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| 1 | Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis: retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction显示文摘我们以前在范畴 II 长期的细菌的前列腺炎(CBP ) 表明了 fluoroquinolone-macrolide 联合治疗的安全和功效。这研究的目的是回顾地基于 azithromycin 的联合为 CBP 比较 microbiological 和二个处理计划的临床的调查结果(500 mg,三次每周) 与一次每日的 500-mg 或 ciprofloxacin 的 750-mg 剂量(Cipro-500 或 Cipro-750 队,分别地) 。azithromycin 的联合管理(1500 有以 750 的率的 ciprofloxacin 的 mg 星期 −1) ;为 4 个星期而非在 500 的 mg 天 −1 ;为 6 个星期的 mg 天 −1 从 62.35 % 增加了根除率;到 77.32 %并且从 71.76 % 的全部的细菌学的成功;到 85.57 %。在煽动性的白血球计数和浆液的疼痛和 voiding 症状 / 症状和重要减小地的重要减少前列腺特定的抗原(PSA ) 在两个组在整个 18 月的后续经期被支撑。射精的疼痛, haemospermia 和早泄显著地在两个组在 microbiological 根除上被稀释,但是后者在 Cipro-750 队更即时减退了。总共, 59 个 Cipro-750 病人显示出 mild-to-severe 在基线的可勃起的机能障碍(编辑) ,当 22 个病人没在 microbiological 根除上并且在整个后续时期有编辑时。在结论 fluoroquinolone-macrolide,治疗在病原体根除和 CBP 症状变细导致了,包括疼痛, voiding 骚乱和性机能障碍。为 4 个星期的 ciprofloxacin 的一次每日的 750-mg 剂量与 500-mg 剂量相比显示出提高的根除率和更低的煽动性的白血房间计数 6 个星期。我们的结果是开的推进未来的确认。 | Vittorio Magri Emanuele Montanari Visnja Skerk Alemka Markotic Emanuela Marras Antonella Restelli Kurt G Naber Gianpaolo Perletti | 2011 | Asian Journal of Andrology2011，13，6： | 12 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications显示文摘意义和在长期的细菌的前列腺炎的精液分析的诊断价值广泛地被辩论了并且仍然保持争论。在前列腺炎病人的细菌学的 workup 调查精液文化的诊断关联,我们回顾地分析了 696 个征兆的病人的一个临床的数据库。所有病人习惯性地受到四眼镜的测试,由精液文化和分析列在后面。这允许从数据库把,并且把三种不同诊断情形测试的“二眼镜”的 pre-/post- 按摩和标准“四眼镜”的测试与“五眼镜”的测试(四眼镜的正 post-VB3 精液文化) 作比较。“五眼镜”的测试在相对敏感和更小的减小显示出 3.6 褶层或 6.5 褶层增加(在为传统的 uropathogens (TU ) 的相对特性的 -13.2% 或 -14.7%) 与四眼镜或二眼镜的测试相比分别地。在 ROC 曲线和 Jouden 下面的区域是索引而积极、否定的可能性的比率比比较仪低,被增加,显示“五眼镜”的试金可能在证实两标准测试的否定结果是优异的。五 -- ,四 -- ,并且二眼镜的测试检测了 TU (Enterobacteriaceae, Enterococci,等等) 在在 130, 56,和 45 个病人的 120, 33,和 20 个病人和不平常的病原体(Streptococci,另外的克积极的种类, Mycoplasmata,和其它) 分别地。当病人们受到药理学治疗时,包括 fluoroquinolone 和 macrolide 的联合,处于根除率的差别都没在与不同测试诊断的组之间被观察,不管病原体范畴。根除与长期的症状 / 症状宽恕被联系;在症状 / 症状分数的重要团体之间的差别都没在整个一个 24 月的离开治疗后续时期被观察。在结论,我们的数据当这测试被用来补充四眼镜的 Meares 和 Stamey 测试时,在前列腺炎病人的诊断 workup 支持精液分析的实用性。microbiological 试金的改进传送重要诊断、治疗学的含意。 | Vittorio Magri Florian M. E. Wagenlehner Emanuele Montanari Emanuela Marras Viviana Orlandi Antonella Restelli Erminio Torresani Kurt G. Naber Gianpaolo Perletti | 2009 | Asian Journal of Andrology2009，11，4： | 2 |
| 4 | Endoscopic Trimodal Imaging Detects Colonic Neoplasia as Well as Standard Video Endoscopy显示文摘 | Teaco Kuiper Frank J.C. van den Broek Anton H. Naber Ellert J. van Soest Pieter Scholten Rosalie Ch. Mallant–Hent Jan van den Brande Jeroen M. Jansen Arnoud H.A.M. van Oijen Willem A. Marsman Jacques J.G.H.M. Bergman Paul Fockens Evelien Dekker | 2011 | Gastroenterology2011，，7： | 2 |
