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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | The UDP N-Acetylgalactosamine 4-Epimerase Gene Is Essential for Mesophilic Aeromonas hydrophila Serotype O34 Virulence显示文摘 | Roci'o Canals Natalia Jime'nez | 2006 | Infect Immun2006，74，： | 1 |
| 3 | The nonmeval- onate pathway supports both monoterpene and ses- quiterpene formation in snapdragon flowers显示文摘 | Natalia D Susanna A Irina O | 2005 | Proc Natl Acad Sci USA2005，102，： | 1 |
| 4 | Safety and feasibility of catheter ablation for atrioventricular nodal re-entrant tachycardia without fluoroscopic guidance显示文摘 | Miguel álvarez Luís Tercedor Isabel Almansa Natalia Ros Ricardo S. Galdeano Francisco Burillo Pablo Santiago Rocío Pe?as | 2009 | Heart Rhythm2009，，12： | 1 |
| 5 | Chemical characterization of the aroma of Grenache rose wines:aroma extract dilution analysis,quantitative determination,and sensory reconstitution studies显示文摘 | VICENTE F NATALIA O ANA E | 2002 | Journal of Agricultural and Food Chemistry2002，50，4： | 1 |
| 6 | Structure–activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity显示文摘 | Bibiana Monson de Souza Marcia Perez dos Santos Cabrera Paulo Cesar Gomes Nathalia Baptista Dias Rodrigo Guerino Stabeli Natalia Bueno Leite Jo?o Ruggiero Neto Mario Sergio Palma | 2015 | Peptides2015，，： | 1 |
| 7 | A monoclonal antibody directed against a candida albicans cell wall mannoprotein exters three anyi-C albicans activities显示文摘 | Maria D M Miren J O Natalia E | 2003 | Infect Immun2003，71，9： | 1 |
| 8 | hTERT methylation and expression in gastric cancer显示文摘 | Carolina Oliveira Gigek Mariana Ferreira Leal Patricia Natalia Oliveira Silva Luara Carolina Frias Lisboa Eleonidas Moura Lima Danielle Queiroz Calcagno Paulo Pimentel Assump??o Rommel Rodriguez Burbano Marilia de Arruda Cardoso Smith | 2009 | Biomarkers2009，，8： | 1 |
| 9 | Ischemic preconditioning modu-lates the expression of several genes,leading to the overproduction ofIL-1Ra,iNOS,and Bcl-2 in a human model of liver ischemia-reperfusion显示文摘 | Alain B Natalia O Franck C | 2005 | Faseb J2005，19，12： | 1 |
| 10 | Comparative 16S rRNA analysis of lake bacterioplankton reveals globally distributed phylogenetic clusters including an abundant group of aetinobacteria显示文摘 | FRANK O G EYGENY Z NATALIA B | 2000 | Applied and Environmental Microbiology2000，66，11： | 1 |
| 11 | Application of zeolitised coal fly ashes to the depuration of liquid wastes 显示文摘 | Emilia O Luis F V Natalia M | 2005 | Fuel2005，84，11： | 1 |
| 12 | New approaches to identification and characterization of tioconazole in raw material and in pharmaceutical dosage forms显示文摘Tioconazole(TCZ), a broad-spectrum antifungal agent, has significant activity against Candida albicans and other Candida species, and therefore, it is indicated for the topical treatment of superficial mycoses.The main goal of this work is to report an exhaustive identification and characterization procedure to improve and facilitate the online quality control and continuous process monitoring of TCZ in bulk material and loaded in two different dosage forms: ovules and nail lacquer. The methodologies were based on thermal(differential scanning calorimetry(DSC), melting point, and thermogravimetry(TG)),spectroscopic(ultraviolet(UV), Raman, near infrared(NIR), infrared spectroscopy coupled to attenuated total reflectance(FTIR-ATR), and nuclear magnetic resonance(NMR)), microscopic and X-ray diffraction(XRD). The TCZ bulk powder showed a high crystallinity, as observed by XRD, with a particles size distribution(3–95 mm) resolved by microscopic measurements. TCZ melting point(82.8 °C) and a degradation peak centered at 297.8 °C were obtained by DSC and DTG, respectively. An unambiguous structure elucidation of TCZ was obtained by mono-and two-dimensional1 H and13 C NMR spectral data analysis. The FTIR-ATR, Raman and NIR spectra of both the raw material and the commercial products were analyzed and their characteristic bands were tabulated. The best methods for TCZ identification in ovules were DSC, TG, XRD, NIR and Raman, while NIR and FTIR-ATR were the most appropriate techniques to analyze it in the nail lacquer. DSC, TG, DRX, Raman, FTIR-ATR and NIR spectroscopy are effective techniques to be used in online process analysis, because they do not require sample preparation, and they are considerably sensitive to analyze complex samples. | Natalia L.Calvo Vera A.Alvarez María C.Lamas Darío Leonardi | 2019 | Journal of Pharmaceutical Analysis2019，9，1： | 1 |
