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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Partitioning evapotranspiration fluxes from a Colorado grassland using stable isotopes: Seasonal variations and ecosystem implications ofelevated atmospheric C02 显示文摘 | Ferretti DF Pendall E Morgan JA Nelson JA Lecain D Mosier AR | 2003 | Plant Soil2003，254，： | 1 |
| 3 | Pathophysiolo- gy of sleep apnea显示文摘 | Dempsey JA Veasey SC Morgan B J | 2010 | Physiol Rev2010，90，1： | 1 |
| 4 | High -dose chemotherapy with hematopietic stem - cell rescue for multiple myeloma 显示文摘 | Child JA Morgan GJ Davies FE | 2003 | N Engl J Med2003，348，19： | 1 |
| 5 | Current issues in gastrointestinal stromal tumors:incidence,molecular biology,and contemporary treatment of localized and advanced disease显示文摘 | Raut CP Morgan JA Ashley SW | 2007 | Curr Opin Gastroenterol2007，23，2： | 1 |
| 6 | A comparison of canal centering ability of four instrumentation techniques 显示文摘 | Short JA Morgan LA Baumgartner JC | 1997 | J Endod1997，23，： | 1 |
| 7 | The effect of soluble and insoluble-fibre supplementation on post-prandial glucose tolerance, insulin and gastric inhibitory polypeptide secretion in healthy subjects显示文摘 | Morgan LM Tredger JA Wright J | 1990 | Br J Nutr1990，64，1： | 1 |
| 8 | Periarticular raft con- structs and fracture stability in split-depression tibial plateau frac-tures显示文摘 | Cross WW 3rd Levy BA Morgan JA | 2013 | Injury2013，44，6： | 1 |
| 9 | Modifiable risk factors for colon cancer显示文摘 | Pavila JA Morgan RO Shaib Y | | 0，，04： | 1 |
| 10 | Periarticular raft constructs and fracture stability in split-depression tibial plateau fractures显示文摘 | Cross WW 3rd Levy BA Morgan JA | 2013 | Injury2013，44，6： | 1 |
| 11 | Diabetes increases the risk of hepatocellular carcinoma in the United States : a population based case control study 显示文摘 | Davila JA Morgan RO Shaib Y | 2005 | Gut2005，54，4： | 1 |
| 12 | Recovery of cellular functions following oxidant injury 显示文摘 | Novak G Aleo MD Morgan JA | 1998 | Am J Physiol Renal Physiol1998，274，3： | 1 |
| 13 | Diabetes increases the risk of hepatocellular carcinoma in the United States:a population based case control study显示文摘 | Davila JA Morgan RO Shaib Y | 2005 | Gut2005，54，4： | 1 |
| 14 | Apolipoprotein E affects the central nervous system response to injury and the devel- opment of cerebral edema 显示文摘 | Lynch JR Pineda JA Morgan D | 2002 | Ann Neurol2002，51，1： | 1 |
| 15 | Syndesmosis fixation: a comparison of three and four cortices of screw fixation without hardware removal 显示文摘 | Moore JA Jr Shank JR Morgan SJ | 2006 | Foot Ankle Int2006，27，8： | 1 |
| 16 | Differences in rat skeletal muscles after incline and decline running显示文摘 | Lynn R Talbot JA Morgan DL | 1998 | J Appl Physiol1998，85，1： | 1 |
| 17 | Diabetes increases the risk of hepatocellular carcinoma in the United States : a population based case control study 显示文摘 | Davila JA Morgan RO Shaib Y | 2005 | Gut2005，54，4： | 1 |
| 18 | Cunrrent issues ingastroin testinal stromal tumors: incidence, molecular biology, and contemporary treatment of localized and advanced disese显示文摘 | Rant CP Morgan JA Ashley SW | 2007 | Curr Opin Gastroentero2007，23，2： | 1 |
| 19 | Measurement reliability显示文摘 | Gliner JA Morgan GA Harmon RJ | 2001 | J Am Acad Child Adolesc Psychiatry2001，40，4： | 1 |
| 20 | Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study 显示文摘 | DAVILA JA MORGAN RO SHAIB Y | 2004 | Gastroenterology2004，127，5： | 1 |
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