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| 1 | Intralesional steroid is beneficial in benign refractory esophageal strictures:A meta-analysis显示文摘AIM To analyze the effect of intralesional steroid injections in addition to endoscopic dilation of benign refractory esophageal strictures.METHODS A comprehensive search was performed in three databases from inception to 10 April 2017 to identify trials, comparing the efficacy of endoscopic dilation to dilation combined with intralesional steroid injections. Following the data extraction, meta-analytical calculations were performed on measures of outcome by the randomeffects method of Der Simonian and Laird. Heterogeneity of the studies was tested by Cochrane's Q and I^2 statistics. Risk of quality and bias was assessed by the Newcastle Ottawa Scale and JADAD assessment tools.RESULTS Eleven articles were identified suitable for analyses, involving 343 patients, 235 cases and 229 controls in total. Four studies used crossover design with 121 subjects enrolled. The periodic dilation index(PDI) was comparable in 4 studies, where the pooled result showed a significant improvement of PDI in the steroid group(MD:-1.12 dilation/month, 95% CI:-1.99 to -0.25 P = 0.012; I^2 = 74.4%). The total number of repeat dilations(TNRD) was comparable in 5 studies and showed a non-significant decrease(MD:-1.17, 95%CI:-0.24-0.05, P = 0.057; I^2 = 0), while the dysphagia score(DS) was comparable in 5 studies and did not improve(SMD: 0.35, 95%CI:-0.38, 1.08, P = 0.351; I^2 = 83.98%) after intralesional steroid injection.CONCLUSION Intralesional steroid injection increases the time between endoscopic dilations of benign refractory esophageal strictures. However, its potential role needs further research. | László Szapáry Benedek Tinusz Nelli Farkas Katalin Márta Lajos Szakó Agnes Meczker Roland Hágendorn Judit Bajor Aron Vincze Zoltan Gyongyi Alexandra Mikó Dezso Csupor Péter Hegyi Balint Eross | 2018 | World Journal of Gastroenterology2018，24，21： | 7 |
| 2 | Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review显示文摘BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF mutation,and additional mutations were registered.The BRAF V600E mutation was found in 297 AM(57%),63 UA(77.7%),3 AC(23%),1 MA(50%),and 5 PA(83.3%).Follicular type predominated with a total of 116 cases(40%),followed by plexiform type with 63 cases(22.1%).Furthermore,both types presented additional mutations,in which alterations in JAK3 P132T,SMARCB1,PIK3CA,CTNNB1,SMO,and BRAF G606E genes were found.Four case reports were found with targeted therapy to BRAF V600E.CONCLUSION The identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated. | Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina | 2020 | World Journal of Clinical Oncology2020，11，1： | 6 |
| 3 | Chronic kidney disease severely deteriorates the outcome of gastrointestinal bleeding: A meta-analysis显示文摘AIM To understand the influence of chronic kidney disease(CKD) on mortality, need for transfusion and rebleeding in gastrointestinal(GI) bleeding patients.METHODS A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or endstage renal disease(ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization(LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model. Heterogeneity was tested by using Cochrane's Q and I2 statistics. Mean difference(MD) and OR(odds ratio) were calculated.RESULTS1063 articles(EMBASE: 589; PubM ed: 459; Cochrane: 15) were found in total. 5 retrospective articles and 1 prospective study were available for analysis. These 6 articles contained data on 406035 patients, of whom 51315 had impaired renal function. The analysis showed a higher mortality in the CKD group(OR = 1.786, 95%CI: 1.689-1.888, P < 0.001) and the ESRD group(OR = 2.530, 95%CI: 1.386-4.616, P = 0.002), and a rebleeding rate(OR = 2.510, 95%CI: 1.521-4.144, P < 0.001) in patients with impaired renal function. CKD patients required more unit red blood cell transfusion(MD = 1.863, 95%CI: 0.812-2.915, P < 0.001) and spent more time in hospital(MD = 13.245, 95%CI: 6.886-19.623, P < 0.001) than the controls.CONCLUSION ESRD increases mortality, need for transfusion, rebleeding rate and LOH among GI bleeding patients. Prospective patient registries and observational clinical trials are crucially needed. | Roland Hágendorn Nelli Farkas Aron Vincze Zoltán Gyongyi Dezso Csupor Judit Bajor Bálint Eross Péter Csécsei Andrea Vasas Zsolt Szakács László Szapáry Péter Hegyi Alexandra Mikó | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 4 | Developments in turbo Brayton technology for low temperature applications显示文摘 | Swift W L Zagrola M V Nellis G F | 1999 | Cryogenics1999，39，12： | 1 |
