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| 1 | Effect of TGF-131 antisense oligodeoxynucleotide on renal function in chronic renal failure rats显示文摘目的:学习是调查转变生长因素( TGF )贝它 1 反的有效性的礼品的目的在改善察觉到 oligodeoxynucleotides ( ODN )在有 导致puromycin 的长期的肾衰竭( CRF )的老鼠的败坏的肾功能 .Methods :盐,嘌呤霉素,puromycin+TGF贝它 1 反感觉 ODN 或 puromycin+scrambled ODN 予被以单方地 nephrecto-mized 老鼠。肾的血液动力学、分泌的大小在经历了外科的 procedure.Results 的使麻木的老鼠被拿:在 CRF 老鼠,在肾的血流( RBF )有显著减小,这被观察, glomerular 率( GFR ),严重蛋白尿,并且几乎6褶层在控制老鼠作为与那相比增加了钠( FE Na^+)的部分排泄(所有 P < 0.05 )。在 CRF 老鼠,有 1 反察觉到的 TGF 贝它的处理,然而并非爬的 ODN,显著地稀释了 RBF, GFR,和蛋白尿的减小并且显著地阻止了 FE Na^+ 的增加,这进一步被观察(所有 P < 0.05 ) 。另外,在 CRF 的肾的肥大组织(P < 0.05 对非肾的失败控制) 是有 TGF-1 反感觉 ODN 的显著地稀释的术后疗法(P < 0.05 ) 。焦点的部分肾小球硬化症在未经治疗、爬的对待 ODN 的 CRF 组仅仅是明显的。这研究的有趣的观察在 CRF 老鼠是那,尽管有显著 attenuating 和TGF贝它的预防效果败坏的肾的功能上的 1 反感觉 ODN ,反感觉处理没在TGF贝它的肾的表示引起任何显著变化 1 在蛋白质 level.Conclusion :一起,获得的数据建议 1 反感觉 ODN 拥有的那TGF贝它在 导致puromycin 的长期的肾衰竭的有益的效果并且在形态学的恶化和处于这个病理学的状态的损害肾的功能部分地依赖于TGF贝它的行动 1 在肾以内。 | Law Chung HIONG Kiew Lik VOON Nor Azizan ABDULLAH Munavvar A SATTAR Nazarina Abdul RAHMAN Abdul Hye KHAN4, Edward James JOHNS | 2008 | Acta Pharmacologica Sinica2008，29，4： | 7 |
| 2 | Discrepancies in the clinical and radiological profiles of COVID-19:A case-based discussion and review of literature显示文摘The current gold standard for the diagnosis of coronavirus disease-19(COVID-19)is a positive reverse transcriptase polymerase chain reaction(RT-PCR)test,on the background of clinical suspicion.However,RT-PCR has its limitations;this includes issues of low sensitivity,sampling errors and appropriate timing of specimen collection.As pulmonary involvement is the most common manifestation of severe COVID-19,early and appropriate lung imaging is important to aid diagnosis.However,gross discrepancies can occur between the clinical and imaging findings in patients with COVID-19,which can mislead clinicians in their decision making.Although chest X-ray(CXR)has a low sensitivity for the diagnosis of COVID-19 associated lung disease,especially in the earlier stages,a positive CXR increases the pre-test probability of COVID-19.CXR scoring systems have shown to be useful,such as the COVID-19 opacification rating score which helps to predict the need of tracheal intubation.Furthermore,artificial intelligence-based algorithms have also shown promise in differentiating COVID-19 pneumonia on CXR from other lung diseases.Although costlier than CXR,unenhanced computed tomographic(CT)chest scans have a higher sensitivity,but lesser specificity compared to RT-PCR for the diagnosis of COVID-19 pneumonia.A semi-quantitative CT scoring system has been shown to predict short-term mortality.The routine use of CT pulmonary angiography as a first-line imaging modality