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| 1 | Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage Ⅲ and Ⅳcolorectal cancer显示文摘AIM To evaluate the prognostic value of the neutrophil-tolymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with colorectal cancer(CRC).METHODS Between April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression models.RESULTS The median follow-up duration was 46 mo(interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR(≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. However, high NLR and high PLR were not prognostic factors in patients with stage Ⅰ and Ⅱ CRC.CONCLUSION In this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage Ⅲ and Ⅳ CRC. | Jae Hyun Kim Jun Yeop Lee Hae Koo Kim Jin Wook Lee Sung Gyu Jung Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2017 | World Journal of Gastroenterology2017，23，3： | 16 |
| 2 | Transparent-cap-fitted colonoscopy shows higher performance with cecal intubation time in difficult cases显示文摘AIM:To investigate the efficacy of cap-fitted colonoscopy(CFC) with regard to cecal intubation time.METHODS:Two hundred and ninety-five patients undergoing screening colonoscopy at Gospel Hospital,Kosin University College of Medicine were enrolled in this randomized controlled trial between January and December 2010.Colonoscopies were conducted by a single endoscopist.Patient characteristics including age,sex,body mass index,history of abdominal surgery,quality of preparation,and the presence of diverticulosis were recorded.RESULTS:One hundred and fifty patients were allocated into a CFC group and 145 into a non-CFC(NCF) group.Cecal intubations were achieved in all patients.Cecal intubation time in the CFC group was significantly shorter than in the NCF group for specific conditions:age ≥ 60 years,prior abdominal surgery,and poor bowel preparation.The number of detected adenomas was higher in the CFC group than in the NCF group(P = 0.040).CONCLUSION:CFC facilitated shortening of the cecal intubation time in difficult cases,and was more sensitive for detecting adenomas than was NCF. | Hyung Hun Kim Seun Ja Park Moo In Park Won Moon Sung Eun Kim | 2012 | World Journal of Gastroenterology2012，18，16： | 7 |
| 3 | Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy显示文摘AIM:To investigate the relationship between the function of vagus nerve and peptide YY 3-36 and ghrelin levels after subtotal gastrectomy.METHODS:We enrolled a total of 16 patients who underwent subtotal gastrectomy due to gastric cancer.All surgeries were performed by a single skilled surgeon.We measured peptide YY 3-36,ghrelin,leptin,insulin,growth hormone levels,and body weight immediately before and one month after surgery.RESULTS:Vagus nerve preservation group showed less body weight loss and less increase of peptide YY 3-36 compared with vagotomy group(-5.56 ± 2.24 kg vs-7.85 ± 1.57 kg,P = 0.037 and 0.06 ± 0.08 ng/mL vs 0.19 ± 0.12 ng/mL,P = 0.021,respectively).Moreover,patients with body weight loss of less than 10% exhibited reduced elevation of peptide YY 3-36 level,typically less than 20% [6(66.7%) vs 0(0.0%),P = 0.011,odd ratio = 3.333,95% confidence interval(1.293,8.591)].CONCLUSION:Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy,and this phenomenon may be related to the suppressed activity of peptide YY 3-36. | Hyung Hun Kim Moo In Park Sang Ho Lee Hyun Yong Hwang Sung Eun Kim Seun Ja Park Won Moon | 2012 | World Journal of Gastroenterology2012，18，30： | 6 |
| 4 | Serum prostate-specific antigen value adjusted for non-cancerous prostate tissue volume in patients undergoing radical prostatectomy: a new predictor of biochemical recurrence in localized or locally advanced prostate cancer显示文摘这研究的目的是调查为全部的肿瘤体积(PSA/tumor 体积) 调整的前列腺特定的抗原(PSA ) 价值和浆液 PSA 价值在激进的前列腺切除术以后作为病理学的调查结果和临床的结果的一个预言者为非癌的前列腺织物体积(NCPV )(PSA/NCPV ) 调整了的浆液的意义。407 个病人的临床、病理学的数据(中部的年龄:66.5 年;变化:41.8 鈥 ? 5.7 年) 回顾地被考察。中部的后续时期是 18.1 个月(范围:1.0 鈥 ? 07.8 个月) 。生物化学的复发被定义为可检测的 PSA 层次(比 0.2 ng ml 大 ? 1 ) 并且生物化学的复发的倍被花是第一次 PSA 变得可检测。在 multivariate 模型, PSA/NCPV 是囊外的扩展和积极外科的边缘的一个独立预言者(P < 0.05 ) ,但是 PSA/tumor 体积不。Kaplan 鈥揗e ier 曲线表明 PSA/NCPV 与生物化学的没有复发的幸存相关(P < 0.001;木头等级测试) 但是 PSA/tumor 体积(P=0.275;木头等级测试) 。PSA/NCPV 也是为 multivariate 考克斯上的生物化学的没有复发的幸存的一个重要独立预示的因素比例的危险分析(P=0.004,相对 risk=2.42 ) 。我们的调查结果建议 PSA/NCPV 与囊外的扩展和外科的边缘地位独立地被联系并且可以是在激进的前列腺切除术以后的 PSA 复发的一个独立预示的变量。 | Ja Hyeon Ku Kyung Chul Moon Sung Yong Cho Cheol Kwak Hyeon Hoe Kim | 2011 | Asian Journal of Andrology2011，13，2： | 3 |
