|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Autoimmune thrombocytopenia in response to splenectomy in cirrhotic patients with accompanying hepatitis C显示文摘瞄准:估计自体免疫的血小板减少的贡献到丙肝病毒相关的肝肝硬化(类型 C 肝硬化) ,我们在联系血小板的免疫球蛋白 G (PAIgG ) 层次和血小板数字之上评估了脾切除术的影响。方法:PAIgG 乳头 ers 和有免疫力的标记与一口未经触动的怒气与一口未经触动的怒气,提交到脾切除术的 17 个类型 C 肝脏硬化症的病人,和 21 non-C 肝硬化在 24 个类型 C 肝脏硬化症的病人被决定。结果:血小板减少(PLT <
15 x 10 (4 )/microL ) 在类型 C,肝硬化与一口未经触动的怒气在所有病人被诊断,提交到脾切除术的 8 个病人,并且在有未经触动的怒气的 19 non-C 肝硬化。在超过 25.0 ng/10 (7 ) 的 PAIgG 的提高的乳头 ers 房间除了一个 splenectomized 病人在所有肝脏硬化症的病人被检测。PAIgG 乳头 ers (ng/10 (7 ) 房间) 与 splenectomized 病人(125.6+/-87.8 ) 或 non-C 肝硬化(152.4+/-127.4 ) 相比在有一口未经触动的怒气(247.9+/-197.0 ) 的类型 C 肝硬化是显著地更高的。PAIgG 乳头 ers 否定地与一口未经触动的怒气在类型 C 肝脏硬化症的病人与血小板计数被相关。与有一口未经触动的怒气的类型 C 肝硬化比较, splenectomized 病人有减少的 CD4/CD8 比率和浆液 neopterin 层次。怒气索引(cm2 ) 否定地在 non-C 肝硬化,然而并非在类型 C 肝硬化与血小板计数被相关。结论:我们的数据显示自体免疫的机制在由 HCV 积极的肝硬化复杂的血小板增多起一个重要作用。另外,脾切除术可以损害 T 房间功能通过,至少部分地, CD4/CD8 比率的减小,因而压制 PAIgG 生产。 | Tetsuro Sekiguchi Takeaki Nagamine Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，8： | 16 |
| 2 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 3 | 中国冬播小麦面粉颗粒度分布及近红外透射光谱测试技术研究显示文摘面粉颗粒度是影响小麦食品加工品质的重要性状。以2 0 0 1- 2 0 0 2年度来自北部冬麦区、黄淮冬麦区、长江中下游冬麦区和西南冬麦区的2 5 6份小麦品种(系)为材料,用激光散射颗粒度分析仪和近红外透射光谱技术对面粉颗粒度进行了研究。结果表明,我国小麦面粉颗粒度分布特点为从北向南,硬质麦分布比例逐渐减少,软质麦分布比例逐渐增大。总体上硬质麦所占比例较高,为5 9. 4 % ,软质麦和混合麦所占比例分别为2 8 .1%和12 .5 %。近红外预测集模型决定系数为0 92 ,与激光散射颗粒度分析仪测试结果之间呈极显著正相关。在建立模型时,采用预测残差平方和及交叉验证处理方法进行了主成分数目选择,并对定标集样品中浓度超常样品和光谱超常样品做2次删除,删除样品数占总样品数的4 .1% ,使定标模型决定系数RSQ从0 . 82提高到0. 92 ,标准误差SEC从12 . 75下降到8 .5 4 ,提高了模型的预测精度,优化了定标模型。此外,根据我国小麦颗粒度大小分布的特点,建立了各麦区的定标模型,其可靠性优于以总参试样品建立的模型。 | 陈锋 Nagamine T 张艳 何中虎 王德森 Hisashi Yoshida | 2005 | 作物学报2005，31，3： | 5 |
| 4 | Reduction of virus burden-induced splenectomy in patients with liver cirrhosis related to hepatitis C virus infection显示文摘瞄准:检验丙肝病毒(HCV ) 在在脾切除术以后的肝脏硬化症的病人的层次和免疫学的标记。方法:HCV RNA 乳头 ers 以及细胞、体液的有免疫力的标记与一口未经触动的怒气在脾切除术以后并且在 32 肝脏硬化症的控制在 20 个肝脏硬化症的病人被决定。结果:浆液 HCV RNA 乳头 ers 比在控制在 splenectomized 病人是更低的(186+/-225 x 10 (3 ) copies/mL 对 541+/-417 x 10 (3 ) copies/mL, P<0.01 ) 。HCV RNA 被判定到自发地控制在 4 个 splenectomized 病人,但是在没有被根除了。自然漂亮房间活动比在控制在 splenectomized 病人是更高的(41.2+/-19.3% 对 24.7+/-15.3% , P<0.01 ) ,并且除了在那些,自然漂亮房间活动否定地与血清型 2-related 感染在 splenectomized 病人被相关到 HCV RNA 乳头 ers。CD4/CD8 比率比在控制在 splenectomized 病人是显著地更低的。结论:调查结果建议那脾切除术可以减少在有 HCV 感染的肝脏硬化症的病人的病毒负担至少部分地,通过自然漂亮房间活动的扩大。 | Tetsuro Sekiguchi Takeaki Nagamine Hitoshi Takagi Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，13： | 4 |
| 5 | Contribution of the toxic advanced glycation end-productsreceptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common malignancies worldwide. The main etiologies of HCC are hepatitis B virus and hepatitis C virus(HCV), and non-hepatitis B/non-hepatitis C HCC(NBNCHCC) has also been identified as an etiological factor. Although the incidence of HCV-related HCC in Japan has decreased slightly in recent years, that of NBNC-HCC has increased. The onset mechanism of NBNC-HCC, which has various etiologies, remains unclear; however, nonalcoholic steatohepatitis(NASH), a severe form of nonalcoholic fatty liver disease, is known to be an important risk factor for NBNC-HCC. Among the different advanced glycation end-products(AGEs) formed by the Maillard reaction, glyceraldehyde-derived AGEs, the predominant components of toxic AGEs(TAGE), have been associated with NASH and NBNC-HCC, including NASH-related HCC. Furthermore, the expression of the receptor for AGEs(RAGE) has been correlated with the malignant progression of HCC. Therefore, TAGE induce oxidative stress by binding with RAGE may, in turn, lead to adverse effects, such as fibrosis and malignant transformation, in hepatic stellate cells and tumor cells during NASH or NASH-related HCC progression. The aim of this review was to examine the contribution of the TAGE-RAGE axis in NASH-related HCC. | Jun-ichi Takino Kentaro Nagamine Takamitsu Hori Akiko Sakasai-Sakai Masayoshi Takeuchi | 2015 | World Journal of Hepatology2015，7，23： | 4 |