| 5 | Epidemiology of nephrolithiasis today 显示文摘 | Amato M Lusini M L Nelli F | 2004 | Urol Int2004，72，1： | 1 |
| 6 | Effects of L-propionylcarnitine on mechanical recovery during reflow in intact hearts显示文摘 | Liedtke A J De Maison L Nellis SH | 1958 | American Journal of Physiology-Heart and Circulatory Physiology1958，255，1： | 1 |
| 7 | Metal biomonitoring with mosses: procedures for correction for soil contamination显示文摘 | Bargagli R Brown D H Nelli L | 1995 | Environmental Pollution1995，89，2： | 1 |
| 8 | Design of an Experimental Ap- paratus for Investigation of a Stirling/Magnetic Cycle 显示文摘 | Nellis G F Smith J L Jr | 1996 | Advances in Cryogenic Engineering1996，41，16： | 1 |
| 9 | Up-front chemotherapy and radiation treatment in newly diagnosed non-small-cell lung cancer with brain metastases: Survey by outcome research network for e- valuation of treatment results in oncology显示文摘 | Moscetti L Nelli F Felici A | 2007 | Cancer2007，109，2： | 1 |
| 10 | Structural determination of the exopolysaccharide of Pseudoalteromonas strain HYD 721 isolated from a deep-sea hydrothermal vent显示文摘 | Hélène Rougeaux Jean Guezennec Russell W Carlson Nelly Kervarec Roger Pichon Philippe Talaga | 1999 | Carbohydrate Research1999，，3： | 1 |
| 11 | Summer immune depression associated with increased susceptibility of the European abalone,Haliotis tuberculata to Vibrio harveyi infection显示文摘 | MARIE-AGNES T NELLY L SYLVAIN H | 2008 | Fish Shellfish Immunol2008，25，6： | 1 |
| 12 | Gemcitabine and cisplatin in the treatment of elderly patients with advanced non-small cell lung cancer: impact of comorbidities on safety and efficacy outcome显示文摘 | Moscetti L Nelli F Padalino D | 2005 | J Chemother2005，17，6： | 1 |
| 13 | Epidemiology o{ neph- rolithiasis today显示文摘 | Amato M Lusini M L Nelli F | 2004 | Urol Int2004，72，1： | 1 |
| 14 | Expansion of gallery forest on Konza Prairie Research Natural Area,Kansas,USA显示文摘 | Knight C L Briggs J M Nellis M D | 1994 | Landscape Ecology1994，9，： | 1 |
| 15 | Developments in Turbo Brayton tchnology for low temperature applications显示文摘 | SWIFT W L ZAGAROLA M V NELLIS G F | 1999 | Cryogenics1999，39，： | 1 |
| 16 | Gemcitabine and cisplatin in the treatment of elderly patients with advanced non - small cell lung cancer: impact of comorbidities on safety and efficacy outcome 显示文摘 | Moscetti L Nelli F Padalino D | 2005 | J Cemother2005，17，6： | 1 |
| 17 | C, emeitabine and eisplatin in the treatment of elderly patients with advanced non-small cell lung cancer:impact of eomorbidities on safety and efficacy outcome显示文摘 | Moscetti L Nelli F Padalino D | 2005 | Chemotherapy2005，17，6： | 1 |
| 18 | Utility of positron emission tomography-computed tomography scan in detecting residual hepatocellular carcinoma post treatment:Series of case reports显示文摘BACKGROUND Multi-phase computed tomography(CT)or magnetic resonance imaging(MRI)has been the standard of care for hepatocellular carcinoma(HCC)diagnosis for years.CASE SUMMARY We report a case series of four patients in whom positron emission tomographycomputed tomography(PET-CT)scan complemented the conventional CT/MRI scans in evaluating treatment response.In these four cases the conventional multi-phase CT and MRI failed to identify residual HCC disease post-treatment,while PET-CT complemented and aided in treatment response evaluation.In each case,the addition of PET-CT identified and located residual HCC disease,allowed retreatment,and altered medical management.CONCLUSION This case series suggests that PET-CT should perhaps play a role in the HCC management algorithm,in addition to the conventional contrast-enhanced multiphase scans. | Jason T Cheng Nelly E Tan Michael L Volk | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 1 |
| 19 | Heavy metals, organochlorines and polycyclic aromatic hy?drocarbons in sperm whales stranded in the southern North Sea during the 199411995 winter显示文摘 | Hoolsbeek L Joiris C R Debacker Virginie Rosse P Nellis?sen J P Gobert Sylvie Bouquegneau Jean-Marie Bossicart M | 1999 | Mar Poll Bull1999，38，4： | 1 |
| 20 | Purification and protective efficacy of monomeric and modified Yersinia pestis capsular FI-V antigen fusion proteins for vaccination against plague显示文摘 | Goodin J L Nellis D F Powell B S | 2007 | Protein Expr Purif2007，53，： | 1 |
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