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| 1 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 2 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 3 | Association of homocysteine and smoking with cerebral microemboli in patients with mechanical heart valves:a transcranial Doppler study显示文摘Objectives Microembolic signals(MES)on transcranial Doppler(TCD)predict stroke and cognitive decline.Plasma levels of total homocysteine(tHcy),a prothrombotic factor,are higher in patients with microemboli in carotid stenosis and in patients with paradoxical embolism.In this study we assessed the association between the level of tHcy and the number of MES in patients with mechanical heart valves(MHVs).Methods TCD monitoring was performed to detect MES before and after breathing 100% oxygen and repeated every 2-4 weeks up to six times.results Twenty-five patients with MHVs(mean age:63.60±10.15 years)participated in this study;15 were men(66.47±7.25 years)and 10 were women(59.30±12.60 years).In total,there were 126 study visits.In multiple regression,higher tHcy was associated with more MES in both preoxygenation(OR 1.34(95%CI 1.07 to 1.68,P=0.009))and postoxygenation(OR 1.40(95% CI 1.07 to 1.83,P=0.01))phases.Current smoking and the length of time between the operation and monitoring also correlated with a higher number of MES before and after breathing oxygen,particularly in women.conclusions Higher tHcy and smoking were associated with a higher MES count in both preoxygenation and postoxygenation phases.Because smoking can be stopped and hyperhomocysteinaemia is treatable,these are clinically important findings. | Alicia Mattia M Reza Azarpazhooh Claudio Munoz Chrysi Bogiatzi Mackenzie A Quantz J David Spence | 2017 | Stroke & Vascular Neurology2017，2，4： | 2 |
| 4 | Ethanol improves lipase immobilization on a hydrophobic support 显示文摘 | BLANCO R M TERREROS P MUNOZ N | 2007 | Journal Molecular Catalysis B: Enzymatic2007，47，12： | 1 |
| 5 | Domain wall scattering explains 300% ballistic magnetoresistance of nanocontacts显示文摘 | Tatara G Zhao Y W Munoz M | 1999 | Phys Rev Lett1999，83，10： | 1 |
| 6 | Continuous aspiration of subglottic secretions in the prevention of ventilator- associated pneumonia in the postoperative period of major heart surgery 显示文摘 | Bouza E Jesu is M PerezRN Patricia Munoz | 2008 | Chest2008，134，5： | 1 |
| 7 | The role of a dechlorinated PVC as compatibiliser for PVC/polyethylene blends显示文摘 | A Zarraga M E Munoz J J Pena | 2002 | Polymer Bulletin2002，，3： | 1 |
| 8 | Hilbert-Huang adysis of BWR neutron detector signals: Application to DR calculation and to corrupted signal analysis显示文摘 | Montesinos M E Munoz - Cobo L Perez C | 2003 | Annals of Nuclear Energy2003，30，： | 1 |
| 9 | Proliferation activety and steroid hormone receptor status in male breast carcinoma显示文摘 | Munoz D E Toro M M Maffini M V | 1998 | J Steroid Biochem Mol Boil1998，67，4： | 1 |
| 10 | Scent of dying cell:The role of attraction signals in the clearance of apoptotic cells and its immunological consequences显示文摘 | Munoz LE Peter C Herrman M | 2010 | Autoimmun Rev2010，9，6： | 1 |
| 11 | The role of tumour necrosis factor,interleukin 6, interferon γ and inducible nitric oxide synthase in the development and pathology of the nervous system显示文摘 | Munoz Femandez M A Fresn M | 1998 | Prog Neurobiol1998，56，3： | 1 |
| 12 | Complex magnetism and magnetic structures of the metastable HoMnO3 perovskite显示文摘 | Munoz A Casals M T Alonso J A | 2001 | Inorg Chem2001，40，： | 1 |
| 13 | Effects of thin-layer boilover on flame geometry and dynamics in large hydrocarbon pool fires 显示文摘 | Ferrero F Munoz M Arealdos J | 2007 | Fuel Processing Technology2007，88，： | 1 |
| 14 | Recognition and management of he-reditary colorectal cancer syndromes 显示文摘 | Herraiz M Munoz - Navas M | 2009 | Rev Esp Enferm Dig2009，101，2： | 1 |
| 15 | Patients with pertrochanteric hip fracture may benefit fron preoperative intravenous iron therapy: a pilot study 显示文摘 | Cuenca J Garcia Erce JA Munoz M | 2004 | Transfusion2004，44，： | 1 |
| 16 | Ki- netic studies on the interactions of heparin and complement proteins using surface plasmon reso- nance显示文摘 | YU H MUNOZ E M EDENS R E | 2005 | Biochim Biophys Acta2005，1726，2： | 1 |
| 17 | Determination of organic acids in grape musts, wines and vinegars by high performance liquid-chromatography显示文摘 | ROMERO E G MUNOZ G S ALVAREZ P J M | 1993 | Journal of Chromatography A1993，655，1： | 1 |
| 18 | Factors mediating the hemodynamic effects of tumor necrosis faetor-α in portal hypertensive rats显示文摘 | Munoz J Albillos A Perez-Paramo M | 1999 | Am J Physial Gastrointest Liver Physiol1999，276，3： | 1 |
| 19 | Neonatal hypoxie-isehemie encephalopathy and total-body eooling显示文摘 | Munoz M Kerrigan JF | 2010 | Semin Pediatr Neurol2010，17，1： | 1 |
| 20 | The mitotic serine threonine kinase, Aurora 2, is a potential target for drug development in human pancreatic cancer显示文摘 | ROJANALA S HAN H MUNOZ R M | 2004 | Mol Cancer Ther2004，3，4： | 1 |
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