| 5 | 利用杀菌剂防治松萎蔫病(英文)显示文摘松萎蔫病是一种非常复杂的病害。据报道,松材线虫(Bursaphelenchus xylophilus)及其携带的细菌诱导了该病,但是对于细菌的的作用尚存争议。笔者筛选出杀细菌剂进行了温室和林间防治松萎蔫病的实验。利用每株3年生赤松(Pinus densiflora)注射3mg的恶喹酸,松萎蔫病防效达到71%。利用恶喹酸或阿维菌素及两者混合物对大约20年生赤松的试验表明,3种处理均显示了很高的防效。以上结果证明伴生细菌是诱导松萎蔫病的必要因素,对松萎蔫病可利用杀细菌剂或杀细菌剂与杀线剂混合物进行防控。 | Jin-Cheol Kim Hyeok Ran Kwon Gyung Ja Choi Yong Ho Choi Kyoung Soo Jang Myung Soo Park Nack-Do Sung Mun Seong Kang Yilseong Moon Seung Kyu Lee | 2010 | 南京林业大学学报(自然科学版)2010，34，5： | 2 |
| 6 | Second-line bismuth-containing quadruple therapy for Helicobacter pylori eradication and impact of diabetes显示文摘AIM To investigate Helicobacter pylori (H. pylori) eradication rates using second-line bismuth-containing quadruple therapy and to identify predictors of eradication failure.METHODS This study included 636 patients who failed firstline triple therapy and received 7d of bismuthcontaining quadruple therapy between January 2005 and December 2015. We retrospectively demonstrated H. pylori eradication rates with respect to the year of therapy as well as demographic and clinical factors. H. pylori eradication was confirmed by a 13C-urea breath test or a rapid urease test at least 4 wk after the completion of bismuth-based quadruple therapy: proton pump inhibitor, metronidazole, bismuth, and tetracycline.RESULTS The overall eradication rates by intention-to-treat analysis and per-protocol analysis were 73.9%( 95% CI : 70.1 %- 77.4%) and 94.5% (95% CI : 92.4%-96.5%), respectively. Annual eradication rates from 2005 to 2015 were 100.0%, 92.9%, 100.0%, 100.0%, 100.0%, 97.4%, 100.0%, 93.8%, 84.4%, 98.9%, and 92.5%, respectively, by per-protocol analysis. A multivariate analysis showed that diabetes mellitus (OR=3.99, 95%CI: 1.56-10.20, P=0.004)was associated with H. pylori eradication therapy failure.CONCLUSION The second-line bismuth-containing quadruple therapy for H. pylori infection is still effective in Korea, and diabetes mellitus is suggested to be a risk factor for eradication failure. | Sung Eun Kim Moo In Park Seun Ja Park Won Moon Jae Hyun Kim Kyoungwon Jung Hae Koo Kim Young Dal Lee | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 7 | Early-stage primary signet ring cell carcinoma of the colon显示文摘Primary signet ring cell carcinoma of the colorectum detected at an early stage is very rare; most cases are detected at an advanced stage. Therefore, its progno-sis is poorer than that of ordinary colorectal cancer. A 56-year-old Korean man was seen at this hospital for management of signet ring cell carcinoma of the co-lon. Colonoscopic examination revealed a Ⅱa-like, ill-defined and flatly elevated 9-mm residual tumor in the cecum. Endoscopic mucosal resection was preformed. Pathological examination of the resected specimen re-vealed signet ring cell carcinoma that had invaded the lamina propria without venous or perineural invasion. Abdominal computed tomography (CT) and positron CT showed no evidence of primary lesions or distant me-tastasis. An additional laparoscopic right-hemicolectomy was performed; no residual tumor or lymph node me-tastasis was found. We report a case of primary signet ring cell carcinoma of the colon detected at an early stage and provide a review of the literature. | Jae Hyun Kim Seun Ja Park Moo In Park Won Moon Sung Eun Kim | 2013 | World Journal of Gastroenterology2013，19，24： | 2 |
| 8 | Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma显示文摘 | Ho Lee Kyung Ryoul Kim Sang Jae Noh Ho Sung Park Keun Sang Kwon Byung-Hyun Park Sung Hoo Jung Hyun Jo Youn Byoung Kil Lee Myoung Ja Chung Dai Ha Koh Woo Sung Moon Kyu Yun Jang | 2011 | Human Pathology2011，，2： | 2 |
| 9 | Effects of bamboo charcoal and bamboo vinegar as antibiotic alternatives on growth performance, immune responses and fecal microflora population in fattening pigs显示文摘 | Gyo Moon CHU Cheol Kyu JUNG Hoi Yun KIM Ji Hee HA Jong Hyun KIM Min Seob JUNG Shin Ja LEE Yuno SONG Rashid Ismael Hag IBRAHIM Jae Hyeon CHO Sung Sill LEE Young Min SONG | 2012 | Animal Science Journal2012，，2： | 2 |
