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| 1 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 2 | Osteoclastic and pleomorphic giant cell tumors of the pancreas:A review of clinical,endoscopic,and pathologic features显示文摘Giant cell tumors of the pancreas come in three varieties-osteoclastic,pleomorphic,and mixed histology.These tumors have distinctive endoscopic,clinical,and cytological features.Giant cell tumors have a controversial histogenesis,with some authors favoring an epithelial origin and others favoring a mesenchymal origin.The true origin of these lesions remains unclear at this time.These are also very rare tumors but proper identification and differentiation from more common pancreatic adenocarcinoma is important.The risk factors of these tumors and the prognosis may be different from those associated with standard pancreatic adenocarcinoma.Recognition of these differences can significantly affect patient care.These lesions have a unique appearance when imaged with endoscopic ultrasound(EUS),and these lesions can be diagnosed via EUS guided Fine Needle Aspiration(FNA).This manuscript will review the endoscopic,clinical,and pathologic features of these tumors. | Jill C Moore Joel S Bentz Kristen Hilden Douglas G Adler | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，1： | 7 |
| 3 | Neuromuscular electrical stimulation and testosterone did not influence heterotopic ossification size after spinal cor injury: A case series显示文摘Neuromuscular electrical stimulation(NMES) and testosterone replacement therapy(TRT) are effective rehabilitation strategies to attenuate muscle atrophy and evoke hypertrophy in persons with spinal cord injury(SCI). However both interventions might increase heterotopic ossification(HO) size in SCI patients. We present the results of two men with chronic traumatic motor complete SCI who also had pre-existing HO and participated in a study investigating the effects of TRT or TRT plus NMES resistance training(RT) on body composition. The 49-year-old male, Subject A, has unilateral HO in his right thigh. The 31-year-old male, Subject B, has bilateral HO in both thighs. Both participants wore transdermal testosterone patches(4-6 mg/d) daily for 16 wk. Subject A also underwent progressive NMES-RT twice weekly for 16 wk. Magnetic resonance imaging scans were acquired prior to and post intervention. Cross-sectional areas(CSA) of thewhole thigh and knee extensor skeletal muscles, femoral bone, and HO were measured. In Subject A(NMES-RT + TRT), the whole thigh skeletal muscle CSA increased by 10%, the knee extensor CSA increased by 17%, and the HO + femoral bone CSA did not change. In Subject B(TRT), the whole thigh skeletal muscle CSA increased by 13% in the right thigh and 6% in the left thigh. The knee extensor CSA increased by 7% in the right thigh and did not change in the left thigh. The femoral bone and HO CSAs in both thighs did not change. Both the TRT and NMES-RT + TRT protocols evoked muscle hypertrophy without stimulating the growth of preexisting HO. | Pamela D Moore Ashraf S Gorgey Rodney C Wade Refka E Khalil Timothy D Lavis Rehan Khan Robert A Adler | 2016 | World Journal of Clinical Cases2016，4，7： | 3 |
| 4 | Application of the cross wavelet transform and wavelet coherence to geophysical time series显示文摘 | Grinsted A. Moore J. C. Jevrejeva S | 2004 | Nonlinear Processes in Geophysics2004，，40： | 3 |
| 5 | , Performance of CrN/MoS2 (Ti) coatings for high wear low friction applications显示文摘 | Carrera S Salas O Moore J J | 2003 | Surface and Coatings Technology2003，167，： | 2 |
| 6 | Tip Clearance Flow in a Linear Turbine Cascade显示文摘 | Moore J Tilton J S | 1988 | ASME Journal of Turbomachinery1988，110，： | 2 |
| 7 | Moore TCP63 expression in conjunetival proliferative diseases: pterygium and laryngo-onyeho- cutaneous( LOC ) syndrome 显示文摘 | Atkinson SD Moore JE Shah S | 2008 | Curr Eye Res2008，33，7： | 1 |
| 8 | A fast string searching algorithm 显示文摘 | Boyer R S Moore J S | 1977 | Communications of the ACM1977，20，10： | 1 |
| 9 | Optimizing somatic embryo production in mango显示文摘 | DeWald S G Litz R E Moore G A | 1989 | Plant physiology and biochemistry1989，114，4： | 1 |
| 10 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 11 | Comparative physiology of Synechococcus and Prochlorococcus : Influence of light and temperature on growth, pigments, fluorescence and absorptive properties显示文摘 | MOORE L R GOERICKE R CHISHOLM S W | 1995 | Marine Ecology Progress Series1995，116，： | 1 |
| 12 | Wavelet denoising techniques with applications to experimental geophysical data 显示文摘 | To A C Moore J R Glaser S D | 2009 | Signal Processing2009，89，2： | 1 |
| 13 | Application of the cross wavelet transform and wavelet coherence to geophysical time series 显示文摘 | Grinsted A Moore J C Jevrejeva S | 2004 | Nonlin Proc Geophys2004，11，56： | 1 |
| 14 | A validation study of the adoles- cent risk-taking questionnaire 显示文摘 | Gullone E Paul J Moore S | 2000 | Behav Change2000，17，3： | 1 |
| 15 | Association between polysomnographic sleep measures and health-related quality of life in obstructive sleep apnea显示文摘 | Moore P Bardwell W A Ancoli-Israel S | 2001 | J Sleep Res2001，10，4： | 1 |
| 16 | prosthetic replacement for the management of unstable intertrochanterie hip frac tures in the elderly显示文摘 | Green S Moore T Proano FBipolar | 1987 | Clin Orthop1987，，224： | 1 |
| 17 | A genome-widesurvey of basic helix-loop-helix factors in Drosophila 显示文摘 | Moore AW Barbel S Jan LY | 2000 | Proc Natl Aead Sei2000，97，10： | 1 |
| 18 | A fast string seatching algorithm显示文摘 | Boyer R S Moore J S | 1977 | Commun ACM1977，20，10： | 1 |
| 19 | A fast string searching algorithm显示文摘 | Boyer R S Moore J S | 1997 | Communications of the ACM1997，20，10： | 1 |
| 20 | The development and application of genetic markers for the Kuruma prawn Penaeus japonicus显示文摘 | Moore S S Whan V Davis G P | 1999 | Aquaculture1999，173，14： | 1 |
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