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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Liver biochemistry profile,significance and endoscopic management of biliary tract complications post orthotopic liver transplantation显示文摘AIM: To correlate the significance of liver biochemical tests in diagnosing post orthotopic liver transplantation (OLT) biliary complications and to study their profile before and after endoscopic therapy. METHODS: Patients who developed biliary complications were analysed in detail for the clinical information,laboratory tests,treatment offered,response to it,follow up and outcomes. The profile of liver enzymes was determined. The safety,efficacy and outcomes of endoscopic retrograde cholangiography (ERC) were also analysed. RESULTS: 40 patients required ERC for 70 biliary complications. GGT was found to be > 3 times (388.1 ± 70.9 U/mL vs 168.5 ± 34.2 U/L,P = 0.007) and SAP > 2 times (345.1 ± 59.1 U/L vs 152.7 ± 21.4 U/L,P = 0.003) the immediate post OLT values. Most frequent complication was isolated anastomotic strictures in 28 (40%). Sustained success was achieved in 26 (81%) patients. CONCLUSION: Biliary complications still remain an important problem post OLT. SAP and GGT can be used as early,non-invasive markers for diagnosis and also to assess the adequacy of therapy. Endoscopic management is usually effective in treating the majority of these biliary complications. | Yogesh M Shastri Nicolas M Hoepffner Bora Akoglu Christina Zapletal Wolf O Bechstein Wolfgang F Caspary Dominik Faust | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 3 | Fluctuations in bovine o- varian follicular fluid composition throughout the oestrous cycle 显示文摘 | NICOLAS M O NADIA G HENRY J L | 2005 | Reproduction2005，129，： | 1 |
| 4 | Preferential Oxidation of Carbon Monoxide in the Presence of Hydrogen (PROX) over Noble Metals and Transition Metal Oxides: Advantages and Drawbacks显示文摘 | Nicolas Bion Florence Epron Máximo Moreno Fernando Mari?o Daniel Duprez | 2008 | Topics in Catalysis (-)2008，，1： | 1 |
| 5 | Pollution by hexachlo-robenzene and pentachlorophenol in the coastat plain of Sāo Paulo state显示文摘 | Nascimento N R Nicola S M C Rezende M O O | 2004 | Geoderma2004，121，34： | 1 |
| 6 | Co- rporate-NGO Collaboration:Co-creating New Business Models for Developing Markets 显示文摘 | NICOLAS M D JONATHAN P D JENNIFER O | 2010 | Long Range Planning2010，43，23： | 1 |
| 7 | Pollution by hexachlorobenzene and pentachlorophenol in the coastal plain of Sao Paulo state, Brazil 显示文摘 | do Nascimento N R Nicola S M C Rezende M 0 O | 2004 | Geoderma2004，121，34： | 1 |
| 8 | Compaction of a granular material under cyclic shear 显示文摘 | Nicolas M Duru P Pouliquen O | 2000 | The European Physical Journal E2000，3，4： | 1 |
| 9 | Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients显示文摘 | Ronald F van Vollenhoven Paul Emery Clifton O Bingham Edward C Keystone Roy M Fleischmann Daniel E Furst Nicola Tyson Neil Collinson Patricia B Lehane | 2013 | Annals of the Rheumatic Diseases2013，，9： | 1 |
| 10 | Design of protein membrane interaction inhibitors by virtual ligand screening,proof of concept with the C2 domain of factor Ⅴ显示文摘 | Segers K Sperandio O Sack M Fischer R Miteva M A Rosing J Nicolaes G A Villoutreix B O | | 0，，： | 1 |
| 11 | A Practical Criterion for the Rapid Detection of Single‐Loop and Double‐Loop Reentry Tachycardias显示文摘 | NICK W.F. LINTON STEPHEN B. WILTON DANIEL SCHERR ASHOK J. SHAH NICOLAS DERVAL FREDERIC SACHER MATTHEW WRIGHT MéLèZE HOCINI MARK D. O’NEILL MICHEL HA?SSAGUERRE PIERRE JA?S | 2013 | J Cardiovasc Electrophysiol2013，，5： | 1 |
| 12 | Water in oil microemulsions as mobile phase in liquid chromatography显示文摘 | Berthod A Nicolas O Porthault M | 1990 | Anal Chem1990，62，14： | 1 |
| 13 | Genetic variation in the interleukin-28B gene is notassociated with fibrosis progression in patients with chronic hepatitis C and known date of infection显示文摘 | M arabita F Aghem o A De Nicola S | 2011 | H epatology2011，54，4： | 1 |
| 14 | Compaction of a granular material under cyclic shear显示文摘 | Nicolas M Duru P Pouliquen O | 2000 | The European Physical Journal E2000，3，4： | 1 |
| 15 | Spontaneous analogizing in engineering design: a comparative analysis of experts and novices显示文摘 | LINDEN J B THOMAS C O NICOLA J M | 2004 | Design Studies2004，25，5： | 1 |
| 16 | Water in oil microemulsions as mobile phase in liquid chromatography 显示文摘 | BERTHOD A NICOLAS O PORTHAULT M | 1990 | Anal Chem1990，62，14： | 1 |
| 17 | Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells显示文摘 | Vilarino N Nicolaou K C Frederick M O | 2007 | Biochem Pharmacol2007，74，2： | 1 |
| 18 | Pollution by hexachlorobenzene and pentachlorophenol in the coastal plain of Sao Paulo state,Brazil显示文摘 | Nascimento N R D Nicola S M C Rezende M O O | 2004 | Geoderma2004，121，1： | 1 |
| 19 | Surveillance of antibiotic resistance evolution and detection of class 1 and 2 integrons in human isolates of multi resistant Salmonella typhimurium obtained in Uruguay be- tween 1976 and 2000显示文摘 | Macedo-Vinasa M Nicolas F Cordeir O | 2009 | Int J Infect Dis2009，，13： | 1 |
| 20 | Water in oil microemulsions as mobile phases in liquid chromatography显示文摘 | BERTHOD A NICOLAS O PORTHAULT M | 1990 | Anal Chem1990，62，14： | 1 |
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