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| 1 | Human NK cells: surface receptors, inhibitory checkpoints, and translational applications显示文摘NK cells play important roles in innate defenses against viruses and in the control of tumor growth and metastasis.The regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface receptors.In humans,major activating receptors involved in target cell killing are the natural cytotoxicity receptors(NCRs)and NKG2D.Activating receptors recognize ligands that are overexpressed or expressed de novo upon cell stress,viral infection,or tumor transformation.The HLA-class I-specific inhibitory receptors,including KIRs recognizing HLA-class I allotypic determinants and CD94/NKG2A recognizing the class-Ib HLA-E,constitute a fail-safe mechanism to avoid unwanted NK-mediated damage to healthy cells.Other receptors such as PD-1,primarily expressed by activated T lymphocytes,are important inhibitory checkpoints of immune responses that ensure T-cell tolerance.PD-1 also may be expressed by NK cells in cancer patients.Since PD-1 ligand(PD-L1)may be expressed by different tumors,PD-1/PD-L1 interactions inactivate both T and NK cells.Thus,the reliable evaluation of PD-L1 expression in tumors has become a major issue to select patients who may benefit from therapy with mAbs disrupting PD-1/PD-L1 interactions.Recently,NKG2A was revealed to be an important checkpoint controlling both NK and T-cell activation.Since most tumors express HLA-E,mAbs targeting NKG2A has been used alone or in combination with other therapeutic mAbs targeting PD-1 or tumor antigens(e.g.,EGFR),with encouraging results.The translational value of NK cells and their receptors is evidenced by the extraordinary therapeutic success of haploidentical HSCT to cure otherwise fatal high-risk leukemias. | Simona Sivori Paola Vacca Genny Del Zotto Enrico Munari Maria Cristina Mingari Lorenzo Moretta | 2019 | Cellular & Molecular Immunology2019，16，5： | 33 |
| 2 | Immunoregulatory func- tion of mesenchymal stem cells 显示文摘 | UCCELLI A MORETTA L PISTOIA V | 2006 | Eur J Immunol2006，36，10： | 1 |
| 3 | Surface NK receptors and their ligands on tumor cells显示文摘 | Moretta L Bottino C Pende D | 2006 | J Semin Immunol2006，18，3： | 1 |
| 4 | Mesenchymal stem cells in health and disease显示文摘 | Uccelli A Moretta L Pistoia V | 2008 | Nat Rev Immunol2008，8，9： | 1 |
| 5 | What is a natural killer cell显示文摘 | Moretta A Bottino C Mingari MC | 2002 | Nat Immunol2002，3，： | 1 |
| 6 | Hnman natural killer cells:their origin,receptors and function显示文摘 | Moretta L Bottino C Pende D | 2002 | Eur J Immunol2002，32，5： | 1 |
| 7 | Mesenchymal stem cells in health anddisease 显示文摘 | Uccelli A Moretta L Pistoia V | 2008 | Nat Rev Immunol2008，8，： | 1 |
| 8 | Mesenchymal stem cells: a new strategy for immunosuppression 显示文摘 | Uccelli A Pistoia V Moretta L | 2007 | Trends Immunol2007，28，5： | 1 |
| 9 | Innate or adaptive immu- nity? The example of natural killer cells 显示文摘 | Vivier E Raulet DH Moretta A | 2011 | Science2011，331，6013： | 1 |
| 10 | Existence of both inhibitory (P58) and activatory (P50) receptors for HLA-C molecules in human natural killer cells 显示文摘 | Sirori S Vitale M | 1995 | J Exp Med1995，182，3： | 1 |
| 11 | Effector and regulatory events during natural killer-dendritic cell interactions显示文摘 | Moretta L Ferlazzo G Bottino C | 2006 | Immunol Rev2006，214，： | 1 |
| 12 | Human cytolytic T lymphocytes expressing HLA class-I-specific inhibitory receptors显示文摘 | Mingari MC Pietra G Moretta L | 2005 | Curr Opin Immunol2005，17，3： | 1 |
| 13 | Human NK-cell receptors 显示文摘 | Moretta L Biassoni R Bottino C | 2000 | Immunol Today2000，21，9： | 1 |
| 14 | Mesenchymal stem ceils in health and disease显示文摘 | Uccelli A Moretta L Pistoia V | | 0，，09： | 1 |
| 15 | Immunoregulatory function of mesenchymal stem cells显示文摘 | Uccelli A Moretta L Pistoia V | | 0，，10： | 1 |
| 16 | Interaction of human mesenchymal stem cells with cells involved in al- loantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype显示文摘 | Maccario R Podesta M Moretta A | 2005 | Haematologica2005，90，4： | 1 |
| 17 | NK cells at the interfacebetween innate and adaptive immunity显示文摘 | Moretta A Marcenaro E Parolini S | 2008 | Cell Death Differ2008，15，2： | 1 |
| 18 | Interaction of human mes- enchymal stem cells with cells involved in alloantigen-specific im mune response, favors the differentiation of CD4 T-cell subsets ex- pressing a regulatory/suppressivephenotype显示文摘 | Maccario R Podest/ M Moretta A | 2005 | Haematologica2005，90，4： | 1 |
| 19 | Mesenchymal stem cells in health and disease 显示文摘 | Uccelli A Moretta L Pistoia V | 2008 | Nat Rev Immunol2008，8，9： | 1 |
| 20 | Immunoregulatory function of mesenchymal stem cells显示文摘 | Uccelli A Moretta L Pistoia V | | 0，，10： | 1 |
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