. Monteagudo G. Cali J. M. Palacios‐Jaraquemada R. Maymon A. A. Arslan N. Patil D. Popiolek K. R. Mittal | 2014 | Ultrasound Obstet Gynecol2014，，4： | 2 |
| 4 | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved显示文摘The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of APP are still poorly understood.APP is considered a multimodal protein due to its role in a wide variety of processes,both in the embryo and in the adult brain.Specifically,APP seems to play a key role in the proliferation,differentiation and maturation of neural stem cells.In addition,APP can be processed through two canonical processing pathways,generating different functionally active fragments:soluble APP-α,soluble APP-β,amyloid-β peptide and the APP intracellular C-terminal domain.These fragments also appear to modulate various functions in neural stem cells,including the processes of proliferation,neurogenesis,gliogenesis or cell death.However,the molecular mechanisms involved in these effects are still unclear.In this review,we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells,as well as the possible signaling pathways that could be implicated in these effects.The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease,and in the search for potential therapeutic targets. | Raquel Coronel Charlotte Palmer Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 5 | Non-surgical management of live ectopic pregnancy with ultrasound-guided local injection :a case series显示文摘 | Monteagudo A Minior VK Stephenson C | 2005 | Ultrasound Obstet Gynecol2005，25，3： | 1 |
| 6 | Evaluation of endometrial polyps 显示文摘 | Goldstein SR Monteagudo A Popiolek D | 2002 | Am J Obstet Gynecol2002，186，： | 1 |
| 7 | A pilot study of atorvastatin treatment in dyslipemid, non‐alcoholic fatty liver patients显示文摘 | E.GóMEZ‐DOMíNGUEZ J. P.GISBERT J. A.MORENO‐MONTEAGUDO L.GARCíA‐BUEY R.MORENO‐OTERO | 2006 | Alimentary Pharmacology & Therapeutics2006，，11： | 1 |
| 8 | Successful management of viable cervical pregnancy by local injection of methotrexate guided by transvaginal ultrasonography显示文摘 | Timor- Tritsch IE Monteagudo A Mandeville EO | 1994 | Am J Obstet Gynecol1994，170，3： | 1 |
| 9 | Immunohistochemical detection of P-glycoprotein in endometrial adenocarcinoma显示文摘 | Axiotis CA Monteagudo C Merino M J | 1991 | Am J Pathol1991，138，： | 1 |
| 10 | Posterior tibial tendoscopy显示文摘 | Monteagudo M Maceira E | 2015 | Foot Ankle Clin2015，20，1： | 1 |
| 11 | Dermato-fibrosarcoma protuberans : a clinicopathological, immuno-histochemical ,genetic ( COLI Al-PDGFB),and therapeu-tic study of low-grade versus high-grade (fibrosarcoma-tous) tumors 显示文摘 | Llombart B Monteagudo C Sanmartfn 0 | 2011 | J Am Acad Dermatol2011，65，： | 1 |
| 12 | Qualified and trained sonographers in the US can perform early fetal anatomy scans between 11 and 14 weeks显示文摘 | Ilan E. Timor-Tritsch Asher Bashiri Ana Monteagudo Alan A. Arslan | 2004 | American Journal of Obstetrics and Gynecology2004，，4： | 1 |
| 13 | A 17bp dele- tion in the Bone Morphogenetic Protein 15 (BMP15) gene is associated to increased prolificacy in the Rasa Aragonesa sheep breed 显示文摘 | Monteagudo L V Ponz R Tejedor M T | 2009 | Animal Reproduction Science2009，110，1： | 1 |
| 14 | Umbilical cord blood banking for unrelated transplantation : Evaluation of cell separation and storge methods显示文摘 | Regidor C Posada M Monteagudo D | 1999 | Exp Hematol1999，27，2： | 1 |
| 15 | Succesful management of viable cervical pregnancy by local injection of methotrexate guided by transvaginal uhrasonography 显示文摘 | TIMOR- TRITSCH IE MONTEAGUDO A MANDEVILLE EO | 1994 | Am J Obstet Gynecol1994，170，： | 1 |
| 16 | Detection of twin reversed arterial perfusion sequence at the time of first-trimester screening显示文摘 | Bornstein E Monteagudo A Dong R | 2008 | J Ultrasound Med2008，27，7： | 1 |
| 17 | Cesarean scar pregnancies:experience of 60 cases 显示文摘 | Timor-Tritsch IE KhatibN Monteagudo A | 2015 | J Ultrasound Med2015，34，4： | 1 |
| 18 | A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis 显示文摘 | Fernandez J Monteagudo J Bargallo X | 2005 | Hepatology2005，42，43： | 1 |
| 19 | Reticulated platelets as a screening test to identify thrombocytopenia aetiology显示文摘 | Monteagudo M Amegual MJ Munoz L | 2008 | QJM2008，101，7： | 1 |
| 20 | Thrombotic thrombocytopenic purpum/hemolytic uremic syndmme:a multivariate analysis of factors predicting the response to plasma exchang 显示文摘 | pereira A Mazzarm R Monteagudo J | 1995 | Ann Hematol1995，70，6： | 1 |
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