in patients with suspected COVID-19 is not justifiable due to the risk of contrast nephropathy.Scoring systems similar to those pioneered in CXR and CT can be used to effectively plan and manage hospital resources such as ventilators.Lung ultrasound is useful in the assessment of critically ill COVID-19 patients in the hands of an experienced operator.Moreover,it is a convenient tool to monitor disease progression,as it is cheap,non-invasive,easily accessible and easy to sterilise.Newer lung imaging modalities such as magnetic resonance imaging(MRI)for safe imaging among children,adolescents and pregnant women are rapidly evolving.Imaging modalities are also essential for evaluating the extra-pulmonary manifestations of COVID-19:these include cranial imaging with CT or MRI;cardiac imaging with ultrasonography(US),CT and MRI;and abdominal imaging with US or CT.This review critically analyses the utility of each imaging modality to empower clinicians to use them appropriately in the management of patients with COVID-19 infection. | Hemant Kumar Cornelius James Fernandez Sangeetha Kolpattil Mohamed Munavvar Joseph M Pappachan | 2021 | World Journal of Radiology2021，13，4： | 2 |
| 3 | The autoclavabte semirigid thoracoscope: the way forward in pleural disease 显示文摘 | Munavvar M Khan MA Edwards J | 2007 | Eur Respir J2007，29，3： | 1 |
| 4 | Hydrogen sulphide and tempol treatments improve the blood pressure and renal excretory responses in spontaneously hypertensive rats显示文摘 | Fiaz ud din Ahmad Munavvar A. Sattar Hassaan A. Rathore Yong Chia Tan Safia Akhtar Oh Hui Jin Yen Pei Pei Nor A. Abdullah Edward J. Johns | 2014 | Renal Failure2014，，： | 1 |
| 5 | The autodavable semirigid thoracoscope:the way forward in pleural disesese显示文摘 | Munavvar M Khan MA Edwards J | | Eur Hespir J0，29，3： | 1 |
| 6 | The autoclavable semirigid thoacoscope:the way forward in pleural disease显示文摘 | Munavvar M Khan MA Edwards J | | 0，，02： | 1 |
| 7 | Theautoclavable semirigth- oracoscope:the way forward in pleural disease 显示文摘 | Munavvar M Khan MA Edwards J | 2007 | Eur Respir J2007，29，3： | 1 |
| 8 | Effect of antisense oliqodeoxynucleotides for ICAM-1 on renal ischaemia-reperfusion injury in the anaesthetised rat显示文摘 | Kiew LV Munavvar AS Law CH | 2004 | J Physiol2004，5573，： | 1 |
| 9 | Effect of antisense oligodeoxynucleotides for ICAM-1 on renal ischaemiareperfusion injury in the anaesthetised rat 显示文摘 | Kiew L V Munavvar A S Law C H | 2004 | Physiology2004，557，3： | 1 |
| 10 | Investigation of the patient with pleural effusion显示文摘 | RAHMAN NM MUNAVVAR M | | 0，，02： | 1 |
| 11 | Pulmonary tuberculosis presenting with central retinal vein occlusion显示文摘 | Fullerton DG Shrivastava A Munavvar M | 2007 | Br J Ophthalmol2007，91，： | 1 |
