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| 1 | 非高密度脂蛋白胆固醇、载脂蛋白A-I及B100、标准脂质测量、脂质比值以及CRP作为女性心血管病危险因素的临床用途显示文摘背景:关于不同脂质测定、非高密度脂蛋白胆固醇(non-HDL-C)、脂质比值、载脂蛋白和C-反应蛋白(CRP)的临床应用,现行心血管危险检测指南仍有争议。
目的:直接比较总胆固醇(totalcholesterol,TC)、低密度脂蛋白胆固醇(LDL-C)、HDL-C、non-HDL-C、载脂蛋白A-I(apoA-I)及B100(apoB100)、高敏C-反应蛋白(高敏CRP)以及TC与HDL-C、LDL-C与HDL-C、apoB100与apoA-I、apoB100与HDL-C比值,在妇女作为将来心血管事件预测指标的临床用途。
设计、地点及参试者:于15 632例起始健康美国妇女进行的前瞻性队列研究。1992年11月至1995年7月人组时年龄≥45岁(4分位范围48~59岁)。所有参试者均经10年随访,观察将来心血管事件的发生情况。
主要观测指标:按照各项生化指标不同基线值而确定的首次主要心血管事件(n=4 764)的风险比(hazard ratios,HRs)及95%可信区间(confidence intervals,CIs)。
结果:在校正年龄、吸烟状况、血压、糖尿病及体重指数后,测量结果在最高5分位者将来发生心血管事件的风险比LDL-C为1.62(95%CI,1.17~2.25),apoA-I为1.75(95%CI,1.30~2.38),TC为2.08(95%CI,1.45~2.97),HDL-C为2.32(95%CI,1.64~3.33),apoB100为2.50(95%CI,1.68~3.72),non-HDL-C为2.51(95%CI,1.69~3.72),高敏CRP为2.98(95%CI,1.90~4.67)(P<0.001,趋势贯穿所有5分位)。脂质比值风险比,apoBl00与apoA-I为3.01(95%CI,2.01~4.50),LDL-C与HDL-C为3.18(95%CI,2.12~4.75),apoB100与HDL-C为3.56(95%CI,2.31~5.47),TC与HDL-C为3.81(95%CI,2.47~5.86)(P<0.001,趋势贯穿所有5分位)。高敏CRP与脂质参数的相关系数范围为-0.33到0.15,以CRP<1、1~3和>3 ms/L为临床分割点,可对每项脂质测量及脂质比值水平增加提供预后危险信息。
结论:non-HDL-C以及TC与HDL-C比值对将来心血管事件的预测效果与载脂蛋白相同或者更好。校正年龄、血压、吸烟、糖尿病和肥胖后,高敏CRP提供的预后信息超越各项脂质测量。 | Paul M Ridker Nader Rifai Nancy R.Cook Gary Bradwin Julie E Buring 徐成斌(译) | 2006 | 美国医学会杂志(中文版)2006，25，3： | 3 |
| 2 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 3 | Additive value of immunoassay-measured fibrinogen and high- sensitivity C-reactive protein levels for predicting incident cardiovascular Events 显示文摘 | Samia Mora Nader Rifai Julie E Buring | 2006 | Circulation2006，114，： | 1 |
| 4 | Metastatic sacral tumors显示文摘 | Nader R Rhines LD Mendel E | 2004 | Neurosurg Clin N Am2004，15，4： | 1 |
| 5 | Effect of perorallyad ministered Lactobacillus macrophage activation in mice 显示文摘 | Perdigon G Nader de Macias M E Alvarez S | 1986 | Infect Immun1986，53，： | 1 |
| 6 | Shell's flue gas desulfurization process显示文摘 | Dautaenberg F W Nader J E | 1971 | Chem Eng Prog1971，67，8： | 1 |
| 7 | Blood Pressure,C- Reactive Protein, and Risk of Future Cardiovascular Events显示文摘 | Blake Gavin J Rifai Nader Buring Julie E | 2003 | Circulation2003，108，24： | 1 |
| 8 | Physical, sexual, and psychological violence in a gynaecological-psychosomatic outpatient sample: Prevalence and implications for mental health显示文摘 | Leithner K Assem-Hilger E~ Naderer A | 2009 | Eur J Obstet Gynecol Reprod Biol2009，144，2： | 1 |
| 9 | Physical, sexual, and psychological violence in a gynaecological-psychosomatic outpatient sample: Prevalence and implications for mental health显示文摘 | Leithner K Assem Hilger E Naderer A | 2009 | Eur J Obst Gynecol Reprod Biol2009，144，2： | 1 |
| 10 | Polycystic ovary syndrome,oral contraceptives and metabolic issues:new perspectives and a unifying hypothesis显示文摘 | Nader S Diamanti-Kandarakis E | | 0，，02： | 1 |
| 11 | Quantification and prediction of the 3D pore network evolution in carbonate reservoir rocks显示文摘 | Boever E D Varloteaux C Nader F H | 2012 | Oil & Gas Science and Technology2012，67，1： | 1 |
| 12 | Influence of probiotic va- ginal lactobacilli on in vitro adhesion of urogenital pathogens to vaginal epithelial cells显示文摘 | ZARATE G NADER MACIAS M E | 2006 | Lett Appl Microbiol2006，43，2： | 1 |
| 13 | Investigation of particle size and amount of alumina on microstructure and mechanical properties of matrix composite made by power metallurgy显示文摘 | Mehdi R Nader P Naser E | 2010 | Materials Science and Engineering A2010，527，45： | 1 |
| 14 | Fasting compared with non fasting lipids and apolipoproteins for predicting incident cardi- ovascular events显示文摘 | Samia M Nader R Julie E | 2008 | Circulation2008，118，： | 1 |
| 15 | Inflammation and Progressive Nephropathy in Type 1 Diabetes in the Diabetes Control and Complications Trial显示文摘 | Lin Julie Glynn Robert J Rifai Nader Manson JoAnn E Ridker Paul M Nathan David M Schaumberg Debra A | 2008 | Diabetes Care2008，，12： | 1 |
| 16 | Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus 显示文摘 | Amorapanth P LeDoux J E Nader K | 2000 | Nat Neurosci2000，3，1： | 1 |
| 17 | Thin absorbing screens using metarnaterial sur-faces显示文摘 | Nader E | 2002 | IEEE2002，2，： | 1 |
| 18 | Optimum active vehicle suspensions with actuator time delay显示文摘 | Nader J Ebrahim E | 2001 | Transactions of the ASME2001，123，： | 1 |
| 19 | Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval 显示文摘 | NADER K SCHAFE G E LE DOUX J E | 2000 | Nature2000，406，6797： | 1 |
| 20 | Metastatic sacral tumors 显示文摘 | Nader R Rhines LD Mendel E | 2004 | Neurosurg Clin N Am2004，15，： | 1 |
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