| 13 | Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P4502E1 as a model of ethanolelicited cytotoxicity显示文摘 | TERRENCE M D NATALIA A O DAHN L C | | 0，，： | 1 |
| 14 | Application of zeolitised coal fly ashes to the depuration of liquid wastes 显示文摘 | Emilia O Luis F V Natalia M | 2005 | Fuel2005，84，11： | 1 |
| 15 | Crystal structure of the 'PhoU-Like'phosphate uptake regulator from Aquifex aeolicus显示文摘 | Vaheh O Natalia O Paul D A | 2005 | J Bacteriology2005，187，12： | 1 |
| 16 | On-line ionic imprinted polymer selective solid-phase extraction of nickel and lead from seawater and their determination by inductively coupled plasma-optical emission spectrometry显示文摘 | Natalia G O Carmen T V Jacobo O R | 2009 | Analytical and Bioanalytical Chemistry2009，395，4： | 1 |
| 17 | Determination of chlormequat and mepiquat in pear,tomato,and wheat flour using on-line solid-phase extraction(Prospekt) coupled with liquid chromatography-electrospray ionization tandem mass spectrometry显示文摘 | SONJA R HEINNICH O NATALIA V | 2002 | J Chromatogr:A2002，966，1： | 1 |
| 18 | Lactic acid bacteria iso- lated from young calves-Characterization and potential as probiotics 显示文摘 | Natalia C M Clara S R Maria C O | 2012 | Research in Veterinary Science2012，92，2： | 1 |
| 19 | Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina显示文摘Given the increasing complexity of cancer care,multidisciplinary tumor boards have become essential in daily clinical oncology practice.The Project Extension for Community Healthcare Outcomes(ECHO)initiative developed an innovative telementoring model using a'hub and spoke'design consisting of a team of experts(hub)that offers a full service to multiple participants(the spokes)during regularly scheduled sessions discussing patients'clinical cases.The Alexander Fleming Cancer Institute in Buenos Aires was the first hub in Latin America to implement Project ECHO for gastrointestinal tumors.In our 3-year experience,80 patients from 37 centers were evaluated within Project ECHO and a range of three to five cases were discussed in each meeting.From our perspective,the impact of this novel approach was a remarkable strategy to reduce care disparities by equalizing access to high-quality medical knowledge in a multidisciplinary environment for medical discussions.Additionally,it was shown to have a cost-effective impact directly on the patients and the local health system,since relevant costs were saved after unnecessary treatments,studies and travel expenses were avoided. | Federico Esteso Natalia Soledad Tissera Juan Manuel O'Connor Romina Luca Eduardo Huertas Fernando Sánchez Loria Ivana Pedraza Alejandro Pairola Fernando Brancato Lisandro Paganini Mariana Kucharczyk Mora Amat Maria Teresa Pombo Mariana Galli Luisina Bruno Luis Caro Andrés Rodriguez Diego Enrico Federico Waisberg Matías Chacón | 2022 | World Journal of Clinical Oncology2022，13，6： | 0 |
| 20 | DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation andmetabolic remodeling显示文摘Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability rate.Over 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new PPGL susceptibility gene[2]. | Sara Mellid Fernando García Luis Javier Leandro-García Alberto Díaz-Talavera Ángel Mario Martínez-Montes Eduardo Gil Bruna Calsina María Monteagudo Rocío Letón Juan María Roldán-Romero María Santos Javier Lanillos Carlos Valdivia Natalia Martínez-Puente Javier de Nicolás-Hernández Scherezade Jiménez Manuel Pérez-Martínez Emiliano Honrado Javier Coloma Ana Cerezo Clara María Santiveri Manel Esteller Ramón Campos-Olivas Eduardo Caleiras Cristina Montero-Conde Cristina Rodríguez-Antona Javier Muñoz Mercedes Robledo Alberto Cascón | 2023 | Cancer Communications2023，43，7： | 0 |
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