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| 1 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 2 | The treatment of black-odorous water using tower bipolar electro-flocculation including the removal of phosphorus,turbidity,sulfion,and oxygen enrichment显示文摘The large amount of municipal wastewater discharged into urban rivers sometimes exceeds the rivers’self-purification capacity leading to black-odorous polluted water.Electro-flocculation has emerged as a powerful remediation technology.Electro-flocculation in a bubble column tower with a bipolar electrode(BPE)was tested in an attempt to overcome the high resistance and weak gas-floatation observed with a monopolar electrode(MPE)in treating such water.The BPE reactor tested had a Ti/Ta2O_(5)-IrO_(2)anode and a graphite cathode with an iron or aluminum bipolar electrode suspended between them.It was tested for its ability to reduce turbidity,phosphate and sulphion and to increase the concentration of dissolved oxygen.The inclusion of the bipolar electrode was found to distinctly improved the system’s conductivity.The system’s electro-flocculation and electrical floatation removed turbidity,phosphate and sulphion completely,and the dissolved oxygen level improved from 0.29 to 6.28 mg/L.An aluminum bipolar electrode performed better than an iron one.Changes in the structure of the microbial community confirmed a significant improvement in water quality. | Huan He Qinjin Yu Chaochao Lai Chen Zhang Muhan Liu Bin Huang Hongping Pu Xuejun Pan | 2021 | Frontiers of Environmental Science & Engineering2021，15，2： | 5 |
| 3 | AI Enabled Wireless Communications with Real Channel Measurements:Channel Feedback显示文摘Artificial intelligence(AI)has shown great potential in wireless communications.AI-empowered communication algorithms have beaten many traditional algorithms through simulations.However,the existing works just use the simulated datasets to train and test the algorithms,which can not represent the power of AI in practical communication systems.Therefore,Peng Cheng Laboratory holds an AI competition,National Artificial Intelligence Competition(NAIC):AI+wireless communications,in which one of the topics is AI-empowered channel feedback system design using practical measurements.In this paper,we give a baseline neural network design,QuanCsiNet,for this competition,and the details of the channel measurements.QuanCsiNet shows excellent performance on channel feedback and the complexity of the neural networks is also given. | Jiajia Guo Xiangyi Li Muhan Chen Peiwen Jiang Tingting Yang Weiming Duan Haowen Wang Shi Jin Quan Yu | 2020 | Journal of Communications and Information Networks2020，5，3： | 2 |
| 4 | Post-mortem tissue proteomics reveals the pathogenesis of multi-organ injuries of COVID-19显示文摘Multi-organ injuries are a major complication of severe Coronavirus Disease 2019(COVID-19).However,its pathogenesis is barely understood.Herein;we profile host responses to fatal SARS-CoV-2 infection by performing quantitative proteomics of 19 post-mortem samples of 8 different organs or tissues,including lungs,liver,intestine,kidney;spleen,brain,heart and muscle,from 3 deceased COVID-19 victims during the first wave of the pandemic(Supplementary Fig.S1A and B,Tables SI-S3). | Yang Qiu Di Wu Wanshan Ning Jiqian Xu Ting Shu Muhan Huang Rong Chen Jiancheng Zhang Yang Han Qingyu Yang Ruiting Li Xiaobo Yang Yaxin Wang Xiaojing Zou Shangwen Pan Chaolin Huang Yu Xue You Shang Xi Zhou | 2021 | National Science Review2021，8，11： | 1 |
| 5 | Cooperative interactions among CTA^+, Br^-and Ag^+ during seeded growth of gold nanorods显示文摘我们在由第四级的铵卤化物和钠油酸盐(NaOL ) 组成的二进制表面活化剂混合物在 Au nanorods (AuNRs ) 的形成机制上执行了全面研究。我们在指导 AuNRs 的各向异性的生长作为关键成分识别 cetyltrimethyl 铵(CTA )-Br-Ag+ 建筑群。在我们推进的 CTA +, Br -和 Ag +,之中基于合作相互作用的改进理解乐意地表明那 AgBr ,它是由 cetyltrimethyl 铵溴化物( CTAB )或 cetyltrimethyl 铵氯化物( CTAC )的 solubilized 微粒,能为 AuNRs 的准备作为 Ag +和 Br -的联合来源被采用。高质量的 AuNRs 的生长能在极其低的溴化物内容(0.1 公里) 下面在 15 min 以内被完成。 | Yong Xu Lei Chen Xingchen Ye Xuchun Wang Jiaqi Yu Yang Zhao Muhan Cao Zhouhui Xia Baoquan Sun Qiao Zhang | 2017 | Nano Research2017，10，6： | 1 |
| 6 | New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine显示文摘Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic. | Hanli Xu Shuye Lin Ziyun Zhou Duoduo Li Xiting Zhang Muhan Yu Ruoyi Zhao Yiheng Wang Junru Qian Xinyi Li Bohan Li Chuhan Wei Keqiang Chen Teizo Yoshimura Ji Ming Wang Jiaqiang Huang | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 7 | Regulation of surface carbides on palladium nanocubes with zeolitic imidazolate frameworks for propyne selective hydrogenation显示文摘The selective hydrogenation of propyne to propylene has attracted great attention in chemical industry for removing trace amount of propyne for producing polymer-grade propylene. As the state-of-the-art catalyst, Pd suffers from the disadvantage of poor propylene selectivity due to the over-hydrogenation of propylene to propane. We here demonstrate that Pd nanocubes (NCs) coated by zeolitic imidazolate frameworks (i.e., Pd NCs@ZIF-8) can serve as highly active and selective catalysts for propyne selective hydrogenation (PSH). Benefitting from the unique properties and abundant groups of ZIF-8, Pd carbide (Pd-C) is formed on the surface of Pd NCs after thermal treatment, which acts the active sites for PSH to propylene. More importantly, the content of Pd-C can be precisely controlled by altering the calcination temperature without aggregation of Pd NCs and obvious changes in the framework of ZIF-8. The formation of Pd-C on Pd NCs@ZIF-8 can strongly suppress the H2 adsorption, and thus selectively catalyze propyne to propylene. Consequently, the optimized catalyst (i.e., Pd NCs@ZIF-8-100) exhibits a propylene selectivity of 96.4% at a propyne conversion of 93.3% at 35 °C and atmospheric pressure. This work may not only provide an efficient catalyst for PSH, but also shed a new light on the catalytic application of ZIFs. | Linzhong Wu Mingyu Chu Jin Gong Muhan Cao Yu Liu Yong Xu | 2021 | Nano Research2021，14，5： | 0 |
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