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| 1 | 选择性CD_(34)^+细胞和非选择性自体外周血干细胞移植治疗多发性骨髓瘤的比较研究显示文摘目的 明确选择性CD3 4+ 细胞自体外周血干细胞移植 (APBSCT)治疗多发性骨髓瘤 (MM)的临床效果。方法 对 2 1例接受CD3 4+ 细胞APBSCT治疗的MM患者 (选择组 )和另外 2 1例接受非选择性APBSCT的MM患者 (对照组 )的造血恢复时间、有效率、生存率、移植相关不良反应、移植费用进行比较。两组病例在年龄、初诊时血清 β2 微球蛋白水平和移植时疾病状态均具有可比性 ,诱导治疗及预处理方案基本相同。结果 与对照组相比 ,选择组患者回输的CD3 4+ 细胞数显著偏低 [对照组和选择组分别为 9.4(1.1~ 15 .0 )× 10 6/kg和 2 .2 (0 .5~ 14.3)× 10 6/kg](P <0 .0 0 1) ,中性粒细胞恢复至≥ 0 .5× 10 9/L和血小板恢复至≥ 2 0× 10 9/L的中位时间 ,在选择组分别为 10d和 9d ,对照组分别为 9.5d(P=0 .35 7)和 4.5d(P =0 .0 0 5 )。两组的治疗有效率相似 (选择组 85 .7% ,对照组 90 .4% ) ,3年无病生存率 (选择组和对照组分别为 32 %和 39% )和总生存率 (选择组和对照组分别为 85 %和 79% )两组相比差异无显著性 ,而且使用非选择性APBSCT可明显降低移植费用。结论 选择性CD3 4+ 细胞APBSCT与非选择性APBSCT相比 ,并不能改善MM的临床治疗结果 ,而且移植费用更大。 | 唐晓文 N Morineau N Milpied P Moreau R Bataille JL Harousseau | 2001 | 中华血液学杂志2001，22，7： | 5 |
| 2 | Acute-on chronic liver failure显示文摘 | Rajiv Jalan Pere Gines Jody C Olson Rajeshwar P Mookerjee Richard Moreau Guadalupe Garcia-Tsao Vicente Arroyo Patrick S Kamath | 2012 | Journal of Hepatology2012，，6： | 4 |
| 3 | Low doses of dexamethasone decrease brain water content of collagenase-induced cerebral hematoma显示文摘 | Vachon P Moreau JP | 2003 | Can J Vet Res2003，67，2： | 1 |
| 4 | HLA- G gene polymorphism in human placentas: possible association of ^*0105 allele with preeclampsia and miscarriage显示文摘 | Moreau P Contu L Alba F | 2008 | Biol Reprod2008，79，3： | 1 |
| 5 | MRI diagnosis of cavernous sinus invasion by pituitary adenomas 显示文摘 | Moreau L Cottier JP Bertrand P | 1998 | J Radiol1998，79，： | 1 |
| 6 | Longitudinal study of bacterial,viral,and fungal infections in adult recipients of bone marrow transplants显示文摘 | Ninin E Milpied N Moreau P | 2001 | Clin Infect Dis2001，33，： | 1 |
| 7 | High- energy electron detection onboard DEMETER: The IDP spectrometer, description and first results on the inner belt显示文摘 | Sauvaud J A Moreau T Maggiolo R Treilhou J P Jacquey C Cros A Coutelier J Rouzaud J Penou E and Gangloff M | 2006 | Planetary and Space Science2006，54，5： | 1 |
| 8 | Subcutaneous versus in- travenous administration of bortezomib in patients with relapsed muhiple mycloma : A randomised, phase 3, non - inferiority study 显示文摘 | Moreau P Pylypenko H Grosicki S | 2011 | Lancet Oncol2011，12，5： | 1 |
| 9 | Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma(MM-003):a randomised,open-label,phase 3trial显示文摘 | San Miguel J Weisel K Moreau P | 2013 | Lancet Oncol2013，14，11： | 1 |
| 10 | Carfihomib and dexamethasone vs bortezomib and dexamethasone in patients with relapsed multiple myeloma: results of the phase 3 study endeavor ( NCT01568866 ) according to age subgroup 显示文摘 | Palumbo A Dimopoulos MA Moreau P | 2015 | Blood2015，126，23： | 1 |
| 11 | Polymers with alternating organosilicon and - conjugated units 显示文摘 | CHICHART P CORRIU R J P MOREAU J J E | 1991 | Chem Mater1991，3，： | 1 |
| 12 | Blood pressure and vascular effects of endot helin blockade in chronic nit ric oxide deficienthypertension显示文摘 | Moreau P Takase H Kung CF | 2007 | Hypertension2007，39，： | 1 |
| 13 | Ethylbenzene Isomer- ization over Bifunctional Platinum Alumina-EUO Catalysts: Location of the Active Sites 显示文摘 | Moreau F Moreau P Gnep N S | 2006 | Microporous Mesoporous Mater2006，90，13： | 1 |
| 14 | Genetic mapping of Ph-2 a single locus controlling partialres instance to phytoph- thora infestans in tomato 显示文摘 | Moreau P Thoquet P Olivier J | 1998 | Mol Plant Microb Interact1998，11，4： | 1 |
| 15 | Non- intentional doping in Sports显示文摘 | Yonamine M Rogrigues Garcia P Moraes Moreau R1 | 2004 | Sports Med2004，84，： | 1 |
| 16 | Recurrent 14q32 transloca- tions determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy 显示文摘 | Moreau P Facon T Leleu X | 2002 | Blood2002，100，5： | 1 |
| 17 | Acute - on - chronic liv-er failure is a distinct syndrome that develops in patients with acutedecompensation of cirrhosis显示文摘 | MOREAU R JALAN R GINES P | 2013 | Gastroenterology2013，144，7： | 1 |
| 18 | Workshop: excess growth and apoptosis: is hyper- tension a case of accelerated aging of cardiovascular cells? 显示文摘 | Hamet P Thorin-Trescases N Moreau P Dumas P Tea BS de- Blois D | 2001 | Hypertension2001，37，22： | 1 |
| 19 | The time window of apoptosis :a new component in the therapeutic strategy for cardiovascular remodling显示文摘 | Hamet P Moreau P Dam TV | 1996 | J Hypertetu1996，14，5： | 1 |
| 20 | Entrenched Knowledge Structures and ConsumerResponse to New Products显示文摘 | MOREAU C P LEHMANN D R MARKMAN AB | 2001 | Journal of MarketingResearch2001，38，1： | 1 |
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