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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Prostasome inhibit the nadph oxidase activity of human neutrophils显示文摘 | Saez F Motta C | 2000 | Molecular human reproduction2000，6，： | 1 |
| 3 | Outgrowth endothelial cells isolated and expanded from human peripheral blood progenitor cells as a potential source of autologous cells for endothelialization of silk fibroin biomaterials显示文摘 | FUNCHS S MOTTA A MIGLIARESI C | 2006 | Biomaterials2006，27，31： | 1 |
| 4 | Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 显示文摘 | Cosconati S Marinelli L La Motta C | 2009 | J Med Chem2009，52，18： | 1 |
| 5 | Robot calibration using a 3D vision-based measurement system with a single camera 显示文摘 | Motta J S T Guilherme C McMaster R | 2001 | Robotics and Computer Integrated Manufacturing2001，17，6： | 1 |
| 6 | Upstream mergers,downstream mergers,and secret vertical contracts显示文摘 | Fumagalli C Motta M | 2001 | Research in Economics2001，55，： | 1 |
| 7 | Newinsight on the so-lidification path ofan alloy 625 weld overlay显示文摘 | Silva C C Miranda H C D Motta M F | 2013 | Journal of Materi- als Research and Technology2013，2，3： | 1 |
| 8 | Sirtl regulates insulin secretion by repressing UCP2 in pancreatic β cells显示文摘 | BORDONE L MOTTA M C PICARD F | 2006 | Plos Biol2006，4，： | 1 |
| 9 | 显示文摘 | Motta A Fambri L Migliaresi C | 2002 | Macromol Chem Phys2002，203，： | 1 |
| 10 | Feeding mulberry leaves to fattening rabbits:effects on growth,carcass characteristics and meat quality显示文摘 | MARTINEZ M MOTTA W CERVERA C | 2005 | Journal of Animal Science2005，80，3： | 1 |
| 11 | Mast cell and dendritic cell-dericed exosomes display a specific lipid composition and unusual membrane organization 显示文摘 | Laulagnier K Motta C Hamdi S | 2004 | Biochem J2004，380，1： | 1 |
| 12 | Outgrowth endothelial cells isolated and expanded from human peripheral blood progenitor cells as a potential source of autologous cells for endothelialization of silk fibroin biomaterials显示文摘 | Fuchs S Motta A Migliaresi C Kirkpatrick CJ | 2005 | Biomaterials2005，27，31： | 1 |
| 13 | The impact of eyclooxygenase 2 and vascular endothelial growth factor C immunoexpression on the prognosis of penile carcinoma 显示文摘 | De Paula AA Motta ED Alencar Rde C | 2012 | J Urol2012，187，1： | 1 |
| 14 | Angiomyolipoma with minimal fat on MDCT= can counts of negative-attenuation pixels aid diagnosis? 显示文摘 | SIMPFENDORFER C HERTS BR MOTTA RAMIREZ GA | 2009 | AJR Am J Ro- entgenol2009，192，2： | 1 |
| 15 | Cellular automata with fuzzy parameters in microscopic study of positive HIV individuals显示文摘 | Motta Jafelice R Bechara B F Z Barros L C | 2009 | Mathematical and Computer Modelling2009，50，2： | 1 |
| 16 | Obstructive sleep and cardiac index 显示文摘 | Guilleminault C Motta J Mihm F | 1986 | Chest1986，89，： | 1 |
| 17 | Naphtho isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors显示文摘 | DA SETTIMO F PRIMOFIORE G LA MOTTA C | 2005 | J Med Chem2005，48，22： | 1 |
| 18 | Measuring Sustainable Income from Mineral Extraction in Brazil显示文摘 | Young C E F Ser6a da Motta R | 1995 | Resources Policy1995，21，2： | 1 |
| 19 | Evaluation of the normal and abnormal bicipital tendon with MR imaging显示文摘 | Cervilla V Motta A Ho C | 1990 | Radiolo gy1990，179，： | 1 |
| 20 | Absence of follicle-stimulating hormone receptor activating mutations in women with iatrogenic ovarian hyperstimulation syndrome 显示文摘 | Brasil Dr Alva C Serafini P Motta E | 2005 | FertilSteril2005，83，6： | 1 |
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