| 10 | Factors Predictive of Adverse Events Following Endoscopic Papillary Large Balloon Dilation: Results from a Multicenter Series显示文摘 | Soo Jung Park Jin Hong Kim Jae Chul Hwang Ho Gak Kim Don Haeng Lee Seok Jeong Sang-Woo Cha Young Deok Cho Hong Ja Kim Jong Hyeok Kim Jong Ho Moon Sang-Heum Park Takao Itoi Hiroyuki Isayama Hirofumi Kogure Se Joon Lee Kyo Tae Jung Hye Sun Lee Todd H. Baron | 2013 | Digestive Diseases and Sciences2013，，4： | 2 |
| 11 | Missed synchronous gastric neoplasm with endoscopic submucosal dissection for gastric neoplasm: Experience in our hospital显示文摘 | Hyung Hun Kim Eun Ju Cho Eunji Noh Seok Reyol Choi Seun Ja Park Moo In Park Won Moon | 2012 | Digestive Endoscopy2012，，1： | 2 |
| 12 | Assessment of colon polyp morphology: Is education effective?显示文摘AIM To determine the inter-observer variability for colon polyp morphology and to identify whether education can improve agreement among observers.METHODS For purposes of the tests, we recorded colonoscopy video clips that included scenes visualizing the polyps. A total of 15 endoscopists and 15 nurses participated in the study. Participants watched 60 video clips of the polyp morphology scenes and then estimated polyp morphology(pre-test). After education for 20 min, participants performed a second test in which the order of 60 video clips was changed(post-test). To determine if the effectiveness of education was sustained, four months later, a third, follow-up test was performed with the same participants.RESULTS The overall Fleiss' kappa value of the inter-observer agreement was 0.510 in the pre-test, 0.618 in the post-test, and 0.580 in the follow-up test. The overall diagnostic accuracy of the estimation for polyp morphology in the pre-, post-, and follow-up tests was 0.662, 0.797, and 0.761, respectively. After education, the inter-observer agreement and diagnostic accuracy of all participants improved. However, after four months, the inter-observer agreement and diagnostic accuracy of expert groups were markedly decreased, and those of beginner and nurse groups remained similar to pre-test levels. CONCLUSION The education program used in this study can improve inter-observer agreement and diagnostic accuracy in assessing the morphology of colon polyps; it is especially effective when first learning endoscopy. | Jae Hyun Kim Kyoung Sik Nam Hye Jung Kwon Youn Jung Choi Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2017 | World Journal of Gastroenterology2017，23，34： | 2 |
| 13 | Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor -1 (Pref-1) 显示文摘 | Lee K Villena JA Moon YS | 2003 | J Clin Invest2003，111，： | 1 |
| 14 | Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolini- um cardiovascular magnetic resonance 显示文摘 | Moon JC McKenna WJ McCrohon JA | 2003 | J Am Coil Cardiol2003，41，： | 1 |
| 15 | thyroglobulin in washout fluid from lymph node fine-needle aspiration biopsy in papillary thyroid cancer: large-scale validation of the cutoff value to determine malignancy and evaluation of discrepant results 显示文摘 | Moon JH Kim YI Lim JA | 2013 | J Clin Endocrinol Metab2013，98，3： | 1 |
| 16 | Differentiation of heart failure related to dilated cardiomyopathy and coronary ar- tery disease using gadolinium-enhanced cardiovascular mag- netic resonance 显示文摘 | McCrohon JA Moon JC Prasad SK | 2003 | Circulation2003，108，： | 1 |
| 17 | Current status ofgene therapy for lung cancerand head-and-neck cancer显示文摘 | Moon C OhY Roth JA | 2003 | Clin Cancer Res2003，9，14： | 1 |
| 18 | Use of 3′-deoxy-3′-[18F]fluorothymidine PET to monitor early responses to radiation therapy in murine SCCVII tumors显示文摘 | You-Jung Yang Jin-Sook Ryu Seog-Young Kim Seung Jun Oh Ki Chun Im Heuiran Lee Sang-wook Lee Kyung Ja Cho Gi-Jeong Cheon Dae Hyuk Moon | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，4： | 1 |
| 19 | Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease显示文摘 | Kim SK Yoo JI Cho BK Hong SJ Kim YK Moon JA | 2003 | Stroke2003，34，12： | 1 |
| 20 | High-resolutionsonographic findings of ovarian granulosa cell tumors:correlation with pathologic findings显示文摘 | Kim JA Chun YK Moon MH | 2010 | Ultrasound Med2010，29，2： | 1 |
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