| 5 | European and Asian guidelines on management and prevention of catheter-associated urinary tract infections显示文摘 | Peter Tenke Bela Kovacs Truls E. Bjerklund Johansen Tetsuro Matsumoto Paul A. Tambyah Kurt G. Naber | 2007 | International Journal of Antimicrobial Agents2007，，： | 2 |
| 6 | Tocopherol isoforms in parenteral lipid emulsions and neutrophil activation显示文摘 | Wanten G Beunk J Naber A | 2002 | Clin Nutr2002，21，5： | 1 |
| 7 | hnpact of admission blood glucose on outcomes of nondiabetic patients with acute ST-elevation myocardiat infarction(from the German Acute Coronary Syndromes (ACOS) Regis- try ) 显示文摘 | Naber CK Mehta RH Junger C | 2009 | Am J C ardiol2009，103，5： | 1 |
| 8 | Rational antibiotictherapy of urinary tract infections显示文摘 | Wagenlehner FM Naber KG Weidner W | 2008 | Med MonatsschrPharm2008，31，： | 1 |
| 9 | Urinary inlection stones 显示文摘 | Biehler KH Eipper E Naber K | 2002 | Int J Antimicrob Agents2002，19，： | 1 |
| 10 | Role of fluoroquinolones in the treatment of serious bacterial urinary tract infection显示文摘 | CARSON C NABER KG | 2004 | Drugs2004，64，12： | 1 |
| 11 | EAU guide-lines for the management of urinary and male genital tractinfections显示文摘 | Naber KG Bergman B Bishop MC | 2001 | Eur Urol2001，40，5： | 1 |
| 12 | Nutrient and drug effects on cholesterol metabolism in the laying hen 显示文摘 | NABER E C | 1983 | Federation Proceedings1983，42，： | 1 |
| 13 | Zinc exchange by blood cells in nearly physiologic standard conditions显示文摘 | Ton H. J. Naber Cornelis J. A. Hamer Wim J. M. Broek Hennie Roelofs | 1994 | Biological Trace Element Research (-)1994，，1： | 1 |
| 14 | EAU guidelines for the management of genitourinary tuberculosis显示文摘 | Cek M Lenk S Naber K G | 2005 | Eur Urol2005，48，3： | 1 |
| 15 | Induction, localization and metal content of hydrogenase in green alga Chlamydomonas reinhardtii显示文摘 | Happe T Mosler B Naber J D | 1994 | Eur J Biochem1994，222，： | 1 |
| 16 | Treatment of severe agintation with olanzapine in 166 patientswith sehizoaffeetive, or bipolar I diaorder显示文摘 | Lambert M Huber CG Naber D etal | 2008 | Pharmaeopsyehat2008，41，5： | 1 |
| 17 | Chlamydial infections in urology显示文摘 | Wagenlehner FM Weidner W Naber KG | 2006 | World J Urol2006，24，1： | 1 |
| 18 | Pressure ulcers and the home health aide:e-valuation of an educational program显示文摘 | Naber JL Perlou M | 2008 | Home Healthe Nurse2008，26，5： | 1 |
| 19 | Nutrient and drug efleets on cholesterol metabolism in the laying hen显示文摘 | Naber E C | 1983 | Federation Proc1983，42，： | 1 |
| 20 | Pharmacokinetic characteristics of antimicrobials and optimal treatment of urosepsis显示文摘 | Wagenlehner FM Weidner W Naber KG | 2007 | Clin Pharmacokinet2007，46，4： | 1 |
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