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| 1 | Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?显示文摘AIM:To evaluate the red cell distribution width(RDW)as an indicator of the presence of non-alcoholic steatohepatitis(NASH)and its association with fibrotic scores.METHODS:A retrospective study was carried out that included sixty-two biopsy proven NASH,32 simple steatosis patients and 30 healthy controls.The correlation between the clinical and histopathological features of NASH patients and RDW values was evaluated.Liver fibrosis scores were measured using a 0 to 4 point scale and were divided in to two groups;fibrosis scores0-1 were termed mild and fibrosis scores 2-4 were termed advanced fibrosis.RDW values were compared between NASH,simple steatosis and healthy controls.Univariate and multivariate analyses were performed to evaluate the independent predicting factors for the presence of liver fibrosis caused by NASH.RESULTS:Patients with NASH had higher RDW values compared with simple steatosis and healthy control groups[14.28%±0.25%vs 13.37%±0.12%,12.96%±0.14%(P<0.01),respectively].Patients with advanced fibrosis had higher RDW values than the mild fibrosis group(15.86%±0.4%vs 13.63%±0.67%,P<0.01,respectively).RDW also correlated with fibrotic scores(r=0.579 andP<0.01).The variables that were significant in the univariate analysis were evaluated in multivariate logistic regression analysis,and RDW was an independent predicting factor of NASH(OR=1.75,95%CI:1.129-2.711,P<0.05).CONCLUSION:RDW a new non-invasive marker that can be used to demonstrate the presence of NASH and indicate advanced fibrotic scores. | Mustafa Cengiz Burcu Aslan Candir Güldal Yilmaz Gülen Akyol Seren Ozenirler | 2013 | World Journal of Gastroenterology2013，19，42： | 8 |
| 2 | Analysis of serum antibody profile against H pylori VacA and CagA antigens in Turkish patients with duodenal ulcer显示文摘AIM: To investigate the frequency of seropositivity aga- inst CagA, VacA proteins and to determine their indepen- dent effects on the development of duodenal ulcer (DU) in Turkish patients. METHODS: The study was designed as a prospective one from a tertiary referral hospital. Dyspeptic patients who were referred to our endoscopy unit for upper gas- trointestinal endoscopy between June 2003 and March 2004 and diagnosed to have DU or nonulcer dyspepsia (NUD) were included. Biopsies from the antrum and body of the stomach were taken in order to assess the current H pylori status by histology, rapid urease test and culture. Fasting sera were obtained from all patients and H pylori status of all sera was determined by IgG antibo- dies using an enzyme-linked immunosorbent assay (ELI- SA) kit. All seropositive patients were further analysed using Western blot assays detecting IgG antibodies aga- inst CagA and VacA proteins. The χ2 test was used for statistical comparison of the values and age-sex adjusted multiple regression analysis was used to determine the independent effects of CagA and VacA seropositivities on the development of DU. RESULTS: Sixty-three patients with DU and 62 patients with NUD were eligible for the final analysis. Seropositi- vity for anti-CagA was detected in 51 of 62 (82%), andin 55 of 63 (87%) patients with NUD and DU, respec- tively (p = no significance), and seropositivity for anti- VacA was found in 25 of 62 (40% ) and in 16 of 63 (25%) patients, with NUD and DU, respectively. CONCLUSION: These findings suggest that none of the- se virulence factors is associated with the development of DU in the studied Turkish patients with dyspepsia. | Yusuf Erzin Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Ahmet Dirican Murat Tuncer Bekir Kocazeybek | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 3 | Isolation and diagnosis of Helicobacter pylori by a new method: Microcapillary culture显示文摘AIM:To investigate the performance of the microcapillary culture method(MCM) in Helicobacter pylori(H.pylori) isolation and diagnosis.METHODS:Microcapillary culture(MC),classical culture(CC),rapid urease(CLO) test,and histopathologic examination(HE) were performed with biopsy samples.Homogenized biopsy samples were loaded into capillary tubes and incubated for 48 h at 37 ℃ without providing a microaerophilic environment.Additionally,three or four loops of the homogenized sample were inoculated in a ready-to-use selective medium(Becton Dickinson,Helicobacter Agar,Modified) specific for the isolation of H.pylori and incubated at 37 ℃ in a microaerophilic atmosphere provided by Campy Gen(Becton Dickinson,Gas Pack).Bacteria reproducing in microcapillary tubes were evaluated in an inverted microscope and also were evaluated after performing a CC with the content.Results obtained by CC,CLO test,and HE were compared with those of MC.The diagnostic performances of the methods used in this study were evaluated for specificity,sensitivity,positive predictive value(PPV),negative predictive value(NPV),and CI.RESULTS:H.pylori was found positive by CLO test +HE and/or CC culture in 26 patient antrum and corpus biopsy samples.In 25(25/26) patient biopsy samples,H.pylori was isolated by MCM,whereas in only 14(14/26) patient biopsy