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| 1 | Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N -substituted-2-(4-phenylethynyl-phenyl)-1 H -benzimidazoles and N -substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1 H -benzimidazoles显示文摘 | Ramanatham Vinodkumar Sanjay Dashrath Vaidya Bobba Venkata Siva Kumar Umesh Nanasaheb Bhise Shekhar Bhaskar Bhirud Uday Chandrakant Mashelkar | 2007 | European Journal of Medicinal Chemistry2007，，5： | 1 |
| 2 | Some new results on time-varying Stratonovich and Itô bilinear stochastic systems显示文摘The bilinear stochasticity of dynamical systems is attributed to the input–output coupling term,where the input is a random input and the state is the output of dynamical systems.Stochastically influenced bilinear systems are described via bilinear stochastic differential equations.In this paper,first we construct a mathematical method for the closed-form solution to a scalar Stratonovich time-varying bilinear stochastic differential equation driven by a vector random input as well as the Itôcounterpart.Second,the analytic results of the paper are applied to an electrical circuit that assumes the structure of a bilinear stochastic dynamic circuit.The noise analysis of the bilinear dynamic circuit is achieved by deriving the mean and variance equations as well.The theory of this paper hinges on the‘Stratonovich calculus’,conversion of the Stratonovich integral into the Itôintegral and characteristic function of the vector Brownian motion.The results of this paper will be useful for research communities looking for estimation and control of bilinear stochastic differential systems. | Nanasaheb S.Patil Shambhu N.Sharma | 2014 | Journal of Control and Decision2014，1，4： | 0 |
| 3 | An evaluation of garlic lectin as an alternative carrier domain for insecticidal fusion proteins显示文摘甘露糖绑定 lectin GNA (雪花莲 lectin ) 被用作一个“搬运人”在在口头的摄取以后穿过昆虫内脏的杀虫的熔化蛋白质的领域。从大蒜灯泡的类似的 lectin, ASAII,作为一种选择被评估了“搬运人”。口头上地送到卷心菜蛾的幼虫的 Recombinant ASAII (Mamestra 黄铜集成通信适配器;鳞翅目) 随后在 haemolymph 被检测,示威运输。包括昆虫神经毒素的熔化蛋白质, ButaIT (Buthus tamulus 杀虫的毒素;红蝎子毒素) 连接了到 ASAII 的 C 终端区域或 GNA 被表示在 Pichia 作为 recombinant 蛋白质(GNA/ButaIT 和 ASA/ButaIT ) 生产牧师。在两个盒子中, lectin 的 C 终端顺序被截断避免 translational 以后解朊作用。包含 GNA 熔化蛋白质由到卷心菜蛾幼虫的注射是有毒的(LD 50≈250 μg/g ) ,并且当美联储在幸存和生长上有否定效果时。它也减少了谷物蚜虫的幸存(Sitobion 一根静脉;Homoptera ) 从出生不满一月的婴儿到由 >70% 的成年人当喂时。相反, ASA-ButaIT 熔化蛋白质对蚜虫无毒,并且没在鳞翅类的幼虫上有效果,当注射时或当喂时。然而,未经触动的 ASA-ButaIT 熔化蛋白质在卷心菜蛾幼虫追随者摄取的 haemolymph 是在场的,证明熔化的那运输发生了。到在在注射或摄取以后的 vivo 的解朊作用的 GNA/ButaIT 和 ASA/ButaIT 的稳定性不同,并且这可以是在决定杀虫的活动的一个因素。 | Elaine Fitches Judith Philip Gareth Hinchliffe Leisbeth Vercruysse Nanasaheb Chougule John A. Gatehouse | 2008 | Insect Science2008，15，6： | 0 |
| 4 | CD44 and CD221 directed magnetic cubosomes for the targeted delivery of helenalin to rhabdomyosarcoma cells显示文摘Confining chemotherapy to tumour sites by means of active targeting nanoparticles(NPs)may increase the treatment effectuality while reducing potential side effects.Cubosomes are one of the next-generation drug delivery nanocarriers by virtue of their biocompatibility and bioadhesion,sizeable payload encapsulation and high thermostability.Herein,an active tumour targeting system towards rhabdomyosarcoma(RMS)cells was evaluated.Cubosomes were loaded with helenalin(a secondary metabolite from Arnica plants),which we have previously shown to induce apoptosis in RMS cells.The functionalization of the cubosomes was accomplished to enable binding to membrane receptors and translocation under a magnetic field.RMS cells overexpress CD44 and CD221 on their membrane surface and,therefore,hyaluronic acid(HA,a ligand for CD44)and antibodies(Abs)against CD221 were coupled to cubosomes via electrostatic attraction and the thiol-Michael reaction,respectively.Magnetization of the cubic phase NPs was achieved by embedding superparamagnetic iron oxide NPs(SPIONPs)into the cubic matrix.Single-function and multi-function cubosomes had Im3m cubic phase structures with well-organized lattice patterns.Conjugation with 2%HA or anti-CD221 half Abs and/or 1%SPIONPs showed significantly higher uptake into RMS cells compared to unfunctionalized cubosomes.CD44 and CD221 directed magnetic(triple-function)cubosomes were capable of internalizing into RMS cells in an energy-independent mechanism.Helenalin-laden triple functionalized cubosomes showed limited impact on the viability of control fibroblast cells,while they induced a high degree cytotoxicity against RMS cells.Profound tumour cell death was observed in both two-dimensional(2D)culture and three-dimensional(3D)tumour spheroids. | Hakmin Mun Yuriy Chaban Tanveer A.Tabish Nanasaheb Thorat Nathan Cowieson CDavid Owen Helen E.Townley | 2023 | Nano Research2023，16，2： | 0 |
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