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| 1 | Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats显示文摘AIM: To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats.METHODS: Ninety male Wistar rats were randomly divided into five groups: Ⅰ (n = 10): controls, Ⅱ (n =20): sham operated, Ⅲ (n = 20): partial hepatectomy 70% (PHx), Ⅳ (n = 20): PHx+BBS (30 μg/kg/d), Ⅴ (n= 20): PHx+NT (300 μg/kg/d). Groups Ⅳ and Ⅴ were treated for 8 days before PHx and 48 h post surgery.At the end of the experiment, on day 10, intestinal barrier function was assessed by measuring endotoxin concentrations in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and villus density, mucosal thickness, mitotic activity and apoptosis in crypts were assessed. In addition, ileal mucosa was analyzed for DNA and protein content and microbiological analysis was performed in cecal contents.To estimate intestinal oxidative stress, lipid peroxidation was determined on tissue homogenates from terminal ileum.RESULTS: BBS or NT administration significantly reduced portal and systemic endotoxemia observed 48 h after partial hepatectomy. In hepatectomized rats (group Ⅲ), a trend towards induction of mucosal atrophy was observed, demonstrated by the reduction of villus density, mucosal thickness, protein content and significant reduction of DNA, while these alterations were reversed by regulatory peptides administration.This trophic effect of BBS and NT was accompanied by induction of mitoses above control levels and a significant reduction of apoptosis in intestinal crypts.Intestinal lipid peroxidation was found significantly lower in PHx group and regulatory peptides exerted an antioxidant action, further decreasing this parameter of oxidative stress. The bacterial population of E. coli and aerobic Gram (+) cocci was increased in cecal content of hepatectomized rats, while this parameter was not affected by the administration of BBS or NT.CONCLUSION: Gut regulatory peptides BBS and NT improve intestinal barrier function and reduce endotoxemia in experimental partial hepatectomy. This effect is, at least in part, mediated by their trophic,antiapoptotic, mitogenic, and antioxidant effect on the intestinal epithelium. This observation might be of potential value in patients undergoing liver resection. | Stelios F Assimakopoulos Ilias H Alexandris Chrisoula D Scopa Panagiotis G Mylonas Konstantinos C Thomopoulos Christos D Georgiou Vassiliki N Nikolopoulou Constantine E Vagianos | 2005 | World Journal of Gastroenterology2005，11，43： | 8 |
| 2 | Abolished circadian rhythm of salivary cortisol in elite artistic gymnasts 显示文摘 | Georgopoulos N A Rottstein L Tsekouras A The- odoropoulou A Koukkou E Mylonas P Polykarpou G Lampropoulou E Iconomou G Legise M Va- genakis A G Markou K B | 2011 | Steroids2011，76，5： | 1 |
| 3 | Modulation of Antioxidant Responses by Arsenic in Maize显示文摘 | POL1DOROS A N SCANDALIOS J G | 1998 | Free Radical Biology and Medicine1998，25，： | 1 |
| 4 | Numerical modelling of shot peening process and corresponding products:Residual stress, surface roughness and cold work prediction 显示文摘 | MYLONAS G I LABEAS G | 2011 | Surface & Coatings Technology2011，205，： | 1 |
| 5 | Bombesin and neurotensin reduce endotoxemia intestinal oxidative stress and apoptosis in experimental obstructive jaundice显示文摘 | Assimakopoulos S F Scopa C D Zervoudakis G Mylonas P G Georgiou C Nikolopoulou V | 2005 | Ann Surg2005，241，： | 1 |
| 6 | Numerical modelling of shot peening process and corresponding products:residual stress,surface roughness and cold work prediction 显示文摘 | Mylonas G I Labeas G | 2011 | Surface and Coat-ings Technology2011，205，19： | 1 |
| 7 | Com- parative efficacy of clove oil and 2 - phenoxyethanol as anesthet- ics in the aquaculture of European sea bass (Dicentrarchus la- brax) and gilthead sea bream( Sparus aurata)at different temper- atures 显示文摘 | MYLONAS C C CARDINALETYI G SIGELAKI l | 2005 | Aquaculture2005，246，14： | 1 |
| 8 | Hydrogen-bonding interaction of an alternating maleic acid-vinyl acetate eopolymer with po显示文摘 | Vasile C Bumbu G G Mylonas Y | 2003 | Polym Int2003，52，12： | 1 |
| 9 | GeneSIS: A GA-based fuzzy segmentation algorithm for remote sensing images 显示文摘 | MYLONAS S K STAVRAKOUDIS D G THEOCHARIS J B | 2013 | Knowledge-Based Sys- tems2013，54，12： | 1 |
| 10 | The use of 18F-FDG PET In the diagnosis of cardiac sarcoidosis : a systematic review and me- laanalysis including the Ontario experience 显示文摘 | Youssef G Leung E Mylonas I | 2012 | J Nucl Med2012，53，2： | 1 |
| 11 | Vascular manifestations of Beh(c)et's disease:report of a case and review of the literature显示文摘 | KOTSIS T MOULAKAKIS K G MYLONAS S | | 0，，06： | 1 |
| 12 | Numerical modelling of shot peening process and corresponding products: residual stress, surface roughness and cold work prediction 显示文摘 | MYLONAS G I LABEAS G | 2011 | Surface and Coatings Technology2011，205，19： | 1 |
| 13 | Polymer colloid and solid particles: Phase behaviour of aqueous mixtures of sodium dodecyl sulfate with a weakly cationically charged acrylamide-based copolymer 显示文摘 | Mylonas G Bokias G Staikos G | 2000 | Progress in Colloid and Polymer Science2000，115，： | 1 |
| 14 | Performance of three biometry devices in patients with different grades of age-related cataract显示文摘 | Mylonas G Sacu S Buehl W | 2011 | Acta Ophthalmol2011，89，： | 1 |
| 15 | Comparative efficacy of clove oil and 2-phenoxyethanol as anesthetics in the aquaculture of European sea bass (Dicentrarchus labrax) and gilthead sea bream (Sparus aurata) at different temperatures显示文摘 | Mylonas C C Cardinaletti G Sigelaki I | 2005 | Aquaculture2005，246，： | 1 |
| 16 | Numerical modelling of shot pee ning process and corresponding products: Residual stress, surface roughness and cold work prediction 显示文摘 | Mylonas G I Labeas G | 2011 | Surface Coatings Technology2011，205，： | 1 |
| 17 | Performance of three biometry devices in patients with different grades of age-related cataract显示文摘 | Mylonas G Sacu S Buehl W | 2011 | Acta Ophthalmol2011，89，3： | 1 |
| 18 | Oral and cranio-maxillufacial surgery in Byzantium 显示文摘 | MYLONAS A I ANDROUTSOS G I LOANNIS S | 2014 | Journal of cranio-maxillofacial surgery2014，42，15： | 1 |
| 19 | GeneSIS: a GA-based fuzzy segmentation algorithm for remote sens- ing images 显示文摘 | Mylonas S K Stavrakoudis D G Theocharis J B | 2013 | Knowledge-Based Systems2013，54，12： | 1 |
| 20 | Performance of three bi-ometry devices in patients with different grades of age-related cataract显示文摘 | Mylonas G Sacu S Buehl W | 2011 | Acta Ophthalmol2011，89，3： | 1 |
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