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| 1 | Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment显示文摘Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a signifi- cant correlation between hepatic steatosis, cardiovascu- lar disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to devel- op hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. There- fore, training programmes in internal medicine, gastroen- terology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and con- comittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging tech- niques and the readily available therapeutic options. | Tim CMA Schreuder Bart J Verwer Carin MJ van Nieuwkerk Chris JJ Mulder | 2008 | World Journal of Gastroenterology2008，14，16： | 35 |
| 2 | Auto immune hepatitis显示文摘To provide an update of the latest trends in epidemiology, clinical course, diagnostics, complications and treatment of auto immune hepatitis(AIH). A search ofthe MEDLINE database was performed using the search terms: 'auto immune hepatitis', 'clinical presentation', 'symptoms', 'signs', 'diagnosis', 'auto antibodies', 'laboratory values', 'serology', 'histopathology', ' h i s t o l o g y ', ' g e n e t i c s ', 'HLA g e n e s ', 'non-HLA genes', 'environment', 'epidemiology', 'prevalence', 'incidence', 'demographics', 'complications', 'HCC', 'PBC', 'PSC', 'corticosteroid', 'therapy', 'treatment', 'alternative treatment'. English-language full-text articles and abstracts were considered. Articles included reviews, meta-analysis, prospective retrospective studies. No publication date restrictions were applied. AIH is an immune meditated progressive inflammatory liver disease that predominantly affects middle-aged females but may affect people of all ages. The clinical spectrum of AIH is wide, ranging from absent or mild symptoms to fulminant hepatic failure. The aetiology of AIH is still unknown, but is believed to occur as the consequence of an aberrant immune response towards an un-known trigger in a genetically susceptible host. In the absence of a gold standard, diagnosis is based on the combination of clinical, biochemical and histopathological criteria. Immunosuppressive treatment has been the cornerstone of treatment since the earliest description of the disease in 1950 by Waldenstr?m. Such treatment is often successful at inducing remission and generally leads to normal life expectancy. Nevertheless, there remain significant areas of unmet aetiological a clinical needs including fundamental insight in disease pathogenesis, optimal therapy, duration of treatment and treatment alternatives in those patients unresponsive to standard treatment regimens. | nicole mf van gerven ynto s de boer chris jj mulder carin mj van nieuwkerk gerd bouma | 2016 | World Journal of Gastroenterology2016，22，19： | 3 |
| 3 | Pravastatin reduces restenosis two years after percutaneous transluminal coronary angioplasty(REGRESS trial)显示文摘 | Mulder HJ Bal ET Jukema JW Zwinderman AH Schalij MJ van Boven AJ | 2000 | Am J Cardiol2000，86，7： | 1 |
| 4 | Clinical outcome scoringof intra ~articular caleaneal fractures显示文摘 | Schepers J Heetveld MJ Mulder PG et a1 | | 0，，： | 1 |
| 5 | Efficient expansion of tumor-infiltrating lymphocytes from solid tumors by stimulation with combined CD3 and CD28 monoclonal antibodies显示文摘 | Mulder MJ Bril H | 1993 | Cancer Immunol Immunother1993，37，： | 1 |
| 6 | The incorporation of different demand concepts in the job demand-control model: effects on health care professionals显示文摘 | De Jonge J Mulder MJ Nijhuis FJ | 1999 | Soc Sci Med1999，48，9： | 1 |
| 7 | Photoacoustic imaging of port-wine stains显示文摘 | Kolkman RG Mulder MJ Glade CP | 2008 | Lasers Surg Med2008，40，3： | 1 |
| 8 | Right ventricular function declines after cardiac surgery in adult patients with congenital heart disease显示文摘 | Schuuring MJ Bolmers PP Mulder BJ | 2012 | Int J Cardiovasc Imaging2012，28，4： | 1 |
| 9 | Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function 显示文摘 | Osborne SE Walthers D Tomljenovic AM Mulder DT Silphaduang U Duong N Lowden MJ Wickham ME Waller RF Kenney LJ Coombes BK | 2009 | Proc Natl Acad Sci USA2009，106，10： | 1 |
| 10 | Motor imagery: the relation between age and imagery capacity 显示文摘 | Mulder T Hochstenbach JB van Heuvelen MJ | 2007 | Hum Mov Sci2007，26，2： | 1 |
| 11 | Patientpredictors foroutcome of gonadotrophin ovulation in-duction in women with normogonadotrophic anovulato-ry infertility:a meta-analysis显示文摘 | Mulders AG Laven JS Eijkemans MJ | 2003 | Hum Reprod Update2003，9，5： | 1 |
| 12 | Clinical outcome scoring of intra-articular calcaneal fractures显示文摘 | Schepers T Heetveld MJ Mulder DG | 2008 | J Foot Ankle Surg2008，47，3： | 1 |
| 13 | Preparation and stability of lipid - coated nanooapsules of cisplatin : anionic phospholipid speciflcity显示文摘 | Velinova MJ Staffhorst RW Mulder WJ | 2004 | Biochim Biophys Acta2004，1663，12： | 1 |
| 14 | Impact of influenza on mortality in relation to age and underlying disease,1967-1989显示文摘 | Mulder PG Beyer WE | 1993 | Int J Epidemiol1993，22，2： | 1 |
| 15 | Retrohyaloid premacular hemorrhage treated by Q-switched Nd- YAG laser 显示文摘 | Tassignon MJ Stempels N Van Mulders L | 1989 | Graefes Arch Clin Exp Ophthalmol1989，227，44： | 1 |
| 16 | Determination of the frequency of HLA antibody secreting B-lymphocytes in alloantigen sensitized individuals显示文摘 | Mulder A Kardol MJ Kamp J | 2001 | Clin Exp Immunol2001，124，1： | 1 |
| 17 | Changes in anti- Mtillerian hormone serum concentrations over time suggest delayed ovarian ageing in normogonadotrophic anovulatory infertility 显示文摘 | Mulders AG Laven JS Eijkemans MJ | 2004 | Hum Reprod2004，19，9： | 1 |
| 18 | Patient predictors for outcome of gonadotmphin ovulation induction in women with normogonadotrophic anovulatory infertility:a meta-analy- sis显示文摘 | Mulders AG Laven JS Eijkemans MJ | 2003 | Hum Reprod Update2003，9，5： | 1 |
| 19 | Clinical outcome scoring of intra articular calcaneal fracture 显示文摘 | Schepers J Heetveld MJ Mulder PG | 2008 | Journal of Foot & Ankle Surgery2008，47，3： | 1 |
| 20 | Clinical out- come scoring of intra-articuiar calcaneal fractures显示文摘 | Schepers J Heetveld MJ Mulder PG | 2008 | J Foot Ankle Surg2008，47，3： | 1 |
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