| 12 | The autoclavable semirigid thoracoscope: theway forward in pleural disease显示文摘 | Munavvar M Khan MA Edwards J | 2007 | Eur Respir J2007，29，3： | 1 |
| 13 | The auto clavable semirigid thoracoscope: the way forward in pleural disease? 显示文摘 | MUNAVVAR M KHAN MA EDWARDS J | 2007 | Eur Respir J2007，29，3： | 1 |
| 14 | Theautoclavable semi- rigthoracoscope: the way forward in pleural disease显示文摘 | Munavvar M Khan MA Edwards J | 2007 | Eur Re- spirJ2007，29，3： | 1 |
| 15 | The autociavablesemi- rigid thoracoscope: the way forward in pleural disease 显示文摘 | Munavvar M Khan MA Edwards J et ai | 2007 | Eur Respir J2007，29，3： | 1 |
| 16 | Functional subtypes of renal α1-adrenoceptor in diabetic and non-diabetic 2KIC Goldblatt renovascular hypertension显示文摘目的:这研究调查在 导致streptozotocin 的糖尿病、非糖尿病的2肾的 导致adrenergically 的肾的血管收缩的回答抓紧的调停的 alpha_1-adrenoceptor 的子类型( 2K1C ) Goldblatt 高血压的 rats.Methods :对肾的神经刺激的肾的血流回答,也不肾上腺素,脱羟肾上腺素,并且美速胺在 nitrendipine , 5-methylurapidil , chloroethylclonidine 和 BMY 7378 .Results 的缺席和存在被测量:肾的血管收缩的回答被 nitrendipine 和 5-methylurapidil 显著地在糖尿病的老鼠稀释(所有 P < 0.05 )。在非糖尿病的老鼠,这些回答被 nitrendipine, 5-methylurapidil,和 BMY 7378 显著地稀释(所有 P < 0.05 ) 。在两个试验性的组, chloroethylclonidine 显著地加重了所有肾上腺素能的刺激引起的肾的血管缩小(所有 P < 0.05 ).Conclusion : 这些观察显示 alpha_(1A )-adrenoceptor 子类型在调停起一个主要作用在糖尿病的 2K1C Goldblatt 高血压的老鼠的导致 adrenergically 的肾的血管缩小。在非糖尿病的 2K1C, Goldblatt 高血压的老鼠, alpha_(1A ) 的贡献和 alpha_(1D )-adrenoceptor 子类型被建议。除了 post-synaptic alpha_1 adrenoceptors,两个在糖尿病、非糖尿病的 2K1C Goldblatt 高血压的老鼠, presynaptic alpha_1 adrenoceptors 的潜在的参与也被建议。 | A ARMENIA Munavvar Abdul SATTAR Nor Azizan ABDULLAH Md Abdul Hye KHAN Edward James JOHNS | 2008 | Acta Pharmacologica Sinica2008，29，5： | 0 |
| 17 | α1B-Adrenoceptors mediate adrenergically-induced renal vasoconstrictions in rats with renal impairment显示文摘这研究检验了alpha_( 1B ) -adrenoceptors 是否涉及调停在有 pathophysiological 和正常生理的 states.Methods 的老鼠的 导致adrenergically 的肾的血管收缩的回答:男 Wistar 京都和自发地高血压的老鼠被 cisplatin 或 streptozotocin 与尖锐肾衰竭或试验性的早糖尿病的肾病导致, 导致respectively.Cisplatin 的肾衰竭被损害肾的功能和显著管状的损坏证实。试验性的早糖尿病的肾病被多糖症,在生理的参数的变化,和肾的功能证实。血液动力学的学习在 cisplatin (肾衰竭)和 4 星期 streptozotocin (试验性的早糖尿病的肾病)的 7 d 以后在 anesthetized 老鼠上被进行 .Results :在有肾衰竭和试验性的早糖尿病的肾病的老鼠,在他们的基线有显著减小肾的血流( P < 0.01 )。基线意味着动脉的血压未改变或更低(所有 P > 0.05 ) 分别地,作为与他们的非肾的失败和非糖尿病的肾病相比在肾衰竭和试验性的早糖尿病的肾病老鼠控制。在有肾的缺陷的老鼠, chloroethylclonidine 引起了加重或变细(所有 P < 0.01 ) 肾上腺素能的刺激得到的肾的血管收缩的回答。在非肾的失败并且在非糖尿病的肾病老鼠,然而, chloroethylclonidine 没在如此的回答引起任何改变( P > 0.05 ) .Conclusion :这研究表明了功能的alpha_( 1B )的存在调停的 -adrenoceptors 在有肾的缺陷的老鼠的 导致adrenergically 的肾的血管缩小,然而并非在有正常的老鼠肾的功能。 | Md Abdul Hye KHAN Munavvar Abdul SATTAR Nor Azizan ABDULLAH Edward James JOHNS | 2008 | Acta Pharmacologica Sinica2008，29，2： | 0 |
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