| 6 | Detection of Loop-Mediated Isothermal Amplification Reaction by Turbidity Derived from Magnesium Pyrophosphate Formation显示文摘 | Yasuyoshi Mori Kentaro Nagamine Norihiro Tomita Tsugunori Notomi | 2001 | Biochemical and Biophysical Research Communications2001，，1： | 3 |
| 7 | Simultaneous recording of epileptiform discharges by MEG and subdural electrodes in temporal lobe epilepsy显示文摘 | Mikuni N Nagamine T Ikeda A | 1997 | Neuroimage1997，5，4： | 2 |
| 8 | Rapamycin inhibition of the G1 to S transition is mediated by effects on eyclin D1 mRNA and protein stability显示文摘 | Hashemolhosseini S Nagamine Y Morley S J | 1998 | J Biol Chem1998，273，14： | 1 |
| 9 | Identification of new puroindoline genotypes and their relationship to flour texture among wheat cultivars显示文摘 | Ohnishi N Nagamine T | 2005 | Journal of Cereal Science2005，41，： | 1 |
| 10 | Accelerated reaction by loop-mediated isothermal amplication using loop primers显示文摘 | Hase T Notomi T | 2002 | Molecular and Cellular Probes2002，16，： | 1 |
| 11 | Detection of loop-mediated isothermal amplification reaction by turbidity derived from magnesium pyrophosphate formation显示文摘 | Nagamine K Tomita N | 2001 | Biochem Biophys Res Commun2001，289，1： | 1 |
| 12 | Effects of androgenic gland ablation on male primary and secondary sexual characteristics in the Malaysian prawn,Macrobrachium rosenbergii(de Man)(Decapoda Palaemomidae),with first evidence of induced feminization in a non-hermaphroditic decapod显示文摘 | Nagamine C Knight A W Maggenti A | 1980 | Gen Comp Endocrinol1980，41，4： | 1 |
| 13 | Rumen bacterial diversity as determined by sequence analysis of 16S rDNA libraries显示文摘 | TAJIMA K AMINOV R I NAGAMINE H | 1999 | FEMS Microbiology and Ecology1999，29，： | 1 |
| 14 | Distinct and Overlapping Patterns of Localization of Bone Morphogenetic Protein(BMP) Family Members and a BMP Type Ⅱ Receptor During Fracture Healing in Rats显示文摘 | T Onishi Y Ishidou T Nagamine | 1998 | Bone1998，22，6： | 1 |
| 15 | Detection of loop-mediated isothermal amplification reaction by turbidity derived from magnesium pyrophosphate formation 显示文摘 | Mori Y Nagamine K Tomita N | 2001 | Biochem Biophys Res Commun2001，289，1： | 1 |
| 16 | Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet显示文摘 | Wataru Motomura Mitsutaka Inoue Takaaki Ohtake Nubuhiko Takahashi Miho Nagamine Satoshi Tanno Yutaka Kohgo Toshikatsu Okumura | 2005 | Biochemical and Biophysical Research Communications2005，，4： | 1 |
| 17 | Induction of gamma delta T cells using zoledronate plus interleu- kin-2 in patients with metastatic cancer显示文摘 | Nagamine I Yamaguchi Y Ohara M | 2009 | Hiroshima J Med Sci2009，58，1： | 1 |
| 18 | Accelerated reaction by loop-mediated isothermal amplification using loop primers显示文摘 | Nagamine K Hase T Notomi T | 2002 | Mol Cell Probes2002，16，3： | 1 |
| 19 | Effectiveness of instillationof triamcinolone acetonide into the middle ear for eo-sinophilic otitis media associated with bronchial asth-ma 显示文摘 | UNO Y NAGAMINE H | 2006 | Ann Allergy Asthma Immunol2006，97，： | 1 |
| 20 | Genetic relationships among Japanese native breeds of chicken based on microsatellite DNA polymorphisms显示文摘 | TAKAHASHI H NIRASAWA K NAGAMINE Y | 1998 | The Journal of Heredity1998，89，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员