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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Evidence for osteocyte regulation of bone homeostasis through RANKL expression显示文摘 | Nakashima T Hayashi M Fukunaga T Kurata K Oh-Hora M Feng J Q B onewald L F K odama T W utz A W agner E F Penninger JM Takayanagi H | | 0，，： | 1 |
| 3 | Heat transfer in a twin-screw multiphase pump:thermal modeling and one application in the petroleum industry 显示文摘 | Nakashima Celso Y Jr Silvio de Oliveira Caetano E F | 2006 | Energy2006，31，15： | 1 |
| 4 | Heat transfer in a twin-screw multiphase pump:Thermal modeling and one application in the petroleum industry显示文摘 | NAKASHIMA C Y OLIVEIRA S D CAETANO E F | 2006 | Energy2006，31，15： | 1 |
| 5 | Antihyperglycemic effects of N-containing sugars derived from mulberry leaves in Streptozocin-induced diabetic mice显示文摘 | Kimura M Chen F J Nakashima N | 1995 | J Trad Med1995，12，： | 1 |
| 6 | , Fluorescence Studies on Binding of Pyrene and Its Derivatives to Humic Acid 显示文摘 | Nakashima K Makia M Ishikawa F | 2007 | Spectrochimica Acta Part A2007，67，： | 1 |
| 7 | Laccase is necessary and nonredundant with peroxidase for lignin polymerization during vascular development in Arabidopsis显示文摘 | Zhao Q Nakashima J Chen F | 2013 | Plant Cell2013，25，10： | 1 |
| 8 | Antihyperglycemic effects of N-containing sugars derived from mulberry leaves in streptozocin-induced diabetic mice显示文摘 | KIMURA M CHEN F NAKASHIMA N | 1995 | Wakan Iyakugaku Zasshi1995，12，3： | 1 |
| 9 | Fullscale test of composite frame under large cyclic loading 显示文摘 | Nakashima M Matsumiya T Suita K Zhou F | 2007 | Journal of Structural Engineering ASCE2007，133，2： | 1 |
| 10 | Feasibility of Ionic Liquids as Alternative Separation Media for Industrial Solvent Extraction Processes显示文摘 | Nakashima K Kubota F Maruyama T | 2005 | Ind Eng Chem Res2005，44，12： | 1 |
| 11 | Preventive effects of Chlorella on cognitive decline in age dependent dementia model mice 显示文摘 | Nakashima Y Ohsawa I Konishi F Hasegawa T Kumamoto S Suzuki Y | 2009 | Neurosci Lett2009，464，： | 1 |
| 12 | Multidirectional micro-switching valve chip with rotary mechanism 显示文摘 | HASEGAWA T NAKASHIMA K OMATSU F | 2008 | Sensors and Actuators: A2008，143，2： | 1 |
| 13 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | 2004 (9451)2004，，9451： | 1 |
| 14 | Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans显示文摘 | Sugiyama Y Nakashima S Mirbod F | 1999 | Med Mycol1999，37，1： | 1 |
| 15 | Overexpression of immediate early gene X - 1 ( IEX - 1 ) enhances gradiation - induced apoptosis of human glioma cell line, U87 -MG显示文摘 | Yamashita K Nakashima S You F | 2009 | Neuropathology2009，29，1： | 1 |
| 16 | Antihyperglycemic Effects of N-containing Sugars derived from Mulberry Leaves is Streptozocin-induced diabetic Mice显示文摘 | KDMJPA M CHEN F J NAKASHIMA N | 1995 | J Wakan Iyakugaku Zasshi1995，，12： | 1 |
| 17 | Finite-element analysis of a composite frame under large lateral cyclic loading显示文摘 | Zhou F Mosalam K M Nakashima M | 2007 | Journal of Structural Engineering ASCE2007，133，7： | 1 |
| 18 | A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis显示文摘 | Vanda A Lennon Dean M Wingerchuk Thomas J Kryzer Sean J Pittock Claudia F Lucchinetti Kazuo Fujihara Ichiro Nakashima Brian G Weinshenker | 2004 | The Lancet2004，，9451： | 1 |
| 19 | Cloning, sequence analysis, and expression of Lactobacillus casei phage PL-1 lysis genes显示文摘 | KASHIGE N NAKASHIMA Y MIAKE F | 2000 | Arch Virol2000，145，8： | 1 |
| 20 | Sulfated pentagalloyl glucose inhibits HIV replication and cytopathic effects in vitro,and reduces HIV infection in hu-PBL-SCID mice显示文摘 | NAKASHIMA H ICHIYAMA K HIRAYAMA F | 1996 | Antiviral Research1996，30，23： | 1 |
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