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| 1 | Physical activity support or weight loss counseling for nonalcoholic fatty liver disease?显示文摘AIM:To determine the clinical effectiveness of intense psychological support to physical activity(PA)in nonalcoholic fatty liver disease(NAFLD),compared with cognitive-behavioral treatment(CBT).METHODS:Twenty-two NAFLD cases received support to exercise,tailored to their motivational needs(PA group).The effects on body weight,physical fitness[6-min walk test,VO2max and the PA-rating(PA-R)questionnaire]and body fat(fatty liver indices and visceral adiposity index)were compared with data obtained in 44 NAFLD subjects enrolled in a CBT program for weight loss,after adjustment for propensity score,calculated on baseline data.Measurements were performed at baseline,at 4-mo and one-year follow-up.Changes in anthropometric,biochemical and PA parameters were tested by repeated measurement ANOVA.Outcome results were tested by logistic regression analysis.RESULTS:At the end of the intensive program,BMI was less significantly reduced in the PA group(-1.09±1.68 kg/m2 vs-2.04±1.42 kg/m2 in the CBT group,P=0.019)and the difference was maintained at 1-year follow-up(-0.73±1.63 vs-1.95±1.88,P=0.012)(ANOVA,P=0.005).PA-R was similar at baseline,when only 14%of cases in PA and 36%in CBT(P=0.120)recorded values≥3.At 4 mo,a PA-R≥3 was registered in 91%of PA and 46%of CBT,respectively(P<0.001)and PA-R≥5(up to 3 h/wk of moderate-toheavy intensity physical activity)was registered in 41%of PA and only 9%of CBT group(P<0.007).The6-min walk test increased by 139±26 m in PA and by only 43±38 m in CBT(P<0.001)and VO2max by8.2±3.8 mL/kg per minute and 3.3±2.7 mL/kg per minute,respectively(P<0.002).After adjustment for propensity,weight loss>7%was significantly associated with CBT group at one year(OR=6.21;95%CI:1.23-31.30),whereas PA-R>3 was associated with PA group(10.31;2.02-52.63).Liver enzymes decreased to values within normal limits in 36%of PA cases and61%of CBT(P<0.070).Estimated liver fat(Kotronen index)fell below the fatty liver threshold in 36%of PA and 34%and CBT cases at one-year(not different).Also the fatty liver index and the visceral adiposity index improved to a similar extent.CONCLUSION:Intensive psychological counseling for PA produces hepatic effects not different from standard CBT,improving physical fitness and liver fat independent of weight loss.Strategies promoting exercise are worth and effective in motivated patients,particularly in lean NAFLD patients where large weight loss cannot be systematically pursued. | Luca Montesi Chiara Caselli Elena Centis Chiara Nuccitelli Simona Moscatiello Alessandro Suppini Giulio Marchesini | 2014 | World Journal of Gastroenterology2014，20，29： | 3 |
| 2 | Growth arrest and suppression of tumorigenicity of bladder-carcinoma cell lines induced by the P16/CDKN2 (p16INK4A, MTS1) gene and other loci on human chromosome 9 显示文摘 | Wu Q Possati L Montesi M | 1996 | Iht J Cancer1996，65，6： | 1 |
| 3 | Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis 显示文摘 | Montesi S B Mathai S K Brenner L N | 2014 | BMC Pulm Med2014，14，： | 1 |
| 4 | Web services quality显示文摘 | Andreozzi S Montesi D Moretti R | 2003 | Proceedings of the International Conference on Computer Communication and Control Technologies(CCCT03) Orlando FL USA2003，7，3： | 1 |
| 5 | Detection of a circovirus-like agent from farmed pheasants in Italy显示文摘 | TERREGINO C MONTESI F MUTINELLI F | 2001 | Vet Rec2001，149，11： | 1 |
| 6 | Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era:a meta-analysis显示文摘 | Beitler JR Shaefi S Montesi SB | 2014 | European Journal of Intensive Care Medicine2014，40，3： | 1 |
| 7 | A survey on uncertainty management in data integration显示文摘 | Magnani M Montesi D | 2010 | Data and Information Quality2010，2，1： | 1 |
| 8 | Prone positioning reduces mortality from acute respiratory distress syn- drome in the low tidal volume era: a meta-analysis显示文摘 | Beitler JR Shaefi S Montesi SB | 2014 | In- tensive Care Med2014，40，3： | 1 |
| 9 | A framework for modeling and evaluating automatic se- mantic reconciliation 显示文摘 | Gal A Anaby-Tavor A Trombetta A Montesi D | 2003 | The VLDB Journal2003，14，1： | 1 |
| 10 | Transactions and updates in deductive databases显示文摘 | Montesi D Bertino E Martelli M | 1997 | IEEE Trans Knowl Data Eng1997，9，5： | 1 |
| 11 | Biomarkers of sleep apnea 显示文摘 | Montesi S B Bajwa E K Malhotra A | 2012 | Chest2012，142，1： | 1 |
| 12 | Mild cognitive im- pairment:epidemiology and dementia risk in an elderly I- talian population 显示文摘 | Ravaglia G Forti P Montesi F | 2008 | J Am Geriatr Soc2008，56，1： | 1 |
| 13 | Effect of hydroxyapatite nanocr3,stals functionalized with lactoferrin in osteogenic differentiation of mesenchymal stem cells 显示文摘 | Montesi M Paaseri S lafi sco M et aL | 2015 | J Biomed Mater Res A2015，103，1： | 1 |
| 14 | Cognitive impairment: epide- miology and dementia risk in an elderly Italian population 显示文摘 | Ravaglia G Forti P Montesi F | 2008 | J Am Geriatr Soc2008，56，1： | 1 |
| 15 | The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials显示文摘 | Montesi SB Edwards BA Malhotra A | 2012 | J Clin Sleep Med2012，8，5： | 1 |
| 16 | Insulin re- sistance: mechanism and implications for carcinogenesis and hepatocellular carcinoma in NASH 显示文摘 | Montesi L Mazzotti A Moscatiello S | 2013 | Hepatol Int2013，7，2： | 1 |
| 17 | Physical activity for the prevention and treatment of metabolic disorders显示文摘 | Luca Montesi Simona Moscatiello Marcella Malavolti Rebecca Marzocchi Giulio Marchesini | 2013 | Internal and Emergency Medicine2013，，8： | 1 |
| 18 | Termination Analysis in Active Databases显示文摘 | Danilo Montesi Maria Bagnato C ritina Dalleara | 1999 | IEEE1999，，： | 1 |
| 19 | Prone positioning re- duces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis显示文摘 | Beitler JR Shaefi S Montesi SB | 2014 | Intensive Care Med2014，40，3： | 1 |
| 20 | Management of Interval Probabilis-tic Data显示文摘 | Magnani M Montesi D | 2008 | Acta Informatica2008，45，2： | 1 |
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