samples,H.pylori was isolatedby CC.CLO test and HE were found positive in 17(17/26) patient biopsy samples.Comparing the results of the isolation of H.pylori by MCM,CC,CLO test,and HE,the sensitivity of the MCM was found as 96%,the specificity as 80%,the PPV as 83%,the NPV as 95%,and the 95%CI as 0.76(χ2 =31.51,P < 0.01) whereas the sensitivity of the CC was found as 54%(χ2 =19.15,P < 0.01),and the sensitivity of the CLO test and HE were found as 65%(χ2 =25.26,P < 0.01).CONCLUSION:This new microcapillary cultivation method for H.pylori has high diagnostic sensitivity compared with CC,HE,and CLO tests. | Adil M Allahverdiyev Melahat Bagirova Reyhan Caliskan Hrisi Bahar Tokman Hayat Aliyeva Gokce Unal Olga Nehir Oztel Emrah Sefik Abamor Hilal Toptas Pelin Yuksel Fatma Kalayci Mustafa Aslan Yusuf Erzin Kadir Bal Bekir S Kocazeybek | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 4 | Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay- directed fractionation techniques显示文摘 | Ekrem Sezik Mustafa Aslan Erdem Yesilada Shigeru Ito | 2004 | Life Sciences2004，，11： | 2 |
| 5 | Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle显示文摘 | Didem Deliorman Orhan Mustafa Aslan G?knur Aktay Ender Ergun Erdem Yesilada Fatma Ergun | 2003 | Life Sciences2003，，20： | 2 |
| 6 | Role of host interleukin 1β gene ( IL-1B ) and interleukin 1 receptor antagonist gene ( IL-1RN ) polymorphisms in clinical outcomes in Helicobacter pylori -positive Turkish patients with dyspepsia显示文摘 | Yusuf Erzin Vedat Koksal Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Süha Goksel Ahmet Dirican Bekir Kocazeybek | 2008 | Journal of Gastroenterology2008，，9： | 1 |
| 7 | The impact responses and the finite element modeling of layered trapezoidal corrugated aluminum core and aluminum sheet interlayer sandwich structures显示文摘 | Cenk K?l??aslan Mustafa Güden ?smet Kutlay Odac? Alper Ta?demirci | 2013 | Materials and Design2013，，： | 1 |
| 8 | Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle显示文摘 | Didem Deliorman Orhan Mustafa Aslan G?knur Aktay Ender Ergun Erdem Yesilada Fatma Ergun | 2003 | Life Sciences2003，，20： | 1 |
| 9 | In vivo antidiabetic and antioxidant potential of Helichrysum plicatum ssp. plicatum capitulums in streptozotocin-induced-diabetic rats显示文摘 | Mustafa Aslan Didem Deliorman Orhan Nilüfer Orhan Ekrem Sezik Erdem Yesilada | 2006 | Journal of Ethnopharmacology2006，，1： | 1 |
| 10 | Role of host interleukin 1β gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia显示文摘 | Yusuf Erzin Vedat Koksal Sibel Altun Ahmet Dobrucali Mustafa Aslan Sibel Erdamar Süha Goksel Ahmet Dirican Bekir Kocazeybek | 2008 | Journal of Gastroenterology2008，，9： | 1 |
| 11 | Comparative evaluation of the flavonoid content in officinal Tiliae flos and Turkish lime species for quality assessment显示文摘 | Gulnur Toker Mustafa Aslan Erdem Yesilada | 2001 | Journal of Pharmaceutical and Biomedical Analysis2001，26，： | 1 |
| 12 | Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes显示文摘 | Mustafa Aslan Nilüfer Orhan Didem Deliorman Orhan Fatma Ergun | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
| 13 | Parathyroid adenoma screening efficacies of different imaging tools and factors affecting the success rates显示文摘 | Erman Cakal Evrim Cakir Alper Dilli Nujen Colak Ilknur Unsal Müyesser Sayki Aslan Basak Karbek Mustafa Ozbek Mehmet Kilic Tuncay Delibasi Mustafa Sahin | 2012 | Clinical Imaging2012，，6： | 1 |
| 14 | The detection of occult HBV infection in patients with HBsAg negative pattern by real-time PCR method显示文摘 | Sena Izmirli Deniz Gozde Celik Pelin Yuksel Suat Saribas Mustafa Aslan Sevgi Ergin Hrisi Bahar Sümeyye Sen Bulent Cakal Ali Oner Bekir Kocazeybek | 2012 | Transfusion and Apheresis Science2012，，3： | 1 |
| 15 | Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants显示文摘 | Ilkay Orhan Mustafa Aslan | 2009 | Journal of Ethnopharmacology2009，，2： | 1 |
| 16 | Experimental investigation of the effect of cutting tool rake angle on main cutting force显示文摘 | Mustafa Günay ?hsan Korkut Ersan Aslan Ulvi ?eker | 2004 | Journal of Materials Processing Tech2004，，1： | 1 |
| 17 | Tu1496 Cold SNARE Polypectomy Versus Standard SNARE Polypectomy in Endoscopic Treatment of Small Polyps显示文摘 | Fatih Aslan Emrah Alper Sezgin Vatansever Zehra Akpinar Mehmet Camci Mahmut Arabul Mustafa Celik Altay Kandemir Serkan Ipek Huseyin Sinan Akay Belkis Unsal | 2013 | Gastrointestinal Endoscopy2013，，5： | 1 |
| 18 | Is peritoneal drainage necessary in childhood perforated appendicitis?—A comparative study显示文摘 | Adnan Narc? ?brahim Karaman Ay?e Karaman Derya Erdo?an Yusuf Hakan ?avu?o?lu Mustafa Kemal Aslan ?zden ?akmak | 2007 | Journal of Pediatric Surgery2007，，11： | 1 |
| 19 | Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used显示文摘 | Hatice Celik Sevim Aslan Felek Ahmet Islam Mustafa A. Safak Necmi Arslan Hakan Gocmen | 2008 | Acta Oto-Laryngologica2008，，12： | 1 |
| 20 | Hypoglycemic activity and antioxidant potential of some medicinal plants traditionally used in Turkey for diabetes显示文摘 | Mustafa Aslan Nilüfer Orhan Didem Deliorman Orhan Fatma Ergun | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
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